Modulatory effects of transcranial magneto-acoustic stimulation on behavior and corticostriatal transmission of oscillatory activity in a mouse model of Parkinson's disease induced by MPTP

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2025-06-19 DOI:10.1016/j.expneurol.2025.115352

Yihao Xu , Shuai Zhang , Jinrui Mi , Xiaochao Lu , Qingzhao Wang , Ruiyang Fan , Jiangwei Lv , Lipeng Xing , Haochen Zhang , Guizhi Xu

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引用次数: 0

Abstract

Background

Transcranial magneto-acoustic stimulation (TMAS) is a novel noninvasive neuromodulation technology that combines ultrasound within a static magnetic field to achieve high spatial resolution and deep brain penetration. However, the effects of TMAS on neural oscillations related to motor deficits in Parkinson's disease (PD) remain poorly understood.

Objective

The objective of this study was to investigate whether TMAS could enhance the propagation and interaction of oscillatory dynamics within the corticostriatal circuit.

Methods

We performed a comprehensive neurological assessment using behavioral tests, in vivo electrophysiological recordings, and immunohistochemistry in male C57BL/6 J mice treated with MPTP, followed by noninvasive brain stimulation.

Results

Our results demonstrate that TMAS: 1) improves locomotor performance and learning abilities in PD mice; 2) reduces phase-amplitude coupling between beta and gamma frequency bands of local field potentials, while enhancing inter-brain interactions and information transmission; 3) modulates neural activity and depresses c-Fos overexpression on the dorsal striatum of PD mice; 4) provides neuroprotection by modulating neuroinflammation and mitigating MPTP-induced neurotoxicity within neural circuits.

Conclusion

These findings highlight the role of TMAS in strengthening the functional organization of the corticostriatal circuit, suggesting its potential as a novel treatment for neuropsychiatric disorders characterized by activity disruptions.

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经颅磁声刺激对MPTP诱导的帕金森病小鼠模型行为学和皮质纹状体振荡活动传递的调节作用

背景：经颅磁声刺激（TMAS）是一种新型的无创神经调节技术，它在静态磁场中结合超声来实现高空间分辨率和脑深部穿透。然而，TMAS对帕金森病（PD）运动缺陷相关的神经振荡的影响仍然知之甚少。目的：本研究的目的是探讨TMAS是否能增强皮质纹状体回路内振荡动力学的传播和相互作用。方法：我们通过行为测试、体内电生理记录和免疫组织化学对MPTP治疗后无创脑刺激的雄性C57BL/6 J小鼠进行了全面的神经学评估。结果：我们的研究结果表明：1)TMAS可以改善PD小鼠的运动能力和学习能力；2)减弱了局部场电位β和γ频段的相幅耦合，增强了脑间相互作用和信息传递；3)调节PD小鼠背纹状体神经活动，抑制c-Fos过表达；4)通过调节神经炎症和减轻mptp诱导的神经毒性在神经回路中提供神经保护。结论：这些发现强调了TMAS在加强皮质纹状体回路的功能组织中的作用，表明它有可能作为一种新的治疗以活动中断为特征的神经精神疾病的方法。

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.