Exploratory Research and Hypothesis in Medicine最新文献_第10页

Pyroptosis in Myocardial Ischemia/Reperfusion Injury: Role of Endoplasmic Reticulum Stress and STING-IRF3 Pathway 心肌缺血/再灌注损伤中的焦亡:内质网应激和STING-IRF3通路的作用

Exploratory Research and Hypothesis in Medicine Pub Date : 2022-02-15 DOI: 10.14218/erhm.2021.00052

Tuo Han, Tingting Zhang, Yajie Fan, Congxia Wang, Yan Zhang

引用次数: 2

Transient Elastography Research Hotspots and Frontiers in Nonalcoholic Fatty Liver Disease: A Bibliometric Study Using CiteSpace 非酒精性脂肪肝瞬态弹性成像研究热点与前沿:基于CiteSpace的文献计量学研究

Exploratory Research and Hypothesis in Medicine Pub Date : 2022-02-14 DOI: 10.14218/erhm.2021.00064

G. Feng, N. He, Qin-qin Yan, Ke Wang, Rong Li, Xiu-Ting Tan, M. Mi

引用次数: 1

Can Regular Exercise Before COVID-19 Disease Upregulate ACE2 and Downregulate TMPRSS2 in Patient’s Cells? COVID-19疾病前的定期运动是否能上调患者细胞中的ACE2并下调TMPRSS2 ?

Exploratory Research and Hypothesis in Medicine Pub Date : 2022-02-10 DOI: 10.14218/erhm.2021.00055

Keivan Gadruni

引用次数: 0

Infection Pattern, Treatment Protocols and Post-COVID-19 Complications–A Survey on 706 COVID-19 Recovered Participants 706名新冠肺炎康复者感染模式、治疗方案及术后并发症调查

Exploratory Research and Hypothesis in Medicine Pub Date : 2022-01-18 DOI: 10.14218/erhm.2021.00069

R. Semwal, Ankit Kumar, A. Chauhan, R. Semwal, Navin Joshi, S. Joshi, D. Semwal

{"title":"Infection Pattern, Treatment Protocols and Post-COVID-19 Complications–A Survey on 706 COVID-19 Recovered Participants","authors":"R. Semwal, Ankit Kumar, A. Chauhan, R. Semwal, Navin Joshi, S. Joshi, D. Semwal","doi":"10.14218/erhm.2021.00069","DOIUrl":"https://doi.org/10.14218/erhm.2021.00069","url":null,"abstract":"Background and objectives: The pandemic of coronavirus disease 2019 (COVID-19) has killed millions of people globally and has severely affected quality of life and global economy. The present randomized survey aimed to collect information based on vaccination, symptoms, treatments, and post-COVID-19 complications from participants that recovered from COVID-19 to find out the disease pattern, trends, and effective treatment protocols. Methods: The information from participants was collected by an online questionnaire that was circulated among the population of India through emails and social media. Results: A total of 706 responses were recorded from participants that recovered from COVID-19 from 20 Indian states. Males and females from all age groups took part in the online survey. Among them, 77% of the participants were not vaccinated and 17% were vaccinated with a single dose and 6% with a booster dose. An average of 27% of the total vaccinated participants had a comorbidity that included diabetes, hypertension, and pulmonary disease. Most of the patients with moderate to severe symptoms preferred allopathic treatment. The adoption level of allopathic treatment was significantly higher ( p = 0.001) than other treatment options. The results showed that 12% of the patients adopted the Ayurvedic treatment and 14% preferred a mixed treatment. Approximately one-third of the participants had various post-COVID-19 complications that were related to breathing and anxiety. Conclusions: The survey concluded that","PeriodicalId":12074,"journal":{"name":"Exploratory Research and Hypothesis in Medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78320583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effectiveness of Combined Extracorporeal Shockwave Therapy and Exercise for Plantar Heel Pain: A Systematic Review 体外冲击波联合运动治疗足底跟痛的疗效:系统综述

Exploratory Research and Hypothesis in Medicine Pub Date : 2022-01-12 DOI: 10.14218/erhm.2021.00059

