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Effect of HSPA8 on the proliferation, apoptosis and immune function of chicken macrophages. HSPA8对鸡巨噬细胞增殖、凋亡及免疫功能的影响。
The international journal of biochemistry & cell biology Pub Date : 2022-02-22 DOI: 10.1016/j.biocel.2022.106186
Huihui Tian, Mengxia Ding, Yujie Guo, Z. Zhu, Yangling Yu, Yadong Tian, Kui Li, Gui-rong Sun, R. Jiang, R. Han, Feng-bin Yan, X. Kang
{"title":"Effect of HSPA8 on the proliferation, apoptosis and immune function of chicken macrophages.","authors":"Huihui Tian, Mengxia Ding, Yujie Guo, Z. Zhu, Yangling Yu, Yadong Tian, Kui Li, Gui-rong Sun, R. Jiang, R. Han, Feng-bin Yan, X. Kang","doi":"10.1016/j.biocel.2022.106186","DOIUrl":"https://doi.org/10.1016/j.biocel.2022.106186","url":null,"abstract":"","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116689258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activin A activation drives renal fibrosis through the STAT3 signaling pathway. 活化素 A 通过 STAT3 信号通路驱动肾脏纤维化。
The international journal of biochemistry & cell biology Pub Date : 2020-10-15 DOI: 10.21203/rs.3.rs-90776/v1
C. Yuan, Lihua Ni, Xiaoyan Wu
{"title":"Activin A activation drives renal fibrosis through the STAT3 signaling pathway.","authors":"C. Yuan, Lihua Ni, Xiaoyan Wu","doi":"10.21203/rs.3.rs-90776/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-90776/v1","url":null,"abstract":"The present study investigated whether TGF-β1 promotes fibrotic changes in HK-2 cells through the Activin A and STAT3 signaling pathways in vitro. Bioinformatics analysis of microarray profiles (GSE20247 and GSE23338) and a protein-protein interaction (PPI) analysis were performed to select hub genes. For the in vitro study, HK-2 cells were exposed to TGF-β1. The expression of Activin A and STAT3 was assayed, and the effect of Activin A and STAT3 expression on fibrosis was assessed (Collagen I and Fibronectin). The bioinformatics study revealed TGF-β1 and Activin A as hub genes. The in vitro study showed that Activin A expression was significantly increased after TGF-β1 incubation. Blocking Activin A attenuated TGF-β1-induced fibrosis. In addition, Activin A blockade attenuated TGF-β1-induced STAT3 signaling pathway activation and related fibrosis. More importantly, STAT3 inhibition by S3I-201 alleviated TGF-β1-induced fibrosis. Activin A promoted cellular fibrotic changes through the STAT3 signaling pathway. Attenuating Activin A expression to mediate the STAT3 signaling pathway might be a strategy for potent renal fibrosis treatment.","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125880297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss. 羟基红花黄A通过表观遗传调节β-连环蛋白促进骨生成和骨骼发育，防止卵巢切除术引起的骨质流失。
The international journal of biochemistry & cell biology Pub Date : 2020-07-01 DOI: 10.21203/rs.3.rs-38205/v1
Peng Wang, W. Min, Ting Zhuo, Ying Li, Lin Weiping, Ding Lingli, Meng Zhang, Chi Zhou, Jinfang Zhang, Gang Li, Hai-bin Wang, Liangliang Xu
{"title":"Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss.","authors":"Peng Wang, W. Min, Ting Zhuo, Ying Li, Lin Weiping, Ding Lingli, Meng Zhang, Chi Zhou, Jinfang Zhang, Gang Li, Hai-bin Wang, Liangliang Xu","doi":"10.21203/rs.3.rs-38205/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-38205/v1","url":null,"abstract":"In clinical treatment, there is increasingly prevalent that traditional Chinese medicine treats common bone diseases including osteoporosis. Hydroxysafflor yellow A (HSYA), one of the essential compounds of Safflower, has been used as the therapy for thrombus, myocardial ischemia, and inflammation, but its effect on osteogenesis through epigenetic control and ovariectomy-induced bone loss in vivo has not been explored. Therefore, the study aimed to explore the function and mechanism of HSYA on bone formation and development. We found HSYA could enhance the cell viability and promote osteogenesis of hBMSCs in vitro. Mechanistically, HSYA could increase the expression of β-catenin leading to its accumulation in the nucleus and activation of downstream targets to promote osteogenesis. Besides, RNA-seq and quantitative RT-PCR and western blot showed KDM7A was significantly increased by HSYA. The occupancy of H3K27me2 on β-catenin promoter was significantly decreased by HSYA, which could be reversed by silencing endogenous KDM7A. More importantly, HSYA promoted bone development in chick embryos and prevented ovariectomy (OVX)-induced bone loss in SD rats. Taken together, our study has shown convincing evidence that HSYA could promote osteogenesis and bone development via epigenetically regulating β-catenin and prevent ovariectomy-induced bone loss.","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131082998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Follistatin.
