Expert Review of Cardiovascular Therapy最新文献

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Impella devices: a comprehensive review of their development, use, and impact on cardiogenic shock and high-risk percutaneous coronary intervention. Impella装置:对其发展、使用以及对心源性休克和高危经皮冠状动脉介入治疗的影响的全面综述。
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-08-08 DOI: 10.1080/14779072.2023.2244874
Tzvi Fishkin, Ameesh Isath, Edmund Naami, Wilbert S Aronow, Avi Levine, Alan Gass
{"title":"Impella devices: a comprehensive review of their development, use, and impact on cardiogenic shock and high-risk percutaneous coronary intervention.","authors":"Tzvi Fishkin,&nbsp;Ameesh Isath,&nbsp;Edmund Naami,&nbsp;Wilbert S Aronow,&nbsp;Avi Levine,&nbsp;Alan Gass","doi":"10.1080/14779072.2023.2244874","DOIUrl":"10.1080/14779072.2023.2244874","url":null,"abstract":"<p><strong>Introduction: </strong>Impella devices have emerged as a critical tool for temporary mechanical circulatory support (TMCS) in the management of cardiogenic shock (CS) and high-risk percutaneous coronary interventions (PCI). The purpose of this review is to examine the history of the different Impella devices, their hemodynamic profiles, and how the data supports their use.</p><p><strong>Areas covered: </strong>This review covers the development and specifications of the Impella 2.5, Impella CP, Impella 5.0/Left Direct (LD), Impella RP, and Impella 5.5 devices. This review also covers the clinical trials that illuminate the Impella devices' use in their appropriate clinical contexts. These studies examine the effectiveness of Impella devices and have begun to yield promising results, demonstrating improved survival rates when compared to the historically high mortality rates associated with CS. It is important to weigh the benefits of Impella devices in light of their contraindications. A literature search was conducted by searching the PubMed database for reviews, meta-analyses, and clinical trials pertinent to Impella devices.</p><p><strong>Expert opinion: </strong>Impella devices are a crucial tool for management of patients undergoing high-risk PCI and those with CS. There is evidence that early Impella implantation is beneficial in the treatment of patients presenting with CS. Further randomized controlled trials are needed to better elucidate the benefits of Impella devices in various clinical settings.</p>","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":"21 9","pages":"613-620"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10219270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of atrial fibrillation in dental practices: a qualitative feasibility study. 牙科实践中心房颤动的筛查:一项定性可行性研究。
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-09-04 DOI: 10.1080/14779072.2023.2254679
Amaar Obaid Hassan, Rosa Moreno Lopez, Deirdre A Lane, Gregory Y H Lip, Rebecca V Harris, Asfa Mughal, Corina Weir
{"title":"Screening of atrial fibrillation in dental practices: a qualitative feasibility study.","authors":"Amaar Obaid Hassan,&nbsp;Rosa Moreno Lopez,&nbsp;Deirdre A Lane,&nbsp;Gregory Y H Lip,&nbsp;Rebecca V Harris,&nbsp;Asfa Mughal,&nbsp;Corina Weir","doi":"10.1080/14779072.2023.2254679","DOIUrl":"10.1080/14779072.2023.2254679","url":null,"abstract":"ABSTRACT Objectives To increase the detection of unknown atrial fibrillation (AF), general practitioners have started screening their patients using small hand-held devices. It is thought that dental settings could be utilized for screening as they have regular access to patients. The aim of this study was to explore the perceptions of dental staff of screening for AF using a hand-held electronic device in primary dental care. Methods The research took place in one large mixed NHS and private general dental practice. Views from staff including dentists, dental therapists, dental nurses, and managers were elicited via semi-structured interviews conducted face-to-face, audio recorded, and transcribed verbatim. Interviews continued until there were no new themes or patterns emerging from the data, and thematic saturation had been achieved. Results Eleven participants were interviewed. The main themes generated were methodology for screening, acceptability for screening within the practice, attitudes to screening, and implementation of screening. Overall, participants were positive about implementing AF screening in a dental practice but expressed concerns about time and remuneration. Staff also gave encouraging feedback regarding the simplicity of the portable screening device. Conclusions Participants felt that AF screening in primary care dental practices was a good concept but may be challenging to implement in NHS Dentistry, especially due to the pandemic.","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":"21 9","pages":"643-649"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10274551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical role of invasive hemodynamics in the evaluation and treatment of structural heart disease. 有创血流动力学在结构性心脏病评估和治疗中的临床作用。
