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A prolyl oligopeptidase ligand blocks memory deficit in a repeated mild traumatic brain injury model 脯氨酸寡肽酶配体阻断重复轻度创伤性脑损伤模型的记忆缺陷。
IF 4.2 2区 医学
Experimental Neurology Pub Date : 2025-09-06 DOI: 10.1016/j.expneurol.2025.115454
Johanna Uhari-Väänänen , Tony Eteläinen , Cheng Zuo , Francesca De Lorenzo , Tommi Kilpeläinen , Timo T. Myöhänen
{"title":"A prolyl oligopeptidase ligand blocks memory deficit in a repeated mild traumatic brain injury model","authors":"Johanna Uhari-Väänänen ,&nbsp;Tony Eteläinen ,&nbsp;Cheng Zuo ,&nbsp;Francesca De Lorenzo ,&nbsp;Tommi Kilpeläinen ,&nbsp;Timo T. Myöhänen","doi":"10.1016/j.expneurol.2025.115454","DOIUrl":"10.1016/j.expneurol.2025.115454","url":null,"abstract":"<div><div>Traumatic brain injury (TBI) impacts up to 60 million people annually. Both severe TBIs and repeated mild TBIs (rmTBIs) can lead to persistent symptoms such as cognitive deficits, and even neurodegenerative diseases like chronic traumatic encephalopathy (CTE). To date, no therapies exist to mitigate the risk of CTE or other chronic symptoms post-TBI. Tau protein accumulation plays a pivotal role in the development of CTE. Recent studies indicate that small-molecular ligands targeting prolyl oligopeptidase (PREP) can decrease Tau accumulation through the activation of protein phosphatase 2 A (PP2A). This led us to investigate whether PREP ligands could alleviate behavioural deficits in an rmTBI mouse model. In our study, mice subjected to five closed-head impacts at 24-h intervals were treated after each hit with either a typical PREP inhibitor, KYP-2047, or a novel PREP ligand, HUP-46. PREP knock-out mice also underwent similar impacts. Results demonstrated significant cognitive deficits in rmTBI mice as measured by the Barnes Maze at a 3-month endpoint. However, HUP-46 successfully mitigated these cognitive deficits, and PREP knock-out mice showed resistance to rmTBI-induced cognitive impairments. HUP-46 notably reduced rmTBI-induced astrogliosis and the levels of p21, a cell-cycle inhibitor and a cellular senescence marker connected with aging-related diseases, in the cortex. Additionally, PREP ligands diminished the phosphorylation of calcium/calmodulin-dependent protein kinase type II (CaMKII) shortly after rmTBI. While Tau accumulation was observed only in the dorsal fornix—an essential white matter tract for hippocampal connectivity—PREP ligands did not significantly affect this accumulation. Collectively, these findings suggest that PREP ligands could serve as a therapeutic intervention post-TBI to lower long-term risks.</div></div>","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"394 ","pages":"Article 115454"},"PeriodicalIF":4.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental Igf1 overexpression sex-specifically impacts mouse placenta structure, altering offspring striatal development and behavior 胎盘Igf1过表达性别特异性影响小鼠胎盘结构，改变后代纹状体发育和行为。
IF 4.2 2区 医学
Experimental Neurology Pub Date : 2025-09-02 DOI: 10.1016/j.expneurol.2025.115453
Annemarie J. Carver , Faith M. Fairbairn , Robert J. Taylor , Shanmukh Boggarapu , Njenga R. Kamau , Amrita Gajmer , Hanna E. Stevens
{"title":"Placental Igf1 overexpression sex-specifically impacts mouse placenta structure, altering offspring striatal development and behavior","authors":"Annemarie J. Carver ,&nbsp;Faith M. Fairbairn ,&nbsp;Robert J. Taylor ,&nbsp;Shanmukh Boggarapu ,&nbsp;Njenga R. Kamau ,&nbsp;Amrita Gajmer ,&nbsp;Hanna E. Stevens","doi":"10.1016/j.expneurol.2025.115453","DOIUrl":"10.1016/j.expneurol.2025.115453","url":null,"abstract":"<div><div>Insulin-like growth factor 1 (IGF1) is primarily produced in the placenta and is essential for neurodevelopment. Specifically, how placental IGF1 production persistently influences the brain is unclear, but with rates of complicated pregnancies on the rise, understanding placental contributions to child outcomes is paramount. We