Exploratory Research and Hypothesis in Medicine最新文献_第3页

Senescence in Aging, Within the Brain and Other Diseases: Mechanisms and Interventions 衰老、脑内和其他疾病中的衰老:机制和干预

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-06-13 DOI: 10.14218/erhm.2023.00018

S. Chakrabarti, D. Chattopadhyay

引用次数: 0

The Association between Consumption of Bitter-taste Vegetables in Asian Culture and Metabolic Syndrome Risk Factors in Children: A Narrative Review 亚洲文化中食用苦味蔬菜与儿童代谢综合征危险因素的关系:一项叙述性综述

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-06-09 DOI: 10.14218/erhm.2022.00129

W. Yang, Kah Yen Lim, Pei-Ling Yen, S. Ong, N. Naumovski, R. Jani

{"title":"The Association between Consumption of Bitter-taste Vegetables in Asian Culture and Metabolic Syndrome Risk Factors in Children: A Narrative Review","authors":"W. Yang, Kah Yen Lim, Pei-Ling Yen, S. Ong, N. Naumovski, R. Jani","doi":"10.14218/erhm.2022.00129","DOIUrl":"https://doi.org/10.14218/erhm.2022.00129","url":null,"abstract":"Childhood obesity has been escalating in Asian countries in recent decades resulting in the younger age groups being diagnosed with metabolic syndrome (MetS). Brassicaceae vegetables that contain high bioactive compounds with anti-inflammatory and anti-oxidative properties might be beneficial in preventing MetS. This narrative review presents; (a) the consumption of vegetables in the world population and the availability of bitter-taste vegetables in Asian culture; (b) the interaction between food preference and childhood obesity and (c) potential associations between the consumption of bitter-taste vegetables in Asian culture and clinical outcomes. A number of online searches were conducted for publications in the English language from the year 1990 until October 2022 with a two-step search strategy adopted: initial searches were conducted in four electronic databases (MEDLINE, CINAHL, EMBASE, and Cochrane Library), and a second search using all identified keywords and indexes by including two additional electronic databases (ProQuest and Scopus). The keywords included “bitter”; “vegetables”; “weight status”; “metabolic profile”, “Asia”, “culture”, and “children”. Brassica vegetables in Asian countries are abundantly available and commonly consumed, yet the overall vegetable intake in children was inadequate or below the recommended daily intake. Childhood obesity can be influenced by their preference for and consumption of bitter-taste vegetables, and excessive body weight is associated with the risk of developing MetS. It remains inconclusive whether brassicas vegetables play a dominant role in the group. Future longitudinal studies to investigate the taste sensitivity, vegetable acceptance, and effect of brassicas vegetables on the risk of MetS in Asian children are warranted.","PeriodicalId":12074,"journal":{"name":"Exploratory Research and Hypothesis in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91381132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clampless Beating Heart Mitral Valve Replacement in Dilated Cardiomyopathy 扩张型心肌病无夹钳搏动心脏二尖瓣置换术

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-06-08 DOI: 10.14218/erhm.2023.00024

A. Boukhmis, Mohammed El-Amin Nouar, K. Khacha, Yacine Djouaher

{"title":"Clampless Beating Heart Mitral Valve Replacement in Dilated Cardiomyopathy","authors":"A. Boukhmis, Mohammed El-Amin Nouar, K. Khacha, Yacine Djouaher","doi":"10.14218/erhm.2023.00024","DOIUrl":"https://doi.org/10.14218/erhm.2023.00024","url":null,"abstract":"Patients with secondary mitral regurgitation (SMR), the majority of which is ischemic, often have atherosclerotic ascending aorta and left ventricular (LV) dysfunction. In these patients, restrictive mitral annuloplasty is associated with a high rate of MR recurrence, aortic cross-clamping increases the stroke rate, and cardioplegic arrest increases postoperative low cardiac output syndrome. To avoid these complications, beating heart mitral valve replacement without aortic cross-clamping has been proposed. Here, we describe two male patients, aged 71 and 54 years, with severe SMR and low left ventricle ejection fraction (LVEF) (24% and 30%, respectively). Beating-heart mitral valve replacement with total chordal sparing was performed without aortic cross-clamping through a full sternotomy. Weaning from cardiopulmonary bypass was easily achieved without use of inotropes. The duration of mechanical ventilation (3 and 6 hours, respectively) and intensive care (24 and 48 hours, respectively) was short. Neither patients presented with postoperative neurological disorders. After a mean follow-up of 66 months, both patients were asymptomatic, without prosthetic valve dysfunction, and their LVEF reached 42% and 51%, respectively. This cases study indicates that for patients with SMR with impaired LV function who are at high risk for cardioplegic arrest, clampless beating heart mitral valve replacement with total preservation of the subvalvular apparatus could reduce stroke incidence, preserve peri-operative LVEF, and allow reverse LV remodeling.","PeriodicalId":12074,"journal":{"name":"Exploratory Research and Hypothesis in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79299087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 2 Diabetes: Is it Time to Target β-cell Heterogeneity? 2型糖尿病:是时候瞄准β细胞异质性了吗?

