European journal of rheumatology最新文献

{"title":"Gingival Involvement in IgG4-Related Disease.","authors":"Sarah Al Qassimi, Rajaie Namas, Ahmed Alduaij, Anastasios Hantzakos, Mahdi Shkoukani","doi":"10.5152/eurjrheum.2025.25023","DOIUrl":"10.5152/eurjrheum.2025.25023","url":null,"abstract":"","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 3","pages":"1-2"},"PeriodicalIF":1.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12607665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstitial Lung Disease Associated with Autoimmune Rheumatic Diseases: An Experience from Türkiye.","authors":"Cemal Bes, Fatih Yildirim, Ramazan Eren, Şerife Ulusan, Rabia Deniz, Bilgin Karaalioglu, Duygu Sevinç Ozgur, Gamze Akkuzu, Barış Demirkol, Mustafa Kağan Erener, Melek Yalçın Mutlu, Erdoğan Çetinkaya","doi":"10.5152/eurjrheum.2025.24117","DOIUrl":"10.5152/eurjrheum.2025.24117","url":null,"abstract":"<p><p>Objective: Interstitial lung disease (ILD) is one of the most challenging involvement of autoimmune rheumatic diseases (ARDs) and could lead to significant morbidity and mortality. In this article, a collaborative work of tertiary rheumatology and pulmonology centers describing demographic, serological, and radiological findings of patients with ARD associated with ILD (ARD-ILD) is presented. Methods: A descriptive, retrospective study, and data related to demographics, clinical, laboratory, radiologic, or histopathological findings of ILD were collected from the study participants' charts. Results: Around 212 patients with ARD-ILD were evaluated. Of the patients, 172 (81.1%) were female and 40 (18.9%) were male. The distribution of the rheumatic diseases was as follows: systemic sclerosis in 114 (53.8%), rheumatoid arthritis in 47 (22.2%), Sjögren's syndrome in 14 (6.6%), inflammatory myopathy in 16 (7.5%) patients, interstitial pneumonia with autoimmune features (IPAF) in 9 (4%) patients, undifferentiated connective tissue disease in 8 (3.8%), and systemic lupus erythematosus in 4 (1.9%). According to the radiological patterns, 71.7% of the patients had nonspecific interstitial pneumonia (NSIP), 13.7% had definite usual interstitial pneumonia (UIP), 8.5% had probable UIP, 3.8% had lymphocytic interstitial pneumonia, 1.9% had organizing pneumonia, and 0.5% had an atypical pattern. Conclusion: This study showed that the most common rheumatic disease causing ILD is still systemic sclerosis, and NSIP is more prominent as a radiological pattern. IPAF, a disease that has entered the literature in recent years, is also an important type of ILD. Given the multisystemic involvement of ARDs, collaboration among different disciplines is undoubtedly crucial in the diagnosis and management of these diseases.</p>","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 3","pages":"1-6"},"PeriodicalIF":1.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aseptic Abscess Associated with Ankylosing Spondylitis-Cause or Effect of Therapy? Case Report.","authors":"Przemysław Borowy, Karol Urbański, Katarzyna Gołojuch, Patrycja Major, Jakub Smyk, Alicja Kamińska, Bogdan Batko, Joanna Szpor","doi":"10.5152/eurjrheum.2025.24079","DOIUrl":"10.5152/eurjrheum.2025.24079","url":null,"abstract":"<p><p>Neutrophil dermatitis is a group of diseases characterized by the leakage of neutrophils in the skin and subcutaneous tissue with a non-infectious, autoinflammatory etiology. These include the aseptic abscess syndrome (AA). Diagnosis is based on histopathological examination and the exclusion of infectious, allergic, and cancer causes. The paper presents the case of a 41-year-old woman with inflammatory spondyloarthropathy (HLA-B27 antigen present), treated with secukinumab, who developed a painful, inflammatory tumor in her right breast. Antibiotic treatment was ineffective, and histopathological exami- nation detected leaching mainly from granulocytes. Infectious and oncological background changes and IgG4+ disease were excluded. After the diagnosis was confirmed, glucocorticoid therapy was started, which brought rapid improvement, but after the dose was reduced, the tumor relapsed. The re-escalation of the steroid dose and the discontinuation of secukinumab coincided with the exacerbation of ankylos- ing spondylitis, which forced the inclusion of upadacitinib, which was effective and well tolerated. Single studies show high efficacy of TNF inhibitors as well as IL-6 or IL-1 blockades in the treatment of AA and sec- ondary prevention in patients with failed steroid therapy. There are no reports of AA cases in the literature during treatment with secukinumab. Treatment with upadacitinib has so far not caused AA recurrence.