hypothesize that placental <em>Igf1</em> expression alters fetal neurodevelopment relevant to neurodevelopmental disorders. Therefore, this study evaluated the effects of placental <em>Igf1</em> overexpression on embryonic and postnatal brain development, particularly for striatum, a region highly linked to neurodevelopmental disorders. Placental overexpression altered placenta structure and function distinctly in females and males. Early differences in placental function altered the trajectory of striatal development, as adult females showed persistent changes in striatal cell composition and behavior while males were less affected. Overall, these results demonstrate that placental <em>Igf1</em> expression alters striatal development and behavior relevant to neurodevelopmental disorders. These findings expand our understanding of placental influence on neurodevelopment and will aid in targeting placental biology in preventive interventions.</div></div>","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"394 ","pages":"Article 115453"},"PeriodicalIF":4.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of concern: "ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage" [EXP NEUROL, Volume 297 (2017) Pages 92-100]. 关注表达：“ErbB4通过激活YAP/PIK3CB信号通路在大鼠蛛网膜下腔出血模型中的保护作用”[EXP NEUROL, vol . 29 (2017) page 92-100]。
IF 4.6 2区 医学
Experimental Neurology Pub Date : 2025-09-01 Epub Date: 2025-05-12 DOI: 10.1016/j.expneurol.2025.115294
{"title":"Expression of concern: \"ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage\" [EXP NEUROL, Volume 297 (2017) Pages 92-100].","authors":"","doi":"10.1016/j.expneurol.2025.115294","DOIUrl":"https://doi.org/10.1016/j.expneurol.2025.115294","url":null,"abstract":"","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"391 ","pages":"115294"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of concern: "Transient exposure of rat pups to hyperoxia at normobaric and hyperbaric pressures does not cause retinopathy of prematurity" [EXP NEUROL, Volume 189 (2004) Pages 150-161]. 关注的表达：“在常压和高压下短暂暴露于高氧下的大鼠幼崽不会引起早产儿视网膜病变”[EXP NEUROL, vol . 189 (2004) Pages 150-161]。
IF 4.6 2区 医学
Experimental Neurology Pub Date : 2025-09-01 Epub Date: 2025-05-13 DOI: 10.1016/j.expneurol.2025.115301
{"title":"Expression of concern: \"Transient exposure of rat pups to hyperoxia at normobaric and hyperbaric pressures does not cause retinopathy of prematurity\" [EXP NEUROL, Volume 189 (2004) Pages 150-161].","authors":"","doi":"10.1016/j.expneurol.2025.115301","DOIUrl":"https://doi.org/10.1016/j.expneurol.2025.115301","url":null,"abstract":"","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"391 ","pages":"115301"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of concern: "RvD1binding with FPR2 attenuates inflammation via Rac1/NOX2 pathway after neonatal hypoxic-ischemic injury in rats" [EXP NEUROL, Volume 320 (2019) 112982]. 关注表达：“rvd1结合FPR2通过Rac1/NOX2途径减轻新生儿缺氧缺血性损伤大鼠的炎症反应”[j].中华医学杂志，vol . 32(2019): 112982。
IF 4.6 2区 医学
Experimental Neurology Pub Date : 2025-09-01 Epub Date: 2025-05-13 DOI: 10.1016/j.expneurol.2025.115293
{"title":"Expression of concern: \"RvD1binding with FPR2 attenuates inflammation via Rac1/NOX2 pathway after neonatal hypoxic-ischemic injury in rats\" [EXP NEUROL, Volume 320 (2019) 112982].","authors":"","doi":"10.1016/j.expneurol.2025.115293","DOIUrl":"https://doi.org/10.1016/j.expneurol.2025.115293","url":null,"abstract":"","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"391 ","pages":"115293"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of concern: "LJ529 attenuates mast cell-related inflammation via A3R-PKCε-ALDH2 pathway after subarachnoid hemorrhage in rats" [EXP NEUROL, Volume 340 (2021) 113686]. 关注表达：“LJ529通过A3R-PKCε-ALDH2途径减轻大鼠蛛网膜下腔出血后肥大细胞相关炎症”[j].中华医学杂志，vol . 34(2021): 113686。
IF 4.6 2区 医学
Experimental Neurology Pub Date : 2025-09-01 Epub Date: 2025-05-12 DOI: 10.1016/j.expneurol.2025.115292
