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Expert Review of Dermatology最新文献

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The role of dynamic infrared imaging in melanoma diagnosis. 动态红外成像在黑色素瘤诊断中的作用。
Expert Review of Dermatology Pub Date : 2013-04-01 DOI: 10.1586/edm.13.15
Cila Herman
{"title":"The role of dynamic infrared imaging in melanoma diagnosis.","authors":"Cila Herman","doi":"10.1586/edm.13.15","DOIUrl":"https://doi.org/10.1586/edm.13.15","url":null,"abstract":"<p><p>Melanoma incidence and the lifetime risk are increasing at an alarming rate in the United States and worldwide. In order to improve survival rates, the goal is to detect melanoma at an early stage of the disease. Accurate, sensitive and reliable quantitative diagnostic tools can reduce the number of unnecessary biopsies, the associated morbidity as well as the costs of care in addition to improving survival rates. The recently introduced quantitative dynamic infrared imaging system QUAINT measures differences in the infrared emission between healthy tissue and the lesion during the thermal recovery process after the removal of a cooling stress. Results from a clinical study suggest that the temperature of cancerous lesions is higher during the first 45-60 seconds of thermal recovery than the temperature of benign pigmented lesions. This small temperature difference can be measured by modern infrared cameras and serve as an indicator for melanoma in modern quantitative melanoma detectors.</p>","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"8 2","pages":"177-184"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1586/edm.13.15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31488918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
The diagnosis of melanoma 黑色素瘤的诊断
Expert Review of Dermatology Pub Date : 2013-04-01 DOI: 10.1586/EDM.13.13
J. Grant-Kels
{"title":"The diagnosis of melanoma","authors":"J. Grant-Kels","doi":"10.1586/EDM.13.13","DOIUrl":"https://doi.org/10.1586/EDM.13.13","url":null,"abstract":"","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"30 1","pages":"95-97"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76885116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Targeted chemotherapy of metastatic melanoma: the impact of tumor cell heterogeneity 转移性黑色素瘤的靶向化疗:肿瘤细胞异质性的影响
Expert Review of Dermatology Pub Date : 2013-04-01 DOI: 10.1586/EDM.13.3
Diane Kovacic, J. Carlson, A. Slominski
{"title":"Targeted chemotherapy of metastatic melanoma: the impact of tumor cell heterogeneity","authors":"Diane Kovacic, J. Carlson, A. Slominski","doi":"10.1586/EDM.13.3","DOIUrl":"https://doi.org/10.1586/EDM.13.3","url":null,"abstract":"Evaluation of: Flaherty KT, Infante JR, Daud A et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N. Engl. J. Med. 367(18), 1694–1703 (2012).The treatment of metastatic melanoma with BRAF inhibitors initially gave dramatic results compared with standard chemotherapy with significant progression-free survival times. Unfortunately, within a matter of months, the melanomas become refractory to anti-BRAF-targeted therapy and some patients experience toxicity in the form of primary cutaneous squamous cell carcinomas. While recent reports of dual therapy targeting the MAPK pathway (e.g., dabrafenib and trametinib) show increased response rates and less toxicity, it is not apparent that overall survival has been significantly impacted. While targeted therapy has significantly altered the management of melanoma, novel approaches and strategies will likely have to be employed to counter melanoma cell heterogeneity and the selection of resistant clones.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"85 1","pages":"131-134"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83072658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Medical honey in professional wound care 医用蜂蜜用于专业伤口护理
Expert Review of Dermatology Pub Date : 2013-02-01 DOI: 10.1586/EDM.12.66
B. Biglari, T. Swing, Axel Büchler, T. Ferbert, A. Simon, G. Schmidmaier, A. Moghaddam
