Free Radicals and Antioxidants最新文献_第5页

Green Tea (Camellia sinensis) Ameliorate Non-alcoholic Fatty Liver Disease Induced by Highly Active Antiretroviral Therapy 绿茶(Camellia sinensis)改善高活性抗逆转录病毒治疗诱导的非酒精性脂肪肝

Free Radicals and Antioxidants Pub Date : 2021-02-01 DOI: 10.5530/FRA.2020.2.14

Dr.Tesaka Wondimnew, S. Genet, N. Gnanasekaran

{"title":"Green Tea (Camellia sinensis) Ameliorate Non-alcoholic Fatty Liver Disease Induced by Highly Active Antiretroviral Therapy","authors":"Dr.Tesaka Wondimnew, S. Genet, N. Gnanasekaran","doi":"10.5530/FRA.2020.2.14","DOIUrl":"https://doi.org/10.5530/FRA.2020.2.14","url":null,"abstract":"Background: Highly Active Antiretroviral Therapy (HAART) has significantly enhanced the life expectancy of HIV-infected patients. However, utilization of HAART has been identified with adverse events including nonalcoholic fatty liver disease (NAFLD). Objectives: The Objective of this experiment was to explore the conceivable protective effect of green tea (Camellia sinensis) hydro-methonolic extract (GTE) on highly active antiretroviral therapy-induced NAFLD in albino Wistar rats. Methods: Thirty adult rats of comparative weights were chosen and divided into 5 groups of six rats each. Group-1 was a control group, Group II was given HAART and served as negative control, Groups III, IV and V were given HAART and 100, 200 and 400 mg/kg of GTE, respectively for sixty days. At the end of experiment day, the rats were fasted overnight sacrificed by cervical dislocation and blood was taken via cardiac puncture. Serum was separated and liver function test was assessed. Liver were excised from the rats, histopathological studies and lipid profiles were also investigated. Results: Elevated levels of serum TGL, total cholesterol, ALT, AST and liver TGL, TBARS and decreased levels of TAC was seen in HARRT treated rats. The amelioration potential of GTE was observed in a dose-dependent manner, the highest dose 400mg/kg more potently ameliorated HAART affected parameters near to the normal control. Conclusion: This consequence of HAART induced NAFLD may be due to oxidative stress by mitochondrial ROS that leads to increased hepatocellular oxidative damage. This may progress to hepatic inflammation and the development of NAFLD. The effect of GTE against NAFLD and oxidative stress might be due to its antioxidant activity and scavenging of reactive oxygen species induced by HAART.","PeriodicalId":12388,"journal":{"name":"Free Radicals and Antioxidants","volume":"47 1","pages":"77-85"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81421320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sphaeranthus indicus: A Promising Antimicrobial Agent 一种很有前途的抗微生物剂

Free Radicals and Antioxidants Pub Date : 2021-02-01 DOI: 10.5530/FRA.2020.2.10

P. Saxena, S. Upadhyay, Shivani Lodha

引用次数: 0

Evaluations of Antioxidant Effects of Selected Medicinal Plant Extracts Claimed to Treat Kidney Stone Disease 声称治疗肾结石的选定药用植物提取物的抗氧化作用评价