{"title":"Expression of concern: \"LJ529 attenuates mast cell-related inflammation via A<sub>3</sub>R-PKCε-ALDH2 pathway after subarachnoid hemorrhage in rats\" [EXP NEUROL, Volume 340 (2021) 113686].","authors":"","doi":"10.1016/j.expneurol.2025.115292","DOIUrl":"https://doi.org/10.1016/j.expneurol.2025.115292","url":null,"abstract":"","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"391 ","pages":"115292"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of concern: "Multiple effects of hyperbaric oxygen on the expression of HIF-1α and apoptotic genes in a global ischemia-hypotension rat model" [EXP NEUROL, Volume 191 (2005) Pages 198-210]. 关注的表达：“高压氧对缺血-低血压大鼠模型中HIF-1α和凋亡基因表达的多重影响”[EXP NEUROL, vol . 191 (2005) Pages 198-210]。
IF 4.6 2区 医学
Experimental Neurology Pub Date : 2025-09-01 Epub Date: 2025-05-12 DOI: 10.1016/j.expneurol.2025.115300
{"title":"Expression of concern: \"Multiple effects of hyperbaric oxygen on the expression of HIF-1α and apoptotic genes in a global ischemia-hypotension rat model\" [EXP NEUROL, Volume 191 (2005) Pages 198-210].","authors":"","doi":"10.1016/j.expneurol.2025.115300","DOIUrl":"https://doi.org/10.1016/j.expneurol.2025.115300","url":null,"abstract":"","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"391 ","pages":"115300"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of concern: "G-CSF attenuates neuroinflammation and stabilizes the blood-brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxia-ischemia in rats" [EXP NEUROL, Volume 272 (2015) Pages 135-144]. 关注的表达：“G-CSF通过PI3K/Akt/GSK-3β信号通路减弱新生儿缺氧缺血后的神经炎症和稳定血脑屏障”[EXP NEUROL, vol . 272 (2015) Pages 135-144]。
IF 4.6 2区 医学
Experimental Neurology Pub Date : 2025-09-01 Epub Date: 2025-05-12 DOI: 10.1016/j.expneurol.2025.115296
{"title":"Expression of concern: \"G-CSF attenuates neuroinflammation and stabilizes the blood-brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxia-ischemia in rats\" [EXP NEUROL, Volume 272 (2015) Pages 135-144].","authors":"","doi":"10.1016/j.expneurol.2025.115296","DOIUrl":"https://doi.org/10.1016/j.expneurol.2025.115296","url":null,"abstract":"","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"391 ","pages":"115296"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of concern: "MFGE8/Integrin β3 pathway alleviates apoptosis and inflammation in early brain injury after subarachnoid hemorrhage in rats" [EXP NEUROL, Volume 272 (2015) Pages 120-127]. 关注表达：“MFGE8/Integrin β3通路在大鼠蛛网膜下腔出血后早期脑损伤中的凋亡和炎症的缓解作用”[j].中华医学杂志，vol . 27 (2015) page 120-127。
IF 4.6 2区 医学
Experimental Neurology Pub Date : 2025-09-01 Epub Date: 2025-05-12 DOI: 10.1016/j.expneurol.2025.115297
{"title":"Expression of concern: \"MFGE8/Integrin β3 pathway alleviates apoptosis and inflammation in early brain injury after subarachnoid hemorrhage in rats\" [EXP NEUROL, Volume 272 (2015) Pages 120-127].","authors":"","doi":"10.1016/j.expneurol.2025.115297","DOIUrl":"https://doi.org/10.1016/j.expneurol.2025.115297","url":null,"abstract":"","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"391 ","pages":"115297"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of concern: "G-CSF ameliorates neuronal apoptosis through GSK-3β inhibition in neonatal hypoxia-ischemia in rats" [EXP NEUROL, Volume 263 (2015) Pages 141-149]. 关注的表达：“G-CSF通过抑制GSK-3β改善新生儿缺氧缺血大鼠的神经元凋亡”[EXP NEUROL, 263 (2015) page 141-149]。
IF 4.6 2区 医学
Experimental Neurology Pub Date : 2025-09-01 Epub Date: 2025-05-13 DOI: 10.1016/j.expneurol.2025.115298
{"title":"Expression of concern: \"G-CSF ameliorates neuronal apoptosis through GSK-3β inhibition in neonatal hypoxia-ischemia in rats\" [EXP NEUROL, Volume 263 (2015) Pages 141-149].","authors":"","doi":"10.1016/j.expneurol.2025.115298","DOIUrl":"https://doi.org/10.1016/j.expneurol.2025.115298","url":null,"abstract":"","PeriodicalId":12246,"journal":{"name":"Experimental Neurology","volume":"391 ","pages":"115298"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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