European Urology Open Science最新文献

{"title":"Preoperative Physical Activity Improvement with the Use of Activity Trackers in Patients Undergoing Radical Cystectomy—A Bicentric, Open-label, Randomised Controlled Trial: A Clinical Study Protocol of the PreAct Trial","authors":"Johannes Hermann Kilz , Marie Angela Sidoti Abate , Victoria Luise Simone Wieland , Luisa Egen , Caelan Max Haney , Aleksander Antoniewicz , Alexander Studier-Fischer , Thomas Stefan Worst , Maurice Stephan Michel , Patrick Honeck , Niklas Westhoff , Maximilian Christian Kriegmair , Karl-Friedrich Kowalewski","doi":"10.1016/j.euros.2024.11.003","DOIUrl":"10.1016/j.euros.2024.11.003","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 78-86"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage Magnetic Resonance Imaging–guided Transurethral Ultrasound Ablation for Localized Radiorecurrent Prostate Cancer","authors":"Mikael Anttinen ,&nbsp;Pietari Mäkelä ,&nbsp;Pertti Nurminen ,&nbsp;Heikki Pärssinen ,&nbsp;Simona Malaspina ,&nbsp;Teija Sainio ,&nbsp;Mikael Högerman ,&nbsp;Pekka Taimen ,&nbsp;Roberto Blanco Sequeiros ,&nbsp;Peter J. Boström","doi":"10.1016/j.euros.2024.11.001","DOIUrl":"10.1016/j.euros.2024.11.001","url":null,"abstract":"<div><h3>Background and objective</h3><div>Toxicity from local salvage therapy for radiorecurrent prostate cancer (PCa) remains a concern. This phase 2 study evaluates the outcomes of salvage magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (sTULSA).</div></div><div><h3>Methods</h3><div>Men with biochemically relapsed, biopsy-proven PCa following definitive radiotherapy underwent whole- or partial-gland sTULSA (NCT03350529). Prostate-confined recurrence was confirmed by MRI and prostate-specific membrane antigen (PSMA) positron emission tomography (PET) computed tomography (CT). The primary endpoints were safety (Clavien-Dindo classification) and efficacy (prostate-specific antigen [PSA], PSMA PET-CT, and MRI-targeted biopsy at 12 mo). The secondary endpoints included functional and survival outcomes.</div></div><div><h3>Key findings and limitations</h3><div>Thirty-nine patients underwent sTULSA (64% whole gland), with a median age of 73 yr (interquartile range [IQR]: 69–77) and PSA of 3.3 ng/ml (IQR: 2–6.2). Three patients had undergone prior salvage therapy, 16 were receiving hormonal therapy at enrollment, and 12 had a history of transurethral interventions. Eighteen patients had incidental urethral strictures on baseline cystoscopy. Over a median follow-up of 40 mo (IQR: 24–55), 56% experienced adverse events. Severe genitourinary toxicity (Clavien-Dindo ≥3 or hospitalization) occurred in 28%, including three patients with puboprostatic fistulas and two patients requiring cystectomy. Leak-free continence was maintained in 53%. At 12 mo, 89% showed no cancer in the targeted area, with a median PSA reduction of 95% (<em>p</em> &lt; 0.001). Five-year metastasis-free, failure-free, and biochemical recurrence–free survival probabilities (95% confidence interval) were 97% (0.93–1.00), 70% (0.54–0.91), and 54% (0.31–0.93), respectively. Limitations included single-arm design and moderate sample size.</div></div><div><h3>Conclusions and clinical implications</h3><div>It has been observed that sTULSA is effective for radiorecurrent PCa, although genitourinary toxicity remains a concern. Further studies should refine patient selection and treatment parameters to improve safety and tolerability.</div></div><div><h3>Patient summary</h3><div>In this study, we examined a new treatment called magnetic resonance imaging–guided transurethral ultrasound ablation for prostate cancer that has returned after radiation therapy. We found that the treatment provided effective and lasting cancer control for most patients. However, a notable number of patients experienced significant genitourinary toxicity, including severe adverse effects affecting urinary function. Careful patient selection is crucial to minimize these adverse effects and ensure the best results.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 69-77"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6 Survival results of PSMA/PET-based salvage radiotherapy for recurrent prostate cancer","authors":"Grivas N.,&nbsp;van Leeuwen P.,&nbsp;Wit E.,&nbsp;Vis A.,&nbsp;Nieuwenhuijzen J.,&nbsp;Pos F.,&nbsp;van der Poel H.","doi":"10.1016/S2666-1683(25)00037-0","DOIUrl":"10.1016/S2666-1683(25)00037-0","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S5"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18 The role of PSMA expression in predicting aggressive disease phenotypes in patients with prostate cancer","authors":"Gandaglia G.,&nbsp;Scuderi S.,&nbsp;Barletta F.,&nbsp;Stabile A.,&nbsp;Cucchiara V.,&nbsp;Montorsi F.,&nbsp;Briganti A.","doi":"10.1016/S2666-1683(25)00021-7","DOIUrl":"10.1016/S2666-1683(25)00021-7","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S21"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12 Predicting pathological tumor volume in prostate cancer lesions using micro-ultrasound and MRI","authors":"Rakauskas A.,&nbsp;Richmond A.,&nbsp;La