General Thoracic and Cardiovascular Surgery最新文献

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A surgical series on endometriosis-related diaphragmatic hernia. 子宫内膜异位症相关膈疝手术系列。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-10-01 Epub Date: 2024-03-10 DOI: 10.1007/s11748-024-02016-y
Antonio Bobbio, Lorenzo Gherzi, Francesco Tormen, Antoine Sion, Mathilde Prieto, Elisa Daffre, Ludovic Fournel, Marco Alifano
{"title":"A surgical series on endometriosis-related diaphragmatic hernia.","authors":"Antonio Bobbio, Lorenzo Gherzi, Francesco Tormen, Antoine Sion, Mathilde Prieto, Elisa Daffre, Ludovic Fournel, Marco Alifano","doi":"10.1007/s11748-024-02016-y","DOIUrl":"10.1007/s11748-024-02016-y","url":null,"abstract":"<p><strong>Background: </strong>Thoracic endometriosis syndrome gives rise to various clinical and radiological manifestations. We reviewed the records of patients operated for intrathoracic migration of abdominal viscera through a diaphragmatic hernia secondary to thoracic endometriosis.</p><p><strong>Methods: </strong>We retrospectively reviewed the single-center prospective collected database of all patients operated for thoracic endometriosis during the twenty years. All cases in which an abdominal organ was found to be herniated into the thoracic cavity were retrieved. Clinical and pathological data are presented and analyzed.</p><p><strong>Results: </strong>Twenty women of median age 36 (range 25-58) years were operated for endometriosis-related diaphragmatic hernia. The hernia was diagnosed concomitantly with endometriosis-related pneumothorax in 13 cases and during the exploration of catamenial thoracic pain in seven cases. There were 18 cases on the right side and two cases on the left side. The median diameter of the hernia was 8 cm (2.5-20 cm). In seventeen cases, the hernia was repaired by direct suture, and in three cases a heterologous prosthesis was positioned. At follow-up, two patients had an episode of recurrent pneumothorax.</p><p><strong>Conclusions: </strong>Diaphragmatic hernia should be ruled out in the presence of endometriosis-related pneumothorax or catamenial thoracic pain. Surgery is indicated to make a pathological diagnosis, restore anatomy, and prevent recurrence in patients presenting with pneumothorax.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"668-673"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of preoperative vitamin D on postoperative atrial fibrillation incidence after coronary artery bypass grafting. 术前维生素 D 对冠状动脉旁路移植术后心房颤动发生率的影响。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-10-01 Epub Date: 2024-03-15 DOI: 10.1007/s11748-024-02020-2
Toktam Alirezaei, Zahra Ansari Aval, Armin Karamian, Arezoo Hayati
{"title":"Effect of preoperative vitamin D on postoperative atrial fibrillation incidence after coronary artery bypass grafting.","authors":"Toktam Alirezaei, Zahra Ansari Aval, Armin Karamian, Arezoo Hayati","doi":"10.1007/s11748-024-02020-2","DOIUrl":"10.1007/s11748-024-02020-2","url":null,"abstract":"<p><strong>Background: </strong>Post-operative atrial fibrillation (POAF) is associated with adverse long-term cardiovascular events.</p><p><strong>Objectives: </strong>This study investigated the effects of a high-dose vitamin D administered preoperatively on the postoperative atrial fibrillation (POAF) incidence in patients with vitamin D deficiency following coronary artery bypass grafting (CABG) surgery.</p><p><strong>Methods: </strong>This randomized controlled clinical trial was conducted on 246 CABG patients with vitamin D deficiency. All patients were randomly divided into intervention and control groups including 123 cases for each group. In the intervention group, from 3 days before surgery, they received a daily dose of 150,000 units of vitamin D orally (50,000 units of Vit D tablet three times a day) and the patients in the control group received placebo tablets before surgery. All patients in the intervention group were assessed continuously for the occurrence of POAF during the recovery period.