The international journal of biochemistry & cell biology Pub Date : 2020-02-08 DOI: 10.32388/2jx58k
K. Patel
{"title":"Follistatin.","authors":"K. Patel","doi":"10.32388/2jx58k","DOIUrl":"https://doi.org/10.32388/2jx58k","url":null,"abstract":"Follistatin, a secreted protein is able to bind and neutralise the actions of many members of the Transforming Growth Factor-beta family of proteins. Follistatin was first implicated in the regulation of follicle-stimulating hormone secretion in the pituitary and subsequently in other regions of the adult body associated with reproductive functions. Recent work has shown that this protein is much more broadly distributed and may also play a significant role during embryogenesis. Gene targetting has shown that follistatin is essential for normal development and in its absence, mice die soon after birth with a range of defects including insufficient muscle development and skeletal abnormalities. A number of diseases have been identified thought to be caused by an over-production of members of the Transforming Growth Factor-beta family of proteins. Therefore it may be possible to use follistatin as a therapeutic agent in these disorders.","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121246580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
Caspase-9. Caspase-9。
The international journal of biochemistry & cell biology Pub Date : 2020-02-08 DOI: 10.1007/3-540-30683-8_247
K. Kuida
{"title":"Caspase-9.","authors":"K. Kuida","doi":"10.1007/3-540-30683-8_247","DOIUrl":"https://doi.org/10.1007/3-540-30683-8_247","url":null,"abstract":"","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129988919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 182
Interleukin-11. Interleukin-11。
The international journal of biochemistry & cell biology Pub Date : 2020-02-07 DOI: 10.32388/ohbpp9
S. Leng, J. A. Elias
{"title":"Interleukin-11.","authors":"S. Leng, J. A. Elias","doi":"10.32388/ohbpp9","DOIUrl":"https://doi.org/10.32388/ohbpp9","url":null,"abstract":"Interleukin-11 (IL-11) is an IL-6-type cytokine that is produced by a variety of stromal cells including fibroblasts, epithelial cells and osteoblasts. It binds to a multimeric receptor complex which contains an IL-11-specific alpha subunit and a promiscuous 130 kDa beta subunit (gp130). IL-11 stimulates multiple aspects of hematopoiesis and hepatocyte production of acute phase response proteins. It also inhibits the genesis of adipocytes, activates osteoclasts, alters neural phenotype, stimulates tissue fibrosis and regulates chondrocyte, synoviocyte and B cell function. In other settings, IL-11 minimizes tissue injury. This may be the result of its ability to protect clonogenic stem cells, regulate epithelial cell proliferation, inhibit apoptosis and inhibit macrophage cytokine production. Thus, IL-11 appears to play an important role in hematopoiesis, bone metabolism and tissue remodeling and may be an important protector of mucosal surfaces.","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117173103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paxillin. 桩蛋白。
The international journal of biochemistry & cell biology Pub Date : 2020-02-02 DOI: 10.32388/xzgv42
C. Turner
{"title":"Paxillin.","authors":"C. Turner","doi":"10.32388/xzgv42","DOIUrl":"https://doi.org/10.32388/xzgv42","url":null,"abstract":"Paxillin is a 68 kDa cytoplasmic protein that localizes to discrete sites of cell attachment to the extracellular matrix called focal adhesions. It is a multi-domain adapter protein capable of interacting with several structural and signaling proteins including vinculin, FAK, PYK2, Src and Crk. Phosphorylation of paxillin in response to integrin-mediated cell adhesion and growth factor stimulation regulates some of these interactions. Thus, paxillin functions as a