Frontiers in Oral Health最新文献

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Editorial: Global excellence in oral health: Europe. 社论:全球口腔健康卓越:欧洲。
Frontiers in Oral Health Pub Date : 2023-01-01 DOI: 10.3389/froh.2023.1219999
V Pavlic, L J Kesic
{"title":"Editorial: Global excellence in oral health: Europe.","authors":"V Pavlic, L J Kesic","doi":"10.3389/froh.2023.1219999","DOIUrl":"https://doi.org/10.3389/froh.2023.1219999","url":null,"abstract":"COPYRIGHT © 2023 Pavlic and Kesic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"4 ","pages":"1219999"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10011486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Inflammasome, purinergic signaling, and immunometabolism in oral health and disease. 社论:口腔健康和疾病中的炎性体、嘌呤能信号和免疫代谢。
Frontiers in Oral Health Pub Date : 2023-01-01 DOI: 10.3389/froh.2023.1236507
Ana Carolina Morandini, Luiz Eduardo Baggio Savio
{"title":"Editorial: Inflammasome, purinergic signaling, and immunometabolism in oral health and disease.","authors":"Ana Carolina Morandini, Luiz Eduardo Baggio Savio","doi":"10.3389/froh.2023.1236507","DOIUrl":"https://doi.org/10.3389/froh.2023.1236507","url":null,"abstract":"COPYRIGHT © 2023 Morandini and Savio. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"4 ","pages":"1236507"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10122323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychologically informed oral health interventions in pregnancy and type 2 diabetes: A scoping review. 妊娠期和 2 型糖尿病患者的口腔健康心理干预:范围综述。
Frontiers in Oral Health Pub Date : 2022-12-21 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1068905
Camilla Böhme Kristensen, Mark Ide, Angus Forbes, Koula Asimakopoulou
{"title":"Psychologically informed oral health interventions in pregnancy and type 2 diabetes: A scoping review.","authors":"Camilla Böhme Kristensen, Mark Ide, Angus Forbes, Koula Asimakopoulou","doi":"10.3389/froh.2022.1068905","DOIUrl":"10.3389/froh.2022.1068905","url":null,"abstract":"<p><strong>Introduction: </strong>Oral health is a critical aspect of gestational diabetes management. Gestational diabetes is high blood glucose levels during pregnancy and is managed like type 2 diabetes with diet and physical activity interventions. This scoping review sets out to discuss why oral health support should also become part of gestational diabetes management.</p><p><strong>Objectives: </strong>The primary objective was to synthesise the existing psychologically informed oral health interventions for pregnant women and individuals with type 2 diabetes, and the extent to which these interventions map on to the COM-B Model. No literature exists on oral health interventions in gestational diabetes, why studies with type 2 diabetes populations were selected instead. The secondary objective was to identify the precise outcomes targeted in the interventions.</p><p><strong>Methodology: </strong>The Joanna Briggs Institute's Methodology for Scoping Reviews was used to conduct this review. The populations of interest were pregnant women and individuals with type 2 diabetes, and eligible concepts were psychologically informed oral health interventions. Quasi-experimental and experimental designs were considered. The Ovid Interface including Embase, Medline, Global Health, APA PsychInfo, Health Management Information, Maternity, Infant Care Database, the Cochrane Library, and CINAHL was used as information sources. The study selection followed the PRISMA guidelines. The first search was conducted on the week commencing the 25th of July 2022, with a follow-up search conducted on the 10th of October 2022.</p><p><strong>Results: </strong>28 records were included for synthesis. The most frequently assessed psychological outcome was oral health knowledge and the most frequently assessed oral clinical outcome was Plaque Index. All studies used an educational intervention approach, while psychological capability in the COM-B Model was targeted in all interventions by increasing oral health knowledge among the participants. The Health Belief Model was the most frequently used theory in the interventions.</p><p><strong>Conclusion: </strong>The results demonstrate that oral health is a recognised aspect of pregnancy and type 2 diabetes. The findings from this review and a qualitative interview study which is under development will inform the first oral health intervention for women with gestational diabetes in the United Kingdom.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"3 ","pages":"1068905"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10506883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paycheck Protection Program (PPP) COVID-19 relief funding for veteran-, minority-, and women- owned dental businesses: A cross-sectional study. 薪酬保护计划 (PPP) COVID-19 为退伍军人、少数民族和妇女拥有的牙科企业提供救济资金:一项横断面研究。
Frontiers in Oral Health Pub Date : 2022-12-15 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1041415
Elizabeth Alpert, Sean G Boynes, Amber Shaver, Annaliese Cothron