{"title":"Medical honey in professional wound care","authors":"B. Biglari, T. Swing, Axel Büchler, T. Ferbert, A. Simon, G. Schmidmaier, A. Moghaddam","doi":"10.1586/EDM.12.66","DOIUrl":"https://doi.org/10.1586/EDM.12.66","url":null,"abstract":"Many physicians and wound care professionals still think honey is a ‘folk remedy’ with no scientific evidence for its use in modern wound care. They believe that after the development of antibiotics and professional treatment strategies, the use of honey to treat wounds is obsolete. Researchers have shown that honey derived from Leptospermum scoparium, so called manuka honey, displays significant antibacterial effects on all clinically relevant bacterial species and also works well in combination with antibiotics. Of particular interest has been manuka honey’s intriguing activity against methicillin-resistant Staphylococcus aureus. Hospitals all over Germany, New Zealand, Australia and Austria are convinced of its benefits and use it regularly. Medical-grade honey and ready-to-use honey dressings are widely available in the EU since 2004. This manuscript intends to deal with the benefits of medical honey in professional wound care.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"101 1","pages":"51-56"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85812332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Nestin-expressing multipotent hair follicle stem cells for regenerative medicine 表达巢蛋白的多能毛囊干细胞用于再生医学
Expert Review of Dermatology Pub Date : 2013-02-01 DOI: 10.1586/EDM.12.68
R. Hoffman
{"title":"Nestin-expressing multipotent hair follicle stem cells for regenerative medicine","authors":"R. Hoffman","doi":"10.1586/EDM.12.68","DOIUrl":"https://doi.org/10.1586/EDM.12.68","url":null,"abstract":"Nestin-expressing hair follicle stem cells of the mouse can differentiate into neurons, glia, keratinocytes, smooth muscle cells and melanocytes in vitro. Nestin-expressing hair follicle stem cells enhanced the rate of nerve regeneration and the restoration of nerve function in mouse models. The nestin-expressing hair follicle stem cells transdifferentiate largely into Schwann cells when implanted in severed nerves or injured spinal cord, which may enhance neuron regrowth. The bulge area of the follicle is the source of the nestin-expressing stem cells of the hair follicle, which migrate from the bulge area to the dermal papilla as well as into the surrounding skin tissues during wound healing. Nestin-expressing stem cells can also be readily isolated from the human scalp, thereby providing an accessible, autologous and safe source of stem cells for potential clinical use.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"84 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83830509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treating atopic dermatitis at the source: corrective barrier repair therapy based upon new pathogenic insights 从源头上治疗特应性皮炎:基于新的致病见解的纠正性屏障修复疗法
Expert Review of Dermatology Pub Date : 2013-02-01 DOI: 10.1586/EDM.12.73
P. Elias, R. Sun, J. Wakefield, M. Man
{"title":"Treating atopic dermatitis at the source: corrective barrier repair therapy based upon new pathogenic insights","authors":"P. Elias, R. Sun, J. Wakefield, M. Man","doi":"10.1586/EDM.12.73","DOIUrl":"https://doi.org/10.1586/EDM.12.73","url":null,"abstract":"Until recently, atopic dermatitis (AD) has been linked to Th1/Th2 cell dysregulation. But now, the opinion that inflammation in AD results from a convergence of inherited and acquired insults to the cutaneous permeability barrier, with variable contributions from inherited abnormalities in innate/adaptive immunity, is becoming increasingly accepted. Current therapy is however, still largely directed towards ameliorating immunologically triggered inflammation, rather than correcting the barrier abnormality. In this article, the authors provide an overview of epidermal barrier function; a review of recent molecular genetic studies pointing to a primary barrier abnormality in AD; a detailed description of new pathogenic insights into AD; and they compare the efficacy of several putative ‘barrier repair’ products currently utilized as adjunctive or primary therapy for AD. The authors also explore the potential of ‘next-generation’ barrier repair approaches that attack specific pathogenic mechanisms in AD (hig...","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"40 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82718955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Can understanding the effect of solar UV radiation on skin’s biomechanical function help prevent skin damage? 了解太阳紫外线辐射对皮肤生物力学功能的影响是否有助于预防皮肤损伤?
