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Abstract P074: MB097: A therapeutic consortium of bacteria clinically-defined by precision microbiome profiling of immune checkpoint inhibitor patients with potent anti-tumor efficacy in vitro and in vivo 摘要P074: MB097:一种由免疫检查点抑制剂患者的精确微生物组谱临床定义的治疗性细菌联合体，在体外和体内具有强大的抗肿瘤功效
Other Topics Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-p074
M. Robinson, K. Vervier, Simon Harris, A. Popple, D. Klisko, Robyn Hudson, G. Bakdash, Laure Castan, C. Villemin, David John Adams, Doreen Milne, C. Booth, C. Parkinson, R. Rabbie, S. Welsh, E. Barker, K. Dalchau, P. Corrie, T. Lawley
{"title":"Abstract P074: MB097: A therapeutic consortium of bacteria clinically-defined by precision microbiome profiling of immune checkpoint inhibitor patients with potent anti-tumor efficacy in vitro and in vivo","authors":"M. Robinson, K. Vervier, Simon Harris, A. Popple, D. Klisko, Robyn Hudson, G. Bakdash, Laure Castan, C. Villemin, David John Adams, Doreen Milne, C. Booth, C. Parkinson, R. Rabbie, S. Welsh, E. Barker, K. Dalchau, P. Corrie, T. Lawley","doi":"10.1158/2326-6074.tumimm21-p074","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p074","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117185902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P068: Automated cell type specific PD-L1 quantification by artificial intelligence using high throughput bleach & stain 15-marker multiplex fluorescence immunohistochemistry in human cancers P068:人工智能高通量漂白剂&染色15标记多重荧光免疫组织化学在人类癌症中自动定量细胞类型特异性PD-L1
Other Topics Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-p068
N. Blessin, E. Bady, T. Mandelkow, Cheng Yang, J. Raedler, R. Simon, C. Fraune, M. Lennartz, S. Minner, E. Burandt, D. Höflmayer, G. Sauter, K. Möller, S. Weidemann
{"title":"Abstract P068: Automated cell type specific PD-L1 quantification by artificial intelligence using high throughput bleach & stain 15-marker multiplex fluorescence immunohistochemistry in human cancers","authors":"N. Blessin, E. Bady, T. Mandelkow, Cheng Yang, J. Raedler, R. Simon, C. Fraune, M. Lennartz, S. Minner, E. Burandt, D. Höflmayer, G. Sauter, K. Möller, S. Weidemann","doi":"10.1158/2326-6074.tumimm21-p068","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p068","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125595079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-045: Targeting HNF1A-dependent cell proliferation and stemness in PDAC using BET inhibitors PO-045:利用BET抑制剂靶向hnf1a依赖性细胞在PDAC中的增殖和干细胞性
Other Topics Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-045
Bharani Muppavarapu, Ethan V. Abel, Melanie M. Mayberry
{"title":"Abstract PO-045: Targeting HNF1A-dependent cell proliferation and stemness in PDAC using BET inhibitors","authors":"Bharani Muppavarapu, Ethan V. Abel, Melanie M. Mayberry","doi":"10.1158/1538-7445.panca21-po-045","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-045","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127232265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-054: A phase II trial of the super-enhancer inhibitor Minnelide in advanced refractory adenosquamous carcinoma of the pancreas (ASCP) PO-054:超增强抑制剂Minnelide治疗晚期难治性胰腺腺鳞癌(ASCP)的II期临床试验
Other Topics Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-054
Nebojsa Skorupan, M. Ahmad, S. Steinberg, J. Trepel, D. Cridebring, Haiyong Han, D. V. Von Hoff, C. Alewine
{"title":"Abstract PO-054: A phase II trial of the super-enhancer inhibitor Minnelide in advanced refractory adenosquamous carcinoma of the pancreas (ASCP)","authors":"Nebojsa Skorupan, M. Ahmad, S. Steinberg, J. Trepel, D. Cridebring, Haiyong Han, D. V. Von Hoff, C. Alewine","doi":"10.1158/1538-7445.panca21-po-054","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-054","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126170198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Abstract PO-049: Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit anti-tumor immunity PO-049:抑制MNK激酶促进巨噬细胞免疫抑制表型，限制抗肿瘤免疫
Other Topics Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-049
Thao N. D. Pham, Christina Spaulding, M. Shields, Mahmoud G. Khalafalla, D. Principe, D. Bentrem, H. Munshi
{"title":"Abstract PO-049: Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit anti-tumor immunity","authors":"Thao N. D. Pham, Christina Spaulding, M. Shields, Mahmoud G. Khalafalla, D. Principe, D. Bentrem, H. Munshi","doi":"10.1158/1538-7445.panca21-po-049","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-049","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131815064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract IA-007: The KPC model has helped advance pancreatic cancer therapy: Agree IA-007: KPC模型有助于推进胰腺癌治疗:同意
