Global health & medicine最新文献_第8页

BACE1 inhibitor drugs for the treatment of Alzheimer's disease: Lessons learned, challenges to overcome, and future prospects^†. 治疗阿尔茨海默病的 BACE1 抑制剂药物：汲取的教训、克服的挑战和未来的前景†。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2024.01033

Arun K Ghosh

引用次数: 0

Comparison of oncological outcomes of upfront androgen receptor signaling inhibitors and combined androgen blockade in Japanese patients with metastatic castration-sensitive prostate cancer. 日本转移性阉割敏感性前列腺癌患者前期雄激素受体信号抑制剂与联合雄激素阻断治疗的肿瘤学疗效比较。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2024.01019

Michio Noda, Taketo Kawai, Kanade Hagiwara, Takahiro Yoshida, Kazuki Yanagida, Yuumi Tokura, Itsuki Yoshimura, Tomoyuki Kaneko, Tohru Nakagawa

{"title":"Comparison of oncological outcomes of upfront androgen receptor signaling inhibitors and combined androgen blockade in Japanese patients with metastatic castration-sensitive prostate cancer.","authors":"Michio Noda, Taketo Kawai, Kanade Hagiwara, Takahiro Yoshida, Kazuki Yanagida, Yuumi Tokura, Itsuki Yoshimura, Tomoyuki Kaneko, Tohru Nakagawa","doi":"10.35772/ghm.2024.01019","DOIUrl":"10.35772/ghm.2024.01019","url":null,"abstract":"In recent years, randomized controlled trials have demonstrated that upfront androgen receptor signaling inhibitors (ARSIs) prolong overall survival (OS) compared with androgen deprivation therapy (ADT) alone or combined androgen blockade (CAB) in patients with metastatic castration-sensitive prostate cancer (mCSPC). However, it remains unclear whether upfront ARSI is superior to CAB in Asian populations, among which the efficacy of ADT/CAB is considered relatively high. In this study, we compared the oncological outcomes of upfront ARSI and CAB in Japanese patients with mCSPC. Patients with mCSPC who underwent systemic therapy between May 2009 and October 2023 were enrolled retrospectively. Propensity score matching (PSM) was performed to compare the castration-resistant prostate cancer-free survival (CRPC-FS), cancer-specific survival (CSS), and OS between patients treated with upfront ARSI (ARSI group) and those treated with CAB (CAB group). In total, 30 and 142 patients were enrolled in the ARSI and CAB groups, respectively. After PSM (25 patients in each group), CRPC-FS was significantly longer in the ARSI group than in the CAB group (median: 36.7 vs. 12.3 months, hazard ratio: 0.44, 95% confidence interval: 0.20-0.97, p = 0.035). No significant differences were observed in CSS or OS between the two groups. In conclusion, when compared to CAB, upfront ARSI might have the potential to extend CRPC-FS among individuals in the Japanese population.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"199-203"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low preoperative hemoglobin A1c level is a predictor of perioperative infectious complications after esophagectomy: A retrospective, single-center study. 术前低血红蛋白 A1c 水平是食管切除术后围手术期感染并发症的预测因素：一项回顾性单中心研究。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2023.01113

Daiki Kato, Kazuhiko Yamada, Naoki Enomoto, Syusuke Yagi, Hanako Koda, Kyoko Nohara

{"title":"Low preoperative hemoglobin A1c level is a predictor of perioperative infectious complications after esophagectomy: A retrospective, single-center study.","authors":"Daiki Kato, Kazuhiko Yamada, Naoki Enomoto, Syusuke Yagi, Hanako Koda, Kyoko Nohara","doi":"10.35772/ghm.2023.01113","DOIUrl":"10.35772/ghm.2023.01113","url":null,"abstract":"This retrospective, single-center study aimed to evaluate the impact of blood glucose (BG) markers on perioperative complications after esophagectomy in a cohort of 176 patients. Study analyses included the correlation of daily maximum BG level and hemoglobin A1c (HbA1c) with clinicopathological factors. Maximum BG levels were significantly higher on postoperative day (POD) 0 than on PODs 2, 3, 5, and 7 (p < 0.05). Additionally, maximum BG levels on PODs 1, 2, and 7 were significantly higher in patients with preoperative HbA1c levels of ≥ 5.6% than in those with preoperative HbA1c levels of < 5.6% (p < 0.05 for all). The rates of any complications and infectious complications were higher in patients with preoperative HbA1c levels of < 5.6% than in those with preoperative HbA1c levels of ≥ 5.6% (p < 0.05 for both). A preoperative HbA1c level of < 5.6% was a significant predictor of infectious complications after esophagectomy by logistic regression analysis (p < 0.05). Maximum BG level after esophagectomy remained high in patients with high preoperative HbA1c levels, whereas a normal HbA1c level was an independent risk factor for infectious complications.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"190-198"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallbladder fossa nodularity in the liver as observed in alcoholic liver disease patients: Analysis based on hepatobiliary phase signal intensity on gadoxetate-enhanced MRI and extracellular volume fraction calculated from routine CT data. 酒精性肝病患者肝脏中的胆囊窝结节：根据钆喷酸增强核磁共振成像的肝胆相信号强度和常规 CT 数据计算的细胞外体积分数进行分析。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2023.01085