Ian Burton, Aisling McCormack

{"title":"The Effectiveness of Combined Extracorporeal Shockwave Therapy and Exercise for Plantar Heel Pain: A Systematic Review","authors":"Ian Burton, Aisling McCormack","doi":"10.14218/erhm.2021.00059","DOIUrl":"https://doi.org/10.14218/erhm.2021.00059","url":null,"abstract":"<abstract><p>Plantar heel pain (PHP) is a common musculoskeletal disorder that is effectively treated with extracorporeal shockwave therapy (ESWT) and exercise. This review aimed to evaluate the effectiveness of combined ESWT and exercise versus other interventions in treating PHP. A systematic review of effectiveness was conducted, adhering to the PRISMA guidelines. Five databases were searched for studies published between January 2000 and September 2021 with 12 studies (n = 861) meeting the inclusion criteria, which compared ESWT and stretching to various other treatments. High-quality evidence indicates that combined ESWT and stretching interventions are more effective than their individual use or botulinum toxin injections, and low-quality evidence of superiority versus ultrasound and stretching. There was moderate quality evidence that combined ESWT and stretching is no more effective than corticosteroid injection, and high-quality evidence that the combination is no more effective than blood-derived injection therapies, custom orthotics, or low-level laser therapy combined with stretching. There is high-quality evidence that topical corticosteroid or laser therapy in combination with ESWT and stretching increases its effectiveness and moderate-quality evidence for the additive effective of dry needling. Overall, combined ESWT and stretching treatments are effective and may be recommended where they are available and practical to implement. Further high-quality studies comparing combined interventions for PHP, including different exercise activities like resistance training, are required. <i>PROSPERO registration number</i>: CRD42020213286</p></abstract>","PeriodicalId":12074,"journal":{"name":"Exploratory Research and Hypothesis in Medicine","volume":"12 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138509145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Possible Natural and Artificial Collective Immunity on New COVID-19 Pandemic Waves in Ukraine and Israel 可能的自然和人工集体免疫对乌克兰和以色列新冠肺炎大流行浪潮的影响

Exploratory Research and Hypothesis in Medicine Pub Date : 2021-11-11 DOI: 10.14218/erhm.2021.00044

I. Nesteruk

{"title":"Influence of Possible Natural and Artificial Collective Immunity on New COVID-19 Pandemic Waves in Ukraine and Israel","authors":"I. Nesteruk","doi":"10.14218/erhm.2021.00044","DOIUrl":"https://doi.org/10.14218/erhm.2021.00044","url":null,"abstract":"Background and objectives: The percentage of vaccinated people in Ukraine and Israel extensively varies. Based on this large difference, the influence of possible collective immunity on the COVID-19 pandemic dynamics in summer 2021 was evaluated. Methods: To clarify the presence of a natural collective immunity, the visible and actual characteristics the COVID-19 epidemic in Ukraine were estimated based on the number of laboratory-confirmed cases (accumulated in May and June 2021), using a generalized SIR-model and parameter identification procedure, and considering the difference between registered and real number of cases. Results: The calculated optimal value of the visibility coefficient shows that most Ukrainians have already been infected with coronavirus, some of whom have been infected more than once. This suggests that Ukrainians have probably achieved a natural collective immunity. Despite the large percentage of fully vaccinated people in Israel (approximately 60%), the emergence of a new epidemic wave after June 15, 2021 was not prevented, and the number of deaths increased after July 5, 2021. A new wave of the pandemic in Ukraine after July 10, 2021 is characterized by a smaller daily number of new COVID-19 cases per capita and new deaths per capita, despite having a much lower number of vaccinated people than in Israel. This can be explained by a much lower level of testing (many cases in Ukraine remain undetected) and possibly by the probable natural immunity of Ukrainians. Conclusions: High levels of vaccination and natural collective immunity are unlikely to prevent new waves of the COVID-19 pandemic caused by mutated coronavirus strains.","PeriodicalId":12074,"journal":{"name":"Exploratory Research and Hypothesis in Medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78771646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Fructose Metabolism and Acute Myeloid Leukemia 果糖代谢与急性髓性白血病

Exploratory Research and Hypothesis in Medicine Pub Date : 2021-11-01 DOI: 10.14218/erhm.2021.00042

Rina Kansal

引用次数: 1

miR-34a/SIRT1 Axis Plays a Critical Role in Regulating Chondrocyte Senescence in Type 2 Diabetes Mellitus miR-34a/SIRT1轴在2型糖尿病软骨细胞衰老调控中起关键作用

Exploratory Research and Hypothesis in Medicine Pub Date : 2021-10-11 DOI: 10.14218/erhm.2021.00029

Debang Li, F. Gao, Chunyan Wu, Zu-jian Liang, Wenju Xiong

引用次数: 1

Arthroscopic Treatment of Atypical Synovial Osteochondromatosis of Infrapatellar Fat Pad: A 4-Year Follow-up Case Report and Literature Review 关节镜治疗髌下脂肪垫不典型滑膜骨软骨瘤病:4年随访病例报告及文献复习

Exploratory Research and Hypothesis in Medicine Pub Date : 2021-09-17 DOI: 10.14218/erhm.2021.00035

Zhibiao Bai, Haibo Zhou, Chao Zhang, Chun Chen

引用次数: 0

Role of Yes-associated Protein-1 in Gastrointestinal Cancers and Hepatocellular Carcinoma. yes相关蛋白-1在胃肠道肿瘤和肝细胞癌中的作用

Exploratory Research and Hypothesis in Medicine Pub Date : 2021-09-01 Epub Date: 2021-06-08 DOI: 10.14218/ERHM.2021.00017

Xia Qian, Wei Zhang, Hua Yang, Lanjing Zhang, Ningling Kang, Jinping Lai

引用次数: 2