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 DOI: 10.1080/14779072.2023.2219058
Joshua Rezkalla, Mackram F Eleid
{"title":"The clinical role of invasive hemodynamics in the evaluation and treatment of structural heart disease.","authors":"Joshua Rezkalla,&nbsp;Mackram F Eleid","doi":"10.1080/14779072.2023.2219058","DOIUrl":"https://doi.org/10.1080/14779072.2023.2219058","url":null,"abstract":"<p><strong>Introduction: </strong>Recognition and evaluation of structural heart disease has become more common in clinical practice and will continue to grow as the population ages. With the growing availability of surgical and transcatheter interventional options, appropriate evaluation and patient selection for therapy is required. While echocardiography can frequently provide the required anatomic and hemodynamic information required to guide therapeutic decisions, there remains subsets of patients in which noninvasive testing yields inconclusive results prompting the need for invasive hemodynamics.</p><p><strong>Areas covered: </strong>This article reviews the indications and strengths of invasive hemodynamics in a variety of structural heart diseases. We describe the utilization and benefits of continuous hemodynamics during transcatheter interventions and review the prognostic information that can be gleaned from changes in hemodynamics after intervention.</p><p><strong>Expert opinion: </strong>The advancement of transcatheter therapies for structural heart disease has sparked a renewed interest in the utilization of invasive hemodynamics. Continued growth and accessibility of comprehensive hemodynamics for clinical practice will rely on clinicians to continually review, refine, and develop procedural techniques beyond the current training standards in order to further advance the field.</p>","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":"21 7","pages":"483-499"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to treat the climate and nature crisis as one indivisible global health emergency. 是时候将气候和自然危机视为一个不可分割的全球卫生紧急事件了。
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-12-10 DOI: 10.1080/14779072.2023.2276518
Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski
{"title":"Time to treat the climate and nature crisis as one indivisible global health emergency.","authors":"Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski","doi":"10.1080/14779072.2023.2276518","DOIUrl":"10.1080/14779072.2023.2276518","url":null,"abstract":"","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"717-719"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71411248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How can we improve the management of individuals with attention deficit hyperactivity disorders and co-occurring cardiometabolic disease? 我们如何改善注意力缺陷多动障碍和合并心脏代谢疾病患者的管理?
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-12-10 DOI: 10.1080/14779072.2023.2279608
Henrik Larsson
{"title":"How can we improve the management of individuals with attention deficit hyperactivity disorders and co-occurring cardiometabolic disease?","authors":"Henrik Larsson","doi":"10.1080/14779072.2023.2279608","DOIUrl":"10.1080/14779072.2023.2279608","url":null,"abstract":"","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"725-728"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
De-escalation strategies in patients with acute coronary syndrome: a step towards precision medicine. 急性冠脉综合征患者的降级策略:迈向精准医学的一步。
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 DOI: 10.1080/14779072.2023.2221851
Felice Gragnano, Antonio Capolongo, Fabrizia Terracciano, Vincenzo De Sio, Pasquale Maddaluna, Fabio Fimiani, Elisabetta Moscarella, Arturo Cesaro, Rocco A Montone, Roberto Bianco, Danilo Lisi, Mario Massimo Mensorio, Angela Annecchiarico, Paolo Calabrò
{"title":"De-escalation strategies in patients with acute coronary syndrome: a step towards precision medicine.","authors":"Felice Gragnano,&nbsp;Antonio Capolongo,&nbsp;Fabrizia Terracciano,&nbsp;Vincenzo De Sio,&nbsp;Pasquale Maddaluna,&nbsp;Fabio Fimiani,&nbsp;Elisabetta Moscarella,&nbsp;Arturo Cesaro,&nbsp;Rocco A Montone,&nbsp;Roberto Bianco,&nbsp;Danilo Lisi,&nbsp;Mario Massimo Mensorio,&nbsp;Angela Annecchiarico,&nbsp;Paolo Calabrò","doi":"10.1080/14779072.2023.2221851","DOIUrl":"https://doi.org/10.1080/14779072.2023.2221851","url":null,"abstract":"<p><strong>Introduction: </strong>Dual antiplatelet therapy (DAPT) with aspirin and a P2Y<sub>12</sub> inhibitor is a cornerstone in the treatment of patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Current international guidelines recommend the use of 12 months of DAPT with newer P2Y<sub>12</sub> inhibitors (i.e. ticagrelor or prasugrel) as first-line therapy in this setting. However, intense and prolonged DAPT regimens are associated with an increased risk of bleeding, with relevant prognostic implications. Recently, a strategy of de-escalation of P2Y<sub>12</sub> inhibitors has been proposed as an alternative to conventional DAPT to mitigate the risk of bleeding while preserving ischemic protection after ACS.