Expert Review of Anti-infective Therapy最新文献_第3页

Clinical treatment of mycobacterial prosthetic joint infections. 分枝杆菌假体关节感染的临床治疗：现有病例的文献回顾。

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-09-01 Epub Date: 2025-07-24 DOI: 10.1080/14787210.2025.2536837

Cristina Ortega-Portas, Alvaro Auñon, Jaime Esteban

{"title":"Clinical treatment of mycobacterial prosthetic joint infections.","authors":"Cristina Ortega-Portas, Alvaro Auñon, Jaime Esteban","doi":"10.1080/14787210.2025.2536837","DOIUrl":"10.1080/14787210.2025.2536837","url":null,"abstract":"Introduction: Prosthetic joint infections (PJIs) caused by mycobacteria are exceptionally rare and often underrecognized in clinical practice.Areas covered: Although most PJIs are due to common bacterial pathogens, Mycobacterium tuberculosis and nontuberculous mycobacteria (NTM) represent a unique subset with distinct microbiological and therapeutic challenges. The presence of biofilms further complicates their management, often requiring intensive pharmacological interventions and surgical strategies. This review analyzes over 300 reported cases of mycobacterial PJIs. The findings indicate that tuberculous PJIs typically occur as late-onset infections and are managed successfully with prolonged antituberculous therapy. In contrast, NTM PJIs - predominantly caused by rapidly growing species - are more heterogeneous in onset, resistance patterns, and treatment responses. Antibiotic regimens are often complex, species-specific, and require guidance from susceptibility testing. Therapeutic decisions often rely on expert consensus and extrapolation from pulmonary disease protocols. Surgical intervention, particularly implant removal, consistently correlates with better outcomes in both groups.Expert opinion: Clinicians must maintain a high index of suspicion in culture-negative PJIs or cases with atypical clinical presentations to reach a proper diagnosis. Once the diagnosis is established, a multidisciplinary approach is crucial for optimizing patient outcomes. Further research is warranted to develop evidence-based strategies for these rare but clinically demanding infections.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"829-841"},"PeriodicalIF":3.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical, scientific and healthcare system consequences of misdiagnosing neonatal sepsis. 误诊新生儿败血症的临床、科学和卫生保健系统后果。

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-09-01 Epub Date: 2025-07-29 DOI: 10.1080/14787210.2025.2538612

Constantin R Popescu, Pascal M Lavoie

{"title":"Clinical, scientific and healthcare system consequences of misdiagnosing neonatal sepsis.","authors":"Constantin R Popescu, Pascal M Lavoie","doi":"10.1080/14787210.2025.2538612","DOIUrl":"10.1080/14787210.2025.2538612","url":null,"abstract":"Introduction: Neonatal sepsis remains a major contributor to morbidity and mortality worldwide, with the highest burden in low- and middle-income countries (LMICs). Generating accurate estimates of disease burden is critical for setting research priorities, informing health policy, and resource allocation. However, in many LMICs, limited access to timely and reliable diagnostic tools severely limits case detection, undermines epidemiological surveillance, and impedes efforts to improve clinical outcomes.Areas covered: This review examines the clinical, scientific, and health system implications of misdiagnosing neonatal sepsis. We describe the challenges of accurate case identification and summarize findings from prospective, multicenter studies showing marked variability in incidence across different geographic and healthcare settings. We explore the sources of this variability and discuss its impact on patient care, clinical trials interpretation, and progress toward reducing the global burden of neonatal sepsis.Expert opinion: The lack of standardized case definition hinders neonatal sepsis research and may contribute to the growing threat of antimicrobial resistance. Addressing this requires acknowledging the substantial uncertainty in current global incidence estimates. More importantly, it demands shifting focus from passive reporting of variability to actively investigating the methodological, sociodemographic, clinical, biological, and systemic drivers that shape sepsis detection and outcomes across diverse settings.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"683-690"},"PeriodicalIF":3.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reevaluating the role of molnupiravir in COVID-19 treatment. 莫那匹韦在COVID-19治疗中的作用再评价

