Experimental and molecular pathology最新文献

{"title":"Corrigendum to “Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune Encephalomyelitis.” [Experimental and Molecular Pathology. 2014; 97(3):470–6. doi: 10.1016/j.yexmp.2014.10.004.]","authors":"Nan Liu , Quan-cheng Kan , Xiao-jian Zhang , Yu-ming Xv , Su Zhang , Guang-Xian Zhang , Lin Zhu","doi":"10.1016/j.yexmp.2022.104837","DOIUrl":"10.1016/j.yexmp.2022.104837","url":null,"abstract":"","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"129 ","pages":"Article 104837"},"PeriodicalIF":3.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9297663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease","authors":"Ahsas Goyal (Assistant Professor),&nbsp;Anant Agrawal,&nbsp;Aanchal Verma,&nbsp;Nandini Dubey","doi":"10.1016/j.yexmp.2022.104846","DOIUrl":"10.1016/j.yexmp.2022.104846","url":null,"abstract":"<div><p>Parkinson's disease is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. Numerous pathological processes including, inflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalance, and apoptosis as well as genetic factors may lead to neuronal degeneration. With the emergence of aging population, the health problem and economic burden caused by PD also increase. Phosphatidylinositol 3-kinases-protein kinase B (PI3K-AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K-AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. The current review provides an overview of the PI3K-AKT signaling pathway and review the relationship between this signaling pathway and PD.</p></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"129 ","pages":"Article 104846"},"PeriodicalIF":3.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9324176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversin upregulates the proliferative ability of colorectal cancer by inducing cell cycle proteins","authors":"Lan Luan ,&nbsp;Nanyang Li ,&nbsp;Keyuan Zhang ,&nbsp;Xiaojie Wang ,&nbsp;Hai Pan","doi":"10.1016/j.yexmp.2023.104850","DOIUrl":"10.1016/j.yexmp.2023.104850","url":null,"abstract":"<div><p>Colorectal cancer (CRC) is a common gastrointestinal tumour with increasing incidence worldwide. However, the underlying molecular mechanism of CRC proliferation is not completely clear. Diversin，as an ankyrin repeat-containing protein, is upregulated in various solid tumours and accelerates cancer progression by promoting cell proliferation and increasing S phase fraction of cells. In this study, 71 CRC samples and corresponding adjacent tissue samples were included. The expression of diversin in tissues was verified via immunohistochemical analysis. The MTS assay and flow cytometry (FCM) was used to measure cell proliferation and cell cycle. Results of immunohistochemical analysis revealed that diversin was highly expressed in human CRC tissues and was significantly associated with tumour differentiation, clinical stage and lymph node metastasis. The analysis based on the CRC data from The Cancer Genome Atlas (TCGA) database showed that a high expression of diversin correlated with the poor prognosis of CRC. Results of the MTS assay indicated that the overexpression of diversin promoted the proliferation of CRC cells, while its downregulation had an inhibitory effect on CRC cell proliferation. FCM analysises presented that diversin increased the flux of the CRC cell cycle from G1 to S and regulated cycle-related proteins, namely, P21, P27, cyclin E, CDK2, cyclin D and CDK4. The results suggest that diversin contributes to CRC proliferation that involves the distribution of the cell cycle. In CRC tissues, the expression of diversin has closely related to the prognosis. The higher the expression levels of diversin, the worse the prognosis. In vitro, diversin could increase the proliferative ability of CRC cells through the G1–S checkpoint and JNK signalling pathway, confirming that diversin contributes to CRC development.</p></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"129 ","pages":"Article 104850"},"PeriodicalIF":3.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10773084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docking is not enough: 17-trifluoromethylphenyl trinor PGF2α is only a very weak ligand of neurokinin-1 receptor","authors":"Joanna Matalińska,&nbsp;Piotr F.J. Lipiński","doi":"10.1016/j.yexmp.2022.104849","DOIUrl":"10.1016/j.yexmp.2022.104849","url":null,"abstract":"<div><p>17-trifluoromethylphenyl trinor prostaglandin F_2α (17-CF₃PTPGF_2α) was reported recently to exhibit in vitro and in vivo anticancer activity. Based solely on the results of in silico molecular docking, it was claimed that this compound is NK1 receptor (NK1R) antagonist and that its activity is through this receptor. In this contribution we show that 17-CF₃PTPGF_2α is only a very weak NK1R ligand (IC₅₀ &gt; 200 μM). In connection with that we discuss the issue of this compound's molecular target. Finally, we briefly narrate on the proper use of molecular docking in biomedical research.