Keisuke Sato, Shinji Tanaka, Hiroshi Urakawa, Ryo Murayama, Eiko Hisatomi, Yukihisa Takayama, Kengo Yoshimitsu

{"title":"Gallbladder fossa nodularity in the liver as observed in alcoholic liver disease patients: Analysis based on hepatobiliary phase signal intensity on gadoxetate-enhanced MRI and extracellular volume fraction calculated from routine CT data.","authors":"Keisuke Sato, Shinji Tanaka, Hiroshi Urakawa, Ryo Murayama, Eiko Hisatomi, Yukihisa Takayama, Kengo Yoshimitsu","doi":"10.35772/ghm.2023.01085","DOIUrl":"10.35772/ghm.2023.01085","url":null,"abstract":"The purpose of this study is to further verify the concept utilizing signal intensity on hepatobiliary phase (HBP) of gadoxetate-enhanced MRI and extracellular volume fraction (ECV) calculated from CT data. Between Jan 2013 and September 2018, consecutive ALD patients who had both quadruple phase CT and gadoxetate-enhanced MRI within six months were retrospectively recruited. Those who had any intervention or disease involvement around gallbladder fossa were excluded. All images were reviewed and ECV was measured by two experienced radiologists. GBFN grades, and their HBP signal intensity or ECV relative to the surrounding background liver (BGL) were analyzed. There were 48 patients who met the inclusion criteria. There were GBFN grade 0/1/2/3 in 11/15/18/4 patients, respectively. The signal intensity on HBP relative to BGL were iso/slightly high/high in 30/15/3 patients, respectively, and ECV ratio (ECV of GBFN divided by that of BGL) was 0.88 ± 0.18, indicating there are more functioning hepatocytes and less fibrosis in GBFN than in BGL. The GBFN grades were significantly correlated to relative signal intensity at HBP (Spearman's rank correlation, p < 0.01, rho value 0.53), and ECV ratio (p < 0.01, rho value -0.45). Our results suggest GBFN in ALD would represent liver tissues with preserved liver function with less fibrosis, as compared to BGL, which are considered to support our hypothesis as shown above.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"183-189"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and associated factors of low vigor in patients living with HIV and hemophilia in Japan: A cross-sectional observational study. 日本艾滋病病毒感染者和血友病患者活力低下的患病率和相关因素：一项横断面观察研究。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2023.01108

Kensuke Komatsu, Sota Kimura, Yoko Kiryu, Aki Watanabe, Ei Kinai, Shinichi Oka, Satoshi Kimura, Junko Fujitani, Mikiko Ogata, Ryogo Minamimoto, Masatoshi Hotta, Kota Yokoyama, Tomoyuki Noguchi, Koubun Imai

{"title":"Prevalence and associated factors of low vigor in patients living with HIV and hemophilia in Japan: A cross-sectional observational study.","authors":"Kensuke Komatsu, Sota Kimura, Yoko Kiryu, Aki Watanabe, Ei Kinai, Shinichi Oka, Satoshi Kimura, Junko Fujitani, Mikiko Ogata, Ryogo Minamimoto, Masatoshi Hotta, Kota Yokoyama, Tomoyuki Noguchi, Koubun Imai","doi":"10.35772/ghm.2023.01108","DOIUrl":"10.35772/ghm.2023.01108","url":null,"abstract":"People living with human immunodeficiency virus (HIV) are at high risk of mental health problems. However, little is known about this risk in HIV-infected patients with hemophilia (HPH) who contracted the virus through blood products. This cross-sectional, observational study assessed patients' mood states and the factors associated with them among Japanese HPH to evaluate the need for psychosocial support. HPH completed self-administered questionnaires (Profile of Mood States [POMS] and General Health Questionnaire-28), neuropsychological tests, and brain magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography/computerized tomography scans. HIV-infected patients with no hemophilia (HPnH) completed POMS and neuropsychological tests. Socio-demographic characteristics and HIV- and hemophilia-related data were obtained from participants' medical records and interviews. A Mann-Whitney U test and chi-squared analyses were conducted. Fifty-six HPH and 388 HPnH completed the questionnaires and neuropsychological tests. HPH had a significantly lower prevalence of tension-anxiety (HPH, 7%; HPnH, 18%; p = 0.049) and a significantly higher prevalence of low vigor (HPH, 63%; HPnH, 32%; p < 0.001). Low vigor in HPH was significantly associated with impaired executive function (low vigor, 66%; high vigor, 33%; p = 0.019) and a social dysfunction score ≥ 3 (moderate; low vigor, 26%; high vigor, 5%; p = 0.047). Our results highlight the high prevalence of low vigor among HPH, leading to impairments in executive and social functions. Therefore, healthcare workers need to pay attention to the vigor, executive function, and social function of HPH.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"174-182"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary artery stenosis in Japanese people living with HIV-1 with or without haemophilia. 伴有或不伴有血友病的日本 HIV-1 感染者的冠状动脉狭窄。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01101

