Frontiers in Neuroanatomy最新文献

{"title":"Characterization of the tyrosine-hydroxylase immunoreactive components of the basal subpallium in sharks-toward an identification of a basal subpallial complex.","authors":"Isabel Rodríguez-Moldes, Catalina Sueiro, Iván Carrera, Idoia Quintana-Urzainqui, Eva Candal","doi":"10.3389/fnana.2025.1620527","DOIUrl":"10.3389/fnana.2025.1620527","url":null,"abstract":"<p><p>Comparative studies on the forebrain across different model organisms are necessary to investigate the origin and degree of evolutionary conservation of this brain region and its derivatives. The catshark <i>Scyliorhinus canicula</i> has become a reliable model representative of cartilaginous fishes (Chondrichthyans), the oldest divergent lineage of extant gnathostomes (jawed vertebrates). Previous studies on the chemoarchitecture, connectivity, and development of the subpallium of <i>S. canicula</i> revealed the existence of subdivisions with an embryological origin and genetic specification similar to those of tetrapods, supporting homology with their basal ganglia and certain amygdaloid components. To better understand the evolutionary origin of these subpallial components, we present here a summary of the main neuroanatomical, chemoarchitectural, and developmental features of the <i>area superficialis basalis</i> of <i>S. canicula</i>, a nuclear aggrupation of the basal forebrain of all Chondrichthyans that has been related to the basal ganglia and the amygdala. Particular emphasis has been placed on characterizing the tyrosine hydroxylase-positive components of the subpallium to discern their involvement in the structural organization of putative basal ganglia homologs in the catshark. We propose a new interpretation that considers the <i>area superficialis basalis</i> as the central part of a subpallial complex formed also by its neighboring territories, where the basic components of the basal ganglia and the amygdala of gnathostomes would be integrated.</p>","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1620527"},"PeriodicalIF":2.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in behavioral preference and calcium binding expression in two <i>Synodontis</i> catfishes with different communication modalities.","authors":"Carlos Daniel Corrales Parada, Iva Udovičić, Giulia Haschei, Boris Philippe Chagnaud","doi":"10.3389/fnana.2025.1589687","DOIUrl":"10.3389/fnana.2025.1589687","url":null,"abstract":"<p><p>Animals use different communication modalities for social interactions, often showing sensory adaptations linked to their preferred signaling system. How such adaptations affect individual processing centers usually remains elusive due to interspecies differences. One system in which such adaptations can be investigated are <i>Synodontis</i> catfish. <i>Synodontids</i> generally use acoustic signals for social communication, but in some species, they generate electric signals. This allows to investigate adaptations of networks associated with social signal detection in closely related species. We investigated potential sensory adaptations in two <i>Synodontis</i> species (<i>Synodontis grandiops</i> - SG and <i>Synodontis nigriventris</i> - SN) with different communication channels. We tested their behavioral preferences toward different sensory modalities and found strong preferences for conspecifics. To investigate potential adaptations at the cellular level, we focused on the torus semicircularis (TS), a major midbrain sensory hub for auditory and electric sensory processing. We found an increase in projections from the anterior tuberal nucleus (AT) to the lateral TS (TSl, which processes electrosensory information) in SN, but no difference in the projections from the central TS (TSc) to AT in either species. An enhanced density of calcium binding proteins in the TSl was found only in SN. As electrocommunication is a derived communication channel in <i>Synodontis</i>, our findings suggest that a shift to electric communication may have led to (i) stronger projections to and from sensory regions, and (ii) a change in neurochemical profile, which together might facilitate social signal detection.</p>","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1589687"},"PeriodicalIF":2.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective vulnerability of stellate cells to gut dysbiosis: neuroanatomical changes in the medial entorhinal cortex.","authors":"Ayishal B Mydeen, Mohammed M Nakhal, Faheema Nafees, Reem Almazrouei, Rasha Alkamali, Mahra Alsulaimi, Omar Aleissaee, Abdulrahman Alzaabi, Mohamed Alfahim, Hamad Almansoori, Shamsa BaniYas, Shaikha Al Houqani, Marim Elkashlan, Safa Shehab, Mohammad I K Hamad","doi":"10.3389/fnana.2025.1589287","DOIUrl":"10.3389/fnana.2025.1589287","url":null,"abstract":"<p><strong>Introduction: </strong>The gut microbiota plays a critical role in regulating brain structure and function via the microbiota-gut-brain axis. Antibiotic-induced gut dysbiosis (AIGD) has been linked to neuroanatomical changes and cognitive deficits. However, its impact on neuronal morphology in layer II of the medial entorhinal cortex (mECII), a region central to spatial memory, remains poorly understood. This study examines how AIGD affects dendritic architecture in mECII stellate and pyramidal island cells.