</p><p><strong>Areas covered: </strong>In this review, we summarize the available evidence on guided and unguided strategies for P2Y<sub>12</sub> inhibitor de-escalation in patients with ACS undergoing PCI.</p><p><strong>Expert opinion: </strong>Among patients with ACS, guided and unguided de-escalation strategies are safe and effective for secondary cardiovascular prevention. Although the implementation of genetic and platelet function tests is of interest for treatment personalization, the routine use of guided de-escalation strategies seems impractical. In this context, unguided de-escalation approaches appear more attractive, convenient, and suitable for contemporary practice.</p>","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":"21 7","pages":"545-551"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9698100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sociodemographic determinants of gender disparity in primary percutaneous coronary intervention in Pakistan. 巴基斯坦初次经皮冠状动脉介入治疗中性别差异的社会人口学决定因素。
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-12-10 DOI: 10.1080/14779072.2023.2277356
Hasan Sohail, Muhammad Rizwan Umer, Muhammad Waqas Afzal, Asif Ullah, Syed Ahmad Salahuddin, Jahanzeb Malik, Waheed Ashraf
{"title":"Sociodemographic determinants of gender disparity in primary percutaneous coronary intervention in Pakistan.","authors":"Hasan Sohail, Muhammad Rizwan Umer, Muhammad Waqas Afzal, Asif Ullah, Syed Ahmad Salahuddin, Jahanzeb Malik, Waheed Ashraf","doi":"10.1080/14779072.2023.2277356","DOIUrl":"10.1080/14779072.2023.2277356","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to contribute to the body of literature on gender disparities after acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PPCI).</p><p><strong>Methods: </strong>We identified all adult patients who had AMI between January 2017, and December 2022 and were in follow-up at our institute. We collected data on PPCI, revascularization strategy, sociodemographic characteristics, and in-hospital complications in the years following the procedure.</p><p><strong>Results: </strong>A total of 5,872 patients who underwent PCI for AMI were included in the study, out of which 2,058 (35%) were women and 3,814 (65%) were men. Regarding the timing of PCI, female patients had a significantly longer median door-to-balloon time compared to male patients (136 minutes vs 108 minutes, P-value = 0.006). Female patients had a significantly higher rate of in-hospital mortality compared to male patients (5.5% vs 1.2%, P-value = 0.011). Multivariate logistic regression analysis showed that female gender, older age, and lower household income were independent predictors of longer door-to-balloon time.</p><p><strong>Conclusion: </strong>This study highlights gender disparities in PPCI in Pakistan, with female patients facing longer door-to-balloon times and higher in-hospital mortality rates. The findings suggest the need for targeted interventions to improve the access and quality of care for female patients with AMI.</p>","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"895-899"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71422004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should atrial fibrillation be considered a vascular disease? The need for a comprehensive vascular approach. 心房颤动应该被认为是一种血管疾病吗?需要一个全面的血管途径。
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-12-10 DOI: 10.1080/14779072.2023.2272652
Carlos Escobar-Cervantes, Antonio Pose Reino, Pablo Díez-Villanueva, Lorenzo Facila, Román Freixa-Pamias, Alfonso Valle, Manuel Almendro-Delia, Clara Bonanad, David Vivas, Carmen Suarez
{"title":"Should atrial fibrillation be considered a vascular disease? The need for a comprehensive vascular approach.","authors":"Carlos Escobar-Cervantes, Antonio Pose Reino, Pablo Díez-Villanueva, Lorenzo Facila, Román Freixa-Pamias, Alfonso Valle, Manuel Almendro-Delia, Clara Bonanad, David Vivas, Carmen Suarez","doi":"10.1080/14779072.2023.2272652","DOIUrl":"10.1080/14779072.2023.2272652","url":null,"abstract":"<p><strong>Introduction: </strong>Atrial fibrillation (AF) cannot be considered an isolated disease. Patients with AF should be managed using a comprehensive approach that is not limited to stroke prevention.</p><p><strong>Areas covered: </strong>In this manuscript, the potential role of AF as a vascular disease that is managed as part of a holistic approach was reviewed.</p><p><strong>Expert opinion: </strong>The residual risk of stroke in patients with AF reaches 1-2% annually, despite appropriate anticoagulation therapy. Additionally, patients with AF may develop cognitive impairment through stroke-independent pathways. Furthermore, patients with AF may have a higher risk of developing atherosclerotic vascular disease in various vascular beds and chronic kidney disease; conversely, patients with atherosclerotic disease may have an increased risk of developing AF. AF should be considered a truly systemic vascular disease, since it brings together several hemodynamic and systemic changes, including inflammation, oxidative stress, activation of the renin-angiotensin-aldosterone and sympathetic systems, as well as a prothrombotic state and endothelial dysfunction. In this regard, patients with AF should be treated based on a holistic approach that is not limited to oral anticoagulation but includes complete vascular protection.</p>","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"779-790"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49689455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insight into tricuspid transcatheter edge-to-edge repair: no longer the forgotten valve. 洞察三尖瓣经导管边缘到边缘修复:不再被遗忘的瓣膜。