</p><p><strong>Results: </strong>In terms of gender, age, and BMI there were no significant differences between intervention and control groups. Our findings showed that the use of vitamin D supplements did not cause a significant change in the duration of intubation and hospitalization. The ratio of POAF following CABG surgery in the control and treatment groups was 26% and 11.4%, respectively (odds ratio = 0.36; 95% CI = 0.18-0.72; P = 0.003).</p><p><strong>Conclusions: </strong>Our findings revealed that high-dose vitamin D supplementation before CABG surgery significantly reduced the incidence of POAF. Further multicenter randomized trials with larger sample sizes are certainly warranted to confirm our results.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"649-655"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to editor: to cover or not to cover, to promote adhesions or not? Comment on: "comparison of early recurrence in young-onset primary spontaneous pneumothorax following surgery using different covering methods". 致编辑的信:盖还是不盖,促进粘连还是不促进粘连?评论:"采用不同覆盖方法手术后年轻原发性自发性气胸早期复发的比较"。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI: 10.1007/s11748-024-02070-6
Dania Nachira, Antonio Giulio Napolitano, Adriana Nocera, Maria Teresa Congedo, Alessia Senatore, Elisa Meacci, Maria Letizia Vita, Stefano Margaritora
{"title":"Letter to editor: to cover or not to cover, to promote adhesions or not? Comment on: \"comparison of early recurrence in young-onset primary spontaneous pneumothorax following surgery using different covering methods\".","authors":"Dania Nachira, Antonio Giulio Napolitano, Adriana Nocera, Maria Teresa Congedo, Alessia Senatore, Elisa Meacci, Maria Letizia Vita, Stefano Margaritora","doi":"10.1007/s11748-024-02070-6","DOIUrl":"10.1007/s11748-024-02070-6","url":null,"abstract":"","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"693-694"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical presentation and surgical outcomes in patients with Shone's complex: a systematic review. 肖恩氏综合征患者的临床表现和手术效果:系统性综述。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI: 10.1007/s11748-024-02067-1
H Shafeeq Ahmed, Purva Reddy Jayaram, Deeksha Gupta
{"title":"Clinical presentation and surgical outcomes in patients with Shone's complex: a systematic review.","authors":"H Shafeeq Ahmed, Purva Reddy Jayaram, Deeksha Gupta","doi":"10.1007/s11748-024-02067-1","DOIUrl":"10.1007/s11748-024-02067-1","url":null,"abstract":"<p><strong>Objective: </strong>Shone's complex comprises of a combination of congenital cardiac anomalies causing obstructions in the left ventricle's inflow and outflow tracts. This systematic review aims to evaluate the clinical features and surgical outcomes of Shone's complex.</p><p><strong>Methods: </strong>An electronic literature search of PubMed and Scopus was performed to identify relevant studies related to the presentation, management, and outcomes of Shone's complex. Two reviewers independently performed selection. Data on study characteristics, participant demographics, interventions, outcomes, and follow-up durations were extracted and analyzed.</p><p><strong>Results: </strong>A total of 691 papers were identified, with 18 studies included in the final analysis. The majority of the studies (n = 12) focused on the pediatric age group. The most common clinical presentations were coarctation of the aorta (n = 17) and mitral stenosis (n = 12). Surgical interventions often involved staged approaches, prioritizing outflow before inflow obstructions. Mitral valve repair was preferred over replacement due to better long-term outcomes (n = 8). Biventricular repair was recommended due to improved postoperative outcomes, but often needed reoperations. Reoperations were common, primarily due to recurrent coarctation (n = 10), subaortic stenosis (n = 8), and mitral valve dysfunction (n = 7). Pulmonary hypertension (n = 10) and arrhythmias (n = 11) were significant complications. Most patients were in modified Ross/NYHA functional class 1 on follow-up. Mortality rates ranged from 4 to 28%, with better outcomes associated with early and strategic surgical interventions.