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The myometrial-cervical ratio: Can a simple sonographic measurement improve diagnosis of adenomyosis in a regional setting? 子宫肌层-子宫颈比率:简单的超声波测量能否改善地区性子宫腺肌症的诊断?
IF 4.5 3区 地球科学
Geological Magazine Pub Date : 2024-02-01 Epub Date: 2023-04-20 DOI: 10.1177/1742271X231164591
Megan Sewell, Samantha Mooney, Erin Cvejic, Kate Stone
{"title":"The myometrial-cervical ratio: Can a simple sonographic measurement improve diagnosis of adenomyosis in a regional setting?","authors":"Megan Sewell, Samantha Mooney, Erin Cvejic, Kate Stone","doi":"10.1177/1742271X231164591","DOIUrl":"10.1177/1742271X231164591","url":null,"abstract":"<p><strong>Introduction: </strong>Adenomyosis is histologically defined by the presence of endometrial glands and stroma in the myometrium. Ultrasound findings of adenomyosis are being redefined to better diagnose adenomyosis pre-operatively.</p><p><strong>Methods: </strong>A single-centre retrospective study was performed at a regional hospital. The myometrial-cervical ratio was calculated on pre-operative ultrasounds, and histopathology reviewed for each case. Logistic regression was used to estimate the association between the myometrial-cervical ratio and adenomyosis confirmed on histopathology, and the area under the receiver operating characteristic curve was calculated. Comparisons were performed based on the presence of fibroids on ultrasound.</p><p><strong>Results: </strong>Complete data were available for 136 benign hysterectomies between 1 January 2015 and 31 December 2020. When the myometrial-cervical ratio was treated as a continuous variable in a logistic regression of adenomyosis on histopathology, there was no statistical evidence (χ<sup>2</sup>(1) < 0.01, <i>p</i> = 0.98) of an association. When cases including fibroids in the myometrial-cervical ratio were excluded, there was a non-significant association between myometrial-cervical ratio and adenomyosis on histopathology (odds ratio = 3.435, 95% confidence interval = 0.964, 12.235; χ<sup>2</sup>(1) = 3.62, <i>p</i> = 0.057); area under the receiver operating characteristic = 0.637 (95% confidence interval = 0.504, 0.770). The optimal myometrial-cervical ratio cutpoint was 1.875 (95% confidence interval = 1.698, 2.051), which achieved 71.43% sensitivity and 60.00% specificity. There was strong statistical evidence (χ<sup>2</sup>(1) = 9.02, <i>p</i> = 0.003) that the myometrial-cervical ratio outperformed standard pre-operative ultrasound identification of adenomyosis.</p><p><strong>Conclusion: </strong>While accuracy remains suboptimal, the myometrial-cervical ratio outperformed standard ultrasound diagnostic features of adenomyosis in a regional setting. The myometrial-cervical ratio may offer a simple imaging measurement for adenomyosis in inexperienced hands when fibroids are absent.</p>","PeriodicalId":12612,"journal":{"name":"Geological Magazine","volume":"79 1","pages":"19-26"},"PeriodicalIF":4.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78728826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The origin of the ultrahigh-pressure Tso Morari complex, NW Himalaya: implication for early Paleozoic rifting 喜马拉雅山西北部超高压措莫拉里复合体的起源:对古生代早期断裂的影响
IF 2.3 3区 地球科学
Geological Magazine Pub Date : 2024-01-25 DOI: 10.1017/s0016756824000025
Takeshi Imayama, Dripta Dutta, Keewook Yi
