Experimental and molecular pathology最新文献_第10页

Retraction notice to “The role of cardiac fibroblasts in post-myocardial heart tissue repair” [Experimental and Molecular Pathology 101/2 (2016) 231–240] 关于“心肌成纤维细胞在心肌后心脏组织修复中的作用”的撤回通知[实验与分子病理学101/2 (2016)231-240]

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104783

Dimitry A. Chistiakov , Alexander N. Orekhov , Yuri V. Bobryshev

引用次数: 0

Neurogranin regulates calcium-dependent cardiac hypertrophy 神经粒蛋白调节钙依赖性心脏肥厚

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104815

Ashton N. Jorgensen , Chowdhury S. Abdullah , Md. Shenuarin Bhuiyan , Megan Watt , Paari Dominic , Gopi K. Kolluru , Christopher G. Kevil , Hyung W. Nam

{"title":"Neurogranin regulates calcium-dependent cardiac hypertrophy","authors":"Ashton N. Jorgensen , Chowdhury S. Abdullah , Md. Shenuarin Bhuiyan , Megan Watt , Paari Dominic , Gopi K. Kolluru , Christopher G. Kevil , Hyung W. Nam","doi":"10.1016/j.yexmp.2022.104815","DOIUrl":"10.1016/j.yexmp.2022.104815","url":null,"abstract":"<div>Intracellular Ca2+-calmodulin (CaM) signaling plays an important role in Ca2+-CaM-dependent kinase (CaMKII) and calcineurin (CaN)-mediated cardiac biology. While neurogranin (Ng) is known as a major Ca2+-CaM modulator in the brain, its pathophysiological role in cardiac hypertrophy has never been studied before. In the present study, we report that Ng is expressed in the heart and depletion of Ng dysregulates Ca2+ homeostasis and promotes cardiac failure in mice. 10-month-old Ng null mice demonstrate significantly increased heart-to-body weight ratios compared to wild-type. Using histological approaches, we identified that depletion of Ng increases cardiac hypertrophy, fibrosis, and collagen deposition near perivascular areas in the heart tissue of Ng null mice. Ca2+ spark experiments revealed that cardiac myocytes isolated from Ng null mice have decreased spark frequency and width, while the duration of sparks is significantly increased. We also identified that a lack of Ng increases CaMKIIδ signaling and periostin protein expression in these mouse hearts. Overall, we are the first study to explore how Ng expression in the heart plays an important role in Ca2+ homeostasis in cardiac myocytes as well as the pathophysiology of cardiac hypertrophy and fibrosis.</div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"127 ","pages":"Article 104815"},"PeriodicalIF":3.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10211459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retraction notice to “Quercetin ameliorates lipopolysaccharide-caused inflammatory damage via down-regulation of miR-221 in WI-38 cells”: [Experimental and Molecular Pathology 108 (2019) 1–8] “槲皮素通过下调WI-38细胞中miR-221改善脂多糖引起的炎症损伤”的撤回通知:[实验与分子病理学]108 (2019)1-8]

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104809

Chong Wang, Zhenghai Qu, Lingpeng Kong, Lei Xu, Mengxue Zhang, Jianke Liu, Zhaochuan Yang

引用次数: 0

Retraction notice to “ Long non-coding RNA LINC00052 regulates miR-608/EGFR axis to promote progression of head and neck squamous cell carcinoma” [Experimental and Molecular Pathology 111 (2019) 104321] “长链非编码RNA LINC00052调控miR-608/EGFR轴促进头颈部鳞状细胞癌进展”撤回通知[实验与分子病理学111 (2019)104321]

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104816

Tianbin Ouyang , Ying Zhang , Shixiong Tang , Yaowen Wang

引用次数: 0

Retraction notice to “Ginsenoside Rg3 inhibits cell growth, migration and invasion in Caco-2 cells by downregulation of lncRNA CCAT1” [Experimental and Molecular Pathology 106 (2019) 131–138] 关于“人参皂苷Rg3通过下调lncRNA CCAT1抑制Caco-2细胞生长、迁移和侵袭”的撤回通知[实验与分子病理学]106 (2019)131-138]

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104785

Jinliang Li , Yuxi Qi

引用次数: 0

Retraction notice to “Long non-coding RNA TUG1 alleviates LPS-induced injury of PC-12 cells by down-regulating microRNA-127” [Experimental and Molecular Pathology 110 (2019) 104287] 关于“长链非编码RNA TUG1通过下调microRNA-127减轻lps诱导的PC-12细胞损伤”的撤回通知[实验与分子病理学110 (2019)104287]

