Functional neurology最新文献_第4页

Clinical and neuroimaging spectrum of hyperglycemia-associated chorea-ballism: systematic review and exploratory analysis of case reports. 高血糖相关性舞蹈症的临床和神经影像学：系统回顾和病例报告的探索性分析。

Functional neurology Pub Date : 2018-10-01

Sergio Alejandro Gómez-Ochoa, Blanca Beatriz Espín-Chico, Gabriel David Pinilla-Monsalve, Bonnie M Kaas, Luis Ernesto Téllez-Mosquera

{"title":"Clinical and neuroimaging spectrum of hyperglycemia-associated chorea-ballism: systematic review and exploratory analysis of case reports.","authors":"Sergio Alejandro Gómez-Ochoa, Blanca Beatriz Espín-Chico, Gabriel David Pinilla-Monsalve, Bonnie M Kaas, Luis Ernesto Téllez-Mosquera","doi":"","DOIUrl":"","url":null,"abstract":"Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome occurring predominantly in elderly females and in the setting of non-ketotic hyperglycemia (NKH). A systematic review was conducted in accordance with the PRISMA statement. Studies published between 1980 and 2018 that reported demographic, clinical, laboratory and imaging features from patients with HCB were screened. 136 studies describing 286 patients were included in the analysis. The patients included had a median age of 72 years; those with ketotic hyperglycemia (KH) were older (p<0.001). Women and NKH patients were the most frequently affected (63% and 92%, respectively). The median glucose level at admission was 420 mg/dL (IQR 328-535), and was significantly higher in KH (p=0.009). Moreover, the absence of a clear lesion on imaging studies and the finding of bilateral imaging evidence of lesions were each more frequent in the KH group (p=0.036 and p=0.008, respectively). 48 cases (19.4%) presented with bilateral CT/MRI lesions, having higher values of plasma osmolarity compared with the patients with unilateral lesions (p=0.011). Every patient received hypoglycemic treatment, but only 174 (60.84%) were prescribed neuroleptics. 213 patients (84.86%) showed a total recovery, after a median of 14 days (IQR 3-31). Bilateral chorea-ballism was supported by bilateral imaging evidence of involvement in only 60% of the cases (positive predictive value). Patients not prescribed neuroleptics, with negative lentiform nucleus involvement, and age within the third tertile (≥ 78 years) had an odds ratio of 6.6 (CI 95% 1.18-141.10) for a complete clinical recovery. Significant differences were identified between types of hyperglycemia and regarding the clinical and imaging laterality features. Furthermore, the predictor variables evaluated showed potential utility for assessing the prognosis of HCB patients.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 4","pages":"175-187"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36924904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved antioxidant defense in the ventral tegmental area increases pain tolerance in male rats. 腹侧被盖区的抗氧化防御增强了雄性大鼠的疼痛耐受性。

Functional neurology Pub Date : 2018-07-01

H Famitafreshi, M Karimian

{"title":"Improved antioxidant defense in the ventral tegmental area increases pain tolerance in male rats.","authors":"H Famitafreshi, M Karimian","doi":"","DOIUrl":"","url":null,"abstract":"The ventral tegmental area (VTA) is a brain region recently shown to interfere with pain perception. According to previous studies, improvement of antioxidant defense mechanisms reduces pain. The aim of this study was to show that lack of social interaction influences oxidative stress in the VTA and that this results in increased pain tolerance. In this study, 21 male Sprague-Dawley rats were randomly divided into 2 groups: paired and socially isolated (SI). After one week of acclimatization, the SI rats were isolated for 14 days and the other rats were paired for the same period. On day 15, pain tolerance was assessed through the tail flick test, and two days later the rats were investigated for anxiety in an elevated plus maze (EPM). Indices of oxidative stress (levels of malondialdehyde, glutathione, nitrite/nitrate and catalase activity in the VTA) were then studied in the animals. Malondialdehyde in the VTA was found to be reduced in the SI rats compared with the paired rats. Furthermore, catalase activity, glutathione and nitrite/nitrate levels in the VTA were increased in SI compared with paired rats. Pain tolerance on the tail flick test was increased in SI rats compared with paired rats, while anxiety, as assessed by EPM, was reduced in the SI rats compared with the paired rats. Improvement of antioxidant defense and reduction of oxidative stress in the VTA increases pain tolerance and reduces anxiety. In this sense, environmental conditions play an important role in pain control.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 3","pages":"149-153"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36699795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice. Neurite定向分散和密度成像可以检测ALS小鼠脊髓的症状前轴突变性。