Other Topics Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-ia-007
K. Olive
{"title":"Abstract IA-007: The KPC model has helped advance pancreatic cancer therapy: Agree","authors":"K. Olive","doi":"10.1158/1538-7445.panca21-ia-007","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-ia-007","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132905166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-043: Cytidine deaminase protects pancreatic cancer cells from replicative stress and drive response to DNA-targeting drugs PO-043:胞苷脱氨酶保护胰腺癌细胞免受复制应激并驱动对dna靶向药物的反应
Other Topics Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-043
A. Lumeau, N. Bery, C. Ribeyre, S. Elkaoutari, G. Labrousse, M. Madrid-Mencía, V. Pancaldi, M. Pillaire, V. Bergoglio, Nelson Dusseti, J. Hoffmann, L. Buscail, M. Lutzmann, P. Cordelier
{"title":"Abstract PO-043: Cytidine deaminase protects pancreatic cancer cells from replicative stress and drive response to DNA-targeting drugs","authors":"A. Lumeau, N. Bery, C. Ribeyre, S. Elkaoutari, G. Labrousse, M. Madrid-Mencía, V. Pancaldi, M. Pillaire, V. Bergoglio, Nelson Dusseti, J. Hoffmann, L. Buscail, M. Lutzmann, P. Cordelier","doi":"10.1158/1538-7445.panca21-po-043","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-043","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117329620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-052: A pilot study of miRNA expression profile in surgically resected pancreatic ductal adenocarcinoma: Initial report from a bi-institutional cohort PO-052:手术切除胰腺导管腺癌中miRNA表达谱的初步研究:来自双机构队列的初步报告
Other Topics Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-052
L. Pompella, Michela Falco, Carlo Caputo, A. Grimaldi, G. Tirino, S. Campione, F. Sparano, M. Iacovino, Chiara Carmen Miceli, C. Molino, M. Montella, R. Franco, G. Galizia, G. Conzo, V. Napolitano, Annamaria Auricchio, F. Cardella, F. Ciardiello, M. Caraglia, A. Lombardi, G. Misso, F. De Vita
{"title":"Abstract PO-052: A pilot study of miRNA expression profile in surgically resected pancreatic ductal adenocarcinoma: Initial report from a bi-institutional cohort","authors":"L. Pompella, Michela Falco, Carlo Caputo, A. Grimaldi, G. Tirino, S. Campione, F. Sparano, M. Iacovino, Chiara Carmen Miceli, C. Molino, M. Montella, R. Franco, G. Galizia, G. Conzo, V. Napolitano, Annamaria Auricchio, F. Cardella, F. Ciardiello, M. Caraglia, A. Lombardi, G. Misso, F. De Vita","doi":"10.1158/1538-7445.panca21-po-052","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-052","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124723120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-039: Antiproliferative activity of inhibitors of RAD51, singly and in combination with chemotherapy drugs, against pancreatic cancer cell lines 摘要PO-039: RAD51抑制剂单独或联合化疗药物对胰腺癌细胞系的抗增殖活性
Other Topics Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-039
P. Ferguson, M. Vincent, Y. Najajreh, B. Shilton, Stephen Ritter, R. Al-Awar, R. Marcellus, M. Mohammed, M. Isaac, James Koropatnnick
{"title":"Abstract PO-039: Antiproliferative activity of inhibitors of RAD51, singly and in combination with chemotherapy drugs, against pancreatic cancer cell lines","authors":"P. Ferguson, M. Vincent, Y. Najajreh, B. Shilton, Stephen Ritter, R. Al-Awar, R. Marcellus, M. Mohammed, M. Isaac, James Koropatnnick","doi":"10.1158/1538-7445.panca21-po-039","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-039","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129992735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-046: The effect of neoadjuvant therapy on immune profiling of pancreatic ductal adenocarcinoma: A prospective study of the PREOPANC-1 randomized controlled trial 摘要PO-046:新辅助治疗对胰腺导管腺癌免疫谱的影响:preopac -1随机对照试验的前瞻性研究
Other Topics Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-046
D. Latifi, W. de Koning, S. P. Lau, F. Grevers, C. van Dam, C. V. van Eijck, D. Mustafa
{"title":"Abstract PO-046: The effect of neoadjuvant therapy on immune profiling of pancreatic ductal adenocarcinoma: A prospective study of the PREOPANC-1 randomized controlled trial","authors":"D. Latifi, W. de Koning, S. P. Lau, F. Grevers, C. van Dam, C. V. van Eijck, D. Mustafa","doi":"10.1158/1538-7445.panca21-po-046","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-046","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132280335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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