</p></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"129 ","pages":"Article 104849"},"PeriodicalIF":3.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10762241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ST2 and the alteration of cobalt, sodium, potassium and calcium concentration in acute inflammation","authors":"Marija S. Stankovic ,&nbsp;Silvio R. De Luka ,&nbsp;Sasa Jankovic ,&nbsp;Srdjan Stefanovic ,&nbsp;Maja Stojanovic ,&nbsp;Jelena Nesovic-Ostojic ,&nbsp;Nina Japundzic-Zigon ,&nbsp;Alexander M. Trbovich","doi":"10.1016/j.yexmp.2022.104820","DOIUrl":"10.1016/j.yexmp.2022.104820","url":null,"abstract":"<div><h3>Introduction</h3><p>ST2 is the receptor for interleukin (IL)-33, the last discovered member of the IL-1 cytokine family. Acute inflammation is an early response of vascularized tissue to injury, in which alteration of micro- and macro-elements occurs. This study aimed to examine the alteration of cobalt, sodium, potassium, and calcium concentration at the site of acute inflammation and the role of ST2 in these alterations.</p></div><div><h3>Material and methods</h3><p>Wild-type (WT) and ST2 knockout (ST2−/−) mice were divided into groups: WT control group (WT-C), ST2 knockout control group (KO-C), WT inflammatory group (WT-I), and ST2 knockout inflammatory group (KO-I). We induced acute inflammation by intramuscular injection<span> of turpentine oil<span> or saline in the case of the control group. After 12 h, we anesthetized mice and collected treated tissues for histopathological analysis and determination of cobalt, sodium, potassium, and calcium concentration by atomic absorption spectrometer.</span></span></p></div><div><h3>Results</h3><p>Histopathological analysis showed the inflammatory infiltrate<span> and cell necrosis in the treated tissue in WT-I and KO-I. The concentration of sodium was significantly lower in WT-I than in WT-C. The concentration of potassium and cobalt was significantly lower in WT-I and KO-I when compared to WT-C and KO-C, respectively. However, the concentration of potassium and cobalt in the tissue was significantly lower in WT-I than in KO-I. The concentration of calcium in the tissue did not significantly differ between groups.</span></p></div><div><h3>Conclusion</h3><p>We reported, to our knowledge for the first time, that ST2 is involved in decreasing sodium, potassium, and cobalt concentration at the site of acute inflammation.</p></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"128 ","pages":"Article 104820"},"PeriodicalIF":3.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10685185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel prognostic index of stomach adenocarcinoma based on immunogenomic landscape analysis and immunotherapy options","authors":"Weijie Xue ,&nbsp;Bingzi Dong ,&nbsp;Yixiu Wang ,&nbsp;Yuwei Xie ,&nbsp;Pu Li ,&nbsp;Zhiqi Gong ,&nbsp;Zhaojian Niu","doi":"10.1016/j.yexmp.2022.104832","DOIUrl":"10.1016/j.yexmp.2022.104832","url":null,"abstract":"<div><p>Stomach adenocarcinoma<span><span><span><span> (STAD) is one of the most common malignant tumors worldwide. In this study, we attempted to construct a valid immune-associated gene prognostic index risk model that can predict the survival of patients with STAD and the efficacy of immune checkpoint inhibitors (ICIs) </span>treatment. </span>Transcriptome<span><span>, clinical, and gene mutational data were obtained from the TCGA database. Immune-related genes were downloaded from the ImmPort and InnateDB databases. A total of 493 immune-related genes were identified to be enriched in functions associated with immune response, as well as in immune and tumor-related pathways. Further, 36 candidate genes related to the overall survival (OS) of STAD were obtained by weighted gene co-expression network analysis (WGCNA). Next, based on a </span>Cox regression<span><span><span> analysis, we constructed an immune-associated gene prognostic index (IAGPI) risk model based on eight genes, which was verified using the GEO STAD cohort. The patients were divided into two subsets according to their risk score. Patients in the low-risk group had better OS than those in the high-risk group. In the low-risk group, there were more CD8<span>, activated memory CD4, and follicular helper T cells, and M1 macrophages, whereas </span></span>monocytes, M2 macrophages, </span>eosinophils<span>, and neutrophils<span> were more abundant in the high-risk group. The patients in the low-risk group were more sensitive to ICIs therapy. The IAGPI risk model can precisely predict the prognosis, reflect the tumor immune microenvironment, and predict the efficacy of ICIs therapy </span></span></span></span></span>in patients with STAD.</span></p></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"128 ","pages":"Article 104832"},"PeriodicalIF":3.