{"title":"The origin of the ultrahigh-pressure Tso Morari complex, NW Himalaya: implication for early Paleozoic rifting","authors":"Takeshi Imayama, Dripta Dutta, Keewook Yi","doi":"10.1017/s0016756824000025","DOIUrl":"https://doi.org/10.1017/s0016756824000025","url":null,"abstract":"<p>The origins and age distribution of the Himalayan high-pressure (HP) and ultrahigh-pressure (UHP) metamorphic rocks are critical for understanding the pre-Himalayan history. Although the protoliths to the UHP Tso Morari eclogites in Ladakh, NW Himalaya are believed to be the Permian Panjal volcanics, the geochronological evidence is absent. Here, we demonstrate that the protoliths of the UHP Tso Morari Complex formed in a continental rift setting at the Indian margin associated with the northern East Gondwana during the Early Paleozoic. Zircon U–Pb dates from eight gneisses and one garnet amphibolite indicate the Early Paleozoic bimodal magmatism of 493–476 Ma, which could be associated with the separation of South China from North India. Except for arc-related eclogites found in the Nidar ophiolite, the eclogites and amphibolites are rift-related, exhibiting enriched light rare earth elements and high concentrations of incompatible elements, along with evidence for crustal contamination. Our findings support the previously reported diversity in the sources and ages of the protoliths of the Himalayan HP–UHP metamorphic rocks along the orogen.</p>","PeriodicalId":12612,"journal":{"name":"Geological Magazine","volume":"3 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluctuation in redox conditions and the evolution of early Cambrian life constrained by nitrogen isotopes in the middle Yangtze Block, South China 华南长江中游区块氮同位素对氧化还原条件波动和寒武纪早期生命演化的制约
IF 2.3 3区 地球科学
Geological Magazine Pub Date : 2024-01-18 DOI: 10.1017/s0016756823000833
Kai Wei, Hansheng Cao, Fajin Chen, Zaiyun Wang, Zhihui An, Hanli Huang, Chunqing Chen
{"title":"Fluctuation in redox conditions and the evolution of early Cambrian life constrained by nitrogen isotopes in the middle Yangtze Block, South China","authors":"Kai Wei, Hansheng Cao, Fajin Chen, Zaiyun Wang, Zhihui An, Hanli Huang, Chunqing Chen","doi":"10.1017/s0016756823000833","DOIUrl":"https://doi.org/10.1017/s0016756823000833","url":null,"abstract":"The Ediacaran–Cambrian (E-C) transition (∼542–517 Ma) witnessed the rapid evolution of Cambrian animals, which was accompanied by carbon cycling anomalies and a significant increase in the concentration of oxygen in Earth’s atmosphere. The mechanisms stimulating the evolution of complex eukaryotes, however, remain problematic, especially concerning the link between biological evolution and contemporaneous changes in the oceanic environment. In this study, integrated δ<jats:sup>13</jats:sup>C<jats:sub>carb</jats:sub>–δ<jats:sup>13</jats:sup>C<jats:sub>org</jats:sub>–δ<jats:sup>15</jats:sup>N compositions were analysed from the YD-4 core samples to understand redox fluctuations and nitrogen cycling of the middle Yangtze Block across the E-C transition. Two negative δ<jats:sup>13</jats:sup>C<jats:sub>carb</jats:sub> excursions (N1 and N2) and a positive δ<jats:sup>13</jats:sup>C<jats:sub>carb</jats:sub> excursion (P1) are identified from the studied samples and are supposedly of primary origin. Constrained by of the U-Pb age, biolithology and pattern of isotopic variation, N1, P1 and N2 are comparable to the Basal Cambrian Carbon Isotope Excursion (BACE), Zhujiaqing Carbon Isotope Excursion (ZHUCE) and Shiyantou Carbon Isotope Excursion (SHICE). We interpreted the decreased δ<jats:sup>15</jats:sup>N values in this study as resulting from intensified atmospheric nitrogen fixation driven by enhanced denitrification associated with expanded marine anoxia, as well as partial ammonium assimilation, while increased δ<jats:sup>15</jats:sup>N values suggest weakened denitrification associated with an amplified oxic water mass. The temporal coincidence of N1 and N2, with two episodes of negative δ<jats:sup>15</jats:sup>N excursions, and of P1, with a positive δ<jats:sup>15</jats:sup>N excursion, suggests that variable oceanic redox conditions and nitrogen bioavailability may have influenced the evolution of the Cambrian eukaryote-dominated community.","PeriodicalId":12612,"journal":{"name":"Geological Magazine","volume":"6 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139495977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tectonic evolution of the Middle-Late Permian orogenic belt in the eastern part of the CAOB: Implications from the magmatism in the Changchun-Kaiyuan area 长春大兴安岭东部中-晚二叠世造山带的构造演化:长春-开原地区岩浆活动的启示
