C Spencer, A Makka, S Singh, J McGuire, N Washaya, G Hein, M Zampoli, K Fieggen
{"title":"Case report: a giant cell-rich gnathic bone lesion in a child with pycnodysostosis.","authors":"C Spencer, A Makka, S Singh, J McGuire, N Washaya, G Hein, M Zampoli, K Fieggen","doi":"10.3389/froh.2023.1188443","DOIUrl":"https://doi.org/10.3389/froh.2023.1188443","url":null,"abstract":"Pycnodysostosis is a skeletal dysplasia characterized by short stature, generalized osteosclerosis, acro-osteolysis, and recognizable facial features. Oral manifestations are commonly described and include a high-arched palate with dental crowding and malocclusion, hypoplastic enamel, and retained deciduous teeth with impacted permanent teeth, and there is an increased risk of developing osteomyelitis of the jaw. We report here the history of a 9-year-old male with the typical facial and skeletal phenotype of pycnodysostosis but novel oral features. He presented with bilateral progressive facial swelling, which caused functional impairment with chewing and contributed to his severe obstructive sleep apnea (OSA). The severity of his OSA required surgical intervention, and the lesions were resected. Extensive bone remodeling and replacement by fibrous tissue were noted on submucosal dissection, and bilateral subtotal maxillectomies were required. The histopathology of the biopsied lesion was consistent with a giant cell-rich lesion. Genetic testing identified a pathogenic homozygous variant in the CTSK gene, c.953G > A, p. (Cys318Tyr). The proband had a good postsurgical response with sustained improvement in his sleep OSA. We present here the history and clinical characteristics of a patient with typical features of pycnodysostosis and an unusual presentation and histopathology of gnathic bone lesions. This report adds to the body of literature on this rare condition and also highlights the finding of giant cell-rich lesions of the gnathic bones. Giant cell-rich lesions in pycnodysostosis have previously been reported in two cases in the literature. While there is not enough evidence to support a certain association with pycnodysostosis, it is prudent to consider regular oral dental reviews in affected individuals to identify pathology early and avoid such life-threatening complications.","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"4 ","pages":"1188443"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9653489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bing-Yan Wang, Grayson Burgardt, Kavitha Parthasarathy, Daniel K Ho, Robin L Weltman, Gena D Tribble, Jianming Hong, Stanley Cron, Hua Xie
{"title":"Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study.","authors":"Bing-Yan Wang, Grayson Burgardt, Kavitha Parthasarathy, Daniel K Ho, Robin L Weltman, Gena D Tribble, Jianming Hong, Stanley Cron, Hua Xie","doi":"10.3389/froh.2023.1212728","DOIUrl":"https://doi.org/10.3389/froh.2023.1212728","url":null,"abstract":"<p><strong>Objectives: </strong>Periodontitis disproportionately affects different racial and ethnic populations. We have previously reported the higher levels of <i>Porphyromonas gingivalis</i> and lower ratios of <i>Streptococcus cristatus</i> to <i>P. gingivalis</i> may contribute to periodontal health disparities. This prospective cohort study was designed to investigate if ethnic/racial groups responded differently to non-surgical periodontal treatment and if the treatment outcomes correlated to the bacterial distribution in patients with periodontitis before treatment.</p><p><strong>Methods: </strong>This prospective cohort pilot study was carried out in an academic setting, at the School of Dentistry, University of Texas Health Science Center at Houston. Dental plaque was collected from a total of 75 African Americans, Caucasians and Hispanics periodontitis patients in a 3-year period. Quantitation of <i>P. gingivalis</i> and <i>S. cristatus</i> was carried out using qPCR. Clinical parameters including probing depths and clinical attachment levels were determined before and after nonsurgical treatment. Data were analyzed using one-way ANOVA, the Kruskal-Wallis test, the paired samples <i>t</i>-test and the chi-square test.</p><p><strong>Results: </strong>The gains in clinical attachment levels after treatment significantly differed amongst the 3 groups-Caucasians responded most favorably, followed by African-Americans, lastly Hispanics, while numbers of <i>P. gingivalis</i> were highest in Hispanics, followed by African-Americans, and lowest in Caucasians (<i>p </i>= 0.015). However, no statistical differences were found in the numbers of <i>S. cristatus</i> amongst the 3 groups.</p><p><strong>Conclusion: </strong>Differential response to nonsurgical periodontal treatment and distribution of <i>P. gingivalis</i> are present in different ethnic/racial groups with periodontitis.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"4 ","pages":"1212728"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9717595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katia Rupel, Matteo Biasotto, Margherita Gobbo, Augusto Poropat, Magdalena Theodora Bogdan Preda, Giuseppe Borruso, Lucio Torelli, Roberto Di Lenarda, Giulia Ottaviani
