General Thoracic and Cardiovascular Surgery最新文献

筛选
英文 中文
Comparison between Zone 2 and Zone 3 distal anastomoses for aortic arch replacement in terms of invasiveness. 主动脉弓置换术中 2 区和 3 区远端吻合的侵袭性比较。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2025-01-01 Epub Date: 2024-05-29 DOI: 10.1007/s11748-024-02045-7
Mamoru Arakawa, Kei Akiyoshi, Yuichiro Kitada, Atsushi Miyagawa, Homare Okamura
{"title":"Comparison between Zone 2 and Zone 3 distal anastomoses for aortic arch replacement in terms of invasiveness.","authors":"Mamoru Arakawa, Kei Akiyoshi, Yuichiro Kitada, Atsushi Miyagawa, Homare Okamura","doi":"10.1007/s11748-024-02045-7","DOIUrl":"10.1007/s11748-024-02045-7","url":null,"abstract":"<p><strong>Objectives: </strong>Zone 2 anastomosis with total cervical branch reconstruction for acute type A aortic dissection and aortic arch aneurysms became possible after stent-graft introduction. This may be an easier procedure and reduce the risk of recurrent laryngeal nerve palsy. Therefore, this study aimed to compare the outcomes between Zone 2 and Zone 3 distal anastomoses.</p><p><strong>Methods: </strong>After evaluating the patient data in our institute between April 2016 and April 2022, the patients in whom distal anastomosis was performed at Zone 2 with a stent-graft were defined as the Zone 2 group (n = 70). The patients in whom distal anastomosis was performed at Zone 3 were defined as the Zone 3 group (n = 24).</p><p><strong>Results: </strong>The incidence of new-onset recurrent nerve palsy was one patient (1.4%) in the Zone 2 group and six patients (25.0%) in the Zone 3 group (p < 0.001). The lower body perfusion arrest time was 44.3 ± 9.1 min in the Zone 2 group and 52.9 ± 12.8 min in the Zone 3 group (p = 0.005). There were no significant differences in in-hospital mortality and morbidities. Multivariable analysis showed that only age was an independent predictor of overall mortality.</p><p><strong>Conclusions: </strong>Performing distal anastomosis at Zone 2 with a frozen elephant trunk or stent-graft reduced the lower body perfusion arrest time and possibly prevented recurrent nerve palsy.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"23-30"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic floating thrombus and COVID‑19. 主动脉漂浮血栓和 COVID-19。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2025-01-01 Epub Date: 2024-09-02 DOI: 10.1007/s11748-024-02080-4
Mesut Engin
{"title":"Aortic floating thrombus and COVID‑19.","authors":"Mesut Engin","doi":"10.1007/s11748-024-02080-4","DOIUrl":"10.1007/s11748-024-02080-4","url":null,"abstract":"","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"70"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-expandable transcatheter valve is a potentially useful option for a failing small surgical aortic bioprosthetic valve. 自体可扩张经导管瓣膜是治疗失败的小手术主动脉生物人工瓣膜的潜在有效选择。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2025-01-01 Epub Date: 2024-06-05 DOI: 10.1007/s11748-024-02048-4
Shohei Morita, Arudo Hiraoka, Genta Chikazawa, Shinya Takahashi, Taichi Sakaguchi, Hidenori Yoshitaka
{"title":"Self-expandable transcatheter valve is a potentially useful option for a failing small surgical aortic bioprosthetic valve.","authors":"Shohei Morita, Arudo Hiraoka, Genta Chikazawa, Shinya Takahashi, Taichi Sakaguchi, Hidenori Yoshitaka","doi":"10.1007/s11748-024-02048-4","DOIUrl":"10.1007/s11748-024-02048-4","url":null,"abstract":"<p><strong>Objective: </strong>Trans-catheter aortic valve implantation inside a failing surgical aortic valve bio-prosthesis has become an alternative for patients at high risk for redo surgical aortic valve replacement. However, the correlation between the size of the failing surgical aortic valve and the occurrence of prosthesis-patient mismatch after trans-catheter implantation is still controversial. The aim of this study is to analyze and report the results in Japanese patients.</p><p><strong>Methods: </strong>Thirty patients who underwent trans-catheter aortic valve implantation inside a failing surgical aortic valve at our hospital were retrospectively reviewed with results from echocardiography and computed tomography.