IF 2.3 3区 地球科学
Geological Magazine Pub Date : 2024-01-10 DOI: 10.1017/s001675682300078x
Nuo Zhang, Zhenghong Liu, Zhongyuan Xu, Gang Li, Xiaojie Dong, Jin Liu, Wenqing Li
{"title":"Tectonic evolution of the Middle-Late Permian orogenic belt in the eastern part of the CAOB: Implications from the magmatism in the Changchun-Kaiyuan area","authors":"Nuo Zhang, Zhenghong Liu, Zhongyuan Xu, Gang Li, Xiaojie Dong, Jin Liu, Wenqing Li","doi":"10.1017/s001675682300078x","DOIUrl":"https://doi.org/10.1017/s001675682300078x","url":null,"abstract":"<p>Various magmatisms during the subduction-collision process are crucial to reveal the long-term tectonic evolution of the eastern Central Asian Orogenic Belt. In this paper, we present major and trace elements of whole-rock, zircon U-Pb dating and Hf isotope of the Shanmen pluton. Results imply that the Shanmen pluton consists of quartz diorite and mylonitic granite, with zircon U-Pb ages of 263.7–259.6 Ma. The studied quartz diorite contains high Sr/Y (51.19–90.87) and (La/Yb)<span>N</span> (7.82–13.62) ratios, and belongs to adakitic rocks. Coupled with the positive ε<span>Hf</span>(t) values of +5.71 to +12.8 with no obvious Eu anomaly, we propose that quartz diorite is the product of the interaction between different degrees of slab melt and the overlying mantle wedge. In contrast, the mylonitic granite has lower MgO (0.28 wt% – 0.47 wt%) contents and positive ε<span>Hf</span>(t) values of +7.79 to +10.15, indicating an affinity with I-type granite originated by partial melting of the intermediate-basic lower crust. The geochemical characteristics and lithological assemblages, along with the Permian magmatic rocks in the Changchun-Kaiyuan area displaying arc rocks affinity, propose their formation is related to the southward subduction of the Paleo-Asian Ocean (PAO). Based on this study and previous evidence, we lean towards adopting a middle-late Permian slab break-off model, wherein the PAO did not close until the late Permian.</p>","PeriodicalId":12612,"journal":{"name":"Geological Magazine","volume":"224 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139413263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contextual relationship between mechanical heterogeneity and dyking: constraints from magma emplacement dynamics of the ca. 2.21 Ga Anantapur–Kunigal mafic dyke swarm, Dharwar Craton, India 机械异质性与岩脉之间的内涵关系:约 2.21 Ga 的阿南塔普尔-库尼加尔岩浆置换动力学对印度达瓦尔克拉通岩脉群的约束2.21Ga的阿南塔普尔-库尼加尔岩浆岩堤群,印度达瓦尔克拉通
IF 2.3 3区 地球科学
Geological Magazine Pub Date : 2024-01-10 DOI: 10.1017/s0016756823000791
Srinjoy Datta, Amiya K. Samal, Sayandeep Banerjee, Rajesh K. Srivastava
{"title":"Contextual relationship between mechanical heterogeneity and dyking: constraints from magma emplacement dynamics of the ca. 2.21 Ga Anantapur–Kunigal mafic dyke swarm, Dharwar Craton, India","authors":"Srinjoy Datta, Amiya K. Samal, Sayandeep Banerjee, Rajesh K. Srivastava","doi":"10.1017/s0016756823000791","DOIUrl":"https://doi.org/10.1017/s0016756823000791","url":null,"abstract":"<p>Mafic dykes are typically emplaced through primary hydraulic fracturing of undeformed crust or may make use of pre-existing crustal inhomogeneities, representing the plumbing systems of a large igneous province. The Eastern Dharwar Craton has dense exposures of several generations of Paleoproterozoic mafic dyke swarms ranging from ca. 2.37 Ga to ca. 1.79 Ga. Herein, using anisotropy of magnetic susceptibility fabric data of mafic dykes and associated host granites, the emplacement systematics of the NW- to W-trending ca. 2.21 Ga Anantapur–Kunigal dyke swarm, displaying a radiating geometry, have been studied to understand magma flow dynamics. A low-angle relationship between the silicate and opaque fabrics and good correlation with magnetic lineation, identified via petrographic studies and shape preferred