Functional neurology最新文献_第6页

Epidemiological and clinical characteristics of 492 patients in a vegetative state in 29 Italian rehabilitation units. What about outcome? 意大利29个康复单位492例植物人的流行病学和临床特征结果呢?

Functional neurology Pub Date : 2018-04-01 DOI: 10.11138/FNEUR/2018.33.2.097

R. Avesani, F. Dambruoso, M. Scandola, R. Formisano, A. De Tanti, S. Ferro, N. Smania, L. Roncari, E. Rossato

{"title":"Epidemiological and clinical characteristics of 492 patients in a vegetative state in 29 Italian rehabilitation units. What about outcome?","authors":"R. Avesani, F. Dambruoso, M. Scandola, R. Formisano, A. De Tanti, S. Ferro, N. Smania, L. Roncari, E. Rossato","doi":"10.11138/FNEUR/2018.33.2.097","DOIUrl":"https://doi.org/10.11138/FNEUR/2018.33.2.097","url":null,"abstract":"Recent studies on recovery of consciousness of subjects in a vegetative state (VS) admitted to rehabilitation units have focused mainly on the identification of prognostic factors, whereas few studies have focused on outcome. The aim of this study was to compare demographic and clinical data and report functional outcome of patients in a VS due to severe acquired brain injury (ABI) of different aetiologies. The study was a retrospective multicentre cohort study and involved 492 patients in a VS due to traumatic (TBI) or non-traumatic (NTBI) severe ABI admitted to 29 Italian rehabilitation units. Demographic and clinical data recorded included age, gender, aetiology, Glasgow Coma Scale score; onset-to-admission interval; length of stay in the rehabilitation unit; the department from which they were referred; and the presence of percutaneous endoscopic gastrostomy or tracheostomy. Recovery of consciousness and disability were evaluated using a discharge Disability Rating Scale. At discharge, 53.11% patients had emerged from VS, with TBI subjects significantly more likely to recover consciousness than NTBI ones. Subjects with NTBI had a significantly worse prognosis than those with TBI, and within the NTBI group, subjects with a cerebrovascular aetiology had a better outcome than those with an anoxic aetiology. Among the patients who emerged from VS, 71.30% of TBI and 83.06% of NTBI subjects presented extremely severe disability. Only 37.93% of subjects affected by TBI and 17.44% of those affected by NTBI who presented extremely severe disability returned home after their rehabilitation stay. Even though almost a half of the patients emerged from VS, a large number of these subjects showed severe disability, often making it impossible for them to return home. This situation has a major impact on the healthcare system.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 2 1","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45918256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Laterality in Parkinson's disease may predict motor and visual imagery abilities. 帕金森氏病的侧边性可以预测运动和视觉成像能力。

Functional neurology Pub Date : 2018-04-01

M R Lo Monaco, A Laudisio, D Fusco, D L Vetrano, D Ricciardi, V Delle Donne, F Proietti, Giuseppe Zuccalà, Maria Caterina Silveri

{"title":"Laterality in Parkinson's disease may predict motor and visual imagery abilities.","authors":"M R Lo Monaco, A Laudisio, D Fusco, D L Vetrano, D Ricciardi, V Delle Donne, F Proietti, Giuseppe Zuccalà, Maria Caterina Silveri","doi":"","DOIUrl":"","url":null,"abstract":"Experimental evidence suggests that motor imagery (MI) engages the same neural substrates supporting actual motor activities and is likely impaired when such substrates are damaged, as in Parkinson's disease (PD). MI intuitively relies on visual imagery (VI), because mental simulations of physical movements depend on the visual retrieval of these movements. Although VI is generally considered a right hemispheric function, the hemispheric dominance of MI is still in dispute. Disparities in sidedness of motor disturbances are a distinctive feature of PD, and recent findings indicate that such disparities may similarly characterize cognition. Specifically, the deficits observed may depend upon which hemisphere is principally involved. Essentially, MI and VI are cognitive tasks subject to differential impairment and reflecting the prevalence of hemispheric impairment in PD. Motor imagery (assessed by the Vividness of Motor Imagery Questionnaire [VMIQ]) and VI (assessed by the Vividness of Visual Imagery Questionnaire [VVIQ] and Test of Visual Imagery Control [TVIC]) were examined in patients with asymmetric PD and in healthy elderly control subjects (HC group). VMIQ scores were similar in PD laterality subsets and the HC group, but VVIQ scores were significantly lower in both PD groups compared with the HC group. TVIC scores were significantly lower in the presence of left motor (right hemispheric) impairment and were predictive of left motor (right hemispheric) impairment. We suspect that MI is strongly reliant on VI and that language may mediate these two functions, to the extent that both are evoked through verbal stimuli. Working memory, both visual and verbal, is also involved in MI and VI tasks. Without due attention to laterality of symptoms, any training incorporating MI and VI may not deliver expected outcomes in the setting of asymmetric PD symptomatology.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 2","pages":"106-111"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36293729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of 500 patients with acute stroke admitted to the University Hospital of Saudi Arabia. Similarities and differences compared with the published literature. 对沙特阿拉伯大学医院收治的500例急性中风患者的回顾。与已发表文献比较异同。