</p><p><strong>Results: </strong>The patients' mean age was 84.5 ± 4.8 years. The mean body surface area was 1.42 ± 0.13 m<sup>2</sup>. The cohort was divided into two groups according to the size of the failing bio-prosthesis: small (≦19 mm) and large (> 19 mm). There were no significant differences in mean pressure gradient (12.2 ± 4.0 mmHg vs. 11.1 ± 1.2 mmHg; p = 0.54) and effective orifice area index (1.00 ± 0.26 cm<sup>2</sup>/m<sup>2</sup> vs. 0.99 ± 0.25 cm<sup>2</sup>/m<sup>2</sup>; p = 0.92) between the groups at 6 months after trans-catheter implantation. The incidence of moderate (38.5% vs. 28.6%; p = 0.59) and severe (0% vs. 7.1%; p = 0.33) prosthesis-patient mismatch was equivalent. There was no significant difference in survival between the two groups (log-rank test p-value = 0.08).</p><p><strong>Conclusions: </strong>Trans-catheter implantation inside a failing small aortic valve did not increase the frequency of prosthesis-patient mismatch in this Japanese cohort.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"31-38"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Mitochondrial respiratory pathways in immature rat heart tissue using different cardioplegic solutions. 更正:未成熟大鼠心脏组织线粒体呼吸途径与不同心脏麻痹溶液的关系。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2025-01-01 DOI: 10.1007/s11748-024-02107-w
Arslan Mamedov, Eglė Rumbinaitė, Sebastian Romann, Dovydas Verikas, Povilas Jakuška, Serik Aitaliyev, Rimantas Benetis, Edgaras Stankevičius
{"title":"Correction: Mitochondrial respiratory pathways in immature rat heart tissue using different cardioplegic solutions.","authors":"Arslan Mamedov, Eglė Rumbinaitė, Sebastian Romann, Dovydas Verikas, Povilas Jakuška, Serik Aitaliyev, Rimantas Benetis, Edgaras Stankevičius","doi":"10.1007/s11748-024-02107-w","DOIUrl":"10.1007/s11748-024-02107-w","url":null,"abstract":"","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"71"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and safety of uniport robotic-assisted thoracoscopic surgery in initial series of anatomical pulmonary resections under learning curve. 单端口机器人辅助胸腔镜手术在学习曲线下解剖肺切除术初始系列中的可行性和安全性。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2025-01-01 Epub Date: 2024-06-15 DOI: 10.1007/s11748-024-02051-9
Hiroyuki Kaneda, Takahito Nakano, Takahiro Utsumi, Tomohiro Murakawa
{"title":"Feasibility and safety of uniport robotic-assisted thoracoscopic surgery in initial series of anatomical pulmonary resections under learning curve.","authors":"Hiroyuki Kaneda, Takahito Nakano, Takahiro Utsumi, Tomohiro Murakawa","doi":"10.1007/s11748-024-02051-9","DOIUrl":"10.1007/s11748-024-02051-9","url":null,"abstract":"<p><strong>Objectives: </strong>Uniport robotic assisted thoracoscopic surgery (U-RATS) is a recently adopted approach in thoracic surgery and is assumed to require a learning curve for surgeons because of technical difficulties. We aimed to verify the feasibility and safety of solo surgery in U-RATS in an initial series of patients, comparing with initial series of uniport video-assisted thoracoscopic surgery (U-VATS).</p><p><strong>Methods: </strong>The surgical and post-operative outcomes of 25 U-RATS cases were compared with 25 U-VATS cases. The da Vinci Xi Surgical System was used for U-RATS procedure. In both groups, the skin incisions were 4 cm in length, and a 30-degree camera was placed at the posterior and upper edges of the incision.</p><p><strong>Results: </strong>Between June and December 2023, 25 patients with lung malignancies underwent anatomical pulmonary resection via U-RATS, including 13 lobectomies and 12 segmentectomies. Patient characteristics did not differ between the groups. The short-term outcomes were similar between the U-RATS and U-VATS groups, except for operation time (median: 214 vs. 157 min, p = 0.0035). The pain scores on postoperative days 1 and 3 were significantly lower in patients who underwent U-RATS than in those who underwent U-VATS (median: 0 vs. 2, p = 0.010; median: 0 vs. 0, p = 0.027, respectively).