{"title":"Age-related differential effects of zinc on concanavalin A-induced capping of human lymphocytes.","authors":"K M Rao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Con A-induced capping of lymphocytes is altered by a number of cytoskeletal modulating agents. Zinc, in the presence of colchicine, demonstrated an age-dependent differential effect on con A-induced capping of human peripheral blood lymphocytes. In general, zinc enhanced capping of lymphocytes from young individuals and suppressed from those of old individuals. The effect of zinc on the cap formation adds further support to the evidence that zinc might be acting on the microfilaments. However, cytochalasin B, another microfilament modulating agent, does not show a differential effect similar to zinc. This suggests that zinc might modify microfilament formation or function in a manner different from cytochalasin B. The proposal that the effects of zinc might be due to its action on calmodulin suggests that calmodulin, the calcium regulating protein, may have a role in the physiological processes associated with aging. Further studies in this area might yield fruitful results in our understanding of the molecular mechanism of senescence.</p>","PeriodicalId":12073,"journal":{"name":"Experimental Gerontology","volume":"17 3","pages":"205-11"},"PeriodicalIF":3.9,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18154958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Author index to volume 22","authors":"","doi":"10.1081/CAR-120028478","DOIUrl":"https://doi.org/10.1081/CAR-120028478","url":null,"abstract":"","PeriodicalId":12073,"journal":{"name":"Experimental Gerontology","volume":"22 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"1974-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/CAR-120028478","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60993000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A M Fedorcáková, E Bachledová, T R Niederland, A Bózner
{"title":"Some organ changes in old and young rats after a pathogenic diet.","authors":"A M Fedorcáková, E Bachledová, T R Niederland, A Bózner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12073,"journal":{"name":"Experimental Gerontology","volume":"3 1","pages":"62-7"},"PeriodicalIF":3.9,"publicationDate":"1968-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16771649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. R. D. Leeuw-Israel, J. M. Arp-Neefjes, C. F. Hollander
{"title":"Quantitative determination of albumin in microlitre amounts of rat serum: With a short note on serum albumin levels in ageing rats","authors":"F. R. D. Leeuw-Israel, J. M. Arp-Neefjes, C. F. Hollander","doi":"10.1016/0531-5565(67)90023-X","DOIUrl":"https://doi.org/10.1016/0531-5565(67)90023-X","url":null,"abstract":"","PeriodicalId":12073,"journal":{"name":"Experimental Gerontology","volume":"2 1","pages":"255-260"},"PeriodicalIF":3.9,"publicationDate":"1967-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0531-5565(67)90023-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54222579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endocrine aspects of ageing in the guppy, Lebistes reticulatus (Peters)—II. The interrenal gland","authors":"A. Woodhead, S. Ellett","doi":"10.1016/0531-5565(66)90015-5","DOIUrl":"https://doi.org/10.1016/0531-5565(66)90015-5","url":null,"abstract":"","PeriodicalId":12073,"journal":{"name":"Experimental Gerontology","volume":"1 1","pages":"159-171"},"PeriodicalIF":3.9,"publicationDate":"1966-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0531-5565(66)90015-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54222207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}