European Urology Open Science最新文献

{"title":"11 Does the percentage of Gleason 4 in targeted prostate biopsies predict the percentage of Gleason 4 at final pathology in prostatectomy specimen? Implications for active surveillance","authors":"Walz J., Cavigla A., Knipper S., Branger N., Brunelle S., Gravis G., Salem N., Pignot G.","doi":"10.1016/S2666-1683(25)00014-X","DOIUrl":"10.1016/S2666-1683(25)00014-X","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S12"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"15 Proteome signatures in urinary extracellular vesicles enable prostate cancer detection","authors":"Bijnsdorp I.V., Erozenci L.A., Knol J.C., Pham T.V., Piersma S.R., Verhaegh G., Schalken J.A., Jenster G., van Royen M.E.,Martens-Uzunova E., Van Moorselaar R.J.A., Jimenez C.R.","doi":"10.1016/S2666-1683(25)00018-7","DOIUrl":"10.1016/S2666-1683(25)00018-7","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S17"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"26 The development of a novel, multi-dimensional tool for the assessment of sexual dysfunction following radical prostatectomy: The RPQ","authors":"Mulhall J.P.","doi":"10.1016/S2666-1683(25)00030-8","DOIUrl":"10.1016/S2666-1683(25)00030-8","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S30"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"23 Efficacy and safety of trans-obturator tape vs. urethral bulking in female stress urinary incontinence. A randomized controlled trial","authors":"Costantini E., Illiano E.","doi":"10.1016/S2666-1683(25)00027-8","DOIUrl":"10.1016/S2666-1683(25)00027-8","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S26"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls","authors":"Reidun Sletten ,&nbsp;Marit Slaaen ,&nbsp;Line Merethe Oldervoll ,&nbsp;Håvard Kjesbu Skjellegrind ,&nbsp;Jūratė Šaltytė Benth ,&nbsp;Lennart Åstrøm ,&nbsp;Øyvind Kirkevold ,&nbsp;Sverre Bergh ,&nbsp;Bjørn Henning Grønberg ,&nbsp;Siri Rostoft ,&nbsp;Asta Bye ,&nbsp;Paul Jarle Mork ,&nbsp;Ola Berger Christiansen","doi":"10.1016/j.euros.2024.11.005","DOIUrl":"10.1016/j.euros.2024.11.005","url":null,"abstract":"<div><h3>Background and objective</h3><div>Whether radical prostate cancer treatment affects long-term physical performance and physical activity in older men is not known. We aimed to compare physical performance and self-reported physical activity between relapse-free older prostate cancer survivors and population-based controls.</div></div><div><h3>Methods</h3><div>A single-centre, cross-sectional study including 109 men aged ≥70 yr receiving robotic-assisted radical prostatectomy (61.5%) or external beam radiotherapy (38.5%) between 2014 and 2018 was conducted. Population-based matched (age, gender, and education) controls (<em>n</em> = 327) were drawn from the Trøndelag Health Study. The primary (the Short Physical Performance Battery [SPPB] summary score) and secondary (gait speed, grip strength, one-legged balance, and the self-reported Physical Activity Index) outcomes were compared between survivors and controls by adjusted linear mixed models.</div></div><div><h3>Key findings and limitations</h3><div>The SPPB score, gait speed, and Physical Activity Index did not differ between survivors (mean age 78.3 yr, mean time since treatment 52.9 mo) and controls (mean age 78.2 yr). Survivors had slightly poorer grip strength (regression coefficient [RC] –5.81, <em>p</em> &lt; 0.001, 95% confidence interval [CI] –7.46; –4.17) and one-legged balance (RC –4.36, <em>p</em> &lt; 0.001, 95% CI –6.72; –2.00; adjusted models), but the clinical significance is uncertain. Small sample size and potential selection of the fittest survivors are limitations that may reduce the generalisability of our findings.</div></div><div><h3>Conclusions and clinical implications</h3><div>3 to 8 yr after radical prostate cancer treatment, older men’s overall physical performance and physical activity level were comparable with those of matched controls. This suggests that the treatment had little impact on functional status.</div></div><div><h3>Patient summary</h3><div>In this study, we investigated physical function in older men several years after they had undergone curatively intended treatment for prostate cancer in comparison with men in a general population of the same age and education. We found that physical function was similar, except slightly poorer grip strength and balance on one leg in men treated for prostate cancer. We conclude that the overall physical function was comparable with that of the general population and believe that this indicates that prostate cancer treatment was well tolerated despite older age.