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Vascular Endothelial Growth Factor Supplementation Enhance Skin Antioxidant Capacity in Hyperglycemic Rats 补充血管内皮生长因子提高高血糖大鼠皮肤抗氧化能力
IF 0.9
gazi university journal of science Pub Date : 2023-01-01 DOI: 10.35378/gujs.1082697
Ebru Uzun, Doç. Dr. Barbaros Balabanli, Ş. C. Cevher
{"title":"Vascular Endothelial Growth Factor Supplementation Enhance Skin Antioxidant Capacity in Hyperglycemic Rats","authors":"Ebru Uzun, Doç. Dr. Barbaros Balabanli, Ş. C. Cevher","doi":"10.35378/gujs.1082697","DOIUrl":"https://doi.org/10.35378/gujs.1082697","url":null,"abstract":"The fundamental reasons for delayed wound healing in diabetic animals include inadequate production of growth factors or their increased devastation. Vascular Growth Factor (VEGF) has a biological role in the healing process of mucosal and skin wounds, especially in the process of new vessel formation. We planned to examine the oxidant-antioxidant events that occur during healing with topical VEGF application in diabetic rats. Experiments were performed 36 adults female Wistar albino rat diabetes induced by streptozotocin. The incisional wounds were made on the dorsal region in the rats. Rats were separated to 3 groups: the untreated (negative control) group (n=12), the chitosan group (n=12), the chitosan + VEGF group (n=12). The treatments were continued for 3 and 7 days, excluding the control and negative control groups. Then, the animals were sacrificed on the 3rd and 7th days of wound healing. Antioxidant and oxidant parameters in skin tissue were measured using biochemical methods. Topical VEGF application was decreased the NOx levels on the 3rd day compared to other groups. Moreover, it increased wound tissue GSH and AA levels, subsequently contributing to the enhance tissue antioxidant capacity. In conclusion, VEGF application increases the antioxidant capacity of the tissue and simultaneously reduces the oxidative stress and thus gives a positive acceleration to the wound healing process.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69795820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Approximate Solution of Singularly Perturbed Burger-Huxley Equation with RDTM 奇异摄动Burger-Huxley方程的近似解
IF 0.9
gazi university journal of science Pub Date : 2023-01-01 DOI: 10.35378/gujs.935885
D. Arslan
{"title":"The Approximate Solution of Singularly Perturbed Burger-Huxley Equation with RDTM","authors":"D. Arslan","doi":"10.35378/gujs.935885","DOIUrl":"https://doi.org/10.35378/gujs.935885","url":null,"abstract":"In this research, the numerical integral method procedure on uniform mesh is used to solve the singularly perturbed problem which has integral boundary value. This method also includes the trapezoid method, the finite difference method, and the Thomas algorithm. The problem is converted to finite difference problem by using finite difference approximations and trapezoid method. Finally, the convergence of the presented method is analyzed through sample application. Thus, the correctness and sufficiency of the method are shown.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69796523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suggesting A Stochastic Measurement Tool for Determining Crime and Safety Indexes: Evidence from Turkey 提出一种确定犯罪和安全指数的随机测量工具：来自土耳其的证据
IF 0.9
gazi university journal of science Pub Date : 2022-12-22 DOI: 10.35378/gujs.1110735
Hamit Erdal, Kemal Gürol Kurtay, Hakan Ayhan Dagistanli
{"title":"Suggesting A Stochastic Measurement Tool for Determining Crime and Safety Indexes: Evidence from Turkey","authors":"Hamit Erdal, Kemal Gürol Kurtay, Hakan Ayhan Dagistanli","doi":"10.35378/gujs.1110735","DOIUrl":"https://doi.org/10.35378/gujs.1110735","url":null,"abstract":"Crime is a phenomenon that disrupts the welfare and structure of society and has become an important problem in both developed and developing countries. In recent years, in parallel with the increasing rate of urbanization all over the world, there has been also a serious increase in crime rates. With the increasing crime rates, the fear of crime has emerged in the individuals who are part of the society. Fear of crime is the degree of anxiety an individual feels about the deterioration of the social structure. This degree of anxiety is expressed by crime and safety indices today. In this study, a new measurement tool is proposed in order to eliminate the effects such as emotional preference, decision-making difficulty, etc. For this purpose, the Stochastic Multi-Criteria Acceptability Analysis-TRI (SMAA-TRI) method, in which the measurement can be made with interval and dispersed values, and the probability theory can be reflected as an effect on the decision analysis, has been utilized to measure the crime and safety indices, determined by online survey up to now, because of the fact that the experts/participants had difficulties in expressing their preferences clearly during their evaluations. It has been determined that the index values obtained as a result of the study coincide with the results of the surveys made with thousands of people and that the SMAA-TRI method can be used effectively in determining the crime/safety indices.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44287244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Hybrid Algorithm for Flow Shop Scheduling Problem with Unavailable Time Periods and Additional Resources 具有不可用时间段和额外资源的Flow Shop调度问题的混合算法
IF 0.9
