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European journal of rheumatology and inflammation最新文献

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Four commonly prescribed non-steroidal anti-inflammatory drugs for rheumatoid arthritis. 类风湿性关节炎常用的四种非甾体类抗炎药。
European journal of rheumatology and inflammation Pub Date : 1991-01-01
E C Huskisson
{"title":"Four commonly prescribed non-steroidal anti-inflammatory drugs for rheumatoid arthritis.","authors":"E C Huskisson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A four-way single-blind crossover study was used to compare the efficacy and tolerance of four non-steroidal anti-inflammatory drugs. In addition, pain intensity was compared during the day, at night, at rest, on walking, in the most painful joint, and with the patients most painful activity. Ninety-six patients with rheumatoid arthritis took single daily doses of controlled release naproxen (N), diclofenac S.R. (D), indomethacin S.R. (I) and standard piroxicam (P). The greatest changes from baseline after treatment were seen in those patients with the highest initial pain measurement scores. Assessments of pain in the morning, in the most painful joint and the most painful activity were more discriminating than those at noon or at rest. Of the treatments, 'N' and 'P' were the most effective in reducing pain, with statistically significant differences from baseline. 'I' was the most effective in reducing morning stiffness. Adverse experiences were generally mild, occurring more frequently on 'I' than on other treatments.</p>","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 2","pages":"8-12"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastroscopic evaluation of the effects of nabumetone on the gastrointestinal mucosa of rheumatic patients. 纳布美酮对风湿病患者胃肠道黏膜影响的胃镜评价。
European journal of rheumatology and inflammation Pub Date : 1991-01-01
G Bianchi Porro, M Petrillo, S Ardizzone, I Caruso, F Montone
{"title":"Gastroscopic evaluation of the effects of nabumetone on the gastrointestinal mucosa of rheumatic patients.","authors":"G Bianchi Porro,&nbsp;M Petrillo,&nbsp;S Ardizzone,&nbsp;I Caruso,&nbsp;F Montone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Endoscopic studies with nabumetone have consistently shown a lower incidence of gastro-duodenal erosive lesions than comparable non-steroidal anti-inflammatory drugs (NSAIDs) including naproxen and ibuprofen.</p>","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 3","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concerns and choices in general practice. 一般实践中的关注点和选择。
European journal of rheumatology and inflammation Pub Date : 1991-01-01
J D Mulder
{"title":"Concerns and choices in general practice.","authors":"J D Mulder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Osteoarthritis is a common problem in general practice and a major indication for NSAIDs. Many patients with osteoarthritis are elderly and therefore particularly at risk from adverse reactions. Co-morbidity and co-prescription may lead to drug interactions. For these reasons, safe NSAIDs are the first choice for this disease.</p>","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 3","pages":"3-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and improved safety--a new anti-arthritic agent. 一种新型抗关节炎药物，疗效好，安全性高。
European journal of rheumatology and inflammation Pub Date : 1991-01-01
M Irani
{"title":"Efficacy and improved safety--a new anti-arthritic agent.","authors":"M Irani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Long term studies with nabumetone have confirmed that it is an effective NSAID, comparable to other agents including aspirin and naproxen. Large scale post-marketing studies have shown high response rates and good tolerance.</p>","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 3","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparative study of nabumetone and indomethacin in ankylosing spondylitis. 纳布美酮与吲哚美辛治疗强直性脊柱炎的比较研究。
European journal of rheumatology and inflammation Pub Date : 1991-01-01
T G Palferman, M Webley
{"title":"A comparative study of nabumetone and indomethacin in ankylosing spondylitis.","authors":"T G Palferman,&nbsp;M Webley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Forty-two patients with ankylosing spondylitis were entered into a double-blind study to compare treatment with indomethacin and a new non-steroidal anti-inflammatory drug, nabumetone. Clinical, laboratory and side-effect profiles were measured over a three month period. Both drugs were effective in relieving pain and morning stiffness, indomethacin was better in alleviating general stiffness, nabumetone resulted in less side-effects. Objective measurements of spinal movements revealed no difference between the two drugs. Nabumetone, available as Relifex, appears as effective as indomethacin in relieving the symptoms of ankylosing spondylitis and is possibly better tolerated.</p>","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 2","pages":"23-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12538625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The case for preventive rheumatology. 预防风湿病学的案例。
European journal of rheumatology and inflammation Pub Date : 1991-01-01
D L Scott, T D Spector
{"title":"The case for preventive rheumatology.","authors":"D L Scott,&nbsp;T D Spector","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 2","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12538622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Droxicam: a pharmacological and clinical review of a new NSAID. Droxicam:一种新的非甾体抗炎药的药理学和临床回顾。
European journal of rheumatology and inflammation Pub Date : 1991-01-01
F Jané, A Rodríguez de la Serna