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 87-95"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xpert Bladder Cancer Detection in Emergency Setting Assessment (XESA Project): A Prospective, Single-centre Trial","authors":"Federica Sordelli ,&nbsp;Antonio Desai ,&nbsp;Filippo Dagnino ,&nbsp;Roberto Contieri ,&nbsp;Sofia Giuriolo ,&nbsp;Marco Paciotti ,&nbsp;Vittorio Fasulo ,&nbsp;Stefano Mancon ,&nbsp;Davide Maffei ,&nbsp;Pier Paolo Avolio ,&nbsp;Giorgio Da Rin ,&nbsp;Federica Maura ,&nbsp;Elena Vanni ,&nbsp;Davide Federico ,&nbsp;Piergiuseppe Colombo ,&nbsp;Giovanni Lughezzani ,&nbsp;Nicolò Maria Buffi ,&nbsp;Paolo Casale ,&nbsp;Alberto Saita ,&nbsp;Massiomo Lazzeri ,&nbsp;Antonio Voza","doi":"10.1016/j.euros.2024.09.001","DOIUrl":"10.1016/j.euros.2024.09.001","url":null,"abstract":"<div><h3>Background and objective</h3><div>Bladder cancer (BC) represents a significant health care challenge and is frequently detected during evaluations for haematuria in emergency departments (EDs). Our aim was to evaluate the clinical performance and economic implications of the Xpert BC Detection (BCD) test for patients presenting to the ED with haematuria to address the pressing need for more efficient and accurate diagnostic tools in this setting.</div></div><div><h3>Methods</h3><div>We conducted a prospective single-centre observational study in the ED of a tertiary university hospital. Patients presenting with gross haematuria as the primary reason for their visit were enrolled. Urine samples collected in the ED were analysed using the Xpert BCD test. The primary outcomes were sensitivity, specificity, and a cost analysis for the Xpert BCD test in comparison to standard diagnostic methods such as urine cytology (UC) and white-light cystoscopy (WLC).</div></div><div><h3>Key findings and limitations</h3><div>The Xpert BCD test exhibited superior sensitivity to UC, particularly in identifying high-grade tumours. Importantly, Xpert BCD implementation has the potential to significantly reduce the number of unnecessary WLC procedures and streamline diagnostic pathways. The cost analysis also highlighted potential cost savings for Xpert BCD adoption in the ED setting.</div></div><div><h3>Conclusions and clinical implications</h3><div>Our findings underscore the promise of Xpert BCD for revolutionising the diagnostic approach to BC in the ED for patients with gross haematuria. Its greater sensitivity and efficiency mean that Xpert BCD has the potential to improve patient care, optimise resource use, and alleviate the economic burden associated with unnecessary procedures.</div></div><div><h3>Patient summary</h3><div>Xpert Bladder Cancer Detection is a simple urine test that detects the presence of five genes associated with bladder cancer. We found that for patients visiting the emergency department because of blood in their urine, use of this test could save time and money over urine cell analysis (UCA) for ruling out or diagnosing bladder cancer. The test was also more sensitive in detecting higher-grade cancers. More research is needed to confirm our results.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 172-179"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Outcomes in Sarcomatoid Renal Cell Carcinoma: Analysis of the National Cancer Data Base","authors":"Luke L. Wang ,&nbsp;Dhruv Puri ,&nbsp;Cesare Saitta ,&nbsp;Franklin Liu ,&nbsp;Jonathan A. Afari ,&nbsp;Margaret F. Meagher ,&nbsp;Kevin Hakimi ,&nbsp;Mimi V. Nguyen ,&nbsp;Aastha Shah ,&nbsp;Saeed Ghassemzadeh ,&nbsp;James D. Murphy ,&nbsp;Juan Javier-Desloges ,&nbsp;Rana R. McKay ,&nbsp;Ithaar H. Derweesh","doi":"10.1016/j.euros.2024.10.002","DOIUrl":"10.1016/j.euros.2024.10.002","url":null,"abstract":"<div><h3>Background and objective</h3><div>Our aim was to determine the clinical characteristics, temporal trends, and survival outcomes for sarcomatoid-dedifferentiated renal cell carcinoma (sRCC), as sRCC has historically had poor prognosis and a contemporary cohort has not been well characterized in a population-based study.</div></div><div><h3>Methods</h3><div>Data for 302 630 RCC cases from 2010 to 2019 were extracted from the National Cancer Data Base, of which 4.1% (12 329) were sRCC. Trend analyses were conducted using the Cochran-Armitage test. Multivariable analyses were used to assess factors associated with sRCC diagnosis and clinicopathologic characteristics associated with all-cause mortality (ACM). Overall survival (OS) was computed via Kaplan-Meier analysis.</div></div><div><h3>Key findings and limitations</h3><div>sRCC incidence increased from 3.9% in 2010 to 4.1% in 2019 (<em>p</em> = 0.020). The incidence of stage I sRCC increased from 14.5% in 2010 to 19.2% in 2019 (<em>p</em> &lt; 0.001). sRCC diagnosis was associated with male sex, tumor size, cN1 status, and collecting duct histology. Worse ACM in localized sRCC was associated with age, tumor size, cN1 stage, collecting duct histology, and positive surgical margins; and was inversely associated with partial nephrectomy (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.49–0.76; <em>p</em> &lt; 0.001). Worse ACM in metastatic sRCC was associated with age, tumor size, cN1, collecting duct histology, positive surgical margins, and no surgery at the primary site (HR 1.66, 95% CI 1.20–2.30; <em>p</em> = 0.006). The 5-yr OS rates for stage I, stage II, stage III, and stage IV sRCC were 74%, 63%, 42%, and 16%, respectively (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions and clinical implications</h3><div>The proportion of sRCC cases overall and of stage I sRCC cases increased from 2010 to 2019, supporting the hypothesis of stage migration and the potential for early sarcomatoid dedifferentiation. Further studies on the causal mechanisms underpinning better survival after partial nephrectomy in localized disease and after cytoreductive surgery in metastatic disease are warranted.