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104790

Huajiang Zheng , Shanshan Hu , Jin Cao, Lufeng Yao, Nan Zhang

引用次数: 0

Retraction notice to “ Baicalin protects human retinal pigment epithelial cell lines against high glucose-induced cell injury by up-regulation of microRNA-145” [Experimental and Molecular Pathology 106 (2019) 123–130] 关于“黄芩苷通过上调microRNA-145保护人视网膜色素上皮细胞免受高糖诱导的细胞损伤”的撤回通知[实验与分子病理学106 (2019)123-130]

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104788

Chunhua Dai , Shanhao Jiang , Cuiying Chu , Meng Xin , Xiufen Song , Bojun Zhao

引用次数: 1

Retraction notice to "TRAF4 promotes endometrial cancer cell growth and migration by activation of PI3K/AKT/Oct4 signaling" [Experimental and Molecular Pathology 108 (2019) 9–16] 关于“TRAF4通过激活PI3K/AKT/Oct4信号促进子宫内膜癌细胞生长和迁移”的撤回通知[实验与分子病理学]108 (2019)9-16]

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104800

Pengmu Xie, Xiuling Wang, Min Kong, Xiuyu Bai, Tao Jiang

引用次数: 0

Single-cell transcriptomes identifies characteristic features of mouse macrophages in liver Mallory-Denk bodies formation 单细胞转录组学鉴定小鼠巨噬细胞在肝脏Mallory-Denk小体形成中的特征

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104811

Rong Zhang , Bei Zhong , Jiashan He , Xinyu Yang , Menghua He , Wuyi Zeng , Jiayi Pan , Zixuan Fang , Jiangtao Jia , Hui Liu

{"title":"Single-cell transcriptomes identifies characteristic features of mouse macrophages in liver Mallory-Denk bodies formation","authors":"Rong Zhang , Bei Zhong , Jiashan He , Xinyu Yang , Menghua He , Wuyi Zeng , Jiayi Pan , Zixuan Fang , Jiangtao Jia , Hui Liu","doi":"10.1016/j.yexmp.2022.104811","DOIUrl":"10.1016/j.yexmp.2022.104811","url":null,"abstract":"<div>Mallory-Denk bodies (MDBs) consist of intracellular aggregates of misfolded proteins in ballooned hepatocytes and serve as important markers of progression in certain liver diseases. Resident hepatic macrophage-mediated inflammation influences the development of chronic liver diseases and cancer. Here, the first systematic study of macrophages heterogeneity in mice was conducted to illustrate the pathogenesis of MDB formation using single-nucleus RNA sequencing (snRNA-seq). Furthermore, we provided transcriptional profiles of macrophages obtained from the fractionation of mouse liver tissues following chronic injury. We equally identified seven discrete macrophage subpopulations, each involved in specific cellular activated pathways such as basal metabolism, immune regulation, angiogenesis, and cell cycle regulation. Among these, a specific macrophage cluster (Cluster4), a subpopulation specifically expressing genes that regulate cell division and the cell cycle, was identified. Interestingly, we found that CCR2 was significantly induced in Cluster2, thereby inducing monocytes to migrate to macrophages to promote MDB pathogenesis. Thus, our study is the first to demonstrate the heterogeneity of macrophages associated with liver MDB formation in mice through single-cell resolution. This serves as the basis for further insights into the pathogenesis of liver MDB formation and molecular mechanisms of chronic liver disease progression.</div>","PeriodicalId":12176,"journal":{"name":"Experimental and molecular pathology","volume":"127 ","pages":"Article 104811"},"PeriodicalIF":3.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0014480022000740/pdfft?md5=a81a1476df396eda5cf9981ab3b6069f&pid=1-s2.0-S0014480022000740-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40517168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Retraction notice to “Brazilein induces apoptosis and G1/G0 phase cell cycle arrest by up-regulation of miR-133a in human vestibular schwannoma cells” [Experimental and Molecular Pathology 107 (2019) 95–101] 关于“Brazilein通过上调miR-133a诱导人前庭神经鞘瘤细胞凋亡和G1/G0期细胞周期阻滞”的撤回通知[实验与分子病理学]107 (2019)95-101]

IF 3.6 4区医学

Experimental and molecular pathology Pub Date : 2022-08-01 DOI: 10.1016/j.yexmp.2022.104782

Zhongyan Mou , Yan Wang , Yongmei Li

引用次数: 0