International Journal of Tropical Diseases最新文献_第5页

In Vitro Evaluation and Molecular Docking Studies of Aryl-Substituted Imidazoles against Leishmania Amazonensis 芳基取代咪唑抗亚马逊利什曼原虫的体外评价及分子对接研究

International Journal of Tropical Diseases Pub Date : 1900-01-01 DOI: 10.23937/2643-461x/1710050

Vargas Julio Alberto Rojas, López América García, Vargas Aliesky Ramírez, Fidalgo Lianet Monzote, Froeyen Matheus

{"title":"In Vitro Evaluation and Molecular Docking Studies of Aryl-Substituted Imidazoles against Leishmania Amazonensis","authors":"Vargas Julio Alberto Rojas, López América García, Vargas Aliesky Ramírez, Fidalgo Lianet Monzote, Froeyen Matheus","doi":"10.23937/2643-461x/1710050","DOIUrl":"https://doi.org/10.23937/2643-461x/1710050","url":null,"abstract":"Leishmaniasis is a disease caused by the protozoan Leishmania that is considered one of the causes of death from parasitic infection worldwide. Looking for the right chemotherapy against leishmaniasis has been difficult because of the high toxicity of the most effective drugs. This disease is considered among the 13 unattended diseases worldwide according to the World Health Organization (WHO). In the present work, the leishmanicidal activity against L. amazonensis promastigote and cytotoxicity of 9 aryl-substituted imidazoles were evaluated. In vitro antileishmanial results indicated that the ligand 1, 2 and 7 exhibited strong activity against L. amazonensis promastigote, but only the compound 1 and 4 showed agood selectivity and cytotoxicity against the parasite. According to the results of the molecular docking, the aromatic substituents have mainly stabilizing hydrophobic interactions with the enzymatic matrix, which shows the probability that the protein trypanothione reductase is the therapeutic target of these compounds as possible antileishmanial drugs.","PeriodicalId":121181,"journal":{"name":"International Journal of Tropical Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129295147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lassa fever in Nigeria: Social and Ecological Risk Factors Exacerbating Transmission and Sustainable Management Strategies 尼日利亚的拉沙热:加剧传播的社会和生态风险因素和可持续管理战略

International Journal of Tropical Diseases Pub Date : 1900-01-01 DOI: 10.23937/2643-461x/1710065

Izah Sylvester Chibueze, Ovuru Kurotimipa Frank, Ogwu Matthew Chidozie

{"title":"Lassa fever in Nigeria: Social and Ecological Risk Factors Exacerbating Transmission and Sustainable Management Strategies","authors":"Izah Sylvester Chibueze, Ovuru Kurotimipa Frank, Ogwu Matthew Chidozie","doi":"10.23937/2643-461x/1710065","DOIUrl":"https://doi.org/10.23937/2643-461x/1710065","url":null,"abstract":"With the advent of COVID-19, infectious diseases are increasingly a cause of concern to both national and international governments as well as non-governmental organizations. This review focusses on Lassa fever incidence, prevalence, and socioecological factors influencing the spread and management of the disease in Nigeria using data mined from the Nigeria Centre for Disease Control and other public databases. Lassa fever and the causative agent Lassa virus (LASV) and vector, Mastomys natalensis is becoming a topical issue despite the neglected tropical disease status. The primary transmission mode of LASV has not been fully comprehended but several social and environmental factors have been implicated to either play a major role in determining the rate of transmission or exacerbating transmission risks. Nonetheless, some transmission route includes faeco-oral, rodent bites, and the consumption of rodent meat. From epidemiolocal studies and surveillance, it is glaring that LASV is a West African phenomenon. In West Africa, about 100,000 to 300,000 new cases of Lassa fever have been reported with a mortality rate of 5,000 persons per year. In Nigeria, Lassa fever has occurred in several states across the six geopolitical zones and the federal capital territory. However, Edo State in the Southsouth geopolitical zone and Ondo State in the Southwest geopolitical zone is the core epicentre of the virus since December 2016 in Nigeria. Some environmental conditions that contribute to exacerbating the incidence of Lassa fever include weak environmental hygiene laws, poor housing, and regional planning, indiscriminate disposal of wastes, poor food handling, and storage, absence of a law against eating Mastomys natalensis , deforestation, and poor agricultural practices as well as climate change.","PeriodicalId":121181,"journal":{"name":"International Journal of Tropical Diseases","volume":"300 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128621025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Assessment of Prevalence of Communicable and Non-Communicable Diseases in a Rural Community and its Neighborhood in Enugu State, Nigeria: A Cross-Sectional Epidemiological Survey from a Health Outreach 尼日利亚埃努古州农村社区及其邻近地区传染病和非传染性疾病流行情况评估:来自卫生外展的横断面流行病学调查

International Journal of Tropical Diseases Pub Date : 1900-01-01 DOI: 10.23937/2643-461x/1710072

Dike Ogbonna N John, Aguiyi-Ikeanyi Chinelo N, Isah Abdulmuminu, Mosanya Adaobi U, Okonkwo-Uzor Nkechi J, Okeke Ginikachukwu N, Beatrice-zita Ohagwu M, Oluebube Onyia C, Ebubechukwu Nchekwube Precious

引用次数: 0

Patient Invaded by 99 Mango Fly Larva - A Case Report 99只芒果蝇幼虫侵害患者1例

International Journal of Tropical Diseases Pub Date : 1900-01-01 DOI: 10.23937/2643-461x/1710068

P. Kohler, H. Glosse, Oezguer Dogan, S. Loff, R. Staubach

引用次数: 0

COVID 19 and Neglected Tropical Diseases in Africa: Perspectives from Ghana 2019冠状病毒病和非洲被忽视的热带病:来自加纳的观点

International Journal of Tropical Diseases Pub Date : 1900-01-01 DOI: 10.23937/2643-461x/1710052

N. Emmanuella, Okereke Melody, Ogunkola Isaac Olushola, Isa Mashkur Abdulhamid, Adebisi Yusuff Adebayo, Lucero-Prisno Iii Don Eliseo

引用次数: 2