Free Radicals and Antioxidants Pub Date : 2021-02-01 DOI: 10.5530/FRA.2020.2.12

T. Alelign, A. Debella, B. Petros

{"title":"Evaluations of Antioxidant Effects of Selected Medicinal Plant Extracts Claimed to Treat Kidney Stone Disease","authors":"T. Alelign, A. Debella, B. Petros","doi":"10.5530/FRA.2020.2.12","DOIUrl":"https://doi.org/10.5530/FRA.2020.2.12","url":null,"abstract":"Introduction: Free radicals are capable of inducing oxidative damage, which causes various human diseases. However, antioxidants reduce the risk of diseases related to reactive oxygen species. Medicinal plants such as Achyranthes aspera leaves, Satureja punctata aerial parts, Aloe pulcherrima gel, Gomphocarpus fruticosus leaves and Commiphora myrrha resins were claimed to treat various ailments including urolithiasis in Ethiopia. Objectives: This study was intended to determine phytochemicals and antioxidant activities of the aforementioned plants. Materials and Methods: Plants were collected and the aqueous crude extracts were prepared. Phytochemicals were screened qualitatively and DPPH(2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay was measured at 517nm using UV-Vis spectrophotometry. Data were analyzed statistically using one-way ANOVA, Dunnett’s comparison test of the Graph Pad Prism version 6. Results: The plant extracts exhibited various phytochemicals such as phenols, flavonoids and tannins, while these were absent in C. myrrha. Steroids and terpenoides were absent in A. pulcherrima and G. fruticosus extracts, respectively. DPPH scavenging capacities of S. punctata, G. fruticosus, A. pulcherrima and A. aspera aqueous extracts were 92.3%, 81.6%, 72.3% and 54.9%, respectively compared to control (Ascorbic acid) showed 87.6%, 94.5%, 92.3% and 95.6%, respectively at inhibitory concentrations of 0.20 mg/ml, 0.78 mg/ ml, 3.13 mg/ml and 12.5 mg/ml, respectively. The IC50 antioxidant values of S. punctata, A. pulcherrima, G. fruticosus, and A. aspera extracts were 0.01 ±0.003 mg/ml, 0.42 ±0.047 mg/ml, 1.64 ±0.147 mg/ml, and 13.51 ±1.08 mg/ml, respectively compared to Ascorbic acid (0.03 ±0.007 mg/ml). Conclusion: The phytoconstituents in S. punctata aqueous extract has the best capability to scavenge DPPH free radicals. Future characterizations of compounds responsible for the antioxidant activities will be required.","PeriodicalId":12388,"journal":{"name":"Free Radicals and Antioxidants","volume":"1 1","pages":"63-68"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83619960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Importance of Epigallocatechin and its Health Benefits 没食子儿茶素的重要性及其对健康的益处

Free Radicals and Antioxidants Pub Date : 2021-02-01 DOI: 10.5530/FRA.2020.2.9

M. H. Shahrajabian, Wenli Sun, Q. Cheng

引用次数: 2

Potential Antioxidant and Antibacterial Properties of Medicinal Plant Trachyspermum ammi L. Seeds 药用植物石竹种子潜在的抗氧化和抗菌特性

Free Radicals and Antioxidants Pub Date : 2021-02-01 DOI: 10.5530/FRA.2020.2.11

Ravi Sahukari, Jyothi Punabaka, Praveen Kumar Yamala, S. Bhasha, V. Ganjikunta, Sathyavelu R. Kesireddy

{"title":"Potential Antioxidant and Antibacterial Properties of Medicinal Plant Trachyspermum ammi L. Seeds","authors":"Ravi Sahukari, Jyothi Punabaka, Praveen Kumar Yamala, S. Bhasha, V. Ganjikunta, Sathyavelu R. Kesireddy","doi":"10.5530/FRA.2020.2.11","DOIUrl":"https://doi.org/10.5530/FRA.2020.2.11","url":null,"abstract":"Background: A highly valued medicinal plant belonging to the family Apiaceae is Trachyspermum ammi L. The seeds of this plant are used as spice and are traditionally used for the treatment of many human and animal illnesses. Objectives: In this research study, we aimed at quantitatively estimating the phytochemicals, antioxidant and antimicrobial activity of different solvent extracts of T. ammi seeds. Methods: Quantification of phenol and flavonoid phytochemicals have been estimated in different solvent extracts of seeds. Further, the antioxidant activity was determined by performing DPPH, lipid peroxidation, reducing capacity and total antioxidant activity assays. Additionally, antibacterial activity was assessed against three bacterial species using well-diffusion method. Results: The findings showed in quantitative estimation that phenols and flavonoids were rich in extracts. Acetone, Methanol and Ethanol extracts were potentially scavenged DPPH radical, lipid peroxidation nullified and metal ions such as Fe and Mo reduced. At the same time, effective antibacterial activity on E. coli, S. aureus and Pseudomonas bacterial species was seen in Chloroform and Methanol extracts and synthesized silver nanoparticles. Conclusion: In conclusion, free radical scavenging, reduction of metals and antibacterial activity of different extracts of T. ammi was indicative of the presence of enormous amounts of phenols and flavonoids. Further work on these extracts needs to be done to isolate the active compounds and, to treat free radicals and related bacterial diseases.","PeriodicalId":12388,"journal":{"name":"Free Radicals and Antioxidants","volume":"70 1","pages":"56-62"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79726424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Wound Healing Activity of Herbal Ointment Containing the Extracts of Hibiscus rosa-sinensis Flowers and Curcuma longa Rhizomes 芙蓉花和姜黄提取物药膏的创面愈合活性