</p><p><strong>Methods: </strong>Mice received a broad-spectrum oral antibiotic cocktail to induce AIGD. Gut microbiota composition was analyzed using 16S rRNA sequencing. Golgi-stained neurons in mECII were assessed for dendritic complexity via Sholl analysis. Iba1 staining evaluated microglial activation in mECII. Intestinal sections were stained with NeuN and CD8 to assess enteric neuron density and inflammation. Microbial abundance was correlated with dendritic parameters.</p><p><strong>Results: </strong>AIGD resulted in significant dysbiosis, including depletion of butyrate-producing taxa (<i>Roseburia</i>, <i>Faecalibacterium</i>) and enrichment of proinflammatory bacteria (<i>Clostridium</i>, <i>Salmonella</i>, <i>Enterococcus</i>). Stellate cells showed marked dendritic atrophy, while pyramidal island cells were unaffected. Dendritic complexity positively correlated with <i>Roseburia hominis</i> and negatively with <i>Enterococcus faecalis</i>. No microglial activation was detected in mECII, but CD8 + T-cell infiltration increased in the gut without changes in NeuN-labeled enteric neurons.</p><p><strong>Discussion: </strong>These findings suggest AIGD selectively alters mECII stellate cell morphology through peripheral immune signaling or microbial metabolites, independent of local microglial activation. This study highlights the role of gut microbiota in shaping neuronal architecture and supports microbiome-targeted strategies to counteract dysbiosis-associated neuroanatomical changes.</p>","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1589287"},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal structure, patterns of the calcium-binding proteins and neuron numbers in small echolocating bats.","authors":"Jovana Maliković, Katja Schönbächler, Ana Luiza F Destro, David P Wolfer, Irmgard Amrein","doi":"10.3389/fnana.2025.1641787","DOIUrl":"10.3389/fnana.2025.1641787","url":null,"abstract":"<p><p>Even though bats are the second most speciose group of mammals, neuroanatomical studies of their hippocampus are rare, particularly of small echolocating bats. Here, we provide a qualitative and quantitative neuroanatomical analysis of the hippocampus of small echolocating bats (Phyllostomidae and Vespertilionidae). Calcium-binding proteins revealed species- and family-specific patterns for calbindin and calretinin. Interneuron staining for both proteins was very rare in phyllostomids, while calretinin marked subpopulations of CA3 pyramidal neurons in both families. Parvalbumin expression was consistent across bats and similar to other species. A unique calretinin-positive calbindin-negative zone was observed at the superficial boundary of the CA3 pyramidal cell layer in phyllostomid bats. This zone defined a gap between pyramidal cells and the zinc-positive mossy fibers. We hypothesize that this gap might either stem from calretinin-positive afferents displacing the zinc-positive mossy fiber boutons, or from a complete segregation of neurochemically distinct mossy boutons. Furthermore, we observed a distinct dorsoventral shift in the length of the upper and lower blade of the granule cell layer in all species. In terms of hippocampal neuron numbers, bats were characterized by a rather small granule cell and subicular neuron population, but a well-developed CA3. In a correspondence analysis, preferred diet segregated phyllostomids into a hilus-dominant omnivorous and frugivorous species group, and a subiculum-dominant group containing vampire bats and nectivorous species. Although the two families overlapped considerably, the cellular composition of the phyllostomid hippocampus can be described as output dominant, while in vespertilionids neuron populations on the hippocampal input side are more dominant. Neuroanatomical and ecological variability and unique traits within echolocating bats as shown here can provide a rich source for investigating structure-function relationships.</p>","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1641787"},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study on the distribution of Pacinian corpuscles in the pancreas.","authors":"Ting Yang, Ke Ren, Xiangquan Chen, Taku Toriumi, Rujia Li, Jun Li, Konosuke Tokita, Shuang-Qin Yi","doi":"10.3389/fnana.2025.1593682","DOIUrl":"10.3389/fnana.2025.1593682","url":null,"abstract":"<p><strong>Background: </strong>Pacinian corpuscles (PCs) are pressure- and vibration-sensitive mechanoreceptors found in hairless skin, external genitalia, joints, ligaments, lymph nodes, prostate, bladder, etc. While they are documented in the pancreas of cats, their presence in the normal pancreas remains speculative.