Ran Nagai, Mikiko Ogata, Shuji Kubota, Masaya Yamamoto, Haruka Uemura, Junko Tanuma, Hiroyuki Gatanaga, Hisao Hara, Shinichi Oka, Yukio Hiroi

{"title":"Coronary artery stenosis in Japanese people living with HIV-1 with or without haemophilia.","authors":"Ran Nagai, Mikiko Ogata, Shuji Kubota, Masaya Yamamoto, Haruka Uemura, Junko Tanuma, Hiroyuki Gatanaga, Hisao Hara, Shinichi Oka, Yukio Hiroi","doi":"10.35772/ghm.2023.01101","DOIUrl":"https://doi.org/10.35772/ghm.2023.01101","url":null,"abstract":"An extremely high prevalence (12.2%) of moderate-to-severe coronary artery stenosis (CAS) was documented in asymptomatic Japanese haemophiliacs living with HIV-1 (JHLH) in our previous study. The cause of this phenomenon remains unknown. We conducted the CAS screening in people living with HIV-1 without haemophilia (PLWH without haemophilia) to compare the prevalence of CAS in JHLH and PLWH without haemophilia and to identify the risk factors including inflammation markers. Ninety-seven age-matched male PLWH without haemophilia who consulted our outpatient clinic between June and July 2021 were randomly selected, and 69 patients who provided informed consent were screened for CAS using coronary computed tomography angiography (CCTA). The number of JHLH cases was 62 in this study. The prevalence of moderate (> 50%) to severe (> 75%) CAS was significantly higher in JHLH [14/57 (24.6%) vs. 6/69 (8.7%), p = 0.015], and the ratio of CAS requiring urgent interventions was significantly higher [7 (12.3%) vs. 1 (1.4%), p = 0.013] in JHLH than in PLWH without haemophilia. Among the inflammatory markers, serum titres of intercellular adhesion molecule-1 (p < 0.05) and interleukin-6 (p < 0.05) in JHLH were significantly higher than those in PLWH without haemophilia. Although some patient demographics were different in the age-matched study, it might be possible to speculate that intravascular inflammation might promote CAS in JHLH.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"124-131"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proposal to apply a "Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment (PERMA)" based approach to manage the COVID-19-related mental health problems in the era of long COVID. 建议采用基于 "积极情绪、参与、关系、意义和成就（PERMA）"的方法，在长 COVID 时代管理与 COVID-19 相关的心理健康问题。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01102

Kai Sun, Rongfeng Zhou, Fang Xu, Hongzhou Lu, Tetsuya Asakawa

{"title":"Proposal to apply a \"Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment (PERMA)\" based approach to manage the COVID-19-related mental health problems in the era of long COVID.","authors":"Kai Sun, Rongfeng Zhou, Fang Xu, Hongzhou Lu, Tetsuya Asakawa","doi":"10.35772/ghm.2023.01102","DOIUrl":"https://doi.org/10.35772/ghm.2023.01102","url":null,"abstract":"Long COVID (LC)-related health problems are highly concerned. Many patients seem to have \"recovered\" from an acute SARS-CoV-2 infection, however, they might experience various symptoms, almost involving all organs and systems. Of those, neuropsychiatric symptoms like depression, anxiety, and post-traumatic stress disorder (PTSD) are not rare. These problems significantly impact the quality of life (QOL) of patients, family, and caregivers, even lead a tragic suicide outcome. Other than the conventional psychological and medical approaches, here, we proposal a positive emotion, engagement, relationships, meaning, and accomplishment (PERMA)-based approach to fight against these COVID-19-related mental health problems (CRMHPs). This approach is characterized by positive psychological interventions and self-achievements, which has been proved to be a powerful tool against mood disorders in common people. Nowadays, abolishment of certain prophylactic measures (such as isolation, lockdown, compulsorily wearing a mask and maintaining social distance, measures to avoid crowding) enables us to have more opportunities to contact patients and implement the PERMA-based approach to the patients with CRMHPs. We believe that application of PERMA-based approach is conducive to alleviate the influence of the CRMHPs and improve their QOL.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"160-163"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient satisfaction with nursing care in infertility patients: A questionnaire survey. 不孕症患者对护理服务的满意度：问卷调查