{"title":"Paycheck Protection Program (PPP) COVID-19 relief funding for veteran-, minority-, and women- owned dental businesses: A cross-sectional study.","authors":"Elizabeth Alpert, Sean G Boynes, Amber Shaver, Annaliese Cothron","doi":"10.3389/froh.2022.1041415","DOIUrl":"10.3389/froh.2022.1041415","url":null,"abstract":"<p><strong>Background: </strong>The Covid-19 pandemic exacerbated dental staffing shortages, which impact care delivery and ultimately oral health equity. Federal funding efforts like the Paycheck Protection Program (PPP) sought to aid traditionally underserved businesses including those owned by veterans, minority racial and ethnic groups, and women.</p><p><strong>Objectives: </strong>(1) To examine differences in PPP funding between veteran- and nonveteran-owned dental care delivery businesses and organizations and (2) to analyze other relevant factors associated with variation in PPP funding levels for dental businesses.</p><p><strong>Methods: </strong>Using publicly available PPP data, we ran unadjusted bivariable and adjusted multivariable linear regression models to estimate associations between loan approval amount and forgiveness amount, veteran status, and relevant covariates.</p><p><strong>Results: </strong>Minority racial and ethnic groups and women received less PPP funding and less loan forgiveness, on average, compared with non-minority groups. In the adjusted model with no missing self-reported demographic observations at <i>p</i> < 0.10, veterans received more PPP funding and loan forgiveness, on average, compared to non-veterans.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first comprehensive analysis of all dental recipients of PPP funding throughout the United States. Despite PPP program intentions and strategies, traditionally underserved dental businesses did not receive increased funding to support employment.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":"3 ","pages":"1041415"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10491013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic review on dental caries preventive and managing strategies among type 2 diabetic patients. 2型糖尿病患者龋齿防治策略的系统综述。
Frontiers in Oral Health Pub Date : 2022-11-18 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.998171
Haoran Chen, Robert Hill, Aylin Baysan
{"title":"Systematic review on dental caries preventive and managing strategies among type 2 diabetic patients.","authors":"Haoran Chen,&nbsp;Robert Hill,&nbsp;Aylin Baysan","doi":"10.3389/froh.2022.998171","DOIUrl":"https://doi.org/10.3389/froh.2022.998171","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this systematic review was to evaluate current evidence to prevent and manage dental caries in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the Participants, Intervention, Comparison, Outcomes and Study Design (PICOS) strategy was used to formulate a structured search: systematic search of PubMed, Cochrane Library, MEDLINE <i>via</i> Ovid, EMBASE, Scopus, Web of Science, and Lilacs without any date limit and/or language restrictions. Two independent reviewers performed data extraction and risk of bias assessments in the included studies. Data homogeneity was assessed according to interventions for treating dental caries in T2DM. Statistical analyses were performed with JMP<sup>®</sup>.</p><p><strong>Results: </strong>Two studies out of 909 were included in the systematic review. Only quantitative studies involving topical applications for management of dental caries in patients with T2DM were included. One study assessed the effect of intensive oral hygiene care program including toothbrushing and interdental cleaning using interproximal brushes and/or dental floss and supragingival debridement by dental hygienist with educational brochures in T2DM, while another investigated the immunologically active salivary substitutes with using Oral Hygiene Instructions (OHI), mouthwash, and moisturizing gel for 6 months. Intensive oral hygiene care program or immunologically active salivary substitutes with using OHI, mouthwash, and moisturizing gel for 6 months were reported to reverse/arrest dental caries in patients with T2DM.</p><p><strong>Conclusion: </strong>The current randomized controlled clinical trials demonstrated that regular extensive oral health education using interdental cleaning aids, mouthwash, moistening gel, and saliva substitutes including lactoperoxidase, lysozyme, glucose oxidase, and lactoferrin could control oral inflammation and contribute to the management of dental caries in patients with T2DM.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020197507, identifier: CRD42020197507.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":" ","pages":"998171"},"PeriodicalIF":0.0,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35208466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: The interplay between the oral Microbiota and rheumatoid arthritis. 社论:口腔微生物群与类风湿关节炎的相互作用。
Frontiers in Oral Health Pub Date : 2022-11-08 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1055482
Daniel Manoil, Nagihan Bostanci, Axel Finckh