{"title":"Knowledge and awareness of oral cancer: A cross-sectional survey in Trieste, Italy.","authors":"Katia Rupel, Matteo Biasotto, Margherita Gobbo, Augusto Poropat, Magdalena Theodora Bogdan Preda, Giuseppe Borruso, Lucio Torelli, Roberto Di Lenarda, Giulia Ottaviani","doi":"10.3389/froh.2023.1056900","DOIUrl":"https://doi.org/10.3389/froh.2023.1056900","url":null,"abstract":"<p><p>The aim of the study was to verify the knowledge on oral cancer and to assess possible differences in awareness and information basing on different demographic and subject-related factors. An anonymous survey was provided to 750 random subjects using online-based questionnaires. Statistical analysis was performed in order to evaluate the influence of demographic variables (gender, age, education) on knowledge of oral cancer and its risk factors. 68.4% of individuals knew about the existence of oral cancer, mostly from media and family/friends. Awareness was significantly influenced by gender and higher education, but not by age. Most participants recognized smoking as a risk factor, but alcohol abuse and sunlight exposure are less known, especially among less educated subjects. On the contrary, our study shows a diffusion of false information: more than 30% of the participants indicated the possible role of amalgam fillings in oral cancer onset, independently of gender, age or education. The results of our study suggest the need for oral cancer awareness campaigns, where school and healthcare professionals should be actively involved in promoting, organizing and finding methods to monitor the medium and long-term efficacy with proper methodological quality.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"4 ","pages":"1056900"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andres Flores-Hidalgo, John Collie, Shae King, Ford T Grant, Nicole E Beasley, Mark E Moss, Thomas R Tempel
{"title":"The use of teledentistry in clinical oral and maxillofacial pathology practice: an institutional experience.","authors":"Andres Flores-Hidalgo, John Collie, Shae King, Ford T Grant, Nicole E Beasley, Mark E Moss, Thomas R Tempel","doi":"10.3389/froh.2023.1063973","DOIUrl":"https://doi.org/10.3389/froh.2023.1063973","url":null,"abstract":"<p><strong>Background: </strong>Although there has been a slight increase in dental professionals since 2011, 98 of North Carolina's 100 counties are designated as Dental Health Professional Shortage Areas by the Heath Resources and Service Administration. This shortage significantly increases disparities and access to primary and specialized oral health care. Also, dental professionals in these remote locations may feel the access and referrals to oral and maxillofacial pathologists cumbersome. In 2020, the COVID-19 pandemic prompted an inevitable surge in the use of digital technology due to the social distancing norms and lockdowns, which forced dental education institutions and practitioners to adjust to new ways of meeting, teaching, and providing dental care. In the present manuscript, we report our institutional experience delivering specialized dental care in rural areas.</p><p><strong>Materials and methods: </strong>We conducted a retrospective case series of diagnosis, management, and outcomes of patients who underwent synchronous or asynchronous virtual and remote examination of oral lesions at ECU School of Dental Medicine and one satellite clinic over seven years. For those cases that concluded on surgical sampling, the clinical impressions, differential diagnoses, and the final diagnosis were compared to assess the accuracy of the clinical exam through teledentistry.</p><p><strong>Results: </strong>The total study population consisted of 71 patients. Most of the remote consultations were done asynchronously. Also, most virtual clinical consultations were initiated due to clinical suspicion of malignancy and infectious/reactive conditions, accounting for 42% and 25.3% of all encounters.</p><p><strong>Conclusions: </strong>The presented data suggest how teledentistry can support clinical practice in rural areas to achieve optimal care for the patient in rural or remote communities. Also, it significantly decreases the travel required, the number of appointments, and increases the speed of diagnosis. Teledentistry is an excellent tool available to all clinicians and can dramatically aid in diagnosing oral mucosa lesions.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"4 ","pages":"1063973"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9949565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum: <i>In vitro</i> activity of anti-rheumatic drugs on release of pro-inflammatory cytokines from oral cells in interaction with microorganisms.","authors":"","doi":"10.3389/froh.2023.1178207","DOIUrl":"https://doi.org/10.3389/froh.2023.1178207","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/froh.2022.960732.].</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"4 ","pages":"1178207"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9294479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alison M Rich, Haizal M Hussaini, Muhammad Aiman Mohd Nizar, Ratu Osea Gavidi, Elizabeth Tauati-Williams, Muhammed Yakin, Benedict Seo
