Experimental & Translational Stroke Medicine最新文献

{"title":"Hypoxia after stroke: a review of experimental and clinical evidence","authors":"P. Ferdinand, C. Roffe","doi":"10.1186/s13231-016-0023-0","DOIUrl":"https://doi.org/10.1186/s13231-016-0023-0","url":null,"abstract":"","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82594494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of the renin angiotensin system in ischaemic stroke","authors":"M. Arroja, Emma J. Reid, C. McCabe","doi":"10.1186/s13231-016-0022-1","DOIUrl":"https://doi.org/10.1186/s13231-016-0022-1","url":null,"abstract":"","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77357717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiology and management of reperfusion injury and hyperperfusion syndrome after carotid endarterectomy and carotid artery stenting.","authors":"Muhammad U Farooq,&nbsp;Christopher Goshgarian,&nbsp;Jiangyong Min,&nbsp;Philip B Gorelick","doi":"10.1186/s13231-016-0021-2","DOIUrl":"https://doi.org/10.1186/s13231-016-0021-2","url":null,"abstract":"<p><p>Cerebral hyperperfusion is a relatively rare syndrome with significant and potentially preventable clinical consequences. The pathophysiology of cerebral hyperperfusion syndrome (CHS) may involve dysregulation of the cerebral vascular system and hypertension, in the setting of increase in cerebral blood flow. The early recognition of CHS is important to prevent complications such as intracerebral hemorrhage. This review will focus on CHS following carotid endarterectomy and carotid artery stenting. We will discuss the typical clinical features of CHS, risk factors, pathophysiology, diagnostic modalities for detection, identification of patients at risk, and prevention and treatment. Although currently there are no specific guidelines for the management of CHS, identification of patients at risk for CHS and aggressive treatment of hypertension are recommended. </p>","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"8 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2016-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13231-016-0021-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34714153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study evaluating the use of ABCD2 score in pre-hospital assessment of patients with suspected transient ischaemic attack: experience and lessons learned.","authors":"Scott Munro,&nbsp;Sally Rodbard,&nbsp;Khalid Ali,&nbsp;Claire Horsfield,&nbsp;Wendy Knibb,&nbsp;Janet Holah,&nbsp;Ottilia Speirs,&nbsp;Tom Quinn","doi":"10.1186/s13231-016-0020-3","DOIUrl":"https://doi.org/10.1186/s13231-016-0020-3","url":null,"abstract":"<p><strong>Background: </strong>Suspected transient ischaemic attack (TIA) is a common presentation to emergency medical services (EMS) in the United Kingdom (UK). Several EMS systems have adopted the ABCD2 score to aid pre-hospital risk stratification and decision-making on patient disposition, such as direct referral to an Emergency Department or specialist TIA clinic. However, the ABCD2 score, developed for hospital use, has not been validated for use in the pre-hospital context of EMS care.</p><p><strong>Methods: </strong>We conducted a pilot study to assess eligibility criteria, recruitment rates, protocol compliance, consent and follow-up procedures to inform the development of a definitive study to validate the ABCD2 tool in pre-hospital evaluation of patients with suspected TIA.</p><p><strong>Results: </strong>From 1st May-1st September 2013, nine patients with an EMS suspected diagnosis of TIA had the TIA diagnosis later confirmed by a specialist from five participating sites. This recruitment rate is comparable to stroke trials in the EMS setting. Bureaucratic obstacles and duplication of approval processes across participating sites took 13 months to resolve before recruitment commenced. Due to the initial difficulty in recruitment, a substantial amendment was approved to modify inclusion criteria, allowing patients with atrial fibrillation and/or taking anticoagulant therapy to participate in the study.</p><p><strong>Conclusions: </strong>It is possible to identify, recruit and follow up patients with suspected TIA in the EMS setting. Training large numbers of EMS staff is required as exposure to TIA patients is infrequent. Significant insight was gained into the complexity of NHS research governance mechanisms in the UK. This knowledge will facilitate the planning of a future adequately powered study to validate the ABCD2 tool in a pre-hospital setting.</p>","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"8 ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2016-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13231-016-0020-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34682326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Artery reopening is required for the neurorestorative effects of angiotensin modulation after experimental stroke.","authors":"Ahmed Alhusban,&nbsp;Anna Kozak,&nbsp;Wael Eldahshan,&nbsp;Adviye Ergul,&nbsp;Susan C Fagan","doi":"10.1186/s13231-016-0019-9","DOIUrl":"https://doi.org/10.1186/s13231-016-0019-9","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1186/s13231-016-0018-x.]