Free Radicals and Antioxidants Pub Date : 2021-02-01 DOI: 10.5530/FRA.2020.2.15

F. Mustaffa, S. Parasuraman, G. Sahgal

引用次数: 1

Long-Term Preservation of Total Phenolic Content and Antioxidant Activity in Extra Virgin Olive Oil: A Physico-biochemical Approach 特级初榨橄榄油中总酚含量和抗氧化活性的长期保存:物理生化方法

Free Radicals and Antioxidants Pub Date : 2020-08-25 DOI: 10.5530/fra.2020.1.2

E. Giannakopoulos, Georgios Salachas, D. Zisimopoulos, S. Barla, Electra Kalaitzopoulou, Polyxeni Papadea, Marianna Skipitari, C. Georgiou

{"title":"Long-Term Preservation of Total Phenolic Content and Antioxidant Activity in Extra Virgin Olive Oil: A Physico-biochemical Approach","authors":"E. Giannakopoulos, Georgios Salachas, D. Zisimopoulos, S. Barla, Electra Kalaitzopoulou, Polyxeni Papadea, Marianna Skipitari, C. Georgiou","doi":"10.5530/fra.2020.1.2","DOIUrl":"https://doi.org/10.5530/fra.2020.1.2","url":null,"abstract":"Objectives: This work, on low-cost controlled freeze methodology for stabilizing the phenolic content in Extra Virgin Olive Oil (EVOO), is evaluated by studying four Quality Indexes (QIs): free acidity, as % of oleic acid (1st-QI); UV-absorption values; K272, K232 and ΔK (2nd-QI); total phenolic content (TPC), as Gallic acid equivalence (3rd-QI); and lipid peroxidation products, as free malondialdehyde (MDA) (4th-QI). Methods: The study of QIs for EVOO under storage, absence of light, at 25, 4, -20 and -80°C, with or without N2-purge showed that the phenolic charge is stabilized for > 12 months, at refrigeration conditions storage (~ 4°C) in the absence of oxygen, whilst the peroxidation of lipids is being kept at a low level. Results: The results showed that the high concentration of natural hydroxylphenols in the EVOO in combination with its degassing (via N2-purge) and storage at ~ 4°C, constitute the optimum conditions for preservation of olive oil as a long-lasting EVOO (LL [legal limit]-EVOO) with high added value. Conclusion: The main scientific contribution of this study is: (i) development and evaluation of a methodology (freeze controlled treatment) for the long-term preservation of EVOO quality, (ii) understanding the physicochemical mechanism and factors determining EVOO quality and (iii) ready-to-use technology for the local and international market.","PeriodicalId":12388,"journal":{"name":"Free Radicals and Antioxidants","volume":"10 1","pages":"04-09"},"PeriodicalIF":0.0,"publicationDate":"2020-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81920660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cardioprotective Effect of Ethanolic Extract of Leaves of Amaranthus cruentus in Isoprenaline-Induced Myocardial Infarction in Rats 苋菜叶乙醇提取物对异丙肾上腺碱致大鼠心肌梗死的心脏保护作用

