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Botulinum neurotoxin type A combined with functional electrical stimulation for upper-limb poststroke spasticity with pain A型肉毒毒素联合功能性电刺激治疗脑卒中后上肢痉挛伴疼痛
IF 1.3
Future Neurology Pub Date : 2018-11-01 DOI: 10.2217/FNL-2018-0020
A. Nikbakht, A. Karshenas, P. Gazerani
{"title":"Botulinum neurotoxin type A combined with functional electrical stimulation for upper-limb poststroke spasticity with pain","authors":"A. Nikbakht, A. Karshenas, P. Gazerani","doi":"10.2217/FNL-2018-0020","DOIUrl":"https://doi.org/10.2217/FNL-2018-0020","url":null,"abstract":"Stroke is a complicated condition that leaves stroke survivors with prolonged disability. Common poststroke conditions are spasticity and pain, which directly affect daily activities and quality of life in these patients. Botulinum neurotoxin type A is an effective and well-tolerated treatment option for upper-limb spasticity. It reduces muscle tone and improves basic upper-limb activities. Functional electrical stimulation is also used widely as a therapeutic modality in the upper-limb muscle rehabilitation. Here, we present a case in which Botulinum neurotoxin type A injections combined with functional electrical stimulation were applied for upper-limb spasticity accompanied with pain in a poststroke patient.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2018-0020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45895412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Role of FABP3 as biomarker in Alzheimer's disease and synucleinopathies FABP3作为生物标志物在阿尔茨海默病和突触核蛋白病中的作用
IF 1.3
Future Neurology Pub Date : 2018-11-01 DOI: 10.2217/FNL-2018-0003
F. Sepe, D. Chiasserini, L. Parnetti
{"title":"Role of FABP3 as biomarker in Alzheimer's disease and synucleinopathies","authors":"F. Sepe, D. Chiasserini, L. Parnetti","doi":"10.2217/FNL-2018-0003","DOIUrl":"https://doi.org/10.2217/FNL-2018-0003","url":null,"abstract":"Lipids are fundamental components of brain cells as they are involved in several essential processes like remodeling of plasma membrane, synaptic function and receptor–ligand interactions. Systemic and brain alterations in lipid metabolism have been linked to the pathogenesis of neurodegenerative disorders like dementia and parkinsonisms. Intracellular transport of lipids is regulated by fatty acid-binding proteins. Recently, a member of this family, the fatty acid-binding protein 3 has been proposed as a potential biomarker across a range of neurodegenerative diseases, including Alzheimer's disease and dementia with Lewy bodies. In this special report, we describe recent progresses in characterizing the role of fatty acid-binding protein 3 in neurodegeneration and its putative role as biomarker measurable in biological fluids.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2018-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46213025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
The importance of comprehensive neuropsychiatric care in the postencephalitic patient 全面的神经精神护理在脑卒中后患者中的重要性
IF 1.3
Future Neurology Pub Date : 2018-11-01 DOI: 10.2217/FNL-2018-0019
Jessica A Harder, T. Mariano
{"title":"The importance of comprehensive neuropsychiatric care in the postencephalitic patient","authors":"Jessica A Harder, T. Mariano","doi":"10.2217/FNL-2018-0019","DOIUrl":"https://doi.org/10.2217/FNL-2018-0019","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2018-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45361986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Dementia screening: a different proposal 痴呆症筛查:一个不同的建议
IF 1.3
Future Neurology Pub Date : 2018-11-01 DOI: 10.2217/FNL-2018-0018
A. Larner
{"title":"Dementia screening: a different proposal","authors":"A. Larner","doi":"10.2217/FNL-2018-0018","DOIUrl":"https://doi.org/10.2217/FNL-2018-0018","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2018-0018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47686563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Collagen-binding Streptococcus mutans tied to cerebral microbleeds and intracerebral hemorrhage 与脑微出血结合的胶原结合变形链球菌与脑出血
IF 1.3
Future Neurology Pub Date : 2018-09-27 DOI: 10.2217/FNL-2018-0016
