Genetic testing and molecular biomarkers最新文献

{"title":"Association of <i>Tenascin-C</i> Gene Polymorphisms with Risk of Acute Coronary Syndrome in South Indian Population: A Case-Control Genetic Association Study.","authors":"Sankar Abirami, Prashant Shankarrao Adole, Kolar Vishwanath Vinod","doi":"10.1089/gtmb.2023.0482","DOIUrl":"10.1089/gtmb.2023.0482","url":null,"abstract":"<p><p><b><i>Background:</i></b> The extracellular matrix (ECM) glycoprotein changes are associated with the pathogenesis and complications of atherosclerosis, leading to acute coronary syndrome (ACS). Tenascin-C (TNC), an ECM protein, has been implemented in the pathogenesis, diagnosis, and prognosis of patients with cardiovascular disease. <b><i>Aim:</i></b> The study aimed to compare the genetic variants of the <i>TNC</i> gene (rs13321, rs2104772, and rs12347433) between South Indians with ACS and healthy participants. <b><i>Materials and Methods:</i></b> This case-control study recruited 150 ACS patients as cases and 150 healthy participants as controls. TNC genotyping was performed using TaqMan 5'-exonuclease allele discrimination assay. Serum TNC levels were measured by enzyme-linked immunosorbent assay. <b><i>Results:</i></b> Serum TNC levels were significantly higher in cases compared with controls. No significant difference was observed in allele and genotype frequencies of rs13321, rs2104772, and rs12347433 between cases and controls, which was confirmed by dominant, recessive, codominant, and homozygotic genetic models. The patients with heterozygous genotypes of rs13321, rs2104772, and rs12347433 had significantly lower serum TNC levels than patients with respective homozygous genotypes. Haplotype analyses revealed that the C-T-A haplotype in the block of rs13321-rs12347433-rs2104772 was associated with lower ACS risk (OR = 0.33, 95% CI: 0.15 - 0.75; <i>p</i> = 0.005). Also, the C-T-T and G-T-A haplotypes of the <i>TNC</i> gene were associated with higher and lower serum TNC levels, respectively. <b><i>Conclusion:</i></b> Our study demonstrated no genetic association between single nucleotide polymorphisms of the <i>TNC</i> gene and ACS risk; however, the C-T-A haplotype of the <i>TNC</i> gene might be associated with reduced ACS risk in South Indians.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":" ","pages":"114-122"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10979666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>TIMP2</i> 418 G/C and MMP Gene Polymorphism with Risk of Urinary Cancers: Systematic Review and Meta-analysis.","authors":"Pemula Gowtham, Koyeli Girigoswami, Anbazhagan Thirumalai, Karthick Harini, Pragya Pallavi, Agnishwar Girigoswami","doi":"10.1089/gtmb.2023.0457","DOIUrl":"10.1089/gtmb.2023.0457","url":null,"abstract":"<p><p><b><i>Aim:</i></b> The matrix metalloproteinases (MMPs) inhibit tissue inhibitors of metalloproteinases (TIMPs), playing a notable role in various biological processes, and mutations in <i>TIMP2</i> genes impact a variety of urinary cancers. In this study, we analyze and evaluate the potential involvement of the <i>TIMP2</i> 418 G/C and MMP gene polymorphism in the etiology of urinary cancer. <b><i>Methodology:</i></b> For suitable case-control studies, a literature search was undertaken from various database sources such as PubMed, EMBASE, and Google Scholar. Incorporated into the analysis were case-control or cohort studies that documented the correlation between <i>TIMP2</i> 418 G/C and urological cancers. MetaGenyo served as the tool for conducting the meta-analysis, employing a fixed-effects model. The collective odds ratios, along with their corresponding 95% confidence intervals, were calculated and presented to assess the robustness of the observed associations. <b><i>Results:</i></b> A total of seven studies involving controls and cases out of recorded 1265 controls and 1154 cases were analyzed to ascertain the significant association of the <i>TIMP2</i> gene with urologic cancer. No statistically significant correlation was observed between allelic, recessive, dominant, and overdominant models for the genetic variant under investigation. A 95% confidence interval (CI) and odds ratio (OR) were computed for each model, considering <i>p</i>-values <0.05. The OR and 95% CI for the allelic model were 0.99 and 0.77-1.27, respectively, whereas the respective values were 1.00 and 0.76-1.32 for the recessive model. In the dominant contrast model, OR and 95% CI were 1.09 and 0.62-1.90, while the same were 0.93 and 0.77-1.12 for the overdominant model. A funnel plot was used to reanalyze and detect the results as statically satisfactory. <b><i>Conclusions:</i></b> As a result of the data obtained, the <i>TIMP2</i> gene polymorphism does not correlate statistically with cancer risk. The significance of this finding can only be confirmed using a large population, extensive epidemiological research, a comprehensive survey, and a better understanding of the molecular pathways associated.