</p><p><strong>Purpose: </strong>The present study therefore investigated the distribution of PCs in the normal human pancreas and compared the findings with those in several other animal species.</p><p><strong>Methods: </strong>The study subjects included 74 human cadaver specimens, 3 <i>Cynictis penicillata</i>, 2 <i>Saguinus mystaxs</i>, 1 <i>Felis domesticus</i>, and 10 <i>Suncus murinus</i>. Pancreatic tissues were prepared as paraffin sections for histological and immunohistochemical analyses of the main constituents of PCs (central axon, inner core, and outer core capsule).</p><p><strong>Results: </strong>PCs were found in the pancreas of five human cadavers (7%), as well as in one <i>C. penicillata</i>, one <i>S. mystax</i> and one <i>F. domesticus</i> but not in <i>S. murinus</i>. The PCs varied in size, with the largest in the human pancreas measuring up to 1,106 μm-far exceeding those in animal pancreata, but less numerous than those in animals. Morphologically, animal PCs were mainly typical oval shapes, whereas PCs in the human pancreas were mostly irregular in shape. In addition, we found that PCs in animals and human pancreata had similar structures, with consistent expression of protein gene product 9.5, in axonic profiles, and diffuse vimentin immunoreactivity in the inner core, outer core, and capsule.</p><p><strong>Conclusion: </strong>This study confirmed the presence of PCs in a small number of healthy humans and some animal pancreata. The number, distribution characteristics, and morphology of PCs in the pancreata of animals and humans are quite different; however, their structures and immunohistochemical profiles are similar. The presence of PCs in the normal human pancreas is also a mystery, and the physiological role of PCs in the human pancreas requires further clarification.</p>","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1593682"},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired modulation of the trigeminal caudal nucleus by the locus coeruleus in diabetic mice: the role of GABAergic and glycinergic neurons.","authors":"Alberto Mesa-Lombardo, Nuria García-Magro, Angel Nuñez, Yasmina B Martin","doi":"10.3389/fnana.2025.1600026","DOIUrl":"10.3389/fnana.2025.1600026","url":null,"abstract":"","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1600026"},"PeriodicalIF":2.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Editorial: 15 years of frontiers in neuroanatomy: the origin of Parkinson's disease.","authors":"Barbara Falquetto, Cristina Nombela, Luiz R G Britto","doi":"10.3389/fnana.2025.1666562","DOIUrl":"https://doi.org/10.3389/fnana.2025.1666562","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnana.2025.1649700.].</p>","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1666562"},"PeriodicalIF":2.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroanatomical mapping of huntingtin-associated protein 1 across the rostral and caudal clusters of mouse raphe nuclei and its immunohistochemical relationships with serotonin.","authors":"Marya Afrin, Md Nabiul Islam, Mirza Mienur Meher, Mir Rubayet Jahan, Kanako Nozaki, Koh-Hei Masumoto, Akie Yanai, Koh Shinoda","doi":"10.3389/fnana.2025.1625793","DOIUrl":"10.3389/fnana.2025.1625793","url":null,"abstract":"<p><p>Huntingtin-associated protein 1 (HAP1) is a crucial component of the stigmoid body (STB) and is recognized as a neuroprotective interactor with causative proteins for several neurodegenerative disorders (NDs). Due to HAP1 protectivity, brain regions rich in STB/HAP1 are typically shielded from neurodegeneration, whereas areas with little or no STB/HAP1 are often affected in NDs. Mounting evidence suggests that serotonin (5-HT) neuron dysfunction contributes to various NDs. While the raphe nuclei denote the origin of 5-HT neurons, HAP1 protectivity has yet to be determined there. To accomplish this, the present study evaluated the expression and detailed neuroanatomical distribution of HAP1 throughout the rostral and caudal clusters of raphe nuclei in adult mice brains and their morphological relationships with 5-HT by employing Western blotting and immunohistochemistry. Our results indicated that in the rostral cluster, HAP1-ir cells were extensively distributed across the caudal linear raphe, median raphe, dorsal raphe, supralemniscal raphe, caudal part of the dorsal raphe, pre-pontine and pontine raphe nuclei. In the caudal cluster, HAP1-ir neurons were disseminated throughout the raphe magnus, raphe obscurus, raphe pallidus, parapyramidal, and raphe interpositus nuclei. Our double-immunofluorescence labeling results confirmed that most of the 5-HT neurons contained HAP1 immunoreactivity throughout the rostral and caudal clusters of the raphe nuclei. These suggest that HAP1 is crucial for modulating/protecting serotonergic functions, plausibly by upholding 5-HT neuronal plasticity/integrity by raising the threshold for neurodegeneration. Our current findings might provide a fundamental basis for further research aimed at elucidating the role of STB/HAP1 in the pathophysiology of serotonin neurons.