M. Ihara, Shuichi Tonomura, Yumi Yamamoto, S. Saito
{"title":"Collagen-binding Streptococcus mutans tied to cerebral microbleeds and intracerebral hemorrhage","authors":"M. Ihara, Shuichi Tonomura, Yumi Yamamoto, S. Saito","doi":"10.2217/FNL-2018-0016","DOIUrl":"https://doi.org/10.2217/FNL-2018-0016","url":null,"abstract":"Genome-wide association and candidate gene studies have identified COL4A1 and COL4A2 as risk genes for intracerebral hemorrhage (ICH), suggesting that the disrupted collagen architecture could be a contributory factor in disease onset. Environmental factors that disrupt the vascular collagen architecture may therefore bring about gene–environmental interactions. Certain oral strains of Streptococcus mutans expressing Cnm, a collagen-binding protein, have been found to be responsible for ICH in a preclinical study. In support of this finding, a population-based study showed a close association between Cnm-positive Streptococcus mutans with cerebral microbleeds, a precursor of ICH, and a hospital-based study between such bacteria with cerebral microbleeds and ICH. Taken together, these findings suggest that Cnm-positive Streptococcus mutans serve as an important environmental factor in ICH.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2018-0016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45265601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Understanding the potential for yoga and tai chi interventions to moderate risk factors for stroke – a scoping review 了解瑜伽和太极干预中风风险因素的潜力-一项范围综述
IF 1.3
Future Neurology Pub Date : 2018-09-01 DOI: 10.2217/FNL-2018-0005
T. Thayabaranathan, M. Immink, Philip Stevens, S. Hillier, A. Thrift, A. Brodtmann, L. Carey, M. Kilkenny, D. Cadilhac
{"title":"Understanding the potential for yoga and tai chi interventions to moderate risk factors for stroke – a scoping review","authors":"T. Thayabaranathan, M. Immink, Philip Stevens, S. Hillier, A. Thrift, A. Brodtmann, L. Carey, M. Kilkenny, D. Cadilhac","doi":"10.2217/FNL-2018-0005","DOIUrl":"https://doi.org/10.2217/FNL-2018-0005","url":null,"abstract":"Following an initial stroke, approximately two in five people will experience another stroke within 10 years. Recurrent strokes are often more severe and fatal. Mindfulness-based interventions (MBIs) that use movement to focus attention, such as yoga and tai chi, may offer a lifestyle strategy in addition to standard rehabilitation options, for moderating risk factors for stroke. We conducted a scoping review to explore the potential for yoga or tai chi to moderate modifiable risk factors for stroke. 26 papers between 1985 and 2017 were identified using online and gray literature databases. Overall, yoga or tai chi may reduce hypertension (up to 16/9 mmHg), and to a lesser extent some lipid and blood sugar levels. Study designs were heterogeneous. Further research on mediating pathways of MBIs, such as yoga or tai chi, on modifiable risk factors for stroke is warranted.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2018-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47582109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Treatment-induced brain plasticity in borderline personality disorder: review of functional MRI studies 边缘型人格障碍治疗诱导的脑可塑性：功能性MRI研究综述
IF 1.3
Future Neurology Pub Date : 2018-09-01 DOI: 10.2217/FNL-2018-0006
Maria Uscinska, S. Bellino
{"title":"Treatment-induced brain plasticity in borderline personality disorder: review of functional MRI studies","authors":"Maria Uscinska, S. Bellino","doi":"10.2217/FNL-2018-0006","DOIUrl":"https://doi.org/10.2217/FNL-2018-0006","url":null,"abstract":"Although neural substrates of symptoms expression in borderline personality disorder (BPD) have been studied extensively, neural mechanisms mediating post treatment amelioration of symptoms remain poorly characterized. Herein present review sheds a critical light on all here-to-date functional MRI findings of brain changes in BPD patients following a treatment with psychotherapy or drugs. Preliminary evidence points to downregulation of neuronal activity within the insula and amygdala, together with differential employment of prefrontal areas, mainly orbitofrontal cortex, anterior cingulate cortex and dorsolateral prefrontal cortex, as well as enhanced functional connectivity between limbic and prefrontal regions induced by dialectical behavioral therapy. Identifying neural circuits behind treatment processes may refine strategies to target specific symptoms, thereby resolving some of the controversies over BPD treatment.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2018-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47806251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