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":" ","pages":"83-90"},"PeriodicalIF":1.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Correction to:</i> The Correlation Between Clinical Phenotype and Genotype of Hereditary Spherocytosis, by Hao Shen, et al. <i>Genet Test Mol Biomarkers</i> 2024; (vol. 28, no. 1; 33-38); doi: 10.1089/gtmb.2023.0307.","authors":"","doi":"10.1089/gtmb.2023.0307.correx","DOIUrl":"10.1089/gtmb.2023.0307.correx","url":null,"abstract":"","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":" ","pages":"131"},"PeriodicalIF":1.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Bowel Disease and Skin Cancer: A Two-Sample Mendelian Randomization Analysis.","authors":"Aoshuang Li, Mengting Yu, Kaiwen Wu, Lei Liu, Xiaobin Sun","doi":"10.1089/gtmb.2023.0480","DOIUrl":"10.1089/gtmb.2023.0480","url":null,"abstract":"<p><p><b><i>Background:</i></b> At present, numerous clinical studies suggest a correlation between inflammatory bowel disease (IBD) and skin cancer. However, some articles present differing views that IBD does not increase the risk of skin cancer. The presence of potential reverse causality and residual confounding is inherent in conventional observational studies. Thus, this study used a two-sample Mendelian randomization (MR) study design to estimate the causal effect of IBD on the risk of skin cancer, including cutaneous malignant melanoma (CMM, also named melanoma skin cancer) and nonmelanoma skin cancer (NMSC). <b><i>Design:</i></b> In this study, a two-sample MR analysis was used to estimate the causal effect of IBD on skin cancer outcomes. The inverse-variance weighted (IVW) method was used as the main MR analysis, with multiple sensitivity analyses conducted to assess the robustness of findings. <b><i>Results</i></b><i>:</i> In examining the association between IBD and NMSC, all <i>p</i>-values of the IVW methods were found to be <0.05, providing evidence for a causal effect of IBD on an increased risk of NMSC. However, IVW for IBD on CMM yielded <i>p</i>-values >0.05, indicating no causal relationship between IBD and CMM. These findings were consistent across other MR methods, with no evidence of pleiotropy or heterogeneity. Sensitivity analyses confirmed the robustness of our results. <b><i>Conclusion:</i></b> Using MR analysis, we found evidence for a causal effect of genetic liability for IBD on an increased risk of NMSC. However, our study did not find sufficient evidence to support a significant impact of IBD on CMM outcomes.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":" ","pages":"91-99"},"PeriodicalIF":1.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiling of Long Non-Coding RNAs in Auricular Cartilage of Patients with Isolated Microtia.","authors":"Run Yang, Yaoyao Fu, Chenlong Li, Yin Chen, Aijuan He, Xin Jiang, Jing Ma, Tianyu Zhang","doi":"10.1089/gtmb.2023.0360","DOIUrl":"10.1089/gtmb.2023.0360","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Microtia is the second most common maxillofacial birth defect worldwide. However, the involvement of long non-coding RNAs (lncRNAs) in isolated microtia is not well understood. This study aimed at identifying lncRNAs that regulate the expression of genes associated with isolated microtia. <b><i>Methods:</i></b> We used our microarray data to analyze the expression pattern of lncRNA in the auricular cartilage tissues from 10 patients diagnosed with isolated microtia, alongside 15 control subjects. Five lncRNAs were chosen for validation using real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR). <b><i>Results:</i></b> We identified 4651 differentially expressed lncRNAs in the auricular cartilage from patients with isolated microtia. By Gene Ontology/Kyoto Encyclopedia of Genes and Genomes pathway (GO/KEGG) analysis, we identified 27 differentially expressed genes enriched in pathways associated with microtia. In addition, we predicted 9 differentially expressed genes as potential cis-acting targets of 12 differentially expressed lncRNAs. Our findings by qRT-PCR demonstrate significantly elevated expression levels of ZFAS1 and DAB1-AS1, whereas ADIRF-AS1, HOTAIRM1, and EPB41L4A-AS1 exhibited significantly reduced expression levels in the auricular cartilage tissues of patients with isolated microtia. <b><i>Conclusions:</i></b> Our study sheds light on the potential involvement of lncRNAs in microtia and provides a basis for further investigation into their functional roles and underlying mechanisms.