{"title":"手性药物制备技术的挑战与解决方案","authors":"Mingrui Zhao, Xiufang Shi, Ninghui Yang","doi":"10.54647/chemistry350041","DOIUrl":null,"url":null,"abstract":"To explore the challenges faced by chiral drug preparation techniques and propose corresponding solutions, We introduce the background and significance of chiral drug preparation technology, Subsequently, we analyze in detail various challenges faced in the current preparation of chiral drugs, including selectivity in asymmetric synthesis, substrate conversion rate, and catalyst selection. In order to address these challenges, a series of solutions, including the use of novel catalysts, optimization of reaction conditions, and improvements in reaction processes were proposed. Through the application of these solutions, various difficulties in the process of chiral drug preparation were successfully overcome, achieving efficient and selective synthesis. The discoveries of these research findings have important theoretical and practical implications for the preparation of chiral drugs and pharmaceutical development. In future research, we will continue to improve chiral drug preparation techniques to enhance synthesis efficiency and yield, at the same time, to meet the","PeriodicalId":125365,"journal":{"name":"SCIREA Journal of Chemistry","volume":" 62","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Challenges and Solutions of Chiral Drug Preparation Techniques\",\"authors\":\"Mingrui Zhao, Xiufang Shi, Ninghui Yang\",\"doi\":\"10.54647/chemistry350041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To explore the challenges faced by chiral drug preparation techniques and propose corresponding solutions, We introduce the background and significance of chiral drug preparation technology, Subsequently, we analyze in detail various challenges faced in the current preparation of chiral drugs, including selectivity in asymmetric synthesis, substrate conversion rate, and catalyst selection. In order to address these challenges, a series of solutions, including the use of novel catalysts, optimization of reaction conditions, and improvements in reaction processes were proposed. Through the application of these solutions, various difficulties in the process of chiral drug preparation were successfully overcome, achieving efficient and selective synthesis. The discoveries of these research findings have important theoretical and practical implications for the preparation of chiral drugs and pharmaceutical development. In future research, we will continue to improve chiral drug preparation techniques to enhance synthesis efficiency and yield, at the same time, to meet the\",\"PeriodicalId\":125365,\"journal\":{\"name\":\"SCIREA Journal of Chemistry\",\"volume\":\" 62\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SCIREA Journal of Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54647/chemistry350041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SCIREA Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54647/chemistry350041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Challenges and Solutions of Chiral Drug Preparation Techniques
To explore the challenges faced by chiral drug preparation techniques and propose corresponding solutions, We introduce the background and significance of chiral drug preparation technology, Subsequently, we analyze in detail various challenges faced in the current preparation of chiral drugs, including selectivity in asymmetric synthesis, substrate conversion rate, and catalyst selection. In order to address these challenges, a series of solutions, including the use of novel catalysts, optimization of reaction conditions, and improvements in reaction processes were proposed. Through the application of these solutions, various difficulties in the process of chiral drug preparation were successfully overcome, achieving efficient and selective synthesis. The discoveries of these research findings have important theoretical and practical implications for the preparation of chiral drugs and pharmaceutical development. In future research, we will continue to improve chiral drug preparation techniques to enhance synthesis efficiency and yield, at the same time, to meet the