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Multifaceted roles of ASB proteins and its pathological significance ASB蛋白的多方面作用及其病理意义
Frontiers in Biology Pub Date : 2018-09-07 DOI: 10.1007/s11515-018-1506-2
Vivek Vishnu Anasa, Palaniyandi Ravanan, P. Talwar
{"title":"Multifaceted roles of ASB proteins and its pathological significance","authors":"Vivek Vishnu Anasa, Palaniyandi Ravanan, P. Talwar","doi":"10.1007/s11515-018-1506-2","DOIUrl":"https://doi.org/10.1007/s11515-018-1506-2","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 1","pages":"376-388"},"PeriodicalIF":0.0,"publicationDate":"2018-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-018-1506-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43352998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Design, molecular docking, synthesis, characterization, biological activity evaluation (against MES model), in-silico biological activity spectrum (PASS analysis), toxicological and predicted oral rat LD50 studies of novel sulphonamide derivatives 新型磺酰胺衍生物的设计、分子对接、合成、表征、生物活性评估(对照MES模型)、计算机生物活性谱(PASS分析)、毒理学和预测大鼠口服LD50研究
Frontiers in Biology Pub Date : 2018-09-04 DOI: 10.1007/s11515-018-1512-4
Ajeet, Arvind Kumar, A. Mishra
{"title":"Design, molecular docking, synthesis, characterization, biological activity evaluation (against MES model), in-silico biological activity spectrum (PASS analysis), toxicological and predicted oral rat LD50 studies of novel sulphonamide derivatives","authors":"Ajeet, Arvind Kumar, A. Mishra","doi":"10.1007/s11515-018-1512-4","DOIUrl":"https://doi.org/10.1007/s11515-018-1512-4","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 1","pages":"425-451"},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-018-1512-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41822958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Effect of a normal protein diet on oxidative stress and organ damage in malnourished rats 正常蛋白质饮食对营养不良大鼠氧化应激和器官损伤的影响
Frontiers in Biology Pub Date : 2018-08-20 DOI: 10.1007/s11515-018-1511-5
H. Gourine, H. Grar, W. Dib, N. Mehedi, A. Boualga, D. Saidi, O. Kheroua
{"title":"Effect of a normal protein diet on oxidative stress and organ damage in malnourished rats","authors":"H. Gourine, H. Grar, W. Dib, N. Mehedi, A. Boualga, D. Saidi, O. Kheroua","doi":"10.1007/s11515-018-1511-5","DOIUrl":"https://doi.org/10.1007/s11515-018-1511-5","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 1","pages":"366-375"},"PeriodicalIF":0.0,"publicationDate":"2018-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-018-1511-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43805729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The journey of gut microbiome – An introduction and its influence on metabolic disorders 肠道微生物组的旅程——简介及其对代谢紊乱的影响
Frontiers in Biology Pub Date : 2018-08-20 DOI: 10.1007/s11515-018-1490-6
Ankita Chattopadhyay, S. Mythili
{"title":"The journey of gut microbiome – An introduction and its influence on metabolic disorders","authors":"Ankita Chattopadhyay, S. Mythili","doi":"10.1007/s11515-018-1490-6","DOIUrl":"https://doi.org/10.1007/s11515-018-1490-6","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 1","pages":"327-341"},"PeriodicalIF":0.0,"publicationDate":"2018-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-018-1490-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48451073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Signal integration in the (m)TORC1 growth pathway. (m)TORC1 生长途径中的信号整合。
Frontiers in Biology Pub Date : 2018-08-01 Epub Date: 2018-07-25 DOI: 10.1007/s11515-018-1501-7
Kailash Ramlaul, Christopher H S Aylett
{"title":"Signal integration in the (m)TORC1 growth pathway.","authors":"Kailash Ramlaul, Christopher H S Aylett","doi":"10.1007/s11515-018-1501-7","DOIUrl":"10.1007/s11515-018-1501-7","url":null,"abstract":"<p><strong>Background: </strong>The protein kinase Target Of Rapamycin (TOR) is a nexus for the regulation of eukaryotic cell growth. TOR assembles into one of two distinct signalling complexes, TOR complex 1 (TORC1) and TORC2 (mTORC1/2 in mammals), with a set of largely non-overlapping protein partners. (m)TORC1 activation occurs in response to a series of stimuli relevant to cell growth, including nutrient availability, growth factor signals and stress, and regulates much of the cell's biosynthetic activity, from proteins to lipids, and recycling through autophagy. mTORC1 regulation is of great therapeutic significance, since in humans many of these signalling complexes, alongside subunits of mTORC1 itself, are implicated in a wide variety of pathophysiologies, including multiple types of cancer, neurological disorders, neurodegenerative diseases and metabolic disorders including diabetes.</p><p><strong>Methodology: </strong>Recent years have seen numerous structures determined of (m)TOR, which have provided mechanistic insight into (m)TORC1 activation in particular, however the integration of cellular signals occurs upstream of the kinase and remains incompletely understood. Here we have collected and analysed in detail as many as possible of the molecular and structural studies which have shed light on (m)TORC1 repression, activation and signal integration.</p><p><strong>Conclusions: </strong>A molecular understanding of this signal integration pathway is required to understand how (m)TORC1 activation is reconciled with the many diverse and contradictory stimuli affecting cell growth. We discuss the current level of molecular understanding of the upstream components of the (m)TORC1 signalling pathway, recent progress on this key biochemical frontier, and the future studies necessary to establish a mechanistic understanding of this master-switch for eukaryotic cell growth.</p>","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 4","pages":"237-262"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116063/pdf/EMS94524.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38374886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between breast arterial calcification on mammography with coronary CT angiography findings 乳腺动脉钙化与冠状动脉造影的关系