</p><p><strong>Conclusions: </strong>The short-term outcomes are similar between the U-RATS and U-VATS groups, except for operation time. U-RATS is considered to be feasible and safe in the initial series of anatomical pulmonary resections performed by a surgeon who was under the learning curve.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"52-57"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of aortic valve reintervention in patients with aortic stenosis undergoing transcatheter aortic valve implantation versus surgical aortic valve replacement: a systematic review and updated meta-analysis of randomized studies. 接受经导管主动脉瓣植入术与手术主动脉瓣置换术的主动脉瓣狭窄患者主动脉瓣再介入的发生率:随机研究的系统回顾和最新荟萃分析。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2025-01-01 Epub Date: 2024-10-03 DOI: 10.1007/s11748-024-02090-2
Julia Goese Groberio, Pedro Henrique Reginato, Rafael Eduardo Streit, Alice Volpato Rocha, Ofonime Chantal Udoma-Udofa, Cynthia Florêncio de Mesquita, André Rivera, Anderson Zampier Ulbrich, Fábio Rocha Farias, Wilton Francisco Gomes
{"title":"Incidence of aortic valve reintervention in patients with aortic stenosis undergoing transcatheter aortic valve implantation versus surgical aortic valve replacement: a systematic review and updated meta-analysis of randomized studies.","authors":"Julia Goese Groberio, Pedro Henrique Reginato, Rafael Eduardo Streit, Alice Volpato Rocha, Ofonime Chantal Udoma-Udofa, Cynthia Florêncio de Mesquita, André Rivera, Anderson Zampier Ulbrich, Fábio Rocha Farias, Wilton Francisco Gomes","doi":"10.1007/s11748-024-02090-2","DOIUrl":"10.1007/s11748-024-02090-2","url":null,"abstract":"<p><strong>Introduction: </strong>Transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) are established interventions for alleviating symptoms and enhancing survival in individuals with severe aortic stenosis (AS). However, the long-term outcomes and incidence of reintervention associated with TAVI and SAVR remain uncertain.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis to compare the incidence of reintervention in TAVI versus SAVR. PubMed, Embase, and Cochrane databases were searched for randomized controlled trials (RCTs). Risk ratios (RR) and 95% confidence intervals (CI) were pooled with a random-effects model. A p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Nine RCTs were included, with 5144 (50.9%) patients randomized to TAVI. Compared with SAVR, TAVI increased reinterventions (RR 1.89; 95% CI 1.29-2.76; p < 0.01) and the need for pacemakers (RR 1.91; 95% CI 1.49-2.45; p < 0.01). In addition, TAVI significantly reduced the incidence of new-onset atrial fibrillation (RR 0.43; 95% CI 0.32- 0.59; p < 0.01). There were no significant differences in all-cause mortality (RR 1.04; 95% CI 0.92-1.16; p = 0.55), cardiovascular mortality (RR 1.04; 95% CI 0.94-1.17; p = 0.44), stroke (RR 0.97; 95% CI 0.80-1.17; p = 0.76), endocarditis (RR 0.96; 95% CI 0.70-1.33; p = 0.82), and myocardial infarction (RR 1.06; 95% CI 0.79-1.41; p = 0.72) between groups.</p><p><strong>Conclusions: </strong>In patients with severe AS, TAVI significantly increased the incidence of reinterventions and the need for pacemakers as compared with SAVR.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"12-22"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of early recurrence in young-onset primary spontaneous pneumothorax following surgery using different covering methods. 使用不同覆盖方法手术后年轻原发性自发性气胸早期复发的比较。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2025-01-01 Epub Date: 2024-06-18 DOI: 10.1007/s11748-024-02049-3
Taiki Takasugi, Motoki Sakuraba, Wataru Arai