</p>","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 3","pages":"1-4"},"PeriodicalIF":1.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Phenotypic Similarities of Patients with Familial Behçet's Disease.","authors":"Kerem Abacar, Ayşe Elif Boncukcuoğlu, Rabia Deniz, Burcu Ceren Uludogan, Dilara Kaş, Elifnur Alkan, Gamzenur Kaya, Tuğçe Bozkurt, Nazife Şule Yaşar Bilge, Cemal Bes, Timuçin Kaşifoğlu, Dennis McGonagle, Tulin Ergun, Haner Direskeneli, Fatma Alibaz-Oner","doi":"10.5152/eurjrheum.2025.24116","DOIUrl":"10.5152/eurjrheum.2025.24116","url":null,"abstract":"<p><p>Background: Behçet's disease (BD) exhibits significant phenotypic diversity. The genetic basis of phenotypic variations in BD has not yet been elucidated. Based on the high frequency of familial BD, we aimed to analyze the familial aggregation of various manifestations of BD in this study. Methods: Patients with BD from 3 Turkish tertiary rheumatology outpatient clinics were evaluated. Demographic and clinical characteristics of the familial group with either a first- or second-degree relative with BD and the non-familial group were compared. Afterward, patients in the familial disease group for 5 years or longer were divided into 2: an \"index patient\" and a \"first-degree relative patient\" and the presence of BD manifestations were compared between these 2 groups. Results: We identified 864 BD patients (mean age (SD): 47.9 (12) years, disease duration (SD): 83.7 (65.3) months) with 251 (29.1%) having a BD family history. Genital ulcers (P =.002) and papulopustular lesions (P < .001) were detected more frequently in the familial group. Also in the familial group, statistically significant correlations were detected between the index patient and the first-degree relativepatient in terms of erythema nodosum-like lesions (r: 0.398, P: .016), pathergy test positivity (r: 0.561, P: .002), peripheral joint involvement (r: 0.563, P < .001) and vascular involvement (r: 0.408, P: .014). Conclusion: Familial BD may differ from sporadic BD. Additionally, erythema nodosum-like lesions, pathergy test positivity, and vascular and joint involvement may tend to show familial aggregation.</p>","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 2","pages":"1-5"},"PeriodicalIF":1.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveitis in Psoriatic Arthritis: A Comprehensive Review.","authors":"Dimitrios Deligeorgakis, Elpida Skouvaklidou, Vasileios Skepastianos, Konstantinos Tsafis, Nikolaos Kougkas","doi":"10.5152/eurjrheum.2025.24078","DOIUrl":"10.5152/eurjrheum.2025.24078","url":null,"abstract":"<p><p>Psoriatic arthritis (PsA) belongs to the spectrum of spondyloarthritides, primarily affecting skin and joints. Apart from skin involvement, other extra-articular manifestations can coexist. Uveitis, although not very frequently encountered, is one of the most serious of them, necessitating prompt diagno- sis and proper treatment to prevent irreversible sight-threatening complications. Psoriatic arthritis related uveitis is usually unilateral, characterized by anterior segment inflammation, with the absence of redness or pain making it possible to miss the diagnosis. This review gives a comprehensive insight into the pathophysiology and clinical manifestations of PsA-related uveitis, along with an exposition of various epidemiologic features, as derived from relevant observational studies. Therapeutic approaches and available treatments are also reviewed. Although definitive recommendations on treatment seem rather challenging for PsA-related uveitis, tumor necrosis factor inhibitors appear to have the lead over other biologic therapies. A multi-disciplinary approach, tight screening, and disease activity control, as well as proper targeted therapy, remain pivotal.</p>","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 2","pages":"1-7"},"PeriodicalIF":1.