orientation analyses of multiple oriented thin sections, suggest a primary flow-related magnetic anisotropy for the studied dyke samples. The classic subparallel relationship between the trend of the dyke planes and magnetic fabric of the associated host granites suggests that the radiating geometry of the ca. 2.21 Ga dyke swarm was supported by a favourable pre-existing structural grain of the country rock. We interpret the magma for the studied dyke swarm was fed laterally from a distant plume. It was emplaced as laterally propagating primary dyke fractures as well as injected into the pre-existing subparallel crustal inhomogeneities. Corroborating all these inferences, a detailed emplacement model for ca. 2.21 Ga Anantapur–Kunigal dyke swarm is also proposed.</p>","PeriodicalId":12612,"journal":{"name":"Geological Magazine","volume":"39 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139413264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking the impact of seismicity on palaeogeographic evolution and sedimentary architecture: A case study from Middle Jurassic succession of Spiti Himalaya 将地震对古地理演变和沉积结构的影响联系起来:斯皮提喜马拉雅中侏罗世演替案例研究
IF 2.3 3区 地球科学
Geological Magazine Pub Date : 2024-01-03 DOI: 10.1017/s0016756823000778
Sabyasachi Mandal, Abha Singh, Santanu Banerjee, Premraj Uddandam, Ranveer Singh Negi
{"title":"Linking the impact of seismicity on palaeogeographic evolution and sedimentary architecture: A case study from Middle Jurassic succession of Spiti Himalaya","authors":"Sabyasachi Mandal, Abha Singh, Santanu Banerjee, Premraj Uddandam, Ranveer Singh Negi","doi":"10.1017/s0016756823000778","DOIUrl":"https://doi.org/10.1017/s0016756823000778","url":null,"abstract":"<p>The traces left by earthquakes in the unlithified sediments, recorded as soft-sediment deformation structures (SSDS), are well reconstructed as palaeo-seismic signals, while the origin of SSDS, seismic vs. Aseismic, is challenging. The present study discusses the origin of SSDS and its implications on palaeoceanography and sediment architecture. In the Middle Jurassic succession of Spiti Himalayan region in India, the topmost part of the Ferruginous Oolitic Formation (FOF) consists of four layers of SSDS and is underlain by the lower member of the Spiti Formation (SF). The sedimentary facies analysis documents the palaeogeographic shift from the middle shelf (carbonate-shale repository: FOF) to the outer shelf (black shale: lower member of SF). The SSDS layers, exhibiting load casts, ball and pillow structures, indicate gravitational instability, while syn-sedimentary faults and insitu breccia are the results of brittle deformation. The dominance of storms in depositional sites often argues for a possible triggering agent for SSDS. Therefore, it was necessary to distinguish between seismic vs. aseismic triggering agents. The lateral continuity, vertical repetition, confinement of SSDS at the top part of FOF and sharp change of facies assemblage indicate seismicity-induced syn-sediment deformation, i.e. seismite. The transition from middle shelf to outer shelf at the onset of seismite indicates that seismic impact possibly caused the rapid subsidence, resulting in the palaeogeographic shift. The rapid transgression is recorded as carbonate-shale repository to anoxic black shale. This study highlights the importance of sedimentological analysis to distinguish the seismite and its implications on palaeogeographic evolution and sedimentary architecture.</p>","PeriodicalId":12612,"journal":{"name":"Geological Magazine","volume":"4 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139083271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryogenian-Ediacaran crustal growth and evolution of the active margin of the Dahomeyide belt, Ghana 加纳达荷美伊德带活动边缘的低温-始新世地壳增长和演化
IF 2.3 3区 地球科学
Geological Magazine Pub Date : 2024-01-02 DOI: 10.1017/s0016756823000808
Daniel Kwayisi, Emmanuel Nyavor, Elikplim Abla Dzikunoo, Iris Ekua Mensimah Fynn, Jacob Kutu, Prosper M Nude
