Gan Pub Date : 1984-11-01

M Bessho, I Jinnai, K Hirashima, K Tanaka, H Tanooka

引用次数: 0

Correlation between drug sensitivity determined by clonogenic cell assay and clinical effect of chemotherapy in patients with primary lung cancer. 原发肺癌患者克隆细胞测定药物敏感性与化疗临床效果的相关性研究。

Gan Pub Date : 1984-11-01

E Shimizu, N Saijo, F Kanzawa, A Hoshi, K Eguchi, T Shinkai, K Tominaga, Y Sasaki, J Fujita, H Nomori

{"title":"Correlation between drug sensitivity determined by clonogenic cell assay and clinical effect of chemotherapy in patients with primary lung cancer.","authors":"E Shimizu, N Saijo, F Kanzawa, A Hoshi, K Eguchi, T Shinkai, K Tominaga, Y Sasaki, J Fujita, H Nomori","doi":"","DOIUrl":"","url":null,"abstract":"Correlation studies between the sensitivity of tumor cells determined by clonogenic cell assay and the clinical effect of chemotherapy were performed in patients with primary lung cancer. Thirty-four of 48 patients showed adequate colony formation (greater than or equal to 30 colonies) to test in vitro chemosensitivity. Colony formation of tumor specimens did not differ with regards to prognostic factors such as sex, age, stage, performance status, and prior chemotherapy. The two criteria of in vitro chemosensitivity employed were greater than 70% and 50% reduction in colony numbers. When in vitro chemosensitivity was defined as a colony reduction of greater than 50%, the true positive rate in the assay was 57%, while the true negative rate was 85%. In this case, the predictive accuracy was 79%. When in vitro chemosensitivity was defined as a colony reduction of greater than 70%, the true positive rate for the assay was 100%, while the true negative rate was 81%. In this case, the predictive accuracy was 82%. By Fisher's exact probability test, the overall in vitro/in vivo correlation was statistically significant (P = 0.042 less than 0.05) with the 50% cut-off point, but was not significant (P = 0.053 greater than 0.05) with the 70% cut-off point.","PeriodicalId":12660,"journal":{"name":"Gan","volume":"75 11","pages":"1030-5"},"PeriodicalIF":0.0,"publicationDate":"1984-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17574880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic preparation and structure determination of QGI, one of the quinoline-DNA base adducts formed in cells treated with 4-nitroquinoline 1-oxide. 喹啉- dna碱基加合物QGI的仿生制备及结构测定。QGI是一种在4-硝基喹啉- 1-氧化物处理的细胞中形成的碱基加合物。

Gan Pub Date : 1984-11-01

M Tada, K H Kohda, Y Kawazoe

引用次数: 0

A new strain of Epstein-Barr virus derived from nasopharyngeal carcinoma hybrid cells. 从鼻咽癌杂交细胞中分离得到一株新的eb病毒。

Gan Pub Date : 1984-11-01

T Takimoto, H Ogura, H Sato, M Hatano

引用次数: 0

Stable intestinal phenotypic expression of gastric and small intestinal tumor cells induced by N-methyl-N'-nitro-N-nitrosoguanidine or methylnitrosourea in rats. n -甲基-n '-硝基-n -亚硝基胍或甲基亚硝基脲诱导大鼠胃和小肠肿瘤细胞的稳定肠道表型表达

Gan Pub Date : 1984-11-01

M Tatematsu, T Katsuyama, C Furihata, H Tsuda, N Ito

{"title":"Stable intestinal phenotypic expression of gastric and small intestinal tumor cells induced by N-methyl-N'-nitro-N-nitrosoguanidine or methylnitrosourea in rats.","authors":"M Tatematsu, T Katsuyama, C Furihata, H Tsuda, N Ito","doi":"","DOIUrl":"","url":null,"abstract":"On the basis of paradoxical concanavalin A (Con A) staining, the tendency of tumor cells of gastric phenotype to shift to intestinal phenotype and the stability of the latter phenotype in stomach tumors of different sizes were examined quantitatively with an image processor. Phenotypic expression of tumors of the small intestine was also studied. One hundred male Wistar rats were given N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) at 50 micrograms/ml in their drinking water for 20 weeks (group 1). Twenty male F344 rats were given methylnitrosourea (MNU) at a dose of 50 mg/kg ip twice a week for 2 weeks (group 2). Rats in group 1 were killed in week 50 of the experiment and rats in group 2 were killed in week 25. In group 1, the percentage areas of intestinal-type cells in small, medium and large adenocarcinoma of the stomach were 0.5, 2.7 and 6.6%, the differences between these values being significant (P less than 0.05-0.01). Intestinal phenotypic expression of tumor cells of the stomach is stable and the proportion of intestinal-type cells in adenocarcinomas of the stomach is higher in the larger tumors. Adenomatous hyperplasias and adenocarcinomas of the small intestine in groups 1 and 2 were all composed entirely of cells of the intestinal type. These results suggested that intestinal-type cells in adenocarcinoma of the stomach did not originate from intestinal metaplasias but from gastric-type cells in stomach adenocarcinomas.","PeriodicalId":12660,"journal":{"name":"Gan","volume":"75 11","pages":"957-65"},"PeriodicalIF":0.0,"publicationDate":"1984-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17574882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Species difference between rats and mice in activities of enzymes activating aromatic amines: effect of dietary 3-methoxy-4-aminoazobenzene. 大鼠和小鼠活化芳香胺酶活性的物种差异:饲粮3-甲氧基-4-氨基偶氮苯的影响。