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between the Monocyte-to-High-Density Lipoprotein-Cholesterol Ratio and Disease Activity in Patients with Psoriatic Arthritis.","authors":"Gizem Varkal, Ipek Türk, Ayşegül Yetişir, Özlem Doğan Ağbuga, Burak Mete, Süleyman Özbek","doi":"10.5152/eurjrheum.2025.24052","DOIUrl":"10.5152/eurjrheum.2025.24052","url":null,"abstract":"<p><p>Background: The aim of this cross-sectional study was to analyze the monocyte-tohigh-density lipoprotein ratio (MHR) as an inflammatory marker in patients with psoriatic arthritis (PsA) and healthy controls (HCs), as well as to determine the association between MHR and PsA severity. Methods: This cross-sectional study included patients with PsA (n= 66) and age and sex-matched HCs (n= 68). Sociodemographic data and laboratory parameters were recorded in the study group. Disease Activity in PSoriatic Arthritis (DAPSA) was used to assess disease activity, while the Health Assessment Questionnaire (HAQ) was used for general health assessments. Disease Activity in PSoriatic Arthritis and HAQ were evaluated in the patient group. We compared sociodemographic, laboratory parameters, and the MHR between patients with PsA and HCs. Factors influencing MHR were assessed by regression analysis. Results: Patients with PsA revealed increased MHR compared to HCs (P= .025). In regression analysis, a DAPSA score of 15 or higher results in a 3.08 unit rise in the MHR, compared to a DAPSA score of 14 or below. In individuals with coronary artery disease (CAD), MHR increases by 7.56 units. Patients with moderate-severe PsA (DAPSA ≥ 15) had significantly elevated levels of C-reactive protein, erythrocyte sedimentation rate, and MHR compared to patients with remission-mild PsA (DAPSA ≤ 14) (P < .001, <.001, .026, respectively). Conclusions: Monocyte-to-high-density lipoprotein ratio can be used as an inflammatory marker in the follow-up of patients with PsA. Patients with PsA without evidence of active disease should also be evaluated for CAD in the presence of a high MHR value.</p>","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 2","pages":"1-5"},"PeriodicalIF":1.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Report of the Immunogenicity of an Inactivated SARS-CoV-2 (COVID-19) Vaccine in Iranian Patients with Autoimmune Diseases.","authors":"Parmida Aminzadeh, Ava Hashempour, Shahab Falahi, Farimah Safari, Maryam Feili, Azra Kenarkoohi","doi":"10.5152/eurjrheum.2025.24057","DOIUrl":"10.5152/eurjrheum.2025.24057","url":null,"abstract":"<p><p>Background: Infectious diseases are responsible for considerable morbidity and mortality worldwide, and coronavirus disease 2019 (COVID-19) is one of these infections. Because of the substantial bur- den on the healthcare system, considerable efforts have been made to immunize the population against severe acute respiratory syndrome coronavirus 2 through vaccination. However, there are considerations regarding the efficacy of vaccines in autoimmune patients. The current study revealed the immunogenicity of inactivated COVID-19 vaccines among the Iranian population with rheumatic diseases. Methods: As the first report from Iran, in this descriptive cross-sectional study, 196 patients were sam- pled; 98 of whom had an autoimmune disease and 98 of whom served as controls. Blood samples were collected and tested with IgM and IgG ELISA kits for COVID-19 antibody (Ab) levels. Some demo- graphic characteristics were recorded. Results: This study revealed an Ab response after inactivated COVID-19 vaccination among 196 par- ticipants, including 98 healthy individuals and 98 autoimmune patients. Our analysis revealed that the case group had a profoundly lower percentage of IgG- and IgM-positive individuals, at 37.7% and 13.2%, respectively, than the control group, which had significantly greater percentages of IgG and IgM Abs, at 86.7% and 65.3%, respectively. Conclusion: Individuals with autoimmune conditions, especially women, presented considerable decreases in IgG levels after vaccination with the inactivated COVID-19 vaccine. It seems that those with autoimmune disorders may experience immune system fatigue, leading to lower Ab levels fol- lowing COVID-19 vaccination. Several potential factors, such as the use of immunosuppressive medi- cations, could explain the reduced Ab response after COVID-19 vaccination. As a result, individuals with compromised immune systems, including those with autoimmune disorders, should be closely monitored and prioritized for additional COVID-19 vaccine doses to improve protection. Furthermore, the possible effects of repeated vaccinations on immune exhaustion and reduced defense against microbial infections highlight the need for further research in this patient population. It can be con- cluded that special vaccine protocols for all kinds of vaccinations should be approved for patients with autoimmune diseases.