{"title":"Comparison of early recurrence in young-onset primary spontaneous pneumothorax following surgery using different covering methods.","authors":"Taiki Takasugi, Motoki Sakuraba, Wataru Arai","doi":"10.1007/s11748-024-02049-3","DOIUrl":"10.1007/s11748-024-02049-3","url":null,"abstract":"<p><strong>Objectives: </strong>The treatment of primary spontaneous pneumothorax not only involves bulla resection via video-assisted thoracic surgery but also covers the lesion. Ideal treatment should minimize adhesions and reduce the recurrence rate. This study aimed to explore different covering methods and compare the frequency of early recurrence for each covering method.</p><p><strong>Methods: </strong>We included 370 subjects with primary spontaneous pneumothorax < 25 years who were treated with video-assisted thoracic surgery from August 2012 to December 2022. Subjects were divided into three groups depending on how the treated lesions were covered. The P group included 162 subjects treated between April 2012 and June 2017 whose lesions were covered using polyglycolic acid sheets on the staple line of the bulla resection lesion. The O group included 93 subjects treated between July 2017 and July 2019 whose lesions were covered with oxidized regenerated cellulose over a polyglycolic acid sheet. The N group included 115 subjects treated between August 2019 and December 2022 whose lesions were covered with oxidized regenerated cellulose over a polyglycolic acid nano sheet.</p><p><strong>Results: </strong>Recurrence rates were 3.7%, 8.6%, and 6.0% in the P, O, and N groups, respectively; however, the differences were not statistically significant. The adhesions were milder in the N group than in the P and O groups.</p><p><strong>Conclusions: </strong>Although both covering methods were effective in preventing recurrence, further studies involving further treatment modifications and longer-term follow-ups are required.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"45-51"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined procedure using a double flap as a surgical option for coarctation of the aorta with delayed diagnosis. 使用双瓣联合手术作为主动脉共动脉瘤延迟诊断的手术选择。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2025-01-01 Epub Date: 2024-08-16 DOI: 10.1007/s11748-024-02071-5
Mitsuru Sato, Naoki Masaki, Sadahiro Sai
{"title":"Combined procedure using a double flap as a surgical option for coarctation of the aorta with delayed diagnosis.","authors":"Mitsuru Sato, Naoki Masaki, Sadahiro Sai","doi":"10.1007/s11748-024-02071-5","DOIUrl":"10.1007/s11748-024-02071-5","url":null,"abstract":"<p><p>Simple coarctation of the aorta is repaired in an infant by direct end-to-end anastomosis of the aorta or subclavian flap aortoplasty. However, some cases are not detected until late childhood. For school-age patients, greater consideration must be given to risks such as postoperative limb ischemia and the potentially harmful effects of any artificial material on future growth. Here, we describe our technique for these patients, in whom the value of direct anastomosis is uncertain, to minimize the amount of synthetic graft material used while achieving successful anatomical repair.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"66-69"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating air leakage from staple line reinforcements in anatomical pulmonary resection (AIRSTOP): a prospective randomized controlled trial protocol. 评估解剖性肺切除术(AIRSTOP)中钉线增强物的漏气:一项前瞻性随机对照试验方案。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-12-26 DOI: 10.1007/s11748-024-02111-0
Jotaro Yusa, Kazuhisa Tanaka, Kohei Takahashi, Yuki Shiko, Takeshi Sugawara, Ichiro Yoshino, Hidemi Suzuki
{"title":"Evaluating air leakage from staple line reinforcements in anatomical pulmonary resection (AIRSTOP): a prospective randomized controlled trial protocol.","authors":"Jotaro Yusa, Kazuhisa Tanaka, Kohei Takahashi, Yuki Shiko, Takeshi Sugawara, Ichiro Yoshino, Hidemi Suzuki","doi":"10.1007/s11748-024-02111-0","DOIUrl":"https://doi.org/10.1007/s11748-024-02111-0","url":null,"abstract":"<p><strong>Background: </strong>Air leakage during pulmonary resection is a major complication in thoracic surgery. It frequently occurs at sites of adhesion dissection, due to lung manipulation, and along the staple lines of automatic suturing devices, particularly in cases of pulmonary fragility such as those of emphysema and interstitial pneumonia. Persistent postoperative air leakage prolongs chest tube indwelling and extends hospitalization time. Staplers with absorbable tissue reinforcements have been introduced for pulmonary resection to prevent intraoperative stapler-related air leakage. This phase II prospective, open-label, randomized, parallel-group trial aims to validate the efficacy of staplers with or without absorbable tissue reinforcements in controlling stapler-related air leakage during anatomical pulmonary resections.