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The Challenges and Solutions of Chiral Drug Preparation Techniques 手性药物制备技术的挑战与解决方案
SCIREA Journal of Chemistry Pub Date : 2024-01-16 DOI: 10.54647/chemistry350041
Mingrui Zhao, Xiufang Shi, Ninghui Yang
{"title":"The Challenges and Solutions of Chiral Drug Preparation Techniques","authors":"Mingrui Zhao, Xiufang Shi, Ninghui Yang","doi":"10.54647/chemistry350041","DOIUrl":"https://doi.org/10.54647/chemistry350041","url":null,"abstract":"To explore the challenges faced by chiral drug preparation techniques and propose corresponding solutions, We introduce the background and significance of chiral drug preparation technology, Subsequently, we analyze in detail various challenges faced in the current preparation of chiral drugs, including selectivity in asymmetric synthesis, substrate conversion rate, and catalyst selection. In order to address these challenges, a series of solutions, including the use of novel catalysts, optimization of reaction conditions, and improvements in reaction processes were proposed. Through the application of these solutions, various difficulties in the process of chiral drug preparation were successfully overcome, achieving efficient and selective synthesis. The discoveries of these research findings have important theoretical and practical implications for the preparation of chiral drugs and pharmaceutical development. In future research, we will continue to improve chiral drug preparation techniques to enhance synthesis efficiency and yield, at the same time, to meet the","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":" 62","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139619166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development Trends in Chiral Drug Synthesis Techniques 手性药物合成技术的发展趋势
SCIREA Journal of Chemistry Pub Date : 2024-01-09 DOI: 10.54647/chemistry150337
Mingrui Zhao, Zhanhui Xu, Ninghui Yang
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引用次数: 0
NATURAL STIMULANT FOR LONG-TERM CONIFEROUS SEEDS 针叶树种子长期生长的天然促进剂
SCIREA Journal of Chemistry Pub Date : 2023-12-26 DOI: 10.54647/chemistry150336
S.V. Soboleva, O.A. Еsyakova, S.V. Ushanov, V.M. Voronin
{"title":"NATURAL STIMULANT FOR LONG-TERM CONIFEROUS SEEDS","authors":"S.V. Soboleva, O.A. Еsyakova, S.V. Ushanov, V.M. Voronin","doi":"10.54647/chemistry150336","DOIUrl":"https://doi.org/10.54647/chemistry150336","url":null,"abstract":"","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":"91 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of molecular interactions between flavones and dengue DENV E – 3 protein by In silico approach 用硅法分析黄酮与登革热病毒E - 3蛋白的分子相互作用
SCIREA Journal of Chemistry Pub Date : 2023-05-15 DOI: 10.54647/chemistry150313
C. Espíndola
{"title":"Analysis of molecular interactions between flavones and dengue DENV E – 3 protein by In silico approach","authors":"C. Espíndola","doi":"10.54647/chemistry150313","DOIUrl":"https://doi.org/10.54647/chemistry150313","url":null,"abstract":"The DENV dengue virus belongs to the Flaviviridae family, a group of four serotypes that circulate freely in the different endemic regions causing dengue disease. This disease is transmitted by the female Aedes aegypti and Aedes albopictus mosquitoes. Due to the variety of serotypes and genotypes existing in the same zone, it has been difficult to develop a vaccine due to the complexity of the immune response against dengue disease. Flavones such as 7,8-dihydroxyflavone-tropoflavin, 5,6,7-trihydroxyflavone-baicalein, and 3',4',5,6tetrahydroxyflavone-luteolin show antiviral activity. The different types of H-Bonds, π-π stacking, and π-cation molecular interactions that occur in the tropoflavin, baicalein, and luteolin, and DENV E-3 protein complexes has been analyzed, and different Kbinding has been identified. Similarly, the linkages between the different flavone and DENV E-3 protein domains for the application of the flavones tropoflavin, baicalein, and luteolin as anti-DENV E-3 agents has been analyzed. Results presented in this study could be useful for compound design and antiviral studies. SCIREA Journal of Chemistry http://www.scirea.org/journal/Chemistry May 15, 2023 Volume 8, Issue 2, April 2023 https://doi.org/10.54647/chemistry150313","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133591381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical rotation in biaxial, achiral and ferroelectric NaNO2-crystal at 296K. 296K下双轴、非手性和铁电纳米2晶体的旋光性。
SCIREA Journal of Chemistry Pub Date : 2023-01-25 DOI: 10.54647/chemistry150294
M. Karppinen
{"title":"Optical rotation in biaxial, achiral and ferroelectric NaNO<sub>2</sub>-crystal at 296K.","authors":"M. Karppinen","doi":"10.54647/chemistry150294","DOIUrl":"https://doi.org/10.54647/chemistry150294","url":null,"abstract":"","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125308105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthsis of the acetals R1OCH2OR2 and R1OCH2OR2 by double alkoxylation of dichloromethane via “mini combinatorial” approach and their anticancer activity in the HeLa cell line 二氯甲烷双烷氧基化缩合物R1OCH2OR2和R1OCH2OR2的合成及其在HeLa细胞中的抗癌活性