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-05-19 DOI: 10.14218/erhm.2023.00028

M. Balasubramanyam

引用次数: 0

Qingfei Paidu Decoction Inhibits LPS-induced Acute Lung Injury by Targeting the Complement Pathway 清肺排毒汤通过补体途径抑制lps诱导的急性肺损伤

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-05-11 DOI: 10.14218/erhm.2022.00127

Dandan Shi, Luna Ge, Lei Yan, Yuang Zhang, Ting Wang, Yun Geng, H. Fan, Ruojia Zhang, Zhurui Shao, Longjie Hu, Jianli Zhao, Shufeng Li, Yi Li, Haojun Shi, Jihong Pan, G. Song, Lin Wang

引用次数: 0

Anemia: A Potential Source of Bias in Clinical Trials of Angiogenesis Inhibitors: A Hypothesis 贫血:血管生成抑制剂临床试验的潜在偏倚来源:一个假设

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-05-11 DOI: 10.14218/erhm.2023.00013

R. Rastmanesh

{"title":"Anemia: A Potential Source of Bias in Clinical Trials of Angiogenesis Inhibitors: A Hypothesis","authors":"R. Rastmanesh","doi":"10.14218/erhm.2023.00013","DOIUrl":"https://doi.org/10.14218/erhm.2023.00013","url":null,"abstract":"Although anemia may cause angiogenesis and neovascularization, especially in ocular situations, neither published nonran-domized clinical trials nor registered clinical trials have reported the anemia status as inclusion or exclusion criteria in their design. Increases in the circulating levels of erythropoietin and vascular endothelial growth factor are proportional to the levels of tissue hypoxia, which are influenced by hematocrit. Erythropoietin is a potent retinal angiogenic factor that is independent of endothelial growth factor and is capable of stimulating ischemia-induced retinal angiogenesis. We suggest that clinical trials investigating anti-vascular endothelial growth factor treatment for retinal neovascularization should measure appropriate variables such as serum erythropoietin, vascular endothelial growth factor, hemoglobin, and hematocrit to yield preliminary data for future trials of angiogenesis inhibitors. Ignoring the anemia status, serum erythropoietin, and/or vascular endothelial growth factor levels could create clinical uncertainty and subtle statistical bias in both systematic reviews and nonrandomized clinical trials that aim to evaluate the efficiency of angiogenesis inhibitors in several medical situations, including but not limited to ocular alterations, rheumatoid arthritis, and many types of cancer, just to mention a few. Implications of this type of bias could be involved in other disease situations in which angiogenesis inhibitors are used for medication, such as different carcinomas as well as metastases. In this hypothesis paper, we suggest that clinical trials of angiogenesis inhibitors should measure appropriate variables such as serum erythropoietin, hemoglobin, and hematocrit and match their participants by anemia and its severity to avoid a game-changing bias in their data analysis.","PeriodicalId":12074,"journal":{"name":"Exploratory Research and Hypothesis in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84011920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Crosstalk Between Vitamin D and Non-alcoholic Fatty Liver Disease 维生素D与非酒精性脂肪肝之间的分子串扰

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-05-11 DOI: 10.14218/erhm.2023.00019

Subendu Sarkar

{"title":"Molecular Crosstalk Between Vitamin D and Non-alcoholic Fatty Liver Disease","authors":"Subendu Sarkar","doi":"10.14218/erhm.2023.00019","DOIUrl":"https://doi.org/10.14218/erhm.2023.00019","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease. The worldwide increasing prevalence of NAFLD has become a cause of concern for clinicians. Furthermore, the molecular mechanism of NAFLD pathogenesis remains poorly understood. Moreover, therapeutic interventions are presently limited. Balanced diet, physical exercise and lifestyle modifications have been recommended. Several studies have revealed that vitamin D deficiency is correlated with NAFLD, and it’s supplementation may play a vital role in this regard. Sufficient information was obtained from full articles written in the English language, and accessible in PubMed, Google Scholar, Web of Science, and Scopus. The increasing prevalence of vitamin D deficiency remains as a global health risk factor, and this is linked to NAFLD pathogenesis. In vitro and in vivo studies, and clinical trials have revealed the beneficial role of vitamin D supplementation to control NAFLD. Vitamin D potentially regulates the molecular pathways associated with NAFLD risk factors, such as obesity, insulin resistance, and diabetes. It acts on adipocytes to control free fatty acid (FFA) trafficking, lipogenesis, and inflammation. Similarly, vitamin D acts on hepatocytes to reduce de novo lipogenesis and cellular FFA trafficking. Furthermore, it acts on pancreatic β-cells to im - prove insulin secretion, cell survival, and cellular functions. Vitamin D supplementation improves glucose uptake and insulin sensitivity. In addition, it decreases inflammation and liver injury, and acts on mitochondria to control reactive oxygen species (ROS)-mediated cellular toxicity. Vitamin D deficiency is a major risk factor for NAFLD pathogenesis. Thus, there is an urgent need to conduct molecular level analysis for further discernments","PeriodicalId":12074,"journal":{"name":"Exploratory Research and Hypothesis in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77246047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Site Infections: Prevalence, Economic Burden, and New Preventive Recommendations 手术部位感染:流行、经济负担和新的预防建议

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-04-24 DOI: 10.14218/erhm.2023.00010

Gülseren Maraş, Y. Sürme

引用次数: 0

Cortical Brain Response to Acute Bouts of Exercise in Patients with Severe Psychiatric Disorders: Report of Three Cases 重度精神疾病患者急性运动时皮质脑反应:附3例报告

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-04-13 DOI: 10.14218/erhm.2023.00011

R. Monteiro-Júnior, Iaggo Raphael David, Iara Heloísa Ramos Mendes, Luciana Aparecida Coutinho, Biancart José Monteiro Júnior, H. N. Oliva

引用次数: 2

The Origin of BPH and Prostate Cancer in Different Prostate Zones and the Impact on the Incidence of Prostate Cancer: A Systematic Review and Update of the Literature for Urologists and Clinicians 不同前列腺区域的前列腺增生和前列腺癌的起源及其对前列腺癌发病率的影响:泌尿科医生和临床医生文献的系统回顾和更新

Exploratory Research and Hypothesis in Medicine Pub Date : 2023-03-30 DOI: 10.14218/erhm.2022.00120

Jake Sellers, Sarah Neal Secrest Horne, W. D. de Riese

引用次数: 0