Frontiers in Biology Pub Date : 2018-08-01 DOI: 10.1007/s11515-018-1510-6
M. Hanafi, Mojgan Samet Zadeh, M. Momeni, Sorour Rajabkordi
{"title":"Relationship between breast arterial calcification on mammography with coronary CT angiography findings","authors":"M. Hanafi, Mojgan Samet Zadeh, M. Momeni, Sorour Rajabkordi","doi":"10.1007/s11515-018-1510-6","DOIUrl":"https://doi.org/10.1007/s11515-018-1510-6","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 1","pages":"309-313"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-018-1510-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49418708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Metastatic tumor cells - genotypes and phenotypes. 转移性肿瘤细胞-基因型和表型。
Frontiers in Biology Pub Date : 2018-08-01 Epub Date: 2018-08-20 DOI: 10.1007/s11515-018-1513-3
Dingcheng Gao, Vivek Mittal, Yi Ban, Ana Rita Lourenco, Shira Yomtoubian, Sharrell Lee
{"title":"Metastatic tumor cells - genotypes and phenotypes.","authors":"Dingcheng Gao,&nbsp;Vivek Mittal,&nbsp;Yi Ban,&nbsp;Ana Rita Lourenco,&nbsp;Shira Yomtoubian,&nbsp;Sharrell Lee","doi":"10.1007/s11515-018-1513-3","DOIUrl":"https://doi.org/10.1007/s11515-018-1513-3","url":null,"abstract":"<p><strong>Background: </strong>Metastasis is the primary cause of mortality in cancer patients. Therefore, elucidating the genetics and epigenetics of metastatic tumor cells and the mechanisms by which tumor cells acquire metastatic properties constitute significant challenges in cancer research.</p><p><strong>Objective: </strong>To summarize the current understandings of the specific genotype and phenotype of the metastatic tumor cells.</p><p><strong>Method and result: </strong>In-depth genetic analysis of tumor cells, especially with advances in the next-generation sequencing, have revealed insights of the genotypes of metastatic tumor cells. Also, studies have shown that the cancer stem cell (CSC) and epithelial to mesenchymal transition (EMT) phenotypes are associated with the metastatic cascade.</p><p><strong>Conclusion: </strong>In this review, we will discuss recent advances in the field by focusing on the genomic instability and phenotypic dynamics of metastatic tumor cells.</p>","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 4","pages":"277-286"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-018-1513-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36566238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Siberian plants: untapped repertoire of bioactive endosymbionts 西伯利亚植物:未开发的生物活性内共生体
Frontiers in Biology Pub Date : 2018-07-31 DOI: 10.1007/s11515-018-1483-5
S. Baker, S. Prudnikova, T. Volova
{"title":"Siberian plants: untapped repertoire of bioactive endosymbionts","authors":"S. Baker, S. Prudnikova, T. Volova","doi":"10.1007/s11515-018-1483-5","DOIUrl":"https://doi.org/10.1007/s11515-018-1483-5","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 1","pages":"157-167"},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-018-1483-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44671134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Prevalence of fragile X syndrome among patients with mental retardation in the west of Iran 伊朗西部智力迟钝患者中脆性X综合征的患病率
Frontiers in Biology Pub Date : 2018-07-27 DOI: 10.1007/s11515-018-1508-0
P. Hadi, K. Haghani, A. Noori-Zadeh, S. Bakhtiyari
{"title":"Prevalence of fragile X syndrome among patients with mental retardation in the west of Iran","authors":"P. Hadi, K. Haghani, A. Noori-Zadeh, S. Bakhtiyari","doi":"10.1007/s11515-018-1508-0","DOIUrl":"https://doi.org/10.1007/s11515-018-1508-0","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 1","pages":"464-468"},"PeriodicalIF":0.0,"publicationDate":"2018-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-018-1508-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44627172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Comparative evaluation of physico-chemical characteristics of biopolyesters P(3HB) and P(3HB-co-3HV) produced by endophytic Bacillus cereus RCL 02 内生蜡样芽孢杆菌RCL02生物聚酯P(3HB)和P(3HB-co-3HV)理化性质的比较评价
Frontiers in Biology Pub Date : 2018-07-27 DOI: 10.1007/s11515-018-1509-z
R. Das, N. R. Saha, A. Pal, D. Chattopadhyay, A. Paul
{"title":"Comparative evaluation of physico-chemical characteristics of biopolyesters P(3HB) and P(3HB-co-3HV) produced by endophytic Bacillus cereus RCL 02","authors":"R. Das, N. R. Saha, A. Pal, D. Chattopadhyay, A. Paul","doi":"10.1007/s11515-018-1509-z","DOIUrl":"https://doi.org/10.1007/s11515-018-1509-z","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"13 1","pages":"297-308"},"PeriodicalIF":0.0,"publicationDate":"2018-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-018-1509-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47035034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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