{"title":"Editorial: The interplay between the oral Microbiota and rheumatoid arthritis.","authors":"Daniel Manoil,&nbsp;Nagihan Bostanci,&nbsp;Axel Finckh","doi":"10.3389/froh.2022.1055482","DOIUrl":"https://doi.org/10.3389/froh.2022.1055482","url":null,"abstract":"COPYRIGHT © 2022 Manoil, Bostanci and Finckh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":" ","pages":"1055482"},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40722267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping of dental graduates' career paths in Hong Kong, Japan and mainland China. 香港、日本及中国内地牙科专业毕业生的职业发展路径图。
Frontiers in Oral Health Pub Date : 2022-11-03 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.994613
Chloe Meng Jiang, Takashi Nishioka, Guang Hong, Hao Yu, Chang-Yuan Zhang, Chun Hung Chu
{"title":"Mapping of dental graduates' career paths in Hong Kong, Japan and mainland China.","authors":"Chloe Meng Jiang,&nbsp;Takashi Nishioka,&nbsp;Guang Hong,&nbsp;Hao Yu,&nbsp;Chang-Yuan Zhang,&nbsp;Chun Hung Chu","doi":"10.3389/froh.2022.994613","DOIUrl":"https://doi.org/10.3389/froh.2022.994613","url":null,"abstract":"<p><p>Dental graduates have a variety of career-path choices. After graduation, they may join private dental practice, government- or hospital-based dental care services, research groups, academia, business or industry. With globalization and frequent international exchange, dental graduates nowadays can explore careers outside their home country. However, dental education systems and job opportunities vary widely across different regions and countries. Diversity of accreditation in dental education, different licensure requirements, and lack of global competencies in dental care often limit the globalization, operation and survival of dental practice and education worldwide. The requirements for professional education and practice can be quite diverse, and these differences will be barriers to dental graduates seeking career development outside their home home country. Fresh dental graduates have minimal experience in job hunting. More specifically, they are unfamiliar with potential career paths. This paper was based on the 4th trilateral symposium 2022 organized by The University of Hong Kong, Tohoku University, and Fujian Medical University, which offered a lecture to discuss career paths for dental graduates in Hong Kong, Japan, and mainland China. The aim of this paper was to provide dentists, particularly fresh graduated dental students, with practical insight into different career paths in Hong Kong (Special Administrative Region of China, SAR), Japan and mainland China, and factors that may influence their career options. It assists dental students in exploring possibilities in dentistry and preparing for their career development after graduation from dental school.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":" ","pages":"994613"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40717644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dental caries and associated factors among diabetic and nondiabetic adult patients attending Bichena Primary Hospital's Outpatient Department. 比奇纳初级医院门诊部糖尿病和非糖尿病成年患者的龋齿及其相关因素
Frontiers in Oral Health Pub Date : 2022-11-02 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.938405
Anley Shiferaw, Girma Alem, Mekonnen Tsehay, Getiye Dejenu Kibret
{"title":"Dental caries and associated factors among diabetic and nondiabetic adult patients attending Bichena Primary Hospital's Outpatient Department.","authors":"Anley Shiferaw,&nbsp;Girma Alem,&nbsp;Mekonnen Tsehay,&nbsp;Getiye Dejenu Kibret","doi":"10.3389/froh.2022.938405","DOIUrl":"https://doi.org/10.3389/froh.2022.938405","url":null,"abstract":"<p><strong>Purpose: </strong>Dental caries is a significant public health issue affecting both the diabetic and nondiabetic populations. However, the problem and associated factors of dental caries among diabetics and nondiabetics patients are not well-known in Ethiopia. This study aims to compare the prevalence of dental caries and associated factors among diabetic and nondiabetic patients at the Outpatient Department of Bichena Primary Hospital in Northwest, Ethiopia.</p><p><strong>Methods: </strong>Institutional based, comparative cross-sectional study was conducted from October 7 to December 6, 2019, among 200 diabetes and 400 nondiabetic adult patients. A consecutive sampling technique was implemented to recruit study participants. Data were collected by a pretested structured questionnaire and analysis was performed in Statistical Package for Social Science version 20. Bivariable and multivariable logistic regressions were employed and variables with a <i>p</i>-value < 0.05 were declared statistically significant.