</p>","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 2","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bromocriptine in Rheumatic Diseases: A Review.","authors":"Jozélio Freire de Carvalho, Ana Tereza Amoedo Martinez","doi":"10.5152/eurjrheum.2025.24080","DOIUrl":"10.5152/eurjrheum.2025.24080","url":null,"abstract":"<p><p>Hyperprolactinemia is frequent in rheumatic diseases. Bromocriptine (BRC) is an antagonist of pro- lactin and was studied in a few rheumatic diseases with controversial results. The aim of the present study was to review articles on BRC in rheumatic diseases. Articles on lupus, rheumatoid arthritis, pso- riatic arthritis (PsA), and reactive arthritis were found. Fourteen articles were found. In lupus, 5 articles evaluated BRC in a 2.5-7.5 mg/day dosage. The follow-up varied from 6 to 14 months. They showed improvement in lupus disease activity (Lupus Disease Activity Index or Lupus activity measure scores) in 4/5; a trend was verified in another article, 1/5, and one study evaluated improvement in the mood of the systemic lupus erythematosus patients. In RA, there are 4 articles with 119 patients. The BRC dosage ranged from 5 mg/day to 10 mg TID. About 2/4 of the articles showed improvements [morn- ing stiffness and Health Assessment Questionnaire (HAQ)], and 2/4 did not show any difference. Regarding PsA and reactive arthritis, 5 articles with 43 patients were found. The BRC dose varied from 2.5 to 30 mg/day. All studies showed improvements of the studied diseases. Side effects were mild and infrequent. In conclusion, BRC seems to be efficacious in a few rheumatic diseases (lupus, PsA, RA, and Reiter's), with mild side effects. Future studies with a larger number of participants and in other rheumatic diseases are needed.</p>","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 2","pages":"1-5"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plantar Fibromatosis/Fascitis in Ankylosing Spondylitis: Why/Where to Inject?","authors":"Berkay Yalçınkaya, Ahmet Furkan Çolak, Murat Kara, Levent Özçakar","doi":"10.5152/eurjrheum.2025.24112","DOIUrl":"10.5152/eurjrheum.2025.24112","url":null,"abstract":"","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 2","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construct Validity and Reliability of the 2-Minute Step Test in Patients with Fibromyalgia.","authors":"Büşra Şirin Ahısha, Nurdan Paker, Fatma Nur Kesiktaş, Derya Buğdaycı, Yelda Soluk Özdemir","doi":"10.5152/eurjrheum.2025.24051","DOIUrl":"10.5152/eurjrheum.2025.24051","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was primarily to assess the validity and reliability of the 2-minute step test (2MST) in patients with fibromyalgia; and secondly, to explore its relationship with the 2-minute walk test (2MWT), the 6-minute walk test (6MWT), as well as fatigue severity and quality of life.</p><p><strong>Methods: </strong>This cross-sectional study involved 55 female patients aged 18-65 diagnosed with fibromyalgia according to the American College of Rheumatology 2010 Diagnostic Criteria. Pain intensity was measured using the Visual Analog Scale, quality of life impact was assessed with the Fibromyalgia Impact Questionnaire, and fatigue severity was evaluated using the Fatigue Severity Scale. Patients underwent initial assessments using the 2MST, 2MWT, and 6MWT. Test-retest reliability of the 2MST was determined with a 7-day interval between assessments.</p><p><strong>Results: </strong>The study included a cohort of participants with an average age of 45.3 ± 7.7 years. The mean score for the 2MST was 51.9 ± 15.6, with a second 2MST yielding a mean score of 56.1 ± 16.4. The reliability of the 2MST was found to be good (ICC=0.925) in patients with fibromyalgia. The 2MSTexhibited significant correlations with the 2MWT (ρ=0.633) and 6MWT (ρ= 0.703).</p><p><strong>Conclusion: </strong>In conclusion, this study demonstrates that the 2MST is a reliable tool for evaluating exercise capacity in individuals with fibromyalgia, showing a negative association with age and pain severity.</p>","PeriodicalId":12066,"journal":{"name":"European journal of rheumatology","volume":"12 2","pages":"1-5"},"PeriodicalIF":1.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}