{"title":"Diagnosis of oral potentially malignant disorders: Overview and experience in Oceania.","authors":"Alison M Rich, Haizal M Hussaini, Muhammad Aiman Mohd Nizar, Ratu Osea Gavidi, Elizabeth Tauati-Williams, Muhammed Yakin, Benedict Seo","doi":"10.3389/froh.2023.1122497","DOIUrl":"https://doi.org/10.3389/froh.2023.1122497","url":null,"abstract":"<p><p>The diagnosis and management of oral potentially malignant disorders (OPMD) should be the same the world over, but there are important nuances in incidence, aetiological factors, and management opportunities that may lead to differences based on ethnogeography. In this review, we update and discuss current international trends in the classification and diagnosis of OPMD with reference to our experience in various regions in Oceania. Oceania includes the islands of Australia, Melanesia (including Papua New Guinea, Fiji, Solomon Islands, Micronesia and Polynesia (including New Zealand, Samoa, Tonga) and hence has diverse populations with very different cultures and a range from well-resourced high-population density cities to remote villages.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"4 ","pages":"1122497"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9386132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ifeanyi Uzochukwu, David Moyes, Gordon Proctor, Mark Ide
{"title":"The key players of dysbiosis in Noma disease; A systematic review of etiological studies.","authors":"Ifeanyi Uzochukwu, David Moyes, Gordon Proctor, Mark Ide","doi":"10.3389/froh.2023.1095858","DOIUrl":"https://doi.org/10.3389/froh.2023.1095858","url":null,"abstract":"<p><p>Noma is a rapidly progressing periodontal disease with up to 90% mortality in developing countries. Poor, immunocompromised and severely malnourished children (2 to 6 years old) are mostly affected by Noma. Prevention and effective management of Noma is hindered by the lack of sufficient cohesive studies on the microbial etiology of the disease. Research efforts have not provided a comprehensive unified story of the disease. Bridging the gap between existing studies gives an insight on the disease pathogenesis. This current systematic review of etiological studies focuses on the key players of dysbiosis in Noma disease. This review was performed in accordance with the Preferred Reporting Items for Systemic review and Meta-Analyses (PRISMA) statement. Web of Science, MEDLINE <i>via</i> PubMed, Cochrane Library, Scopus, and Science Direct were searched electronically for clinical trials which applied culture dependent or molecular techniques to identify oral microbiota from Noma patients. Trials which involved periodontal diseases except Noma were excluded. After screening 275 articles, 153 full-texts articles were assessed for eligibility of which eight full text articles were selected for data extraction and analysis. The results show that 308 samples from 169 Noma participants (6 months to 15 years old) have been used in clinical trials. There was some variance in the microbiome identified due to the use of 3 different types of samples (crevicular fluid, subgingival plaque, and swabbed pus) and the ambiguity of the stage or advancement of Noma in the studies. Other limitations of the studies included in this review were: the absence of age-matched controls in some studies; the constraints of colony morphology as a tool in distinguishing between virulent fusobacterium genus at the species level; the difficulty in culturing spirochaetes in the laboratory; the choice of primers in DNA amplification; and the selection of probe sets in gene sequencing. This systematic review highlights spirochaetes and P. intermedia as putative trigger organisms in Noma dysbiosis, shows that F. nucleatum promotes biofilms formation in late stages of the disease and suggests that future studies should be longitudinal, with high throughput genome sequencing techniques used with gingival plaque samples from early stages of Noma.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"4 ","pages":"1095858"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9145755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}