</p><p><strong>Results: </strong>A total of 582 patients were involved in the study with a response rate of 97.0%. The prevalence of dental caries was 67.9% [95% confidence interval (CI): 63.2%-72.8%] and 79.6% (95% CI: 74.0%-85.70%) in nondiabetic and diabetic group, respectively. Females gender [adjusted odds ratio (AOR) = 1.79, 95% CI: 1.15-2.77], poor oral hygiene (AOR = 2.95, 95% CI: 1.71-5.11), lack of regular teeth cleaning habits (AOR = 3.26, 95% CI: 2.13-4.97), feeling dry mouth (AOR = 2.31, 95% CI: 1.11-4.81), sugared tea drinking (AOR = 2.00, 95% CI: 1.18-3.38), inadequate oral health knowledge (AOR = 3.51, 95% CI: 2.19-5.62), and khat chewing (AOR = 2.14, 95% CI: 1.24-3.71) were significantly associated factors with high prevalence of dental caries.</p><p><strong>Conclusion: </strong>The prevalence of caries was significantly higher among diabetics than nondiabetics. Oral health education with preventive measures such as improving teeth cleaning practice, reducing sugary foods and drinks intake, and improving oral hygiene practice of patients should be mainstreamed along with diabetic follow-up care.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":" ","pages":"938405"},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40717645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Editorial: Highlights in oral infections and microbes 2021/2. 社论:口腔感染和微生物的重点研究2012 /2。
Frontiers in Oral Health Pub Date : 2022-11-02 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1040789
Georgios N Belibasakis, Oleh Andrukhov, Robert P Allaker
{"title":"Editorial: Highlights in oral infections and microbes 2021/2.","authors":"Georgios N Belibasakis,&nbsp;Oleh Andrukhov,&nbsp;Robert P Allaker","doi":"10.3389/froh.2022.1040789","DOIUrl":"https://doi.org/10.3389/froh.2022.1040789","url":null,"abstract":"COPYRIGHT © 2022 Belibasakis, Andrukhov and Allaker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":" ","pages":"1040789"},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40717643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluating clinical utility of subgingival and salivary endotoxin activity levels as periodontal biomarkers. 评估龈下和唾液内毒素活性水平作为牙周生物标志物的临床应用。
Frontiers in Oral Health Pub Date : 2022-11-01 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1029806
Svetislav Zaric, Alexander Strachan, Yuko Kurushima, Anbo Dong, Clare McIlwaine, Zoe Harrington, Luigi Nibali, Andrew Foey, Mark Ide
{"title":"Evaluating clinical utility of subgingival and salivary endotoxin activity levels as periodontal biomarkers.","authors":"Svetislav Zaric,&nbsp;Alexander Strachan,&nbsp;Yuko Kurushima,&nbsp;Anbo Dong,&nbsp;Clare McIlwaine,&nbsp;Zoe Harrington,&nbsp;Luigi Nibali,&nbsp;Andrew Foey,&nbsp;Mark Ide","doi":"10.3389/froh.2022.1029806","DOIUrl":"https://doi.org/10.3389/froh.2022.1029806","url":null,"abstract":"Objectives The use of periodontal biomarkers for identification and monitoring of unique patient populations could foster better stratification of at-risk groups, increase access to treatment for those most in need, facilitate preventive measures and improve personalised care plans. The aim of this study was to examine the diagnostic and prognostic utility of oral lipopolysaccharides as bacterially-derived periodontal biomarkers. Methods Periodontal parameters were recorded, and saliva and subgingival plaque samples were collected at the beginning of the study from periodontally healthy volunteers and periodontitis patients, and three months after completion of conventional periodontal treatment in the periodontitis group. Endotoxin activity in the samples was measured using the recombinant factor C assay. Associations between clinical periodontal parameters and subgingival and salivary endotoxin activities were analysed using a multivariate regression model, while the ROC curve was applied to estimate the sensitivity, specificity and c-statistics for salivary and subgingival endotoxin activities as diagnostic biomarkers for periodontitis. Results Significant correlations were found between subgingival endotoxin activities, probing pocket depth and periodontal diagnosis, which were independent from patients' age, gender and smoking status. In addition, subgingival endotoxin levels had high specificity and sensitivity in detecting periodontal health and disease (0.91 and 0.85 respectively). Salivary endotoxin activity was positively associated with periodontal diagnosis, mean probing pocket depth, percentages of sites over 4 mm and full mouth bleeding score. However, it was inferior in discriminating patients with stable periodontium from those with periodontitis (sensitivity = 0.69, specificity = 0.61) compared to subgingival endotoxin activity. Conclusions Subgingival endotoxin activity has good diagnostic and prognostic values as a site-specific periodontal biomarker and is not influenced by the patient's age, gender or smoking status. In contrast, salivary endotoxin activity, as a patient-level biomarker, is dependent on patient's age, has poorer diagnostic and prognostic capability, but shows good correlations with disease susceptibility and both its extent and severity.","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":" ","pages":"1029806"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40709331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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