</p><p><strong>Conclusion: </strong>Early diagnosis and biventricular repair were associated with better outcomes while transplantation was often an eventuality. Standardized diagnostic criteria, long-term follow-up, and consensus guidelines are needed to improve the management of this congenital heart disease.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"621-640"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Prognostic significance of preoperative to postoperative serum carcinoembryonic antigen ratio after lobectomy for lung adenocarcinoma. 更正:肺腺癌肺叶切除术后术前与术后血清癌胚抗原比值的预后意义。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-10-01 DOI: 10.1007/s11748-024-02056-4
Go Kamimura, Masaya Aoki, Mihiro Iwamoto, Yusei Tsuneyoshi, Shoichiro Morizono, Tadashi Umehara, Aya Harada-Takeda, Koki Maeda, Toshiyuki Nagata, Kazuhiro Ueda
{"title":"Correction to: Prognostic significance of preoperative to postoperative serum carcinoembryonic antigen ratio after lobectomy for lung adenocarcinoma.","authors":"Go Kamimura, Masaya Aoki, Mihiro Iwamoto, Yusei Tsuneyoshi, Shoichiro Morizono, Tadashi Umehara, Aya Harada-Takeda, Koki Maeda, Toshiyuki Nagata, Kazuhiro Ueda","doi":"10.1007/s11748-024-02056-4","DOIUrl":"10.1007/s11748-024-02056-4","url":null,"abstract":"","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"695"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of lobar shifting following right upper lobectomy on postoperative pulmonary function. 右上肺叶切除术后肺叶移位对术后肺功能的影响。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-10-01 Epub Date: 2024-03-26 DOI: 10.1007/s11748-024-02019-9
Sanae Kuroda, Kenji Miura, Nahoko Shimizu, Yoshitaka Kitamura, Wataru Nishio
{"title":"The effect of lobar shifting following right upper lobectomy on postoperative pulmonary function.","authors":"Sanae Kuroda, Kenji Miura, Nahoko Shimizu, Yoshitaka Kitamura, Wataru Nishio","doi":"10.1007/s11748-024-02019-9","DOIUrl":"10.1007/s11748-024-02019-9","url":null,"abstract":"<p><strong>Objectives: </strong>Lobes occasionally displace after lobectomy, referred to as \"lobar shifting\". However, the benefits, especially in postoperative pulmonary function, remain controversial. This study aimed to measure the effect of lobar shifting on postoperative pulmonary function especially in the right upper lobe.</p><p><strong>Methods: </strong>This retrospective study includes 273 right upper lobectomy patients (lobectomy group) and 24 right upper segmentectomy patients (segmentectomy group) from 2012 to 2021. The lobectomy group was further subdivided based on their Synapse Vincent<sup>®</sup> image: with their postoperative middle lobe bronchus shifted toward the head (shift group: 176 cases) and without (non-shift group: 97 cases). Several factors were examined to determine the cause of lobar shifting. The rate of measured actual postoperative forced expiratory volume in 1 s (FEV1.0) to predicted postoperative FEV1.0 was analyzed and compared among the three groups.</p><p><strong>Results: </strong>Factors that correlated with lobar shifting included age (p < 0.001), a relatively small middle lobe volume (p = 0.03), no adhesions (p < 0.001), and good upper/middle and middle/lower lobulation (p = 0.04, p = 0.02). The rate of measured actual postoperative FEV1.0 to predicted postoperative FEV1 for the shift, non-shift, and segmentectomy groups were 112.5%, 107.9%, and 103.1% (shift vs non-shift: p = 0.04, shift vs segmentectomy: p = 0.02, non-shift vs segmentectomy: p = 0.19).</p><p><strong>Conclusions: </strong>Lobar shifting after right upper lobectomy is influenced by morphological factors and may have a beneficial impact on postoperative pulmonary function.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"674-683"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140293338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Comparison of early recurrence in young-onset primary spontaneous pneumothorax following surgery using different covering methods. 更正:使用不同覆盖方法手术后年轻原发性自发性气胸早期复发的比较。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-10-01 DOI: 10.1007/s11748-024-02063-5