Rosa S.,&nbsp;Vietti-Violi N.,&nbsp;Valerio M.","doi":"10.1016/S2666-1683(25)00015-1","DOIUrl":"10.1016/S2666-1683(25)00015-1","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S13"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25 Novel biomaterials for stress urinary incontinence: development of a clinically relevant large animal model to mimic suburethral implantation","authors":"Osman N.I.,&nbsp;Bullock A.,&nbsp;Farr N.,&nbsp;Workman V.,&nbsp;MacNeil S.,&nbsp;Chapple C.","doi":"10.1016/S2666-1683(25)00029-1","DOIUrl":"10.1016/S2666-1683(25)00029-1","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages S28-S29"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Antimicrobial Strategies Associated with Clinical Cure and Increased Microbiological Eradication in Patients with Complicated Urinary Tract Infections and High Risk of Relapse","authors":"José Medina Polo ,&nbsp;Jose Luis Alfonso Sánchez ,&nbsp;Jorge Arca-Suárez ,&nbsp;Ángel Estella ,&nbsp;Pablo González ,&nbsp;Martí Blasco ,&nbsp;Alicia Gil ,&nbsp;Leonor del Mar Periañez Párraga ,&nbsp;Francisco Javier Membrillo de Novales","doi":"10.1016/j.euros.2024.12.001","DOIUrl":"10.1016/j.euros.2024.12.001","url":null,"abstract":"<div><h3>Background and objective</h3><div>Complicated urinary tract infections (cUTIs) are serious, potentially life-threatening infections that occur in patients with an increased disease progression risk. Antimicrobial resistance represents an important health issue worldwide, contributing to relapses, which can generate further resistances. It is necessary to clarify the role of microbiological eradication as an additional objective in the management of cUTIs. Some publications suggest that relapses relate to insufficient bacterial suppression in the urinary tract. This study focuses on generating a consensus on how patients with cUTIs would benefit from effective antimicrobial agents associated with higher rates of bacterial eradication.</div></div><div><h3>Methods</h3><div>The nominal group technique was followed: systematic literature review, development of a questionnaire, expert panel meeting to discuss results, individual review of draft consensus document, and expert panel meeting to discuss final views and finalise the consensus document.</div></div><div><h3>Key findings and limitations</h3><div>Experts identified risk factors for cUTIs (patients with a higher risk of relapse, physiological obstruction of urinary tract, immune suppression, and previous relapse), and patients who would benefit most from a therapeutic strategy combining clinical cure and aim for microbiological eradication. While experts agreed that the scientific evidence discourages repetition of urine cultures after treatment, they proposed recommendations to prioritise antibiotics with higher evidence of microbiological eradication and close follow-up in patients with a higher risk of relapse, considering any symptoms appearing following clinical cure of the cUTI.</div></div><div><h3>Conclusions and clinical implications</h3><div>Selection of active antimicrobial agents associated with increased microbiological eradication should be prioritised in patients with cUTIs and a high risk of relapse.</div></div><div><h3>Patient summary</h3><div>Complicated urinary tract infections (cUTIs) occur in patients with an increased risk of disease progression or are caused by multidrug-resistant uropathogens. Antimicrobial resistance is of concern as it can result in relapses. Antimicrobial therapeutic strategies associated with increased microbiological eradication in cUTI patients with a high risk of relapse are crucial to prevent relapses and development of antibiotic resistance.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 165-171"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4 Percutaneous nephrolithotomy: Impact of intraoperative stone culture","authors":"Knoll T.,&nbsp;Lieb S.","doi":"10.1016/S2666-1683(25)00035-7","DOIUrl":"10.1016/S2666-1683(25)00035-7","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"17 The risk of venous thromboembolism after cystectomy and prostatectomy with or without a pelvic lymph-node dissection","authors":"Akre O.,&nbsp;Rautiola J.,&nbsp;Björklund J.,&nbsp;Zelic R.,&nbsp;Pellegrino F.,&nbsp;Vincent P.H.,&nbsp;Aly M.,&nbsp;Falconer H.,&nbsp;Wiklund P.","doi":"10.1016/S2666-1683(25)00020-5","DOIUrl":"10.1016/S2666-1683(25)00020-5","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages S19-S20"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10 External validation of a digital pathology-based multimodal artificial intelligence prostatebiopsy biomarker in a prospective, real-world prostate cancer cohort treated with radicalprostatectomy","authors":"Bjartell A.S.,&nbsp;Krzyzanowska A.,&nbsp;Liu V.,&nbsp;Thierney M.,&nbsp;Joyce T.,&nbsp;Sjöström M.,&nbsp;Palominos-Rivera M.M.,&nbsp;Chen E.,&nbsp;Kraft A.,&nbsp;Esteva A.E, Feng F.","doi":"10.1016/S2666-1683(25)00013-8","DOIUrl":"10.1016/S2666-1683(25)00013-8","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S11"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}