The epidemiology, etiology and Chuh and Zawar’s diagnostic criteria of Gianotti–Crosti syndrome

Gianotti–Crosti syndrome (GCS) consists of a sudden eruption of small papules or papulovesicles over the face, buttock and extensor surfaces of limbs, generalized lymphadenopathy and acute nonicteric hepatitis in young children. Most early cases were caused by hepatitis B virus. Adults could also suffer from GCS. Other viruses may now be more pertinent than hepatitis B virus. The authors no longer need lymphadenopathy or hepatitis to make a diagnosis. The disease is self-limiting. Complications are uncommon. The inclusion and exclusion criteria of studies in GCS are nonuniform, rendering low homogeneity of study subjects. A validated diagnostic criteria would allow subjects in all studies more homogenous so that valid meta-analyses and systemic reviews can be performed. Data from subjects with GCS seen in specialist settings only might be biased. Recruitment in primary care settings with specifically trained primary care physicians and application of a valid and standardized diagnostic criteria might be c...