scaffold for the recruitment of molecules into a signal transduction complex that is closely apposed to the plasma membrane. This is likely to facilitate the efficient processing of external stimuli that modulate important cellular events including cell adhesion, cell motility and growth control. Since paxillin interacts with several proteins known to cause cell transformation, the binding sites for these proteins on paxillin represent potential targets for therapeutic agents.","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132054152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Calpain. Calpain。
The international journal of biochemistry & cell biology Pub Date : 2020-02-02 DOI: 10.32388/wrjqhm
B. Perrin, A. Huttenlocher
{"title":"Calpain.","authors":"B. Perrin, A. Huttenlocher","doi":"10.32388/wrjqhm","DOIUrl":"https://doi.org/10.32388/wrjqhm","url":null,"abstract":"The calcium-dependent thiol proteases, calpains, are widely expressed with ubiquitous and tissue specific isoforms. Calpains have been implicated in basic cellular processes including cell proliferation, apoptosis and differentiation. The focus of the current review is to summarize recent findings implicating calpains in cytoskeletal rearrangements and cell migration. Calpain cleaves many cytosolic proteins and therefore to be effective and limited in its scope, calpain activity has to be tightly regulated both temporally and spatially. Some mechanisms of regulation include calcium, growth factor-mediated phosphorylation and membrane targeting. Calpain inhibition reduces migration rates and inhibits cell invasiveness. Two putative mechanisms of calpain action during migration include its role as a signaling intermediate, acting upstream of Rho, and its effects on focal adhesion structure and disassembly. Therefore, calpains and downstream signaling molecules may be future targets for therapeutic interventions to treat cancer or chronic inflammation.","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130689861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crystal structure of a recombinant Vatairea macrocarpa seed lectin 重组大菱鲆种子凝集素的晶体结构
The international journal of biochemistry & cell biology Pub Date : 2016-01-27 DOI: 10.2210/pdb4xtm/pdb
B. L. Sousa, J. C. Silva-Filho, Prashant Kumar, A. Lyskowski, G. A. Bezerra, P. Delatorre, B. D. Rocha, R. Cunha, C. Nagano, K. Gruber, B. Cavada
{"title":"Crystal structure of a recombinant Vatairea macrocarpa seed lectin","authors":"B. L. Sousa, J. C. Silva-Filho, Prashant Kumar, A. Lyskowski, G. A. Bezerra, P. Delatorre, B. D. Rocha, R. Cunha, C. Nagano, K. Gruber, B. Cavada","doi":"10.2210/pdb4xtm/pdb","DOIUrl":"https://doi.org/10.2210/pdb4xtm/pdb","url":null,"abstract":"","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133769099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WITHDRAWN: CD151 gene delivery promotes functional neovascularization after myocardial infarction in pigs 撤回:CD151基因传递促进猪心肌梗死后的功能性新生血管
The international journal of biochemistry & cell biology Pub Date : 2009-01-22 DOI: 10.1016/J.BIOCEL.2009.01.008
H. Zuo, Zheng-xiang Liu, Xiao-chun Liu, Jun Yang, Tao Liu, S. Wen, Xin A. Zhang, K. Cianflone, Daowen Wang
{"title":"WITHDRAWN: CD151 gene delivery promotes functional neovascularization after myocardial infarction in pigs","authors":"H. Zuo, Zheng-xiang Liu, Xiao-chun Liu, Jun Yang, Tao Liu, S. Wen, Xin A. Zhang, K. Cianflone, Daowen Wang","doi":"10.1016/J.BIOCEL.2009.01.008","DOIUrl":"https://doi.org/10.1016/J.BIOCEL.2009.01.008","url":null,"abstract":"","PeriodicalId":121221,"journal":{"name":"The international journal of biochemistry & cell biology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131719450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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