Functional neurology Pub Date : 2018-07-01 DOI: 10.11138/FNEUR/2018.33.3.155

Rodolfo Gabriel Gatto, S. M. Mustafi, M. Amin, T. Mareci, Yu-chien Wu, R. Magin

{"title":"Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice.","authors":"Rodolfo Gabriel Gatto, S. M. Mustafi, M. Amin, T. Mareci, Yu-chien Wu, R. Magin","doi":"10.11138/FNEUR/2018.33.3.155","DOIUrl":"https://doi.org/10.11138/FNEUR/2018.33.3.155","url":null,"abstract":"Neurite orientation dispersion and density imaging (NODDI), a MRI multi-shell diffusion technique, has offered new insights for the study of microstructural changes in neurodegenerative diseases. Mainly, the present study aimed to determine the connection between NODDI-derived parameters and changes in white matter (WM) abnormalities at early stages of amyotrophic lateral sclerosis (ALS). Spinal cords from ALS mice (G93A-SOD1 mice) were scanned in a Bruker Avance III HD 17.6T magnet. Fluorescent axonal-tagged mice (YFP, G93A-SOD1 mice) were used for quantitative histological analysis. NODDI showed a decrease in intra-cellular volume fraction (-24%) and increases in orientation dispersion index (+35%) and isotropic volume fraction (+33%). In addition, histoathological results demonstrated a reductions in axonal area (-11%) and myelin content (-29%). A histological decrease in WM intra-axonal space (-71%) and an increase in the extra-axonal compartment (+22%) were also detected. Our studies demonstrate that NODDI may be a suitable technique for detecting presymptomatic spinal cord WM microstructural degeneration in ALS.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 3 1","pages":"155-163"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45691962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Effects of a nutraceutical combination in patients with chronic lumbosacral radicular pain. 一种营养药物组合治疗慢性腰骶神经根性疼痛的效果。

Functional neurology Pub Date : 2018-07-01

C Geroin, S Tamburin, G Pagano, Marialuisa Gandolfi, Michele Tinazzi

引用次数: 0

Effects on balance skills and patient compliance of biofeedback training with inertial measurement units and exergaming in subacute stroke: a pilot randomized controlled trial. 生物反馈训练对亚急性脑卒中患者平衡技能和依从性的影响:一项随机对照试验。

Functional neurology Pub Date : 2018-07-01

A Lupo, A M Cinnera, A Pucello, M Iosa, P Coiro, S Personeni, Francesca Gimigliano, Giovanni Iolascon, Stefano Paolucci, G Morone

{"title":"Effects on balance skills and patient compliance of biofeedback training with inertial measurement units and exergaming in subacute stroke: a pilot randomized controlled trial.","authors":"A Lupo, A M Cinnera, A Pucello, M Iosa, P Coiro, S Personeni, Francesca Gimigliano, Giovanni Iolascon, Stefano Paolucci, G Morone","doi":"","DOIUrl":"","url":null,"abstract":"Stroke patients have reduced balance and postural control that limits their activities of daily living and participation in social life. Recently, many exergaming systems based on video-biofeedback have been developed for balance training in neurological conditions, however their efficacy remains to be proven. The aim of this study was to investigate the effects on balance skills and patient compliance of biofeedback training based on inertial measurement units and exergaming in subacute stroke. The enrolled subjects were randomized into two groups: subjects allocated to the experimental group performed 10 sessions of biofeedback balance training using inertial sensors, whereas subjects allocated to the control group performed 10 sessions of conventional balance training. All subjects were assessed at T0 (pre-treatment), T1 (posttreatment) and T2 (1-month follow-up). The Berg Balance Scale, Rivermead Mobility Index and modified Barthel Index were used to assess balance, mobility and global disability, respectively. To assess the severity of the stroke and its effects on the patient we used the National Institutes of Health Stroke Scale and the Canadian Neurological Scale. Finally, a static force platform evaluating stabilometric parameters was used to assess balance skills. Fifteen subjects with subacute stroke (4F; age 57.80 ± 13.7) completed the experimental protocol. The analysis showed a significant improvement in balance skills and in the overall clinical outcomes in the experimental group compared with the control group; the experimental group also showed better compliance with the training. The biofeedback system of the device used in this study probably enhances neuroplasticity mechanisms of postural and balance skills in subacute stroke patients.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 3","pages":"131-136"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36699796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An acute neurological complication of Crohn's disease. 克罗恩病急性神经系统并发症。