Functional neurology Pub Date : 2018-04-01

A Zafar

引用次数: 0

If you want to understand what it really means to live with cluster headache, imagine... fostering empathy through European patients' own stories of their experiences. 如果你想了解丛集性头痛的真正含义，想象一下……通过欧洲病人自己的经历来培养同理心。

Functional neurology Pub Date : 2018-01-01 DOI: 10.11138/fneur/2018.33.1.057

Paolo Rossi, P Little, E R De La Torre, A Palmaro

引用次数: 4

Apathy in Parkinson's disease: differences between caregiver's report and self-evaluation. 帕金森病的冷漠:照顾者报告与自我评价的差异

Functional neurology Pub Date : 2018-01-01 DOI: 10.11138/fneur/2018.33.1.031

V Valentino, Alessandro Iavarone, M Amboni, F Moschiano, M Picillo, V Petretta, G Cicarelli

{"title":"Apathy in Parkinson's disease: differences between caregiver's report and self-evaluation.","authors":"V Valentino, Alessandro Iavarone, M Amboni, F Moschiano, M Picillo, V Petretta, G Cicarelli","doi":"10.11138/fneur/2018.33.1.031","DOIUrl":"https://doi.org/10.11138/fneur/2018.33.1.031","url":null,"abstract":"Apathy is a state of diminished goal-directed speech, motor activity and emotions. The prevalence of apathy in Parkinson's disease (PD) ranges from 16 to 62%. Several studies have investigated the relationships between apathy and other dimensions of PD, but little is known about possible discrepancies between self-evaluation (SE) and caregiver reporting (CR) of this symptom. The aim of this study is twofold: 1) to investigate the differences in apathy evaluations according to the point of view from which apathy is reported (SE vs CR); 2) to identify the possible relationships between each of the two evaluations (SE and CR) and cognitive and affective dimensions of PD. Forty-eight patients with PD were assessed using the Apathy Evaluation Scale (AES) in its SE and CR versions (AES-SE and AES-CR); cognitive, affective and behavioral symptoms were also assessed. AES-SE scores were significantly higher than AESCR ones. Neither AES version correlated with depression, whereas both correlated with motor impairment, disease stage and behavioral symptoms. Mini-Mental State Examination and Frontal Assessment Battery scores showed significant negative correlations only with AES-SE scores. Our findings suggest that the point of view from which apathy is seen can lead to significant discrepancies, even when using the same tool. This should be taken into account in order to obtain correct assessment of this disabling and distressing symptom.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 1","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/fneur/2018.33.1.031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35990929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

A role for accelerometry in the differential diagnosis of tremor syndromes. 加速度计在震颤综合征鉴别诊断中的作用。

Functional neurology Pub Date : 2018-01-01 DOI: 10.11138/fneur/2018.33.1.045

F Bove, G Di Lazzaro, D Mulas, F Cocciolillo, D Di Giuda, A R Bentivoglio

{"title":"A role for accelerometry in the differential diagnosis of tremor syndromes.","authors":"F Bove, G Di Lazzaro, D Mulas, F Cocciolillo, D Di Giuda, A R Bentivoglio","doi":"10.11138/fneur/2018.33.1.045","DOIUrl":"https://doi.org/10.11138/fneur/2018.33.1.045","url":null,"abstract":"Accelerometry is a reliable tool for gauging the occurrence, amplitude and frequency of tremor. However, there is no consensus on criteria for accelerometric diagnosis of tremor syndromes. We enrolled 20 patients with essential tremor (ET), 20 with dystonic tremor (DT), and 20 with classic parkinsonian tremor (PD-T), all meeting accepted clinical criteria. All the patients underwent dopamine transporter imaging (by means of single-photon emission computed tomography) and triaxial accelerometric tremor analysis. The latter revealed groupwise differences in tremor frequency, peak dispersion, spectral coherence, unilaterality and resting vs action tremor amplitude. From the above, five diagnostic criteria were extrapolated for each condition. Receiver operating characteristic curves, depicting criteriabased scoring of each tremor type, showed negligible declines in specificity for scores ≥4 in patients with ET or DT and scores ≥3 in patients with PD-T, thus providing a simple scoring method (accelerometrically derived) for differential diagnosis of the principal tremor syndromes.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 1","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/fneur/2018.33.1.045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35990825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Mechanical thrombectomy for acute ischemic stroke: the therapeutic window is larger but still "time is brain». 机械取栓治疗急性缺血性脑卒中:治疗窗口较大，但仍“时间就是大脑”。