{"title":"Cryogenian-Ediacaran crustal growth and evolution of the active margin of the Dahomeyide belt, Ghana","authors":"Daniel Kwayisi, Emmanuel Nyavor, Elikplim Abla Dzikunoo, Iris Ekua Mensimah Fynn, Jacob Kutu, Prosper M Nude","doi":"10.1017/s0016756823000808","DOIUrl":"https://doi.org/10.1017/s0016756823000808","url":null,"abstract":"<p>The study presents detailed petrographical, geophysical, structural and geochemical data of the internal nappes zone to establish the deformational history, origin and tectonic setting and constrain the crustal growth and evolution of the active margin of the Dahomeyide belt. Two main lithological units, (i) deformed meta-granitoids (migmatites and gneisses) and (ii) undeformed granitoids, dominate the internal nappes zone. The granitoids are generally I-type, metaluminous to weakly peraluminous, low-K tholeiite to high-K calc-alkaline and of tonalite, granodiorite and granite affinity. The overall trace element patterns of the studied granitoids characterized by the enriched LILE and depleted HFS, with negative peaks of Nb-Ta, Sr, P and Ti, are indications of arc-related magmatism. Structural analysis reveals four deformation phases (D<span>1</span>-D<span>4</span>). D<span>1</span> represents Northwest-Southeast (NW-SE) Pan African shortening associated with a continent-continent collision, resulting in westward nappe stacking. Progressive NW-SE shortening resulted in D<span>2</span> and D<span>3</span> top-to-the-NW dextral and sinistral thrusting events during the Pan-African orogeny. D<span>4</span> is an extensional event likely associated with the orogenic collapse phase. The gneisses and migmatites, with dominant axial planar foliations, point to their formation in a collisional setting or influence by the Pan-African collisional processes. Continental-arc signatures in these rocks imply continental subduction during their protolith formation. The intrusive granitoid and pegmatite are undeformed, meaning late- to post-orogenic emplacement. These findings suggest that the internal nappes zone archived the subduction-collision and post-collisional phase of the Pan-African orogeny and recorded large-scale migmatization and granitoid emplacement due to partial melting of thickened lower crust between Mid-Cryogenian and late Ediacaran.</p>","PeriodicalId":12612,"journal":{"name":"Geological Magazine","volume":"203 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139078668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of blackcurrant extract on indole and ammonia productions in an in vitro human fecal culture model. 黑加仑提取物对体外人体粪便培养模型中吲哚和氨生成的影响
IF 3.1 3区 地球科学
Geological Magazine Pub Date : 2024-01-01 Epub Date: 2023-09-07 DOI: 10.12938/bmfh.2022-094
Nanami Ishiguro, Takayuki Hayashi, Miho Okayama, Taiki Yamaguchi, Mamiko Kohno, Hirosato Kawakami, Tohru Mitsunaga, Kohei Nakamura, Mizuho Inagaki
{"title":"Effects of blackcurrant extract on indole and ammonia productions in an <i>in vitro</i> human fecal culture model.","authors":"Nanami Ishiguro, Takayuki Hayashi, Miho Okayama, Taiki Yamaguchi, Mamiko Kohno, Hirosato Kawakami, Tohru Mitsunaga, Kohei Nakamura, Mizuho Inagaki","doi":"10.12938/bmfh.2022-094","DOIUrl":"10.12938/bmfh.2022-094","url":null,"abstract":"<p><p>Blackcurrant is available as a traditional medicine in Europe. However, the detailed effects of blackcurrant on the human gut microbiota remain unknown. In this study, we investigated the prebiotic effects of a blackcurrant extract using a human fecal culture model in six healthy subjects. Feces were individually inoculated into a medium with or without the blackcurrant extract and then fermented for 48 hr under anaerobic conditions. The results obtained from analysis of samples from the fermented medium demonstrated that after 48 hr of fermentation, the pH of the medium with the blackcurrant extract was significantly decreased (control, 6.62 ± 0.20; blackcurrant extract, 6.41 ± 0.33; p=0.0312). A 16S rRNA gene sequencing analysis of the microbiota of the fermented medium showed a significant increase in the relative abundance of <i>Bifidobacteriacea</i>e. In measuring the concentrations of putrefactive components in the fermented medium, we found that the blackcurrant extract significantly reduced ammonia levels and displayed a tendency toward reduced indole levels. Our results suggest that blackcurrant extract could be a potential ingredient for relief of putrefactive components in the gut.