Functional neurology Pub Date : 2018-07-01

F Battista, E Tinella, Carlo Colosimo

引用次数: 0

Shaping a pain-free future for cluster headache patients. The Declaration of Paris. 为丛集性头痛患者打造无痛未来。巴黎宣言

Functional neurology Pub Date : 2018-07-01

Paolo Rossi, S Bruce, M A De Pascual, H Muller, Ewa Kalina Tyminski, E R De La Torre

引用次数: 0

Chronic stroke: an oxymoron or a challenge for rehabilitation? 慢性中风：是矛盾的说法还是康复的挑战？

Functional neurology Pub Date : 2018-07-01

Alessio Baricich, S Carda

引用次数: 0

Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice. 神经突定向弥散和密度成像可以检测ALS小鼠脊髓症状前轴突变性。

Functional neurology Pub Date : 2018-07-01

R G Gatto, S M Mustafi, M Y Amin, T H Mareci, Yu-Chien Wu, R L Magin

{"title":"Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice.","authors":"R G Gatto, S M Mustafi, M Y Amin, T H Mareci, Yu-Chien Wu, R L Magin","doi":"","DOIUrl":"","url":null,"abstract":"Neurite orientation dispersion and density imaging (NODDI), a MRI multi-shell diffusion technique, has offered new insights for the study of microstructural changes in neurodegenerative diseases. Mainly, the present study aimed to determine the connection between NODDI-derived parameters and changes in white matter (WM) abnormalities at early stages of amyotrophic lateral sclerosis (ALS). Spinal cords from ALS mice (G93A-SOD1 mice) were scanned in a Bruker Avance III HD 17.6T magnet. Fluorescent axonal-tagged mice (YFP, G93A-SOD1 mice) were used for quantitative histological analysis. NODDI showed a decrease in intra-cellular volume fraction (-24%) and increases in orientation dispersion index (+35%) and isotropic volume fraction (+33%). In addition, histoathological results demonstrated a reductions in axonal area (-11%) and myelin content (-29%). A histological decrease in WM intra-axonal space (-71%) and an increase in the extra-axonal compartment (+22%) were also detected. Our studies demonstrate that NODDI may be a suitable technique for detecting presymptomatic spinal cord WM microstructural degeneration in ALS.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 3","pages":"155-163"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212765/pdf/nihms-1585126.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36699798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The required coefficient of friction in Parkinson's disease: people with freezing of gait. 帕金森病所需的摩擦系数:步态冻结的人。

Functional neurology Pub Date : 2018-07-01

Ana Francisca Rozin Kleiner, Diana M Cubillos, C Pinto, A P Salazar, R R Marchese, R M L Barros, M Galli, A S Pagnussat

{"title":"The required coefficient of friction in Parkinson's disease: people with freezing of gait.","authors":"Ana Francisca Rozin Kleiner, Diana M Cubillos, C Pinto, A P Salazar, R R Marchese, R M L Barros, M Galli, A S Pagnussat","doi":"","DOIUrl":"","url":null,"abstract":"The required coefficient of friction (RCOF) is frequently reported in the literature as an indicator of slip propensity, a consequence of the collisional aspect of legged locomotion. Little is known about the RCOF in pathological gait. Therefore, this study aimed to quantify the RCOF in subjects with Parkinson's disease (PD) and freezing of gait (FOG) during the OFF-pharma phase, and to investigate the interplay between RCOF parameters and ankle kinematic and kinetic gait variables. Fourteen subjects with PD and 14 healthy age-matched subjects were instructed to walk barefoot at self-selected speed over a force platform. The RCOF curve was obtained as the ratio between the tangential and vertical ground reaction forces. Then, the following discrete variables were identified: P1COF (the peak at the loading response phase), V1COF (the valley at midstance phase) and P2COF (the peak at push-off phase). Stepwise multiple regressions were applied to observe the influence of the gait speed and ankle kinematic and kinetic gait variables on RCOF variables. In subjects with PD and FOG the gait speed is a predictor of the RCOF in the loading response phase; plantarflexion and the plantarflexion moment are strong predictors of the RCOF in midstance; finally, push-off power is a predictor of RCOF increasing in the push-off phase. These results characterized the biomechanical strategies adopted by subjects with PD and FOG during gait in order to avoid falls.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"33 3","pages":"137-142"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36699794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0