SCIREA Journal of Chemistry Pub Date : 2023-01-25 DOI: 10.54647/chemistry150291
M. Joselice e Silva,, Erwelly Barros de Oliveira, Jaciana dos Santos Aguiar, Alexander Y.Nazarenko, Gilson Bezerra, B. Doboszewski
{"title":"Synthsis of the acetals R<sub>1</sub>OCH<sub>2</sub>OR<sub>2</sub> and R<sub>1</sub>OCH<sub>2</sub>OR<sub>2</sub> by double alkoxylation of dichloromethane via “mini combinatorial” approach and their anticancer activity in the HeLa cell line","authors":"M. Joselice e Silva,, Erwelly Barros de Oliveira, Jaciana dos Santos Aguiar, Alexander Y.Nazarenko, Gilson Bezerra, B. Doboszewski","doi":"10.54647/chemistry150291","DOIUrl":"https://doi.org/10.54647/chemistry150291","url":null,"abstract":"","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127951104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetics of Aging of Large Colloidal Quantum Dots of Lead Selenide 硒化铅大胶体量子点老化动力学研究
SCIREA Journal of Chemistry Pub Date : 2022-06-24 DOI: 10.54647/chemistry15265
W. Palosz, S. Trivedi, Janet L. Jensen
{"title":"Kinetics of Aging of Large Colloidal Quantum Dots of Lead Selenide","authors":"W. Palosz, S. Trivedi, Janet L. Jensen","doi":"10.54647/chemistry15265","DOIUrl":"https://doi.org/10.54647/chemistry15265","url":null,"abstract":"","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":"280 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116309897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of process related Dapsone impurities : Selective diazotization of aromatic di-amine 氨苯砜工艺相关杂质的合成:芳香二胺的选择性重氮化
SCIREA Journal of Chemistry Pub Date : 2022-04-17 DOI: 10.54647/chemistry15253
Mahesh Bandishti, Balaji Chaugule, C. Pramanik, G. Karhade, Ashok Chaudhari
{"title":"Synthesis of process related Dapsone impurities : Selective diazotization of aromatic di-amine","authors":"Mahesh Bandishti, Balaji Chaugule, C. Pramanik, G. Karhade, Ashok Chaudhari","doi":"10.54647/chemistry15253","DOIUrl":"https://doi.org/10.54647/chemistry15253","url":null,"abstract":"","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125909379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topological study of refractive indices, atomic charges, polar and axial vectors of second rank and optical rotation in α-HgS (cinnabar) at 296 K 296 K α-HgS(朱砂)的折射率、原子电荷、第二级极性和轴向矢量及旋光度的拓扑研究
SCIREA Journal of Chemistry Pub Date : 2022-02-12 DOI: 10.54647/chemistry15252
M. Karppinen
{"title":"Topological study of refractive indices, atomic charges, polar and axial vectors of second rank and optical rotation in α-HgS (cinnabar) at 296 K","authors":"M. Karppinen","doi":"10.54647/chemistry15252","DOIUrl":"https://doi.org/10.54647/chemistry15252","url":null,"abstract":"The magnitude and sense of optical rotation are determined from the point charge model in a nonpolar, chiral, covalently bonded and semiconducting α-HgS (cinnabar) crystal. Atomic charges of Hg and S are variables in the iteration of topological equivalence between the inverted ratios of the second electric moments and the corresponding optical refractive indices of the α-HgS crystal. Vector cross products of the wave vector in the propagation direction of light and the second electric moments in the other two semi-axis directions of the quadric specify the handedness of axial vectors of second rank and the refractive indices comprise the magnitudes of them. The calculated axial vectors contain information of optical rotation and the handedness of the dominant component of them reveals the sense of rotational character of the crystal. They are converted to principal gyration tensor components and the magnitude and sense of rotation are computed in the direction of optic axis of the quadric. The sense of optical rotation is opposite to the sense of the helical arrangement of the atoms. The magnitude and sense of optical rotation solely arises from the asymmetric distribution of point charges and SCIREA Journal of Chemistry http://www.scirea.org/journal/Chemistry February 12, 2022 Volume 7, Issue 1, February 2022 https://doi.org/10.54647/chemistry15252","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125708981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topological approach to atomic charges, electric moments, axial vectors, spontaneous polarization and optical rotation in α-LiIO3 at 296 K. 296k α-LiIO3原子电荷、电矩、轴向矢量、自发偏振和光旋的拓扑研究。
SCIREA Journal of Chemistry Pub Date : 2022-01-05 DOI: 10.54647/chemistry15232
M. Karppinen
{"title":"Topological approach to atomic charges, electric moments, axial vectors, spontaneous polarization and optical rotation in α-LiIO3 at 296 K.","authors":"M. Karppinen","doi":"10.54647/chemistry15232","DOIUrl":"https://doi.org/10.54647/chemistry15232","url":null,"abstract":"","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126385888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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