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-09-01 Epub Date: 2025-06-18 DOI: 10.1080/14787210.2025.2511955

Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam

引用次数: 0

Can we prevent azole-resistant Candida parapsilosis from becoming the next Candidozyma auris? 我们能否防止耐唑假丝酵母菌成为下一个金黄色假丝酵母菌？

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-08-22 DOI: 10.1080/14787210.2025.2544694

Stephan Steixner, Angelika Bauer, Philipp Grubwieser, Cornelia Lass-Flörl

引用次数: 0

Can we improve ART outcomes for adolescents living with HIV? 我们能否改善感染艾滋病毒的青少年的抗逆转录病毒治疗结果？

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-08-08 DOI: 10.1080/14787210.2025.2544695

Caroline Foster

引用次数: 0

Correction. 修正。

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-08-08 DOI: 10.1080/14787210.2025.2535828

引用次数: 0

Phage- and enzybiotic-coated urinary catheters to prevent recurrent multidrug-resistant bacterial infections. 噬菌体和酶包膜导尿管预防复发性多药耐药细菌感染。

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-08-06 DOI: 10.1080/14787210.2025.2541717

Michał Wójcicki, Martyna Cieślik, Katarzyna Haraźna, Agnieszka Sobczak-Kupiec, Andrzej Górski, Ewa Jończyk-Matysiak

{"title":"Phage- and enzybiotic-coated urinary catheters to prevent recurrent multidrug-resistant bacterial infections.","authors":"Michał Wójcicki, Martyna Cieślik, Katarzyna Haraźna, Agnieszka Sobczak-Kupiec, Andrzej Górski, Ewa Jończyk-Matysiak","doi":"10.1080/14787210.2025.2541717","DOIUrl":"10.1080/14787210.2025.2541717","url":null,"abstract":"Introduction: Catheter-associated urinary tract infections (CAUTIs) are among the most prevalent hospital-acquired infections, posing a serious clinical and economic burden, particularly in the context of rising antibiotic resistance. Biofilm formation on indwelling catheters by multidrug-resistant uropathogens further complicates treatment and prevention, underscoring the urgent need for alternative, non-antibiotic solutions.Areas covered: This article explores the potential of bacteriophage- and enzybiotic-coated urinary catheters as an innovative strategy to prevent recurrent bacterial infections. We review the clinical significance of biofilm formation on the surface of urinary catheters, the role of phages and their lytic enzymes in disrupting biofilms, and the clinical evidence supporting the efficacy of phage therapy. The reference list was compiled through a structured search of peer-reviewed studies and case reports, particularly from recent years, available in the PubMed database.Expert opinion: Phage- and enzybiotic-functionalized catheters represent a promising non-antibiotic approach to CAUTI prevention. These biological agents offer targeted antibacterial activity, disrupt biofilms, and reduce the risk of drug resistance development. Their integration into catheter design may significantly improve infection control, reduce antibiotic use, and align with global antimicrobial stewardship goals. However, clinical standardization and regulatory clarity are crucial for advancing their implementation in routine clinical practice.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"1-16"},"PeriodicalIF":3.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penile microbiomes have important implications for HIV susceptibility and broader reproductive health. 阴茎微生物组对艾滋病毒易感性和更广泛的生殖健康具有重要意义。

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-08-03 DOI: 10.1080/14787210.2025.2541712

Rameen Jamil, Jessica L Prodger, Ronald M Galiwango, Cindy M Liu, Aaron A R Tobian, Rupert Kaul

引用次数: 0

Building upon the core elements of antifungal stewardship: practical recommendations for effective antifungal stewardship in resource-limited settings. 建立在抗真菌管理的核心要素：在资源有限的设置有效的抗真菌管理的实用建议。

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-08-01 Epub Date: 2025-04-10 DOI: 10.1080/14787210.2025.2479011

Arunaloke Chakrabarti, Rita Oladele, Elizabeth Hermsen, Maria Lavinea Novis de Figueiredo, Patricia Muñoz, Melissa Johnson