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-12-10 DOI: 10.1080/14779072.2023.2286010
Rongfeng Xu, Zhenyu Cai, Jiandong Ding, Genshan Ma
{"title":"Insight into tricuspid transcatheter edge-to-edge repair: no longer the forgotten valve.","authors":"Rongfeng Xu, Zhenyu Cai, Jiandong Ding, Genshan Ma","doi":"10.1080/14779072.2023.2286010","DOIUrl":"10.1080/14779072.2023.2286010","url":null,"abstract":"<p><strong>Introduction: </strong>Tricuspid regurgitation (TR) is one of the most prevalent types of valvular heart disease linked to poor prognosis in patients with heart failure and is usually ignored. TR has received considerable attention due to the progressive advancements in transcatheter therapies in recent years.</p><p><strong>Areas covered: </strong>With relatively solid data and rapid technological advancements, tricuspid transcatheter edge-to-edge repair (T-TEER) is the most frequently employed in a series of tricuspid transcatheter interventional treatments for TR. However, the efficacy and technical benefits of T-TEER are limited because of the unique anatomical characteristics and pathological mechanisms of the tricuspid valve. The aim of this review is to summarize reported data on current status of T-TEER and to provide an expert opinion regarding the challenges it is now experiencing and future development direction and approach.</p><p><strong>Expert opinion: </strong>T-TEER is a significant treatment for TR, but its effectiveness and technical promotion are limited due to the tricuspid valve unique anatomical characteristics and pathological mechanisms. The selection criteria for suitable patients, the choice of when to intervene, device innovation, the advancement of ultrasound technology, and the volume of evidence in evidence-based medicine all indicate that the disorder of TR will eventually be better treated and understood.</p>","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"877-885"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138046629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing older people with atrial fibrillation and preventing stroke: a review of anticoagulation approaches. 管理患有心房颤动的老年人并预防中风:抗凝方法综述。
IF 2
Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-12-13 DOI: 10.1080/14779072.2023.2276892
Leona A Verma, Peter E Penson, Asangaedem Akpan, Gregory Y H Lip, Deirdre A Lane
{"title":"Managing older people with atrial fibrillation and preventing stroke: a review of anticoagulation approaches.","authors":"Leona A Verma, Peter E Penson, Asangaedem Akpan, Gregory Y H Lip, Deirdre A Lane","doi":"10.1080/14779072.2023.2276892","DOIUrl":"https://doi.org/10.1080/14779072.2023.2276892","url":null,"abstract":"<p><strong>Introduction: </strong>Oral anticoagulants (OACs) are the cornerstone of stroke prevention in atrial fibrillation (AF), but prescribing decisions in older people are complicated. Clinicians must assess the net clinical benefit of OAC in the context of multiple chronic conditions, polypharmacy, frailty and life expectancy. The under-representation of high-risk, older adult sub-populations in clinical trials presents the challenge of choosing the right OAC, where a 'one-size-fits-all' approach cannot be taken.</p><p><strong>Areas covered: </strong>This review discusses OAC approaches for stroke prevention in older people with AF and presents a prescribing aid to support clinicians' decision-making. High-risk older adults with multiple chronic conditions, specifically chronic kidney disease, dementia/cognitive impairment, previous stroke/transient ischemic attack or intracranial hemorrhage, polypharmacy, frailty, low body weight, high falls risk, and those aged ≥75 years are considered.</p><p><strong>Expert opinion: </strong>Non-vitamin K antagonist OACs are the preferred first-line OAC in older adults with AF, including high-risk subpopulations, after individual assessment of stroke and bleeding risk, except those with mechanical heart valves and moderate-to-severe mitral stenosis. Head-to-head comparisons of NOACs are not available, therefore the choice of drug (and dose) should be based on an individual's risk (stroke and bleeding) and incorporate their treatment preferences. Treatment decisions must be person-centered and principles of shared decision-making applied.</p>","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":"21 12","pages":"963-983"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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