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European journal of respiratory diseases最新文献

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The effect of a peptide aldehyde reversible inhibitor of elastase on a human leucocyte elastase-induced model of emphysema in the hamster. 肽醛可逆性弹性酶抑制剂对人白细胞弹性酶诱导的仓鼠肺气肿模型的影响。
European journal of respiratory diseases Pub Date : 1987-11-01
A J Kennedy, A Cline, U M Ney, W H Johnson, N A Roberts
{"title":"The effect of a peptide aldehyde reversible inhibitor of elastase on a human leucocyte elastase-induced model of emphysema in the hamster.","authors":"A J Kennedy,&nbsp;A Cline,&nbsp;U M Ney,&nbsp;W H Johnson,&nbsp;N A Roberts","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The peptide aldehyde Ro 31-3537, N alpha-(1-adamantanesulphonyl)-N epsilon-(4-carboxybenzoyl)-L-lysyl-L-alanyl-L- valinal, is a reversible competitive, hydrophilic, specific inhibitor of elastase. Its Ki against human leucocyte elastase is 6 x 10(-8) M. The effect of this compound has been studied on a model of emphysema in the hamster induced by multiple sequential intratracheal doses of human leucocyte elastase. Concomitant intratracheal dosing of 200 micrograms of inhibitor with the enzyme significantly reduces lung damage as measured by quasi-static lung compliance and by histological assessment of the emphysema.</p>","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"71 5","pages":"472-8"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14567961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant fibrous histiocytoma of the pulmonary artery. 肺动脉恶性纤维组织细胞瘤。
European journal of respiratory diseases Pub Date : 1987-10-01
J Verhaert, J Van Meerbeeck, J Vander Sande, R Dion, N Bourgeois, T Ceelen, A Minette
{"title":"Malignant fibrous histiocytoma of the pulmonary artery.","authors":"J Verhaert,&nbsp;J Van Meerbeeck,&nbsp;J Vander Sande,&nbsp;R Dion,&nbsp;N Bourgeois,&nbsp;T Ceelen,&nbsp;A Minette","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"71 4","pages":"321-3"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13964761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soluble antigen fluorescent antibody (SAFA) test is not useful in childhood tuberculosis. 可溶性抗原荧光抗体(SAFA)检测在儿童结核病中无效。
European journal of respiratory diseases Pub Date : 1987-10-01
V K Srivastava, S S Uppal, N Laisram, A Narayan, Shriniwas
{"title":"Soluble antigen fluorescent antibody (SAFA) test is not useful in childhood tuberculosis.","authors":"V K Srivastava,&nbsp;S S Uppal,&nbsp;N Laisram,&nbsp;A Narayan,&nbsp;Shriniwas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The diagnostic value of the soluble antigen fluorescent antibody (SAFA) test in childhood tuberculosis was studied in 117 children in the age group 0-12 years; 79 cases belonged to the study group, 23 children were non-tuberculous controls and 15 were tuberculin-negative healthy controls. The SAFA test was positive in 35 of 44 children with only pulmonary tuberculous lesions (80%) and in 21 of 35 children with other types of tuberculosis (60%). In the 23 non-tuberculous and 15 healthy controls it was positive in 11 cases (48%) and 7 cases (47%), respectively. The sensitivity, specificity and predictivity of the test were found to be 71%, 53% and 72%, respectively. The diagnostic value of the SAFA test was thus found to be low in childhood tuberculosis, especially in disseminated disease and tuberculous meningitis.</p>","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"71 4","pages":"292-4"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14446586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ceftazidime treatment of chronic Pseudomonas infection in patients with cystic fibrosis. 头孢他啶治疗慢性假单胞菌感染伴囊性纤维化患者。
European journal of respiratory diseases Pub Date : 1987-10-01
G Fluge, A Digranes, H Michalsen, T Stiris, T Bergan, E K Qvigstad
{"title":"Ceftazidime treatment of chronic Pseudomonas infection in patients with cystic fibrosis.","authors":"G Fluge,&nbsp;A Digranes,&nbsp;H Michalsen,&nbsp;T Stiris,&nbsp;T Bergan,&nbsp;E K Qvigstad","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty-one patients with cystic fibrosis (CF), aged 1-18 years, with chronic lower respiratory tract infection caused by Pseudomonas aeruginosa, received 38 treatment courses of ceftazidime of 10-14 days duration. A favorable clinical response was observed in 28 of the 38 treatment courses. The minimal inhibitory concentration values of ceftazidime for the Pseudomonas isolates were concentrated around 0.5-1.0 mg/l, although a wide range of sensitivities was found (less than 0.03-32 mg/l). P. aeruginosa was eliminated after five treatment courses, but recurred after 1 month in four of these patients. The organism was permanently eradicated in one patient until his death 8 months later. Ceftazidime was well tolerated. The doses used in this study (50 mg/kg body weight i.v. twice daily) should probably be increased in order to achieve better microbiological response.</p>","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"71 4","pages":"239-43"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14446738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenesis of shrinking pleuritis with atelectasis--"rounded atelectasis". 收缩性胸膜炎伴肺不张的发病机制——“圆形肺不张”。
European journal of respiratory diseases Pub Date : 1987-10-01
L Dernevik, P Gatzinsky
