General pharmacology最新文献_第2页

Pharmacokinetics of verapamil in lactating rabbits. Prediction of verapamil distribution into rabbit milk. 维拉帕米在泌乳兔体内的药动学。维拉帕米在兔乳中的分布预测。

General pharmacology Pub Date : 2000-04-01 DOI: 10.1016/S0306-3623(00)00066-5

C. Solans, J. Aramayona, M. Bregante, L. Fraile, S. Rueda, M. A. García

引用次数: 2

Abstracts from 7th Biannual Conference on Vascular Endothelium: source and target of inflammatory mediators; June 24-July 3, 2000, Knossos Royal Village, Crete, Greece. 第七届血管内皮:炎症介质的来源和靶点;2000年6月24日至7月3日，希腊克里特岛克诺索斯皇家村。

General pharmacology Pub Date : 2000-01-01 DOI: 10.1016/s0306-3623(00)00069-0

引用次数: 0

Stimulation of angiotensin subtype 2 receptor reduces basal cGMP levels in the neointima of rat aorta after balloon injury. 刺激血管紧张素亚型2受体降低大鼠主动脉球囊损伤后新生内膜cGMP基础水平。

General pharmacology Pub Date : 1994-09-15 DOI: 10.1016/0021-9150(94)94082-7

M. Moroi, M. Fukazawa, M. Ishikawa, J. Aikawa, A. Namiki, T. Yamaguchi

引用次数: 2

Arrhythmogenic actions of class III antiarrhythmic drugs in spontaneously beating rabbit sino-atrial node cells. III类抗心律失常药物对自搏兔窦房结细胞的致心律失常作用。

General pharmacology Pub Date : 1993-11-01 DOI: 10.1016/0928-4680(94)91024-3

H. Satoh

引用次数: 5

Effects of an inhibitor of GABA-aminotransferase (gamma-vinyl-GABA) on the spatial navigation deficit induced by nicotinic blockade. gaba -氨基转移酶抑制剂(γ -乙烯基- gaba)对烟碱阻断诱导的空间导航缺陷的影响。

General pharmacology Pub Date : 1993-01-01 DOI: 10.1016/0306-3623(93)90027-u

M Mazurkiewicz, J Sirviö, P J Riekkinen

引用次数: 1

The effect of BE 2254 on the metabolic response stimulated by pyrogen in rabbits. BE 2254对家兔热原刺激下代谢反应的影响。

General pharmacology Pub Date : 1993-01-01 DOI: 10.1016/0306-3623(93)90031-r

Z Szreder

引用次数: 3

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. NS-398，一种新型非甾体抗炎药，具有有效的镇痛和解热作用，对胃的损害最小。

General pharmacology Pub Date : 1993-01-01 DOI: 10.1016/0306-3623(93)90018-s

N Futaki, K Yoshikawa, Y Hamasaka, I Arai, S Higuchi, H Iizuka, S Otomo

{"title":"NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.","authors":"N Futaki, K Yoshikawa, Y Hamasaka, I Arai, S Higuchi, H Iizuka, S Otomo","doi":"10.1016/0306-3623(93)90018-s","DOIUrl":"https://doi.org/10.1016/0306-3623(93)90018-s","url":null,"abstract":"1. NS-398 (N-[2-cyclohexyloxy-4-nitrophenyl] methanesulfonamide) is a new non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. 2. The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac. In rat adjuvant arthritis, NS-398 showed a therapeutic effect comparable to that seen with loxoprofen but less than that seen with indomethacin and diclofenac. 3. The analgesic potency of NS-398 in rat adjuvant arthritic pain was much the same as that of indomethacin, and was about 3-5 times higher than that of diclofenac and loxoprofen. In the Randall-Selitto method in rats, NS-398 was 2-7 times as potent as loxoprofen, diclofenac and indomethacin. In acetic acid-induced writhing in mice, NS-398 was equipotent to indomethacin and diclofenac. 4. In LPS-induced fever in rats, NS-398 was 1.5-4.5 times as potent as loxoprofen and indomethacin, but less potent than diclofenac. 5. NS-398 produced little gastric ulceration in doses of up to 1000 mg/kg, while reference drugs produced distinct stomach lesions in doses of 10-30 mg/kg. 6. NS-398 inhibited prostaglandin (PG) endoperoxide synthase from sheep seminal vesicle microsomes less potent than that of ibuprofen.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"24 1","pages":"105-10"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(93)90018-s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19464739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 346

The effects of propranolol on skeletal muscle contraction, lipid peroxidation products and antioxidant activity in experimental hyperthyroidism. 心得安对实验性甲亢骨骼肌收缩、脂质过氧化产物及抗氧化活性的影响。

General pharmacology Pub Date : 1993-01-01 DOI: 10.1016/0306-3623(93)90034-u

Z Zaiton, Z Merican, B A Khalid, J B Mohamed, S Baharom

{"title":"The effects of propranolol on skeletal muscle contraction, lipid peroxidation products and antioxidant activity in experimental hyperthyroidism.","authors":"Z Zaiton, Z Merican, B A Khalid, J B Mohamed, S Baharom","doi":"10.1016/0306-3623(93)90034-u","DOIUrl":"https://doi.org/10.1016/0306-3623(93)90034-u","url":null,"abstract":"1. The mean levels of lipid peroxidation products, namely conjugated diene and malonaldehyde, were increased in the soleus muscles of hyperthyroid cats, while the mean glutathione peroxidase activity was decreased. No corresponding similar changes were noted in the fast extensor digitorum longus muscles and serum. 2. Propranolol administration prevented the increase in conjugated diene level in the soleus muscles of hyperthyroid cat but not the malonaldehyde level. It also prevented the reduction in glutathione peroxidase activity in the slow oxidative soleus muscles of hyperthyroid cats. 3. Maximal twitch tension, subtetanic tension and maximum tetanic tension of soleus and EDL muscles were reduced in hyperthyroid cats. Propranolol administration for 5 weeks to hyperthyroid cats did not prevent the reduction in tension of contractions of these muscles. 4. It is suggested that lipid peroxidation might not be responsible for the myopathy in hyperthyroidism and propranolol administration does not improve skeletal muscle function in hyperthyroid animals.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"24 1","pages":"195-9"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(93)90034-u","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19465884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Acetylcholinesterase changes in hearts with sinus rhythm and atrial fibrillation. 窦性心律和心房颤动时心脏乙酰胆碱酯酶的变化。

General pharmacology Pub Date : 1993-01-01 DOI: 10.1016/0306-3623(93)90019-t

R A Gonzalez, E O Campos, C Karmelic, S Moran, N C Inestrosa

引用次数: 12

Endogenous dopamine differently affects N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine and cocaine binding to the dopamine uptake complex. 内源性多巴胺不同程度地影响N-[1-(2-苯并(b)噻吩基)环己基]哌啶和可卡因与多巴胺摄取复合物的结合。

General pharmacology Pub Date : 1993-01-01 DOI: 10.1016/0306-3623(93)90033-t

T Maurice, G Barbanel, J Vignon

引用次数: 10