</p>","PeriodicalId":12612,"journal":{"name":"Geological Magazine","volume":"117 1","pages":"23-28"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78560846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury. 针对微生物组改善脊髓损伤后的肠道健康和呼吸功能。
3区 地球科学
Geological Magazine Pub Date : 2023-12-21 DOI: 10.1101/2023.06.23.546264
Jessica N Wilson, Kristina A Kigerl, Michael D Sunshine, Chase E Taylor, Sydney L Speed, Breanna C Rose, Chris M Calulot, Brittany E Dong, Tara R Hawkinson, Harrison A Clarke, Adam D Bachstetter, Christopher M Waters, Ramon C Sun, Phillip G Popovich, Warren J Alilain
{"title":"Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury.","authors":"Jessica N Wilson, Kristina A Kigerl, Michael D Sunshine, Chase E Taylor, Sydney L Speed, Breanna C Rose, Chris M Calulot, Brittany E Dong, Tara R Hawkinson, Harrison A Clarke, Adam D Bachstetter, Christopher M Waters, Ramon C Sun, Phillip G Popovich, Warren J Alilain","doi":"10.1101/2023.06.23.546264","DOIUrl":"10.1101/2023.06.23.546264","url":null,"abstract":"<p><p>Spinal cord injury (SCI) is a devastating condition characterized by impaired motor and sensory function, as well as internal organ pathology and dysfunction. This internal organ dysfunction, particularly gastrointestinal (GI) complications, and neurogenic bowel, can reduce the quality of life of individuals with an SCI and potentially hinder their recovery. The gut microbiome impacts various central nervous system functions and has been linked to a number of health and disease states. An imbalance of the gut microbiome, i.e., gut dysbiosis, contributes to neurological disease and may influence recovery and repair processes after SCI. Here we examine the impact of high cervical SCI on the gut microbiome and find that transient gut dysbiosis with persistent gut pathology develops after SCI. Importantly, probiotic treatment improves gut health and respiratory motor function measured through whole-body plethysmography. Concurrent with these improvements was a systemic decrease in the cytokine tumor necrosis factor-alpha and an increase in neurite sprouting and regenerative potential of neurons. Collectively, these data reveal the gut microbiome as an important therapeutic target to improve visceral organ health and respiratory motor recovery after SCI.</p><p><strong>Research highlights: </strong>Cervical spinal cord injury (SCI) causes transient gut dysbiosis and persistent gastrointestinal (GI) pathology.Treatment with probiotics after SCI leads to a healthier GI tract and improved respiratory motor recovery.Probiotic treatment decreases systemic tumor necrosis factor-alpha and increases the potential for sprouting and regeneration of neurons after SCI.The gut microbiome is a valid target to improve motor function and secondary visceral health after SCI.</p>","PeriodicalId":12612,"journal":{"name":"Geological Magazine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10769193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79188538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ordovician sedimentation and basin development in the North Armorican Massif, NW France: Field evidence from the northern Cotentin Peninsula 法国西北部北阿莫里卡山丘的奥陶纪沉积和盆地发育:来自科唐坦半岛北部的实地证据
IF 2.3 3区 地球科学
Geological Magazine Pub Date : 2023-12-14 DOI: 10.1017/s0016756823000754
David J. Went
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