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10328775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial community profiling by next-generation DNA sequencing of adenocarcinoma of the prostate with evidence of ochratoxin A producing fungi","authors":"Stephen E. Fry ,&nbsp;Mitchell Kaye ,&nbsp;Dara S. Missan ,&nbsp;Christian Becker ,&nbsp;Matthew Shabilla ,&nbsp;Delyn Martinez ,&nbsp;Erin Bossert ,&nbsp;Jeremy Ellis","doi":"10.1016/j.yexmp.2022.104831","DOIUrl":"10.1016/j.yexmp.2022.104831","url":null,"abstract":"<div><h3>Background</h3><p>Prostatic carcinomas are a leading cancer and leading cause of mortality in the developed world. The etiology is diverse with underlying patient genetics, environmental factors, and microbial associations. Sequencing DNA for microbes allows the detection of potential disease relationships.</p></div><div><h3>Objective</h3><p>Targeted 16S (prokaryotic) and 18S (eukaryotic) rDNA sequencing was performed to map the tumor microbial flora.</p></div><div><h3>Design</h3><p>Twelve patients undergoing elective laparoscopic prostatectomy for biopsy proven adenocarcinoma of the prostate were enrolled. PCR and amplicon based sequencing was conducted; a portion of the sequencing results were confirmed by special stains.</p></div><div><h3>Setting</h3><p>Patients were recruited by the urologist were prospectively scheduled for radical prostatectomy by ‘Da Vinci’ robotically assisted procedure in an outpatient setting. Samples were portioned in the hospital surgical suite at the time of prostatectomy.</p></div><div><h3>Participants</h3><p>Male patients were requested to enter the study on a first come basis. Outcome Measurement and Statistical Analysis: Average age of the 12 participants was 64.3 years.</p></div><div><h3>Results and limitations</h3><p>DNA reads were detected and by ‘best match’ were identified belonging to Perkinsus, Hydrurus, Diversispora and Funneliformis genera, few samples displayed bacteria. Out of the 12 total patients, 11 patients had detectable DNA sequences matching arbuscular mycorrhizal fungi in the Glomeromycetes Class; Funneliformis mosseae and Diversasporum versiformis. Specific PCR for arbuscular mycorrhizal fungi failed to confirm Glomeromycetes Class; in-depth taxonomic analysis suggests a newer fungal grouping, not falling within an accepted Phylum of fungi. Calcoflour white staining of histological sections confirmed potential fungal markers in all 12 cases. Ochratoxin A antigen was identified by immunofluorescence in all 12 patient samples. The study was limited by the low sample volume and disease free normal controls.</p></div><div><h3>Conclusions</h3><p>Fungi may play a significant role in adenocarcinoma of the prostate.</p></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"128 ","pages":"Article 104831"},"PeriodicalIF":3.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0014480022000946/pdfft?md5=e7aa9fd3770a6f4078827dd710806fca&pid=1-s2.0-S0014480022000946-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10397158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of immunohistochemistry in crushed areas of pulmonary neuroendocrine carcinoma","authors":"Hava Kuçuk ,&nbsp;David Laville ,&nbsp;Pierre Dal-Col ,&nbsp;Violaine Yvorel ,&nbsp;Abdulrazzak Sulaiman ,&nbsp;Sophie Bayle-Bleuez ,&nbsp;Philippe Cosmo ,&nbsp;Jean-Michel Vergnon ,&nbsp;Olivier Tiffet ,&nbsp;Anne-Laure Desage ,&nbsp;Fabien Forest","doi":"10.1016/j.yexmp.2022.104836","DOIUrl":"10.1016/j.yexmp.2022.104836","url":null,"abstract":"<div><p><span>Immunohistochemical demonstration of neuroendocrine differentiation is often performed in routine diagnostic practice for lung </span>neuroendocrine carcinoma<span><span><span>. However, these carcinomas are often crushed, especially on small specimens. The value of immunohistochemistry on crushed areas is not known. We aimed to assess the value of immunohistochemical markers in crushed areas. We performed a retrospective study of 299 patients with a diagnosis of pulmonary neuroendocrine carcinoma. We showed that the markers TTF-1, </span>synaptophysin, </span>chromogranin A, CD56, and INSM1 were more often negative in crushed areas compared with well-preserved areas. The proliferation index with anti-Ki67 was decreased but remained on average around 90%. For all markers, the percentage of labeled cells was lower than in the preserved areas. Finally, we show that cases without labeling in the crushed areas and maintained labeling in the non-crushed areas have a lower percentage of labeling than cases without this labeling mismatch. Finally, there were no false positives of these stains.</span></p><p>Neuroendocrine markers are valid in crushed areas when positive. However, the percentage of labeled cells may be lower than on preserved areas and lead to false negatives. Finally, the proliferation index, although decreased, remains close to that on preserved areas.</p></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"128 ","pages":"Article 104836"},"PeriodicalIF":3.