{"title":"Pathogenesis of shrinking pleuritis with atelectasis--\"rounded atelectasis\".","authors":"L Dernevik,&nbsp;P Gatzinsky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pathogenesis of \"shrinking pleuritis with atelectasis\" or \"rounded atelectasis\" is discussed on the basis of 37 operated patients and on experiments on cadaver lungs. Peroperative dissections with microscopic examinations and the results of experiments with the cadaver lungs support the concept that the lesion is caused by an inflammatory reaction in the visceral layer of the pleura, caused by asbestos fibers. The inflammation occurs in stages, with deposition of connective tissue that shrinks and causes considerable atelectasis of the underlying pulmonary parenchyma. Compression of the lung due to fluid collecting in the pleural cavity involved was not noted.</p>","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"71 4","pages":"244-9"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14811858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma cell granuloma of the lung. 肺浆细胞肉芽肿。
European journal of respiratory diseases Pub Date : 1987-10-01
R Rutsaert, J Verhaert, A Goovaerts, E Schoofs, N Buyssens
{"title":"Plasma cell granuloma of the lung.","authors":"R Rutsaert,&nbsp;J Verhaert,&nbsp;A Goovaerts,&nbsp;E Schoofs,&nbsp;N Buyssens","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"71 4","pages":"317-20"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14811864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A near fatal asthma attack in a patient unaware of deteriorating lung function. 在没有意识到肺功能恶化的病人中发生的近乎致命的哮喘发作。
European journal of respiratory diseases Pub Date : 1987-10-01
A J Williams, S E Church
{"title":"A near fatal asthma attack in a patient unaware of deteriorating lung function.","authors":"A J Williams,&nbsp;S E Church","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"71 4","pages":"259-62"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14811859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soluble antigen fluorescent antibody (SAFA) test is not useful in childhood tuberculosis. 可溶性抗原荧光抗体(SAFA)检测在儿童结核病中无效。
European journal of respiratory diseases Pub Date : 1987-10-01 DOI: 10.1097/00006454-198806000-00024
V. Srivastava, S. Uppal, N. Laisram, A. Narayan, Shriniwas
{"title":"Soluble antigen fluorescent antibody (SAFA) test is not useful in childhood tuberculosis.","authors":"V. Srivastava, S. Uppal, N. Laisram, A. Narayan, Shriniwas","doi":"10.1097/00006454-198806000-00024","DOIUrl":"https://doi.org/10.1097/00006454-198806000-00024","url":null,"abstract":"The diagnostic value of the soluble antigen fluorescent antibody (SAFA) test in childhood tuberculosis was studied in 117 children in the age group 0-12 years; 79 cases belonged to the study group, 23 children were non-tuberculous controls and 15 were tuberculin-negative healthy controls. The SAFA test was positive in 35 of 44 children with only pulmonary tuberculous lesions (80%) and in 21 of 35 children with other types of tuberculosis (60%). In the 23 non-tuberculous and 15 healthy controls it was positive in 11 cases (48%) and 7 cases (47%), respectively. The sensitivity, specificity and predictivity of the test were found to be 71%, 53% and 72%, respectively. The diagnostic value of the SAFA test was thus found to be low in childhood tuberculosis, especially in disseminated disease and tuberculous meningitis.","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"15 1","pages":"292-4"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81294855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Pulmonary paragonimiasis presenting as a hemorrhagic pleural effusion. 肺吸虫病表现为出血性胸腔积液。
European journal of respiratory diseases Pub Date : 1987-10-01
S A Al-Mohaya, M Al-Sohaibani, H Bukhari, H Knox-Macaulay
{"title":"Pulmonary paragonimiasis presenting as a hemorrhagic pleural effusion.","authors":"S A Al-Mohaya,&nbsp;M Al-Sohaibani,&nbsp;H Bukhari,&nbsp;H Knox-Macaulay","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"71 4","pages":"314-6"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14811863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nebulised adrenaline in acute severe asthma: comparison with salbutamol. 肾上腺素雾化治疗急性重症哮喘:与沙丁胺醇比较。
European journal of respiratory diseases Pub Date : 1987-10-01
M O Coupe, U Guly, E Brown, P J Barnes
{"title":"Nebulised adrenaline in acute severe asthma: comparison with salbutamol.","authors":"M O Coupe,&nbsp;U Guly,&nbsp;E Brown,&nbsp;P J Barnes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Adrenaline may have beneficial effects in asthma in addition to a direct beta-adrenoceptor mediated bronchodilatation, such as alpha-receptor mediated reduction in microvascular leakage and oedema, and inhibition of bronchoconstrictor neural pathways. We have compared the bronchodilator effect of nebulised adrenaline (1 mg) with nebulised salbutamol (2.5 mg) in patients with acute severe asthma. Eighteen patients admitted with acute asthma (mean peak expiratory flow 22% predicted) were randomised to receive either adrenaline or salbutamol in a double-blind fashion and, after 15 min, were changed to the alternative nebulisation to determine if there was any additional bronchodilation. There were no differences between the increase in PEF after adrenaline (mean +/- SEM increase 99 +/- 20.5 L/min) or after salbutamol (119 +/- 22.7 L/min). Heart rate fell after each nebuliser and there was no difference between treatments. PaO2 rose after adrenaline (0.5 +/- 0.15 kPa), but fell after salbutamol (-0.2 +/- 0.11 kPa). These results suggest that nebulised adrenaline is as effective as a nebulised beta-agonist in acute asthma and is without significant side-effects. The theoretical advantages conferred by alpha-agonist activity do not produce any additional bronchodilation but may prevent any fall in PaO2 due to ventilation-perfusion mismatching.</p>","PeriodicalId":12053,"journal":{"name":"European journal of respiratory diseases","volume":"71 4","pages":"227-32"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14811117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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