Taiki Takasugi, Motoki Sakuraba, Wataru Arai
{"title":"Correction: Comparison of early recurrence in young-onset primary spontaneous pneumothorax following surgery using different covering methods.","authors":"Taiki Takasugi, Motoki Sakuraba, Wataru Arai","doi":"10.1007/s11748-024-02063-5","DOIUrl":"10.1007/s11748-024-02063-5","url":null,"abstract":"","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"696"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of taurine on vascular dysfunction in an in vitro ischemia-reperfusion model of rat thoracic aorta. 牛磺酸对大鼠胸主动脉体外缺血再灌注模型血管功能障碍的影响
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-09-30 DOI: 10.1007/s11748-024-02089-9
Ariyan Teimoori, Halit Güner Orhan, Elif Demirtaş, Nargiz Zeynalova, Oğuzhan Ekin Efe, Selda Emre Aydıngöz
{"title":"Effect of taurine on vascular dysfunction in an in vitro ischemia-reperfusion model of rat thoracic aorta.","authors":"Ariyan Teimoori, Halit Güner Orhan, Elif Demirtaş, Nargiz Zeynalova, Oğuzhan Ekin Efe, Selda Emre Aydıngöz","doi":"10.1007/s11748-024-02089-9","DOIUrl":"https://doi.org/10.1007/s11748-024-02089-9","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective of this study was to evaluate the protective effect of taurine on endothelial dysfunction in a vascular ischemia-reperfusion (IR) model.</p><p><strong>Methods: </strong>Thoracic aortas of 9 male Sprague-Dawley rats (350-500 g) were cut into rings and randomized into control (n = 7), IR (n = 8), IR + taurine 1 mM (n = 7), IR + taurine 10 mM (n = 8), IR + taurine 30 mM (n = 8), and IR + taurine 100 mM (n = 5) groups. Aortic rings in the IR group were stored in 0.9% saline at 4 °C for 24 h, placed in Krebs-Henseleit solution gassed with 95%O<sub>2</sub> + 5%CO<sub>2</sub> at 37 °C, and exposed to sodium hypochlorite (200 μM) for 30 min. Responses to KCl (80 mM), phenylephrine (10<sup>-10</sup>-10<sup>-4</sup> M), acetylcholine (10<sup>-10</sup>-10<sup>-4</sup> M), and sodium nitroprusside (SNP, 10<sup>-11</sup>-10<sup>-5</sup> M) were recorded. E<sub>max</sub> (maximum response) and pD<sub>2</sub> (negative logarithm of concentration producing half-maximum response) were calculated.</p><p><strong>Results: </strong>IR decreased KCl contraction (control 1047 ± 176 mg, IR 682 ± 128 mg, p = 0.0007), which was reversed by 30 and 100 mM taurine (960 ± 313 mg, p = 0.02 and 1066 ± 488 mg, p = 0.02, respectively). IR impaired phenylephrine, acetylcholine, and SNP responses (p < 0.0001). Taurine did not affect IR-impaired phenylephrine contractions. IR decreased both pD<sub>2</sub> (control, 7.1 ± 0.1; IR, 6.0 ± 0.2; p < 0.01) and E<sub>max</sub> (control, 83.5 ± 2.7%; IR, 26.8 ± 2.5%; p < 0.0001) of acetylcholine relaxation, both of which were reversed by 100 mM taurine (pD<sub>2,</sub> 7.2 ± 0.1; p < 0.001; E<sub>max,</sub> 45.4 ± 2.6%; p < 0.0001). For SNP relaxation, IR decreased pD<sub>2</sub> (control 8.2 ± 0.1, IR 7.7 ± 0.1, p < 0.01), which was reversed by 100 mM taurine (8.5 ± 0.1, p < 0.0001).</p><p><strong>Conclusion: </strong>Taurine protects endothelial function after IR injury. Further studies should explore the mechanism of this effect and the potential of adding taurine to vascular graft storage solutions.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival impact of pathologic features after salvage lung resection following definitive chemoradiotherapy or systemic therapy for initially unresectable lung cancer. 最初无法切除的肺癌患者在接受明确的化放疗或全身治疗后进行挽救性肺切除术,其病理特征对存活率的影响。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-09-27 DOI: 10.1007/s11748-024-02086-y
Naoyuki Oka, Tomoyuki Hishida, Kaoru Kaseda, Yuri Suzuki, Yu Okubo, Kyohei Masai, Keisuke Asakura, Katsura Emoto, Hisao Asamura