gazi university journal of science Pub Date : 2022-12-21 DOI: 10.35378/gujs.1108155
F. Özçeli̇k, T. Saraç
{"title":"A Hybrid Algorithm for Flow Shop Scheduling Problem with Unavailable Time Periods and Additional Resources","authors":"F. Özçeli̇k, T. Saraç","doi":"10.35378/gujs.1108155","DOIUrl":"https://doi.org/10.35378/gujs.1108155","url":null,"abstract":"In machine scheduling problems, not all machines are always available. They may be interrupted periodically for reasons such as planned maintenance, lunch and rest breaks. However, this situation is often ignored in the literature or these time periods are considered as fixed. In this study, flow shop scheduling problem with unavailable time periods is discussed. In the considered problem, unavailable time periods are not fixed, they can be pulled forward to prevent the idle times. A MIP model and a genetic algorithm have been developed for the considered problem. The performance of the proposed solution methods is demonstrated using randomly generated test problems. With the developed genetic algorithm, GAMS results are improved by an average of 26,82%.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49036462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discretization and Stability Analysis for a Generalized Type Nonlinear Pharmacokinetic Models 一类广义非线性药代动力学模型的离散化及稳定性分析
IF 0.9
gazi university journal of science Pub Date : 2022-12-19 DOI: 10.35378/gujs.1027381
M. Kocabiyik, Mevlüde YAKIT ONGUN
{"title":"Discretization and Stability Analysis for a Generalized Type Nonlinear Pharmacokinetic Models","authors":"M. Kocabiyik, Mevlüde YAKIT ONGUN","doi":"10.35378/gujs.1027381","DOIUrl":"https://doi.org/10.35378/gujs.1027381","url":null,"abstract":"Estimating effects of drugs at different stages is directly proportional to the duration of recovery and duration of pulling through with the disease. For this reason, solving Pharmacokinetic models that investigate these effects is very important. In this study, numerical solutions of this type of one, two and three compartment nonlinear Pharmacokinetic models have been studied. Distributed order differential equations are used for the solution of the model. Numerical solutions have been found with the density function contained in distributed order differential equations and different values of this function. A Nonstandard finite difference scheme has been used for numerical solutions. Finally, stability analysis of equilibrium points of obtained discretized system has also been expressed with the help of the Schur-Cohn criteria.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44032004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical modeling of buckling of carbon nanotubes reinforced sandwich-structured composite shells resting on elastic foundations 碳纳米管增强三明治结构复合材料壳弹性地基屈曲分析模型
IF 0.9
gazi university journal of science Pub Date : 2022-12-14 DOI: 10.35378/gujs.998265
A. Timesli
{"title":"Analytical modeling of buckling of carbon nanotubes reinforced sandwich-structured composite shells resting on elastic foundations","authors":"A. Timesli","doi":"10.35378/gujs.998265","DOIUrl":"https://doi.org/10.35378/gujs.998265","url":null,"abstract":"This article presents the buckling behavior of carbon nanotubes reinforced sandwich-structured composite shells supported by elastic foundations. The sandwich-structured configuration is composed of three layers, an isotropic core, and two nanocomposite face sheets. Carbon nanotubes fibers are applied to reinforce nanocomposite face sheets of sandwich composite shells. It is assumed that the distribution of reinforcements across the shell thickness is uniform or functionally graded. Under the assumption of the thin shell, the equilibrium equation of the buckling response of CNT-RSSC shells is obtained. The pre-buckling stresses by applying Airy’s stress function and an adjacent equilibrium criterion to establish the stability equation associated with the buckling state are obtained. The effects of different types of CNTs' reinforcement, volume fractions, geometrical parameters, core to face sheet thickness ratio, and elastic foundations on the mechanical buckling analysis are examined.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43783134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recommendations for Improvement of the Thermal Performance of an Office Building Based on Retrofitting the Glazed Curtain Wall 基于玻璃幕墙改造的办公楼热工性能改善建议
IF 0.9
gazi university journal of science Pub Date : 2022-12-08 DOI: 10.35378/gujs.997496
Neşe Di̇kmen, Canan Altundaş
{"title":"Recommendations for Improvement of the Thermal Performance of an Office Building Based on Retrofitting the Glazed Curtain Wall","authors":"Neşe Di̇kmen, Canan Altundaş","doi":"10.35378/gujs.997496","DOIUrl":"https://doi.org/10.35378/gujs.997496","url":null,"abstract":"Glazed curtain wall systems have become indispensable particularly in office buildings due to their light weight, aesthetic appearance, easy installation and resistance to climate conditions. Curtain walls however, also have problems in terms of thermal efficiency because of their wide, glazing windows and metal frames that have high thermal conductivity. The aim of this study is to offer proposals for improving the thermal performance of an office building with a glass curtain wall system built in a hot-humid climate zone. An office building constructed in Antalya, Turkey was modelled with the help of DesignBuilder energy simulation software and various modifications were made on the model in order to improve the thermal performance of the building. With the improvements proposed in the study, it is possible to decrease the annual thermal loads of the whole building by 6.6%, and the annual thermal loads of the space with the curtain wall by 33.2%. The study revealed that, applying an additional envelope is more effective than lowering the U-value of the glass of the curtain wall in terms of thermal performance improvement.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46020440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sintering of Iron Powders by Resistance Heating Technique 用电阻加热技术烧结铁粉