</div></div><div><h3>Patient summary</h3><div>We analyzed trends and outcomes for a type of aggressive kidney cancer (sarcomatoid renal cell carcinoma, sRCC) using records from the National Cancer Data Base. We found that the percentage of sRCC cases among all kidney cancers increased from 2010 to 2019. Factors such as tumor size and patient age were linked to worse survival. Surgery to remove the cancer was linked to better survival.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 96-105"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"14 PSA based intermediate endpoints to compare cancer specific survival difference between radiotherapy and radical prostatectomy for the treatment of localized prostate cancer","authors":"Wiklund P.,&nbsp;Falagario U.,&nbsp;Pellegrino F.,&nbsp;Lantz A.,&nbsp;Akre O.","doi":"10.1016/S2666-1683(25)00017-5","DOIUrl":"10.1016/S2666-1683(25)00017-5","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages S15-S16"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"16 Can we \"smell\" something important?","authors":"Cornford P.,&nbsp;Dawson J.,&nbsp;Yassaie O.,&nbsp;Lazarowicz H.,&nbsp;Tharmaratnam K.,&nbsp;Garyia-Finana M.,&nbsp;Probert C.","doi":"10.1016/S2666-1683(25)00019-9","DOIUrl":"10.1016/S2666-1683(25)00019-9","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S18"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex Ureteral Reconstruction via Open or Robotic Ureteroplasty with a Buccal Mucosa Onlay Graft: A Two-center Comparison","authors":"Antonio Andrea Grosso ,&nbsp;Fabrizio Di Maida ,&nbsp;Daniele Paganelli ,&nbsp;Simon Udo Engelmann ,&nbsp;Emily Rinderknecht ,&nbsp;Christoph Eckl ,&nbsp;Sebastian Kälble ,&nbsp;Alexey Barskov ,&nbsp;Rino Oriti ,&nbsp;Sofia Giudici ,&nbsp;Christoph Pickl ,&nbsp;Maximilian Burger ,&nbsp;Andrea Mari ,&nbsp;Andrea Minervini ,&nbsp;Roman Mayr","doi":"10.1016/j.euros.2024.11.002","DOIUrl":"10.1016/j.euros.2024.11.002","url":null,"abstract":"<div><h3>Background and objective</h3><div>Management of a long proximal ureteral stricture is challenging. Buccal mucosal graft (BMG) ureteroplasty is a reliable technique for ureteral reconstruction that avoids the morbidity of bowel interposition or autotransplantation. We compared open and robotic BMG ureteroplasty in a two-center study.</div></div><div><h3>Methods</h3><div>We compared prospectively recorded data for 26 patients who underwent robotic or open BMG ureteroplasty at two academic institutions. Stricture location and length, previous reconstructive interventions, complications, and success rates were assessed and compared. A descriptive statistical analysis was performed.</div></div><div><h3>Key findings and limitations</h3><div>We compared ten patients in the robotic group and 16 in the open group. Stricture location had similar distributions in the open versus robotic group (pelvic junction, 25% vs 20%; proximal ureter, 56.3% vs 60%; middle ureter, 18.7% vs 20%). Median stricture length was significantly longer in the robotic group (26 vs 17 mm; <em>p</em> = 0.01). The rate of previous reconstructive interventions was higher in the robotic group (80% vs 37.5%; <em>p</em> = 0.001). However, previous reconstructive interventions were more complex for the open surgery group. There were no intraoperative complications, and postoperative complication rates were similar in the open and robotic groups (18.7% vs 20%; <em>p</em> = 0.19). Median intraoperative blood loss was significantly lower in the robotic group (300 vs 175 ml; <em>p</em> = 0.03). The success rate was 93.7% in the open group and 90.0% in robotic group.</div></div><div><h3>Conclusions and clinical implications</h3><div>We observed high success rates and low perioperative morbidity for both open and robotic BMG ureteroplasty. The robotic approach was associated with significantly lower intraoperative blood loss.</div></div><div><h3>Patient summary</h3><div>Narrowing of the ureter, which is the tube draining urine from the kidney into the bladder, may need surgical treatment. For reconstruction of long segments, use of a tissue graft from the inside of the mouth is an effective surgical option. Robot-assisted surgery is as safe as open surgery and is associated with lower blood loss.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 125-131"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11722170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}