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":"28 2","pages":"50-58"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of Long Noncoding RNA PCAT1 in Iranian Patients with Colorectal Cancer and Its Performance as a Potential Diagnostic Biomarker.","authors":"Negin Sadi Khosroshahi, Shabnam Koulaeizadeh, Adel Abdi, Sama Akbarzadeh, Seyed Mehran Hashemi Aghdam, Ali Rajabi, Reza Safaralizadeh","doi":"10.1089/gtmb.2023.0676","DOIUrl":"10.1089/gtmb.2023.0676","url":null,"abstract":"<p><p><b><i>Background:</i></b> Long noncoding RNAs (lncRNAs) as critical molecules play an essential role in the development of cancers. In colorectal cancer (CRC), various lncRNAs are related to cell proliferation, apoptosis, migration, and invasion. <i>LncRNA</i> prostate cancer-associated transcript 1 (<i>PCAT-1</i>), as an oncogenic factor, is a diagnostic biomarker that regulates cell proliferation, migration, invasion, and apoptosis. <b><i>Methods:</i></b> This study evaluated the relationship between <i>PCAT-1</i>, CRC occurrence, and pathological features of Iranian patients. The studied samples included 100 colorectal tumor tissues and 100 adjacent healthy tissues of Iranian CRC patients. RNAs were extracted from cancerous and noncancerous tissues to synthesize complementary DNA. The expression level of <i>PCAT-1</i> was assessed using the real-time PCR method, and the data analysis was assessed using SPSS software. <b><i>Results:</i></b> In this study, expression level of <i>PCAT-1</i> in tumor tissue was significantly increased in Iranian patients, and pathological studies of the patients had no significant relationship with the <i>PCAT-1</i> expression profile. <b><i>Conclusion:</i></b> Our results suggested that the high expression of <i>PCAT-1</i> resulted in the occurrence of colorectal tumor tissues in Iranian patients, which can be considered a diagnostic biomarker in CRC.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":"28 2","pages":"65-69"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Interleukin-17A and Interleukin-17F Gene Polymorphisms with Atopic Dermatitis in Chinese Children.","authors":"Chen Shen, Yunling Li, Jian Huang, Jing Li, Guoqiang Qi, Zhu Zhu, Huiwen Zheng","doi":"10.1089/gtmb.2023.0379","DOIUrl":"10.1089/gtmb.2023.0379","url":null,"abstract":"<p><p><b><i>Background:</i></b> Atopic dermatitis (AD) is a chronic, recurrent inflammatory disease associated with an unbalanced immune response in the upper layers of the skin tissue, mostly starting in childhood. As important factors in gene expression regulation, polymorphisms in interleukin (IL)-17A and IL-17F may be associated with the susceptibility and severity of AD. <b><i>Methods:</i></b> Blood samples and clinical information were obtained from 132 patients with AD and 100 healthy children. Using multiplex polymerase chain reaction and next-generation sequencing, five potential single-nucleotide polymorphisms (SNPs) of IL-17A and IL-17F were genotyped in all participants. The relationship between SNPs and susceptibility to or severity of AD was examined by analyzing haplotypes and genetic models. <b><i>Results:</i></b> The IL-17A rs3819025 polymorphism was substantially associated with higher AD risk in both the allele model (<i>p</i> = 0.03; odds ratio [OR] = 1.76; confidence interval [CI]: 1.05-2.95) and the dominant model (<i>p</i> = 0.04, OR = 1.85; CI: 1.03-3.33). There was no correlation between AD susceptibility and the IL-17A (rs2275913 and rs4711998) or IL-17F (rs763780 and rs12203736) SNPs (all <i>p</i> > 0.05). Additionally, the five IL-17A and IL-17F SNPs did not significantly differ across the mild-to-moderate and severe subgroups (all <i>p</i> > 0.05). <b><i>Conclusions:</i></b> The IL-17A/rs3819025 polymorphism was linked to the development of AD, whereas the IL-17F polymorphism was unrelated to the susceptibility to and severity of AD. The IL-17A polymorphism may provide valuable information to speculate on the susceptibility to AD in Chinese Han children.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":"28 2","pages":"43-49"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Analysis of Gene Biomarkers for Ovarian Cancer.","authors":"Xiaodan Wang, Chengmao Xie, Chang Lu","doi":"10.1089/gtmb.2023.0222","DOIUrl":"10.1089/gtmb.2023.0222","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To identify potential diagnostic markers for ovarian cancer (OC) and explore the contribution of immune cells infiltration to the pathogenesis of OC. <b><i>Methods:</i></b> As the study cohort, two gene expression datasets of human OC (GSE27651 and GSE26712, taken as the metadata) taken from the Gene Expression Omnibus (GEO) database were combined, comprising 228 OC and 16 control samples. Analysis was performed to identify the differentially expressed genes between