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01044

Jing Wang, Lisha Li, Jing Zhou, Xinyao Pan, Qing Qi, Hongmei Sun, Ling Wang

{"title":"Patient satisfaction with nursing care in infertility patients: A questionnaire survey.","authors":"Jing Wang, Lisha Li, Jing Zhou, Xinyao Pan, Qing Qi, Hongmei Sun, Ling Wang","doi":"10.35772/ghm.2023.01044","DOIUrl":"https://doi.org/10.35772/ghm.2023.01044","url":null,"abstract":"Infertility remains a persistent global reproductive health challenge, with causative factors encompassing abnormalities in both the male and female reproductive systems. Typically, female partners seek initial consultations for infertility concerns, often within the context of routine annual well-woman check-ups. Nurses providing preventive care play a crucial role, conducting initial diagnostic assessments, and addressing certain causes of infertility. Patient satisfaction serves as a vital indicator of care quality. Identifying factors contributing to patient satisfaction with nursing services is crucial, yet research in this area has been limited. This study aimed to compare infertility patients' assessments of nurse quality and satisfaction with hospital services. The findings could offer valuable insights for healthcare providers, hospitals, and policymakers, guiding improvements in nursing care delivery and enhancing patient satisfaction in China's infertility treatment sector. By understanding patients' perspectives and experiences, healthcare providers can make necessary adjustments to improve care quality and patient outcomes. The sample included 1200 patients, and data collection utilized a self-assessment questionnaire, with percentages employed for analysis. Nurses are integral to caring for infertility patients during visits and conducting research to advance fertility care practices.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"141-148"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developments and current challenges in the process of cell culture-based seasonal influenza vaccine manufacture in Japan. 日本基于细胞培养的季节性流感疫苗生产过程中的发展和当前挑战。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01070

Itsuki Hamamoto

{"title":"Developments and current challenges in the process of cell culture-based seasonal influenza vaccine manufacture in Japan.","authors":"Itsuki Hamamoto","doi":"10.35772/ghm.2023.01070","DOIUrl":"https://doi.org/10.35772/ghm.2023.01070","url":null,"abstract":"Seasonal influenza is an acute respiratory infection primarily caused by influenza A and B viruses, which circulate annually and cause substantial morbidity and mortality worldwide. Annual influenza vaccination is currently the most effective measure for preventing influenza and greatly reduces the risk of disease severity and the incidence of complications and death. Annual seasonal influenza vaccines are traditionally produced in Japan and many other countries using viruses propagated in embryonated chicken eggs. However, at present, the effectiveness of the seasonal influenza vaccines has some significant limitations, partly because of egg-adaptive mutations in the antigenic sites of the influenza virus haemagglutinin, which are caused by the continued evolution of seasonal influenza viruses. To overcome the limitations of egg-based influenza vaccine production, a mammalian cell culture-based influenza vaccine production system has been developed in Japan in the past decade as an alternative to the current production method. In this review, I have summarised the progress in the development of cell-based seasonal influenza vaccines and discussed the technological challenges encountered in the development of influenza vaccines.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"93-100"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of aids to relieve vulvodynia during the postpartum period. 开发缓解产后外阴炎的辅助工具。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01045

Kaori Watanabe, Yumiko Totsu

{"title":"Development of aids to relieve vulvodynia during the postpartum period.","authors":"Kaori Watanabe, Yumiko Totsu","doi":"10.35772/ghm.2023.01045","DOIUrl":"https://doi.org/10.35772/ghm.2023.01045","url":null,"abstract":"Postpartum women live with a low quality of life due to pain caused by episiotomy and perineal laceration. In particular, they endure pain when sitting for long periods of time to breastfeed. The purpose of this study is to develop a sitting aid to alleviate postpartum vulvodynia. This study was conducted in the following four phases from July 2017 to May 2019. They are: material selection and molding, cleaning and disinfection testing, pressure distribution measurement testing, and trial testing by postpartum women. The main material was a 100% polypropylene object with a three-dimensional reticular fiber spring structure and fiber density of 3.8 kg/m2. As a result, a sitting aid that withstands washing and disinfection well in the medical field and is breathable. It had moderate resilience and elasticity and reduced pressure on the seating surface for women weighing approximately 45 kg and 55 kg, but we were skeptical about its use for women weighing more than that. The completed sitting aid is noninvasively effective in improving the quality of life of many postpartum women, but the density and thickness of the main material should be reexamined to meet the needs of women in a wider weight range. In addition, a self-administered questionnaire survey of trial users revealed that some women did not experience relief from vulvodynia even after using the sitting aid. Such women also had physical problems such as discomfort in the lower back, difficulty breastfeeding, and difficulty standing up. For women with multiple physical problems, individual causes should be addressed.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"149-155"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0