{"title":"Survival impact of pathologic features after salvage lung resection following definitive chemoradiotherapy or systemic therapy for initially unresectable lung cancer.","authors":"Naoyuki Oka, Tomoyuki Hishida, Kaoru Kaseda, Yuri Suzuki, Yu Okubo, Kyohei Masai, Keisuke Asakura, Katsura Emoto, Hisao Asamura","doi":"10.1007/s11748-024-02086-y","DOIUrl":"https://doi.org/10.1007/s11748-024-02086-y","url":null,"abstract":"<p><strong>Purpose: </strong>Salvage surgery for primary lung cancer is expected to become increasingly common. This study aimed to clarify the survival impact of pathologic characteristics after salvage surgery.</p><p><strong>Methods: </strong>Consecutive patients who underwent salvage surgery following definitive chemoradiotherapy or systemic therapy for initially unresectable lung cancer from 2010 to 2020 were enrolled in this study. The tumor slides were reviewed to determine the size of the tumor bed and the proportions of viable tumor, necrosis, and stroma.</p><p><strong>Results: </strong>A total of 23 patients were evaluated, and 18 had clinical stage IIIB-IV disease. Six received chemoradiotherapy and 17 received systemic therapy alone. A major pathologic response (MPR, ≤ 10% of viable tumor) was observed in 6 patients, and 4 patients achieved a pathological complete response. The 3-year overall and recurrence-free survival rates (OS and RFS) were 78.6% and 59.2%, respectively. There was no significant difference in OS between patients with and without MPR, and even non-MPR patients achieved a favorable 3-year OS of 70.2%. Meanwhile, patients with high (≥ 30%) stroma showed significantly better OS than those with low (< 30%) stroma (3-year OS: 100% vs. 23.3%, p < 0.001).</p><p><strong>Conclusions: </strong>This study showed that the proportion of stroma can be useful for predicting long-term survival after salvage surgery. Further large-scale studies are warranted to confirm the current findings.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison between OK-432 and Talc for pleurodesis in patients with persistent pulmonary air leak: a Japanese nationwide retrospective database study. 比较 OK-432 和滑石粉对持续性肺气漏患者胸膜腔穿刺术的效果:一项日本全国性回顾性数据库研究。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-09-26 DOI: 10.1007/s11748-024-02088-w
Jumpei Taniguchi, Shotaro Aso, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
{"title":"Comparison between OK-432 and Talc for pleurodesis in patients with persistent pulmonary air leak: a Japanese nationwide retrospective database study.","authors":"Jumpei Taniguchi, Shotaro Aso, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga","doi":"10.1007/s11748-024-02088-w","DOIUrl":"https://doi.org/10.1007/s11748-024-02088-w","url":null,"abstract":"<p><strong>Objectives: </strong>OK-432 (Picibanil<sup>®</sup>) and talc are used in patients with persistent pulmonary air leaks. However, it is unclear which of these two agents is more effective.</p><p><strong>Methods: </strong>This retrospective study used data from the Japanese Diagnosis Procedure Combination inpatient database. Patients with pneumothorax who underwent chemical pleurodesis between July 2010 and March 2022 were included in this study. The patients were categorized into two groups: the OK-432 and talc groups. The primary outcome measure was treatment failure, defined as a composite of requirement for additional surgical procedures, bronchoscopic interventions, or chemical pleurodesis. The secondary outcome measures were in-hospital mortality, length of hospital stay, 30-day readmission, and incidence of interstitial lung diseases after hospitalization. To compare the outcomes between the groups, 1:4 propensity score matching was conducted.</p><p><strong>Results: </strong>Among the 4179 eligible patients, 3551 and 628 patients underwent chemical pleurodesis using OK-432 and talc, respectively. Propensity score matching yielded 2508 and 627 patients who underwent chemical pleurodesis using OK-432 and talc within seven days of admission, respectively. The frequency of treatment failure in the talc group (37.5% vs. 31.4%; P = 0.006) was lower than that in the OK-432 group with no significant differences in other outcomes.</p><p><strong>Conclusions: </strong>Medical professionals can consider talc as the initial pleurodesis agent for patients with persistent air leaks.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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