</p>","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1625793"},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relative withdrawal of GFAP-An essential component of brain evolution.","authors":"Mihály Kálmán","doi":"10.3389/fnana.2025.1607603","DOIUrl":"10.3389/fnana.2025.1607603","url":null,"abstract":"<p><p>The glial fibrillary acidic protein (GFAP) is the principal intermediate filament protein and histochemical marker for astroglia. It appears contradictory that there are extended GFAP-poor or even GFAP-free areas in the brains of various vertebrate clades: cartilaginous and ray-finned fishes, and amniotes. The \"Relevant Subsections: Extended GFAP-free areas in various vertebrates\" section in this study reviews our GFAP mapping studies on the brains of 58 species within these clades, as well as mappings from other authors, and demonstrates that these areas appeared independently from one another in the more advanced groups of different clades; it raises the supposition that the lack of GFAP is an apomorphic phenomenon. The GFAP expression has withdrawn mainly relatively: the GFAP-immunonegative areas increased more than the immunopositive ones. Primarily, regions that expanded and increased in complexity during evolution lack GFAP immunopositivity (except for their perivascular glia). The absence of GFAP expression, however, does not indicate the lack of astroglia. In the areas immunonegative to GFAP, astrocytes were visualized using other markers, such as glutamine synthetase or S-100 protein. In birds and mammals, lesions induced GFAP expression in these areas. It shows that the ability to express GFAP is not lost but has become facultative. These data suggest that the lack of GFAP production may provide an evolutionary advantage. The \"Discussion\" section relates the GFAP \"withdrawal\" to other steps of evolution: the increasing complexity and thickening of the brain wall, as well as the appearance of the astrocytes, particularly protoplasmic astrocytes, and then examines the proposed evolutionary advantages and disadvantages of the absence of GFAP. The role of the relative \"withdrawal\" of GFAP expression in brain evolution remains to be definitively answered. The most probable candidates may include the absence of synthesizing an unnecessary protein, improved adaptation of astrocytes to the demands of neurons, and an increased capacity for synaptic plasticity. In contrast, one must consider that the withdrawal of GFAP may not be a primary phenomenon but rather a consequence of the evolution of neural networks.</p>","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1607603"},"PeriodicalIF":2.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The orca (<i>Orcinus orca</i>) pituitary gland: an anatomical, immunohistochemical and ultrastructural analysis.","authors":"Paula Alonso-Almorox, Alfonso Blanco, Carla Fiorito, Jose C Gómez-Villamandos, M A Risalde, Javier Almunia, Antonio Fernández","doi":"10.3389/fnana.2025.1626079","DOIUrl":"10.3389/fnana.2025.1626079","url":null,"abstract":"<p><p>The pituitary gland is central to endocrine regulation in vertebrates, coordinating key physiological processes such as growth, reproduction, and stress responses. In cetaceans, and particularly in large odontocetes like orcas (Orcinus orca), understanding pituitary structure is essential for advancing neuroendocrine research and informing welfare and health assessments. Despite their ecological, cognitive, and conservation significance, detailed morphological studies of the orca pituitary gland remain scarce. In this study, we conducted a comprehensive structural and ultrastructural analysis of the orca pituitary gland using postmortem samples from four captive individuals. We combined computed tomography, histology, immunohistochemistry, and transmission electron microscopy to examine the gland's anatomical organization and cellular composition. Our results reveal features consistent with other cetaceans as well as species-specific characteristics, including the distribution and morphology of endocrine cells within the adenohypophysis and neurohypophysis. These findings provide the first integrated anatomical and ultrastructural reference for the orca pituitary gland, offering valuable insights into cetacean neuroendocrinology and supporting improved species-specific welfare evaluation, health monitoring, and management practices for orcas under human care.</p>","PeriodicalId":12572,"journal":{"name":"Frontiers in Neuroanatomy","volume":"19 ","pages":"1626079"},"PeriodicalIF":2.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}