针对微生物组改善脊髓损伤后的肠道健康和呼吸功能。

IF 2 3区 地球科学 Q3 GEOSCIENCES, MULTIDISCIPLINARY
Jessica N Wilson, Kristina A Kigerl, Michael D Sunshine, Chase E Taylor, Sydney L Speed, Breanna C Rose, Chris M Calulot, Brittany E Dong, Tara R Hawkinson, Harrison A Clarke, Adam D Bachstetter, Christopher M Waters, Ramon C Sun, Phillip G Popovich, Warren J Alilain
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引用次数: 0

摘要

脊髓损伤(SCI)是一种破坏性疾病,其特征是运动和感觉功能受损以及内脏器官病变和功能障碍。这种内脏器官功能障碍,尤其是胃肠道(GI)并发症和神经源性肠道,会降低脊髓损伤患者的生活质量,并有可能阻碍他们的康复。肠道微生物群影响中枢神经系统的各种功能,并与多种健康和疾病状态有关。肠道微生物组失衡(即肠道菌群失调)会导致神经系统疾病,并可能影响 SCI 后的恢复和修复过程。在这里,我们研究了颈椎高位截瘫对肠道微生物组的影响,发现截瘫后会出现短暂的肠道菌群失调和持续的肠道病理变化。重要的是,益生菌治疗可改善肠道健康,并通过全身胸透测量呼吸运动功能。与这些改善同时出现的是肿瘤坏死因子-α细胞因子的全身性下降,以及神经元萌发和神经元再生潜能的增加。这些数据共同揭示了肠道微生物组是改善内脏器官健康和脊髓损伤后呼吸运动恢复的重要治疗靶点:研究亮点:颈椎脊髓损伤(SCI)会导致短暂的肠道菌群失调和持续性胃肠道(GI)病理变化。SCI后使用益生菌治疗可使胃肠道更健康,并改善呼吸运动功能的恢复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury.

Spinal cord injury (SCI) is a devastating condition characterized by impaired motor and sensory function, as well as internal organ pathology and dysfunction. This internal organ dysfunction, particularly gastrointestinal (GI) complications, and neurogenic bowel, can reduce the quality of life of individuals with an SCI and potentially hinder their recovery. The gut microbiome impacts various central nervous system functions and has been linked to a number of health and disease states. An imbalance of the gut microbiome, i.e., gut dysbiosis, contributes to neurological disease and may influence recovery and repair processes after SCI. Here we examine the impact of high cervical SCI on the gut microbiome and find that transient gut dysbiosis with persistent gut pathology develops after SCI. Importantly, probiotic treatment improves gut health and respiratory motor function measured through whole-body plethysmography. Concurrent with these improvements was a systemic decrease in the cytokine tumor necrosis factor-alpha and an increase in neurite sprouting and regenerative potential of neurons. Collectively, these data reveal the gut microbiome as an important therapeutic target to improve visceral organ health and respiratory motor recovery after SCI.

Research highlights: Cervical spinal cord injury (SCI) causes transient gut dysbiosis and persistent gastrointestinal (GI) pathology.Treatment with probiotics after SCI leads to a healthier GI tract and improved respiratory motor recovery.Probiotic treatment decreases systemic tumor necrosis factor-alpha and increases the potential for sprouting and regeneration of neurons after SCI.The gut microbiome is a valid target to improve motor function and secondary visceral health after SCI.

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来源期刊
Geological Magazine
Geological Magazine 地学-地球科学综合
CiteScore
4.70
自引率
0.00%
发文量
111
审稿时长
3 months
期刊介绍: Geological Magazine, established in 1864, is one of the oldest and best-known periodicals in earth sciences. It publishes original scientific papers covering the complete spectrum of geological topics, with high quality illustrations. Its worldwide circulation and high production values, combined with Rapid Communications and Book Review sections keep the journal at the forefront of the field. This journal is included in the Cambridge Journals open access initiative, Cambridge Open Option.
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