Free Radicals and Antioxidants Pub Date : 2020-08-25 DOI: 10.5530/fra.2020.1.5

Priya Bisen, A. Chaturvedi, A. Ganeshpurkar, Nazneen Dubey

{"title":"Cardioprotective Effect of Ethanolic Extract of Leaves of Amaranthus cruentus in Isoprenaline-Induced Myocardial Infarction in Rats","authors":"Priya Bisen, A. Chaturvedi, A. Ganeshpurkar, Nazneen Dubey","doi":"10.5530/fra.2020.1.5","DOIUrl":"https://doi.org/10.5530/fra.2020.1.5","url":null,"abstract":"Cite this article: Bisen P, Chaturvedi A, Ganeshpurkar A, Dubey N. Cardioprotective Effect of Amaranthus cruentus Extracton Isoprenaline Induced Myocardial Infraction in Rats. Free Radicals and Antioxidants. 2020;10(1):23-8. ABSTRACT Objectives: The present study is focused to evaluate cardioprotective activity of ethanolic extract of Amaranthus cruentus. Methods: Amaranthus cruentus extract (Dose 200mg/kg and 400mg/kg) in isoprenaline induced myocardial infarction in rats. The ethanolic extract of Amaranthus cruentus was prepared and subjected to acute toxicity in albino rats. The extract was given orallyat two different doses 200mg/kg and 400mg/. Isoprenaline was administered subcutaneously (85mg/kg s.c.). Results: The histopathological examination revealed mild infarction and inflammation in isoprenaline treated rats. The ethanolic extract of Amaranthus cruentus showed significant cardio protective effect by decreasing the serum level of LDL and VLDL cholesterol levels. The biochemical parameters (AST, ALT and ALP) and HDL cholesterol levels were restored. Conclusion: The outcome of the present study suggested cardioprotective activity of Amaranthus cruentus extract.","PeriodicalId":12388,"journal":{"name":"Free Radicals and Antioxidants","volume":"130 1","pages":"24-28"},"PeriodicalIF":0.0,"publicationDate":"2020-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77205865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and Free Radical Scavenging Activities of Newbouldia laevis Leaf extracts 青叶提取物的抗氧化和自由基清除活性

Free Radicals and Antioxidants Pub Date : 2020-08-25 DOI: 10.5530/fra.2020.1.3

A. Salemcity, V. Nwaneri-Chidozie, Emmanuel Adameh, Magdalene E Effiong

{"title":"Antioxidant and Free Radical Scavenging Activities of Newbouldia laevis Leaf extracts","authors":"A. Salemcity, V. Nwaneri-Chidozie, Emmanuel Adameh, Magdalene E Effiong","doi":"10.5530/fra.2020.1.3","DOIUrl":"https://doi.org/10.5530/fra.2020.1.3","url":null,"abstract":"Objectives: Oxidative stress is implicated in the etiology of life-threatening disease conditions. Newbouldia laevis (NL) have been used in folk medicine for stress related conditions, however, there is paucity of reports suggesting a connection between its efficacy and a possible antioxidant property. The aim of this study was to evaluate the antioxidant properties of NL leaf extracts. Methods: The methanol extract of NL was partitioned to obtain the chloroform fraction (CFNL) and the aqueous fraction (AFNL). Following standard laboratory procedures, the parameters were measured spectrophotometrically. Results: The MFNL recorded the highest activity for DPPH (76.4%), while all extracts only showed slight hydrogen peroxide scavenging capacity. Total antioxidant capacity at uniform concentration revealed an increasing order of activity from AFNL to MENL, correlating with total phenol contents which is in the same order. Furthermore, the extracts inhibited lipid peroxidation in a concentration dependent manner, with MENL recording the highest inhibition of 19.5%. The MENL however had the highest vitamin C concentration of 165.44mg/100ml. Conclusion: The above results not only demonstrate the antioxidant properties of NL, but suggests this as one of its possible mechanism of action and indicates the presence of potent principles with potential for application in stress related ailments.","PeriodicalId":12388,"journal":{"name":"Free Radicals and Antioxidants","volume":"50 1","pages":"10-15"},"PeriodicalIF":0.0,"publicationDate":"2020-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76544529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Glutamate Receptors in Schizophrenia: A Review 精神分裂症中的谷氨酸受体:综述

Free Radicals and Antioxidants Pub Date : 2020-08-25 DOI: 10.5530/fra.2020.1.1

Shivani Lodha, S. Upadhyay, K. S. Baghel, Y. Ahmad

引用次数: 0