. </p>","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"8 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2016-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13231-016-0019-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34578783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artery reopening is required for the neurorestorative effects of angiotensin modulation after experimental stroke.","authors":"Ahmed Alhusban,&nbsp;Anna Kozak,&nbsp;Wael Eldashan,&nbsp;Adviye Ergul,&nbsp;Susan C Fagan","doi":"10.1186/s13231-016-0018-x","DOIUrl":"https://doi.org/10.1186/s13231-016-0018-x","url":null,"abstract":"<p><strong>Background: </strong>Blood flow restoration with fibrinolysis and thrombectomy is recommended to limit injury in stroke patients with proximal artery occlusion. Angiotensin receptor blockers have been shown to be neuroprotective in models of permanent and temporary occlusion, but the benefits on expression of trophic factors have been seen only when the artery is reopened. It is possible that early artery opening with endovascular intervention may increase the likelihood of identifying an effective combination therapy for patients.</p><p><strong>Methods: </strong>Normotensive male Wistar rats were subjected to mechanical middle cerebral artery occlusion (either temporary or permanent), followed by randomization to receive candesartan (0.3 mg/kg IV) or saline. Functional outcome, infarct size, and biochemical changes were assessed 24 h after ischemia induction.</p><p><strong>Results: </strong>Lack of reperfusion blunted candesartan induced neuroprotection (p < 0.05) and reduced the improvement of functional outcome (p < 0.05). With reperfusion, candesartan increased mature BDNF expression in the contralateral hemisphere (p < 0.05) and activated prosurvival (Akt-GSK3-β) signaling (p < 0.05). Without reperfusion, candesartan significantly reduced VEGF expression and MMP activation and increased NOGO A expression, creating an environment hostile to recovery.</p><p><strong>Conclusion: </strong>Candesartan induced pro-recovery effects are dependent on the presence of reperfusion.</p>","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"8 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2016-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13231-016-0018-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34355920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report on the 7th scientific meeting of the Association for the Advancement of Young Academics in Neurology (NEUROWIND e.V.) held in Motzen, Germany, October 30–November 1, 2015","authors":"T. Korn, C. Kleinschnitz, T. Magnus, S. Meuth, R. Linker","doi":"10.1186/s13231-016-0017-y","DOIUrl":"https://doi.org/10.1186/s13231-016-0017-y","url":null,"abstract":"","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74336444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral collateral circulation in experimental ischemic stroke","authors":"E. Cuccione, Giada Padovano, A. Versace, C. Ferrarese, S. Beretta","doi":"10.1186/s13231-016-0015-0","DOIUrl":"https://doi.org/10.1186/s13231-016-0015-0","url":null,"abstract":"","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85017971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment with FTY720 has no beneficial effects on short-term outcome in an experimental model of intracerebral hemorrhage","authors":"F. Schlunk, W. Pfeilschifter, K. Yiğitkanlı, E. Lo, C. Foerch","doi":"10.1186/s13231-016-0016-z","DOIUrl":"https://doi.org/10.1186/s13231-016-0016-z","url":null,"abstract":"","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85588514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docosahexaenoic acid improves behavior and attenuates blood-brain barrier injury induced by focal cerebral ischemia in rats.","authors":"Sung-Ha Hong,&nbsp;Larissa Khoutorova,&nbsp;Nicolas G Bazan,&nbsp;Ludmila Belayev","doi":"10.1186/s13231-014-0012-0","DOIUrl":"https://doi.org/10.1186/s13231-014-0012-0","url":null,"abstract":"<p><strong>Background: </strong>Ischemic brain injury disrupts the blood-brain barrier (BBB) and then triggers a cascade of events, leading to edema formation, secondary brain injury and poor neurological outcomes. Recently, we have shown that docosahexaenoic acid (DHA) improves functional and histological outcomes following experimental stroke. However, little is known about the effect of DHA on BBB dysfunction after cerebral ischemia-reperfusion injury. The present study was designed to determine whether DHA protects against BBB disruption after focal cerebral ischemia in rats.</p><p><strong>Methods: </strong>Physiologically-controlled SD rats received 2 h middle cerebral artery occlusion (MCAo). DHA (5 mg/kg) or vehicle (saline) was administered I.V. at 3 h after onset of MCAo. Fluorometric quantitation of Evans Blue dye (EB) was performed in eight brain regions at 6 h, 24 h or 72 h after MCAo. Fluorescein isothiocynate (FITC) - dextran leakage and histopathology was evaluated on day 3 after stroke.</p><p><strong>Results: </strong>Physiological variables were stable and showed no significant differences between groups. DHA improved neurological deficits at 24 h, 48 h and 72 h and decreased EB extravasation in the ischemic hemisphere at 6 h (by 30%), 24 h (by 48%) and 72 h (by 38%). In addition, EB extravasation was decreased by DHA in the cortex and total hemisphere as well. FITC-dextran leakage was reduced by DHA treatment on day 3 by 68% compared to the saline group. DHA treatment attenuated cortical (by 50%) and total infarct volume (by 38%) compared to vehicle-treated rats on day 3 after stroke.</p><p><strong>Conclusions: </strong>DHA therapy diminishes BBB damage accompanied with the acceleration of behavioral recovery and attenuation of the infarct volume. It is reasonable to propose that DHA has the potential for treating focal ischemic stroke in the clinical setting.</p>","PeriodicalId":12158,"journal":{"name":"Experimental & Translational Stroke Medicine","volume":"7 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2015-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13231-014-0012-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33020885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}