Expert Review of Dermatology Pub Date : 2013-02-01 DOI: 10.1586/EDM.12.72
Krysta Biniek, R. Dauskardt
{"title":"Can understanding the effect of solar UV radiation on skin’s biomechanical function help prevent skin damage?","authors":"Krysta Biniek, R. Dauskardt","doi":"10.1586/EDM.12.72","DOIUrl":"https://doi.org/10.1586/EDM.12.72","url":null,"abstract":"","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"32 1","pages":"5-6"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81343844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical treatments for cutaneous warts: an update 皮肤疣的局部治疗:最新进展
Expert Review of Dermatology Pub Date : 2013-02-01 DOI: 10.1586/EDM.12.74
G. Micali, M. Nasca, S. Gibbs, C. Bennett, R. Holland
{"title":"Topical treatments for cutaneous warts: an update","authors":"G. Micali, M. Nasca, S. Gibbs, C. Bennett, R. Holland","doi":"10.1586/EDM.12.74","DOIUrl":"https://doi.org/10.1586/EDM.12.74","url":null,"abstract":"Evaluation of: Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R. Topical treatments for cutaneous warts. Cochrane Database Syst. Rev. 9, CD001781 (2012).Cutaneous warts are common skin lesions caused by human papillomavirus infection. Their treatment is aimed at relieving a patient’s physical and psychological discomfort, and at preventing spread of infection by autoinoculation. The aim of the article under review is to describe the outcome of current therapies for cutaneous warts according to randomized controlled trials. Results from pooled data show that significantly higher remission rates may be expected with salicylic acid and cryotherapy, best if used in combination. Limited data on adverse effects suggest that these are mild, well tolerated and more common with cryotherapy.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"37 1","pages":"15-17"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75501545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The epidemiology, etiology and Chuh and Zawar’s diagnostic criteria of Gianotti–Crosti syndrome Gianotti-Crosti综合征的流行病学、病因学及Chuh和Zawar诊断标准
Expert Review of Dermatology Pub Date : 2013-02-01 DOI: 10.1586/EDM.12.69
A. Chuh, V. Zawar
{"title":"The epidemiology, etiology and Chuh and Zawar’s diagnostic criteria of Gianotti–Crosti syndrome","authors":"A. Chuh, V. Zawar","doi":"10.1586/EDM.12.69","DOIUrl":"https://doi.org/10.1586/EDM.12.69","url":null,"abstract":"Gianotti–Crosti syndrome (GCS) consists of a sudden eruption of small papules or papulovesicles over the face, buttock and extensor surfaces of limbs, generalized lymphadenopathy and acute nonicteric hepatitis in young children. Most early cases were caused by hepatitis B virus. Adults could also suffer from GCS. Other viruses may now be more pertinent than hepatitis B virus. The authors no longer need lymphadenopathy or hepatitis to make a diagnosis. The disease is self-limiting. Complications are uncommon. The inclusion and exclusion criteria of studies in GCS are nonuniform, rendering low homogeneity of study subjects. A validated diagnostic criteria would allow subjects in all studies more homogenous so that valid meta-analyses and systemic reviews can be performed. Data from subjects with GCS seen in specialist settings only might be biased. Recruitment in primary care settings with specifically trained primary care physicians and application of a valid and standardized diagnostic criteria might be c...","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"217 1","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89105221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Dermatological aspects of rhinosporidiosis 鼻孢子虫病的皮肤病学方面
Expert Review of Dermatology Pub Date : 2013-02-01 DOI: 10.1586/EDM.12.76
S. Arseculeratne, G. Arseculeratne
{"title":"Dermatological aspects of rhinosporidiosis","authors":"S. Arseculeratne, G. Arseculeratne","doi":"10.1586/EDM.12.76","DOIUrl":"https://doi.org/10.1586/EDM.12.76","url":null,"abstract":"Rhinosporidial lesions in the skin are pathogenetically classified as primary, secondary and as components of disseminated disease. Estimates of the incidence of rhinosporidiosis in various sites vary between 1 and 8% of all cases of rhinosporidiosis. The disease is mainly of occupational origin after exposure to ground waters and is noncontagious and noninfectious. Cutaneous rhinosporidial lesions are diverse in morphologies, and definitive diagnosis is provided by skin-histopathology with the conventional HE multiple extensive sessile growths, when surgery is difficult, will need drug therapy. Surface application of biocides is ineffective.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":"151 1","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82281196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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