the OC and control samples, while support vector machine analysis using the recursive feature elimination algorithm and least absolute shrinkage and selection operator regression were performed to identify candidate biomarkers that could discriminate OC. In addition, immunohistochemistry staining was performed to verify the diagnostic value and protein expression levels of the candidate biomarkers. The GSE146553 dataset (OC <i>n</i> = 40, control <i>n</i> = 3) was used to further validate the diagnostic values of those biomarkers. Further, the proportions of various immune cells infiltration in the OC and control samples were evaluated using the CIBERSORT algorithm. <b><i>Results:</i></b> CLEC4M, PFKP, and SCRIB were identified as potential diagnostic markers for OC in both the metadata (area under the receiver operating characteristic curve [AUC] = 0.996, AUC = 1.000, AUC = 1.000) and GSE146553 dataset (AUC = 0.983, AUC = 0.975, AUC = 0.892). Regarding immune cell infiltration, there was an increase in the infiltration of follicular helper dendritic cells, and a decrease in the infiltration of M2 macrophages and neutrophils, as well as activated natural killer (NK) cells and T cells in OC. CLEC4M showed a significantly positive correlation with neutrophils (<i>r</i> = 0.57, <i>p</i> < 0.001) and resting NK cells (<i>r</i> = 0.42, <i>p</i> = 0.0047), but a negative correlation with activated dendritic cells (<i>r</i> = -0.33, <i>p</i> = 0.032). PFKP displayed a significantly positive correlation with activated NK cells (<i>r</i> = 0.36, <i>p</i> = 0.016) and follicular helper T cells (<i>r</i> = 0.32, <i>p</i> = 0.035), but a negative correlation with the naive B cells (<i>r</i> = -0.3, <i>p</i> = 0.049) and resting NK cells (<i>r</i> = -0.41, <i>p</i> = 0.007). SCRIB demonstrated a significantly positive correlation with plasma cells (<i>r</i> = 0.39, <i>p</i> = 0.01), memory B cells (<i>r</i> = 0.34, <i>p</i> = 0.025), and follicular helper T cells (<i>r</i> = 0.31, <i>p</i> = 0.04), but a negative correlation with neutrophils (<i>r</i> = -0.46, <i>p</i> = 0.002) and naive B cells (<i>r</i> = -0.48, <i>p</i> = 0.0012). <b><i>Conclusion:</i></b> CLEC4M, PFKP, and SCRIB were identified and verified as potential diagnostic biomarkers for OC. This work and identification of the three biomarkers may provide guidance for future studies into the mechanism and treatment of OC.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":"28 2","pages":"70-81"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Era for Genetic Testing and Molecular Biomarkers.","authors":"Sharon F Terry","doi":"10.1089/gtmb.2024.29084.persp","DOIUrl":"10.1089/gtmb.2024.29084.persp","url":null,"abstract":"","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":" ","pages":"41-42"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Receptor Polymorphisms in a Spanish Cohort of Parkinson's Disease Patients.","authors":"Saray Canales-Cortés, Mario Rodríguez-Arribas, María F Galindo, Joaquín Jordan, Ignacio Casado-Naranjo, José M Fuentes, Sokhna M S Yakhine-Diop","doi":"10.1089/gtmb.2023.0344","DOIUrl":"10.1089/gtmb.2023.0344","url":null,"abstract":"<p><p><b><i>Background:</i></b> Vitamin D receptor (VDR) is a nuclear hormone receptor widely expressed in the substantia nigra. Its association with an increased risk of Parkinson's disease (PD) is based on vitamin D deficiency and/or different polymorphisms in its gene receptor. This fact has been demonstrated by several case-control studies. <b><i>Materials and Methods:</i></b> Consequently, we investigated the association between VDR <i>Apa</i>I, <i>Bsm</i>I, <i>Fok</i>I, and <i>Taq</i>I gene polymorphisms and PD in a Spanish cohort that included 54 cases and 17 healthy controls. The detection of single nucleotide polymorphisms (SNPs) was performed using a polymerase chain reaction-restriction fragment length polymorphism. <b><i>Results:</i></b> Our data indicate that the SNPs were not associated with the age of onset of PD, nor with the occurrence of motor symptoms. However, only <i>Bsm</i>I polymorphism was significantly associated with PD in this Spanish cohort. In fact, <i>Bsm</i>I genotype was five times higher among PD patients than among controls, and the A allele was considered as a genetic risk for PD. Additionally, the combination of <i>Fok</i>I and <i>Bsm</i>I polymorphisms was significantly associated with PD and could represent a risk factor. <b><i>Conclusion:</i></b> We conclude that <i>Apa</i>I, <i>Taq</i>I, and <i>Fok</i>I polymorphisms were not associated with PD, but <i>Bsm</i>I could be a risk factor for PD in this randomized population.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":"28 2","pages":"59-64"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}