Functional neurology Pub Date : 2018-01-01 DOI: 10.11138/fneur/2018.33.1.005

C Zivelonghi, S Tamburin

引用次数: 7

Multicentre registry of brain-injured patients with disorder of consciousness: rationale and preliminary data. 意识障碍脑损伤患者多中心登记：基本原理和初步数据。

Functional neurology Pub Date : 2018-01-01 DOI: 10.11138/fneur/2018.33.1.019

A Pascarella, S Fiorenza, O Masotta, V Tibollo, D Vella, Anna Maria Nardone, Marta Rossi, P Volanti, F Madonia, Gaetano Cstronovo, D De Cicco, Caterina Guarnaschelli, M P Achilli, C Chiapparino, M T Angelillo, M A Tommasi, F Pisano, G Grioni, G Vezzadini, G Ferriero, S Salvaderi, R Bellazzi, Anna Estraneo

{"title":"Multicentre registry of brain-injured patients with disorder of consciousness: rationale and preliminary data.","authors":"A Pascarella, S Fiorenza, O Masotta, V Tibollo, D Vella, Anna Maria Nardone, Marta Rossi, P Volanti, F Madonia, Gaetano Cstronovo, D De Cicco, Caterina Guarnaschelli, M P Achilli, C Chiapparino, M T Angelillo, M A Tommasi, F Pisano, G Grioni, G Vezzadini, G Ferriero, S Salvaderi, R Bellazzi, Anna Estraneo","doi":"10.11138/fneur/2018.33.1.019","DOIUrl":"10.11138/fneur/2018.33.1.019","url":null,"abstract":"Diagnostic accuracy and reliable estimation of clinical evolution are challenging issues in the management of patients with disorders of consciousness (DoC). Longitudinal systematic investigations conducted in large cohorts of patients with DoC could make it possible to identify reliable diagnostic and prognostic markers. On the basis of this consideration, we devised a multicentre prospective registry for patients with DoC admitted to ten intensive rehabilitation units. The registry collects homogeneous and detailed data on patients' demographic and clinical features, neurophysiological and neuroimaging findings, and medical and surgical complications. Here we present the rationale and the design of the registry and the preliminary results obtained in 53 patients with DoC (vegetative state or minimally conscious state) enrolled during the first seven months of the study. Data at 6-month post-injury follow-up were available for 46 of them. This registry could be an important tool for collecting high-quality data through the application of rigorous methods, and it could be used in the routine management of patients with DoC admitted to rehabilitation settings.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 1","pages":"19-30"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901937/pdf/19-30.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35990928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a nutraceutical combination in patients with chronic lumbosacral radicular pain. 一种营养药物组合治疗慢性腰骶神经根性疼痛的效果。

Functional neurology Pub Date : 2018-01-01 DOI: 10.11138/FNeur/2018.33.3.125

C. Geroin, Stefano Tamburin, G. Pagano, M. Gandolfi, M. Tinazzi

引用次数: 0

Pharmacological differences and clinical implications of various botulinum toxin preparations: a critical appraisal. 各种肉毒杆菌毒素制剂的药理学差异和临床意义:一个关键的评价。

Functional neurology Pub Date : 2018-01-01 DOI: 10.11138/fneur/2018.33.1.007

A Ferrari, M Manca, V Tugnoli, L Alberto

{"title":"Pharmacological differences and clinical implications of various botulinum toxin preparations: a critical appraisal.","authors":"A Ferrari, M Manca, V Tugnoli, L Alberto","doi":"10.11138/fneur/2018.33.1.007","DOIUrl":"https://doi.org/10.11138/fneur/2018.33.1.007","url":null,"abstract":"Three different type A botulinum neurotoxins (BoNTAs) - onabotulinumtoxinA, abobotulinumtoxinA and incobotulinumtoxinA) - are currently marketed in Europe to treat several conditions. Differences between BoNTA preparations, which depend on their specific biotypes and manufacturing processes, lead to clinically relevant pharmacotherapeutic dissimilarities. All three available products are separately recognized and reviewed in American Academy of Neurology guidelines. The neurotoxin load/100U is likewise different among the different BoNTAs, with the result that the specific potency of the 150kD BoNTA neurotoxin is calculated as 137 units/ng for onabotulinumtoxinA, 154 units/ng for abobotulinumtoxinA, and 227 units/ng for incobotulinumtoxinA. It is important for clinicians to have all three BoNTAs available in order to choose the most suitable preparation for the specific indication in the single patient. Commercially available BoNTAs must be recognized as different from one another, and therefore as non-interchangeable. The essential experience of the clinician is of the utmost importance in choosing the most appropriate treatment.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 1","pages":"7-18"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/fneur/2018.33.1.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35990927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28