{"title":"Building upon the core elements of antifungal stewardship: practical recommendations for effective antifungal stewardship in resource-limited settings.","authors":"Arunaloke Chakrabarti, Rita Oladele, Elizabeth Hermsen, Maria Lavinea Novis de Figueiredo, Patricia Muñoz, Melissa Johnson","doi":"10.1080/14787210.2025.2479011","DOIUrl":"10.1080/14787210.2025.2479011","url":null,"abstract":"Introduction: Despite the crucial importance of effective AFS in resource-limited settings, such settings remain comparatively underserved and underrepresented in terms of resource-setting-specific guidance and research. Further practical contextualization and application of current AFS best practices is thus necessary.Areas covered: A panel of leading experts from diverse countries (India, Nigeria, Spain, and the US) was brought together to provide recommendations for practical and effective implementation of AFS in resource-limited settings. We have adapted and contextualized the Centers for Disease Control and Prevention's (CDC) seven core elements and the Mycoses Study Group Education and Research Consortium's (MSGERC) recommendations for facilities in resource-limited settings through a resource-stratified approach. Where relevant to facilities based on their context and respective resources across multiple dimensions, facilities may choose to prioritize certain recommendations that may be more immediately actionable before implementing others.Expert opinion: We recommend future studies to examine the efficacy, cost-effectiveness, and practicality of our recommendations in resource-limited settings to enable them to effectively prioritize, channel or gradually increase resource capacity at hand. AFS interventions should be integrated within a larger systemic framework (e.g. city, state, national, regional, international) with collaboration among institutional leadership, ID specialists, healthcare workers, public, policymakers, and pharmaceutical industry.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"597-615"},"PeriodicalIF":3.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive Candida in the abdomen: how to differentiate infection from colonization. 腹部侵袭性念珠菌：如何区分感染与定植。

IF 3.8 2区医学

Expert Review of Anti-infective Therapy Pub Date : 2025-08-01 Epub Date: 2025-06-11 DOI: 10.1080/14787210.2025.2516553

Corentin Deckers, Isabel Montesinos, Pierre Emmanuel Plum, Matteo Bassetti, Patrick M Honoré

{"title":"Invasive Candida in the abdomen: how to differentiate infection from colonization.","authors":"Corentin Deckers, Isabel Montesinos, Pierre Emmanuel Plum, Matteo Bassetti, Patrick M Honoré","doi":"10.1080/14787210.2025.2516553","DOIUrl":"10.1080/14787210.2025.2516553","url":null,"abstract":"Introduction: Intra-abdominal candidiasis (IAC) is a serious complication in critically ill patients, particularly after abdominal surgery or trauma. Differentiating Candida colonization from invasive infection is crucial, as misdiagnosis can lead to inappropriate antifungal use, increased resistance, and worse outcomes. However, IAC remains underrecognized due to the limitations of conventional culture-based diagnostics. Relevant literature was identified through a non-systematic search of the PubMed database.Areas covered: This review highlights the challenges in diagnosing and managing IAC, focusing on the limitations of traditional culture methods and the potential of non-culture-based diagnostics. Biomarkers such as 1-3-β-D-glucan (BDG) and Candida albicans germ tube antibody (CAGTA), along with molecular assays, improve diagnostic accuracy but have varying sensitivity and specificity, requiring a multimodal approach. Management involves early diagnosis, source control, and targeted antifungal therapy. Current guidelines, largely based on candidemia, recommend echinocandins as first-line therapy, with fluconazole for stable patients and amphotericin B for resistant strains.Expert opinion: Despite advances, IAC-specific research is lacking, necessitating improved diagnostic tools and tailored therapies. There is a need for more targeted studies to refine diagnostic algorithms and therapeutic strategies. Future efforts should focus on developing rapid, high-sensitivity and specific diagnostic tools, optimizing antifungal stewardship, and individualizing treatment approaches.","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":" ","pages":"585-595"},"PeriodicalIF":3.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0