IF 0.9
gazi university journal of science Pub Date : 2022-12-05 DOI: 10.35378/gujs.1003395
F. Atar, A. Kurt
{"title":"Sintering of Iron Powders by Resistance Heating Technique","authors":"F. Atar, A. Kurt","doi":"10.35378/gujs.1003395","DOIUrl":"https://doi.org/10.35378/gujs.1003395","url":null,"abstract":"In this study, powder metal samples of 15x15x4 mm dimensions of Fe powders were produced at different pressures (650,850,1050 MPa) and were sintered in atmospheric environment with the help of resistance sintering method applied for the first time using electric resistance welding. The sintered and green densities of the powder metal samples were measured and their sinterability in the unprotected environment was examined. Powder metal specimens were sintered successfully with the electric resistance welding technique in an unprotected environment and high density values such as 98% were obtained. In addition, the effects of electric resistance heating technique on sintering were investigated by performing hardness analysis and microscopic examination of sintered samples.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45843692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of the Definition of Weld Penetration, Depth of Fusion and Throat Thickness on Fillet Welds 角焊缝熔深、熔深和喉道厚度定义的回顾
IF 0.9
gazi university journal of science Pub Date : 2022-12-01 DOI: 10.35378/gujs.1137178
Umut Yaşar Uzunali, H. Çuvalcı
{"title":"Review of the Definition of Weld Penetration, Depth of Fusion and Throat Thickness on Fillet Welds","authors":"Umut Yaşar Uzunali, H. Çuvalcı","doi":"10.35378/gujs.1137178","DOIUrl":"https://doi.org/10.35378/gujs.1137178","url":null,"abstract":"In this study, definitions of Weld Penetration (WP), Depth of Fusion (DOF) and Throat Thickness (TT) in fillet welds according to related standards are reviewed. WP, DOF and TT are crucial dimensions for welded joints since these values determine the weld quality. In AWS A3.0, ISO2553, Eurocode EN 1993-1-8 and DIN EN ISO 17659, these terms are defined, explained and shown in figures. Each standard makes its own definition related with WP, DOF and TT. Moreover, when looking at these standards, it is seen that definitions are always made in terms of unit of length. In some studies, assessment of fusion or penetration (FOP) rate on fillet welds is performed as the ratio of the maximum FOP depth to the material thickness. Depth assessment taking into consideration unit of length is not ideal for accurate evaluation of FOP rates especially on fillet welds. Method taking into consideration unit of area will be more suitable as it allows accurate assessment of FOP rates in welded joints. In this review, it is also suggested that the evaluation of FOP rate on fillet welds should be determined in terms of unit of area rather than length.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48735302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Hydrogen Diffusion Profile of Different Metallic Materials for a Better Understanding of Hydrogen Embrittlement 研究不同金属材料的氢扩散曲线，更好地理解氢脆
IF 0.9
gazi university journal of science Pub Date : 2022-11-21 DOI: 10.35378/gujs.1090824
M. F. Kapci, B. Bal
{"title":"Investigation of Hydrogen Diffusion Profile of Different Metallic Materials for a Better Understanding of Hydrogen Embrittlement","authors":"M. F. Kapci, B. Bal","doi":"10.35378/gujs.1090824","DOIUrl":"https://doi.org/10.35378/gujs.1090824","url":null,"abstract":"In this study, hydrogen diffusion profiles of different metallic materials were investigated. To model hydrogen diffusion, 1D and 2D mass diffusion models were prepared in MATLAB. Iron, nickel and titanium were selected as a material of choice to represent body-centered cubic, face-centered cubic, and hexagonal closed paced crystal structures, respectively. In addition, hydrogen back diffusion profiles were also modeled after certain baking times. Current results reveal that hydrogen diffusion depth depends on the microstructure, energy barrier model, temperature, and charging time. In addition, baking can help for back diffusion of hydrogen and can be utilized as hydrogen embrittlement prevention method. Since hydrogen diffusion is very crucial step to understand and evaluate hydrogen embrittlement, current set of results constitutes an important guideline for hydrogen diffusion calculations and ideal baking time for hydrogen back diffusion for different materials. Furthermore, these results can be used to evaluate hydrogen content inside the material over expensive and hard to find experimental facilities such as, thermal desorption spectroscopy.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69795962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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