TDP-43 depletion: mechanism of neuronal cell death in ALS TDP-43缺失:肌萎缩侧索硬化症神经元细胞死亡的机制
IF 1.3
Future Neurology Pub Date : 2018-08-01 DOI: 10.2217/FNL-2018-0010
Akira Kitamura
{"title":"TDP-43 depletion: mechanism of neuronal cell death in ALS","authors":"Akira Kitamura","doi":"10.2217/FNL-2018-0010","DOIUrl":"https://doi.org/10.2217/FNL-2018-0010","url":null,"abstract":"Trans activation response DNA/RNA-binding protein 43 kDa (TDP-43) regulates RNA splicing and stability. TDP-43 is a component of ubiquitin-positive inclusion bodies of motor neurons from patients with amyotrophic lateral sclerosis, suggesting a role in disease pathogenesis. Toxic intracellular TDP-43 aggregation may cause neuronal cell death. The loss of TDP-43 in animal models causes lethality in early development. Furthermore, TDP-43 knockdown in adult animals and cells increases aberrant splicing. Uridine-rich small nuclear RNA (U snRNA) regulation is disrupted in cultured neuroblastoma cells with TDP-43 knockdown and in motor neurons in amyotrophic lateral sclerosis. Aberrant mRNA splicing and U snRNA expression are likely key processes in neuronal cell death. We review the research history and future perspectives of aberrant splicing by TDP-43 loss.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2018-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48084520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An update on vitamin D and B deficiency in the pathogenesis and treatment of diabetic neuropathy: a narrative review 维生素D和B缺乏在糖尿病神经病变发病机制和治疗中的最新进展:叙述性综述
IF 1.3
Future Neurology Pub Date : 2018-08-01 DOI: 10.2217/FNL-2017-0034
U. Alam, A. Nelson, D. Cuthbertson, R. Malik
{"title":"An update on vitamin D and B deficiency in the pathogenesis and treatment of diabetic neuropathy: a narrative review","authors":"U. Alam, A. Nelson, D. Cuthbertson, R. Malik","doi":"10.2217/FNL-2017-0034","DOIUrl":"https://doi.org/10.2217/FNL-2017-0034","url":null,"abstract":"Diabetic peripheral neuropathy (DPN) is highly prevalent and affects up to 50% of patients with diabetes. Painful neuropathic symptoms may occur in a third of patients with diabetes and is a major cause of sleep disturbance, morbidity and poor quality of life. Effective treatment of DPN remains a major challenge as current therapeutic options have a number of undesirable side effects and only provide a partial response to neuropathic pain. Furthermore, there are a lack of treatments that modulate the natural history of DPN. A growing body of evidence suggests that vitamin B and vitamin D may have analgesic effects and neuroprotective benefits in DPN. This narrative review explores the role of these vitamins in DPN. Given their limited side effects, further mechanistic studies and good quality randomized controlled trials of their putative analgesic ability are required to define the role of vitamin B and D in DPN.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2017-0034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49135803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The management of epilepsy during pregnancy 妊娠期癫痫的治疗
IF 1.3
Future Neurology Pub Date : 2018-08-01 DOI: 10.2217/FNL-2018-0012
M. Eadie
{"title":"The management of epilepsy during pregnancy","authors":"M. Eadie","doi":"10.2217/FNL-2018-0012","DOIUrl":"https://doi.org/10.2217/FNL-2018-0012","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2018-0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47245438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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