</p><p><strong>Methods: </strong>Overall, 120 patients will be randomized into two groups: one that will undergo conventional anatomical pulmonary resection and the other in which staplers with absorbable tissue reinforcements will be used. The primary endpoint will be intraoperative stapler-related air leakage. Data will be analyzed between 2024 and 2025.</p><p><strong>Discussion: </strong>This trial will validate the effectiveness and safety of staple line reinforcements in controlling intraoperative air leakage during anatomical pulmonary resections, potentially leading to optimized strategies for patients with conditions such as emphysema and interstitial pneumonia.</p><p><strong>Trial registration: </strong>This trial has been registered with the Japan Registry of Clinical Trials 1032220620 ( https://jrct.niph.go.jp/latest-detail/jRCTs031230224 ).</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of HLA mismatch between donors and recipients on postoperative outcomes in cadaveric lung transplantation. 供体和受体HLA不匹配对尸体肺移植术后预后的影响。
IF 1.1 4区 医学
General Thoracic and Cardiovascular Surgery Pub Date : 2024-12-09 DOI: 10.1007/s11748-024-02109-8
Hidenao Kayawake, Ichiro Sakanoue, Satona Tanaka, Yojiro Yutaka, Yoshihiro Nishino, Akira Matsumoto, Taiki Ryo, Taichi Matsubara, Daisuke Nakajima, Hiroshi Date
{"title":"Influence of HLA mismatch between donors and recipients on postoperative outcomes in cadaveric lung transplantation.","authors":"Hidenao Kayawake, Ichiro Sakanoue, Satona Tanaka, Yojiro Yutaka, Yoshihiro Nishino, Akira Matsumoto, Taiki Ryo, Taichi Matsubara, Daisuke Nakajima, Hiroshi Date","doi":"10.1007/s11748-024-02109-8","DOIUrl":"https://doi.org/10.1007/s11748-024-02109-8","url":null,"abstract":"<p><strong>Objectives: </strong>Generally, HLA matching between donors and recipients is not performed in lung transplantation (LTx). Therefore, whether HLA mismatch between donors and recipients (D/R mismatch) influences postoperative outcomes after LTx remains uncertain. In this study, we investigated the influence of D/R mismatch on postoperative outcomes after cadaveric LTx (CLT).</p><p><strong>Methods: </strong>A total of 140 CLT procedures were performed between 2012 and 2020. After excluding 5 recipients with preformed DSA and 1 recipient undergoing re-LTx, 134 recipients were enrolled in this retrospective study. The postoperative outcomes were compared between recipients with higher and lower D/R mismatches.</p><p><strong>Results: </strong>The median D/R mismatch (A/B/DR loci) was 4.0 (range, 1-6). When dividing these 134 recipients into two groups (H group [D/R mismatch ≥ 5, n = 57] and L group [D/R mismatch ≤ 4, n = 77]), there were no significant differences in the patient backgrounds. The lengths of hospital and intensive care unit stays were similar (p = 0.215 and p = 0.37, respectively). Although the overall survival was not significantly better in the H group than in the L group (p = 0.062), chronic lung allograft dysfunction-free survival was significantly better in the H group than in the L group (p = 0.027). Conversely, there was no significant difference in the cumulative incidence of de novo donor-specific anti-HLA antibodies (dnDSAs) between the two groups (p = 0.716).</p><p><strong>Conclusions: </strong>No significant difference in dnDSA development was observed between patients with higher and lower D/R HLA mismatches. Given the favorable outcomes in the high HLA mismatch group, CLTs can be performed safely in recipients with high D/R HLA mismatches.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信