Gan Pub Date : 1984-11-01

M Degawa, M Kojima, Y Hashimoto

引用次数: 0

Increased incorporation of 5-fluorodeoxyuridine into DNA of human T-lymphoblastic cell lines. 人t淋巴母细胞DNA中5-氟脱氧尿苷掺入增加。

Gan Pub Date : 1984-11-01

M Tanaka, K Kimura, S Yoshida

引用次数: 0

Modifying potential of thirty-one chemicals on the short-term development of gamma-glutamyl transpeptidase-positive foci in diethylnitrosamine-initiated rat liver. 31种化学物质对二乙基亚硝胺引发的大鼠肝脏γ -谷氨酰转肽酶阳性灶短期发展的修饰潜力。

Gan Pub Date : 1984-10-01

H Tsuda, R Hasegawa, K Imaida, T Masui, M A Moore, N Ito

{"title":"Modifying potential of thirty-one chemicals on the short-term development of gamma-glutamyl transpeptidase-positive foci in diethylnitrosamine-initiated rat liver.","authors":"H Tsuda, R Hasegawa, K Imaida, T Masui, M A Moore, N Ito","doi":"","DOIUrl":"","url":null,"abstract":"The modifying potential of 31 different compounds on the development of gamma-glutamyl transpeptidase-positive (gamma-GT+) liver cell lesions was compared in an in vivo short-term assay system. Rats were initially given a single dose (200 mg/kg) of diethylnitrosamine intraperitoneally and 2 weeks later were treated with test compounds for 6 weeks and then sacrificed, all rats being subjected to partial hepatectomy at week 3. Modifying potential was scored by comparing the number and area (mm2)/cm2 of induced gamma-GT+ foci with those of the corresponding control group given DEN alone. 2-Acetylaminofluorene, 3'-methyl-4-dimethylaminoazobenzene, dimethylnitrosamine, phenobarbital, barbital, dipyrone and deoxycholic acid caused a significant enhancement of both the number and area of foci. 4-Acetylaminofluorene, ethionine, benzo[alpha]pyrene, disulfiram and cholic acid had a moderate enhancing effect, whereas slight, but not unequivocal, increases in gamma-GT+ foci were observed after captafol, glutathione, sodium ascorbate and taurine administration. In contrast, acetaminophen, ethoxyquin, butylated hydroxyanisole, butylated hydroxytoluene, and ethyl alcohol showed clear inhibitory effects. It is concluded that the present short-term in vivo system has practical application for the screening of modifying agents for liver tumorigenesis including hepatocarcinogens.","PeriodicalId":12660,"journal":{"name":"Gan","volume":"75 10","pages":"876-83"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17217364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell growth-inhibitory effects of derivatives of antitumor cyclic hexapeptide RA-V obtained from Rubiae radix (V). 茜草抗肿瘤环六肽RA-V衍生物的细胞生长抑制作用。

Gan Pub Date : 1984-10-01

H Itokawa, K Takeya, N Mori, M Takanashi, H Yamamoto, T Sonobe, S Kidokoro

引用次数: 0

Kinetics of nitrosation of thioproline, the precursor of a major nitroso compound in human urine, and its role as a nitrite scavenger. 硫脯氨酸的亚硝化动力学及其作为亚硝酸盐清除剂的作用，硫脯氨酸是人尿中一种主要亚硝基化合物的前体。

Gan Pub Date : 1984-10-01

T Tahira, M Tsuda, K Wakabayashi, M Nagao, T Sugimura

引用次数: 0

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