{"title":"Droxicam: a pharmacological and clinical review of a new NSAID.","authors":"F Jané,&nbsp;A Rodríguez de la Serna","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Droxicam acts by inhibition of PGE2 varies. Although it belongs to the oxicam family, it is characterised by being a pro-drug of piroxicam, the molecule undergoing conversion by hydrolysis once dissolved in the digestive tract. This allows us to suppose in principle that, there being less contact between the active drug (piroxicam) and the gastric mucosa, the side effects in the said mucosa would be slight. The studies which have already been performed in healthy volunteers and in patients with osteoarthritis and rheumatoid arthritis, to evaluate the efficacy and the tolerance of droxicam in patients suffering from such clearly inflammatory processes demonstrate an analgesic potential and anti-inflammatory effects which become noticeable after two weeks of treatment, and the drug is well-tolerated.</p>","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 4","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12539350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse events with droxicam in the early clinical trials. 在早期临床试验中的不良事件。
European journal of rheumatology and inflammation Pub Date : 1991-01-01
J Sánchez, A Bartlett, A Costa, J Estruch, R Estiarte, C Soucheiron
{"title":"Adverse events with droxicam in the early clinical trials.","authors":"J Sánchez,&nbsp;A Bartlett,&nbsp;A Costa,&nbsp;J Estruch,&nbsp;R Estiarte,&nbsp;C Soucheiron","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study analyses the results of 8 randomized, controlled clinical trials and one open study carried out with droxicam (a new NSAID, pro-drug of piroxicam), comparing the adverse events and gastrointestinal tolerance of this compound against those of the control drugs used in these trials. The frequency of adverse events was lower in the droxicam treated patients. Adverse events concerning the gastrointestinal area were also lower. No differences were found in the distribution of adverse events by age of sex among the drugs compared. The pattern of side effects found was that expected in all non-steroidal anti-inflammatory agents. These results seem to sustain the hypothesis of a better tolerance of droxicam than that of piroxicam, indomethacin or diclofenac, especially in the gastrointestinal area.</p>","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 4","pages":"50-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12539353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic activity, clinical and gastric tolerance of 20mg daily dose of droxicam in comparison with piroxicam in patients with degenerative joint disease. 对退行性关节疾病患者每日剂量20mg的droxicam与piroxicam的治疗活性、临床和胃耐受进行比较
European journal of rheumatology and inflammation Pub Date : 1991-01-01
E Schüetz, J Sánchez, J García-Barbal, J F Sarti, C Reuter, F J Harrison
{"title":"Therapeutic activity, clinical and gastric tolerance of 20mg daily dose of droxicam in comparison with piroxicam in patients with degenerative joint disease.","authors":"E Schüetz,&nbsp;J Sánchez,&nbsp;J García-Barbal,&nbsp;J F Sarti,&nbsp;C Reuter,&nbsp;F J Harrison","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The efficacy and safety of droxicam were compared with piroxicam in a pilot study in twenty patients with degenerative joint disease. After a one week washout period a baseline gastroscopy was carried out. Treatment during the following 4 weeks was randomised to droxicam or piroxicam. Safety and tolerance parameters were monitored at weekly intervals. Pain was evaluated with two visual analogue scales (VAS) (patient and investigator). Affected joints, articular index (AI), patient's status and a daily living activities questionnaire were also evaluated. Another gastroscopy was carried out at the end of the treatment period. Droxicam and piroxicam relieved all symptoms significantly without statistically significant clinical differences. Both groups showed no drug related side effects in the laboratory values. In the gastroscopic examinations two patients of the droxicam group and four of piroxicam group had minor gastric erosions after four weeks of treatment without any accompanying clinical symptoms.</p>","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 4","pages":"21-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12539348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Double-blind, randomized and parallel comparison between droxicam and diclofenac sodium in patients with coxarthrosis and gonarthrosis. 双氯芬酸钠与羟基昔康治疗关节关节病的双盲、随机、平行比较。
European journal of rheumatology and inflammation Pub Date : 1991-01-01
J R Corts Giner, J J García Borrás
{"title":"Double-blind, randomized and parallel comparison between droxicam and diclofenac sodium in patients with coxarthrosis and gonarthrosis.","authors":"J R Corts Giner,&nbsp;J J García Borrás","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This double-blind clinical trial compares droxicam, a new non-steroidal anti-inflammatory agent and the reference compound diclofenac sodium. After a 7 day placebo run-in period, 80 patients with gonarthrosis and coxarthrosis were randomized to receive 20mg/day of droxicam and 150mg/day of diclofenac for 6 weeks. Evaluations were carried out at weeks 0 (placebo run-in), 2,3, and 6. Both drugs showed statistically significant improvements in all clinical measurements (index of severity, pain intensity, morning stiffness, maximal forced flexion and extension of the knee) after 6 weeks of treatment. Investigator's and patient's opinions were consistent with these results. The consumption of paracetamol was significantly lower amongst patients treated with droxicam. Withdrawals due to lack of therapeutic efficacy did not occur. A lower incidence of side effects, mostly upper gastrointestinal symptoms, was noticed amongst droxicam-treated patients. However, two patients in the droxicam group were withdrawn at week 3 and two days after week 6 because of epigastric pain and nausea, and cutaneous rash, respectively. Both study drugs are of benefit in reducing pain and improving joint motion and function in patients with coxarthrosis and gonarthrosis.</p>","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"11 4","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12539349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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