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10397696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix","authors":"Laurie B. Joseph ,&nbsp;Marion K. Gordon ,&nbsp;Peihong Zhou ,&nbsp;Rita A. Hahn ,&nbsp;Hamdi Lababidi ,&nbsp;Claire R. Croutch ,&nbsp;Patrick J. Sinko ,&nbsp;Diane E. Heck ,&nbsp;Debra L. Laskin ,&nbsp;Jeffrey D. Laskin","doi":"10.1016/j.yexmp.2022.104807","DOIUrl":"10.1016/j.yexmp.2022.104807","url":null,"abstract":"<div><p><span><span>Sulfur mustard (SM; bis(2-chloroethyl) sulfide) is a highly reactive bifunctional </span>alkylating agent<span> synthesized for chemical warfare. The eyes are particularly sensitive to SM where it causes irritation, pain, photophobia<span><span>, and blepharitis, depending on the dose and duration of exposure. In these studies, we examined the effects of SM vapor on the corneas of New Zealand white male rabbits. Edema and hazing of the cornea, signs of acute injury, were observed within one day of exposure to SM, followed by </span>neovascularization<span>, a sign of chronic or late phase pathology, which persisted for at least 28 days. Significant epithelial-stromal separation ranging from ~8–17% of the epithelial surface was observed. In the stroma, there was a marked increase in CD45</span></span></span></span>⁺<span><span><span><span> leukocytes and a decrease of keratocytes<span><span><span>, along with areas of disorganization of collagen fibers. SM also disrupted the corneal </span>basement membrane and altered the expression of </span>perlecan, a </span></span>heparan sulfate </span>proteoglycan, and cellular </span>fibronectin<span>, an extracellular matrix<span> glycoprotein<span><span>. This was associated with an increase in basement membrane matrix metalloproteinases including </span>ADAM17, which is important in remodeling of the basement membrane during wound healing. Tenascin-C, an extracellular matrix glycoprotein, was also upregulated in the stroma 14–28 d post SM, a finding consistent with its role in organizing structural components of the stroma necessary for corneal transparency. These data demonstrate that SM vapor causes persistent alterations in structural components of the cornea. Further characterization of SM-induced injury in rabbit cornea will be useful for the identification of targets for the development of ocular countermeasures.</span></span></span></span></p></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"128 ","pages":"Article 104807"},"PeriodicalIF":3.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9541513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum levels of matrix metalloproteinases as prognostic markers for severe dengue with plasma leakage","authors":"Srinivasan Sivasubramanian ,&nbsp;Sundhar Mohandas ,&nbsp;Vidya Gopalan ,&nbsp;Karthikeyan Govindan ,&nbsp;Poovazhagi Varadarajan ,&nbsp;Krishnasamy Kaveri ,&nbsp;Kunka Mohanram Ramkumar","doi":"10.1016/j.yexmp.2022.104821","DOIUrl":"10.1016/j.yexmp.2022.104821","url":null,"abstract":"<div><h3>Background</h3><p>Plasma leakage is a major pathogenic manifestation of severe dengue<span><span> and is a precursor of life-threatening complications associated with dengue<span>. Accumulating evidence indicates the role of Matrix Metalloproteinases (MMPs) in mediating </span></span>vascular permeability<span> and plasma leakage following induction by the dengue virus. This study aims to investigate the utility of MMP-2, MMP-3, and MMP-9 in predicting the severity of dengue infection and further explore the relationship of these markers with the pathogenic factors associated with plasma leakage.</span></span></p></div><div><h3>Methods</h3><p>The dengue-positive subjects were classified into mild and severe dengue groups based on the manifestation of warning signs. The samples in each group and healthy controls were quantified for basic laboratory characteristics. The levels of MMP-2, MMP-3, MMP-9, and Macrophage migration inhibitory factor (MIF) were estimated in all serum samples using a multiplex bead-based assay.</p></div><div><h3>Results</h3><p>MMP-2 and MMP-9 were markedly elevated in severe dengue patients compared to mild dengue patients and healthy controls. No alteration in the circulating levels of MMP-3 was observed between the study groups. ROC curve analysis indicated that MMP-2 and MMP-9 exhibited good potential for predicting severe dengue. Notably, an increase in MMP-9 was associated with increased MIF and Hematocrit levels in severe dengue patients.</p></div><div><h3>Conclusion</h3><p>MMP-2 and MMP-9 could serve as prognostic biomarkers for severe dengue. These findings also identify the association of MMP-9 with markers of plasma leakage, thereby encouraging further studies to explore the therapeutic potential of targeting MMP-9 in managing plasma leakage in severe dengue.</p></div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"128 ","pages":"Article 104821"},"PeriodicalIF":3.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10396593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}