European Neuropsychopharmacology最新文献

{"title":"Chronic stress and brain kynurenine pathway: addressing unresolved issues with a meta-analytic approach of preclinical studies, translational implication for psychiatric disorders","authors":"Andrea de Bartolomeis ,&nbsp;Michele Fornaro ,&nbsp;Elena Scopetta ,&nbsp;Claudio Ricci ,&nbsp;Antonella Irano ,&nbsp;Giuseppe De Simone ,&nbsp;Stefano Comai ,&nbsp;Felice Iasevoli ,&nbsp;Claudio Caiazza","doi":"10.1016/j.euroneuro.2025.10.005","DOIUrl":"10.1016/j.euroneuro.2025.10.005","url":null,"abstract":"<div><div>The kynurenine pathway (KP) has emerged as a key mediator of inflammation and synaptic plasticity, which play a significant role in the pathophysiology of chronic stress (CS). CS, in turn, is a major environmental factor in the development of psychiatric disorders. Despite growing evidence linking the KP to psychiatric disorders, the mechanisms underlying its alterations under CS remain poorly understood. To address this gap, we conducted the first comprehensive meta-analysis of preclinical rodent studies. Our goal was to systematically evaluate, within controlled experimental paradigms: (1) how, to what extent, and in which brain regions CS affects the KP; (2) which neurochemical pathways are most impacted by CS. We searched PubMed/MEDLINE, EMBASE, Scopus for preclinical studies until 06/27/2025. We performed a systematic review and meta-analysis following a pre-determined protocol (PROSPERO:CRD42023459414), considering KP metabolites and enzymes as outcomes (Standardized Mean Difference=SMD). SYRCLE/CAMARADES tools assessed quality and risk-of-bias. 59 studies entered the meta-analyses. CS proved to increase hippocampal and cortical overall concentrations of kynurenine (SMD=1.71,95 %C.I.[0.99,2.42], <em>p</em> &lt; 0.01,I²=91.3 %,<em>k</em> = 23,<em>n</em> = 508; SMD=1.54,95 %C.I.[1.08,2.01],<em>p</em> &lt; 0.01,I²=57.77 %,<em>k</em> = 16,<em>n</em> = 247), as well as kynurenine/tryptophan ratio and quinolinic acid. KYNA concentrations decreased in the hippocampus and cortex. KP enzyme expression/activity, including Indoleamine-2,3-Dioxygenase, Tryptophan-2,3-Dioxygenase, Kynurenine-3-Monoxygenase, increased. These findings support a shift of tryptophan metabolism towards the KP following CS. Particularly, the increase in neurotoxic quinolinic acid (NMDAR-agonist) and decrease in KYNA (NMDA-antagonist) may disrupt the neuroprotection/excitotoxic neuronal balance, influencing neuroplasticity. The KP may play a key role in the pathophysiology of CS-associated behaviors, and could serve to highlight potential targets for novel therapeutic strategies, specifically for treatment resistance.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"101 ","pages":"Pages 22-40"},"PeriodicalIF":6.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145470939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant use in pregnancy and neonatal outcomes: reassuring findings from an asian cohort","authors":"Qing Ren ,&nbsp;Mingyi Gu ,&nbsp;Xin Wang","doi":"10.1016/j.euroneuro.2025.10.003","DOIUrl":"10.1016/j.euroneuro.2025.10.003","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"101 ","pages":"Page 6"},"PeriodicalIF":6.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is psychosis an obstetric condition? Revisiting the role of early-life environmentally stressful events","authors":"Inmaculada Baeza ,&nbsp;Clemente García-Rizo","doi":"10.1016/j.euroneuro.2025.10.002","DOIUrl":"10.1016/j.euroneuro.2025.10.002","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"101 ","pages":"Pages 3-4"},"PeriodicalIF":6.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: On clinical predictors of treatment-resistant depression: Comments on validation strategy, predictor independence, and clinical implementation","authors":"Jianjie Ju ,&nbsp;Jingjing Chen ,&nbsp;Shuo Lin","doi":"10.1016/j.euroneuro.2025.08.581","DOIUrl":"10.1016/j.euroneuro.2025.08.581","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"100 ","pages":"Page 1"},"PeriodicalIF":6.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell atlas of schizophrenia peripheral immunity implicates neutrophil-driven inflammation and adaptive immune suppression","authors":"Ying Jiang,&nbsp;Lu Hou,&nbsp;Shiming Li,&nbsp;Zhiqiang Du,&nbsp;Rongrong Lu,&nbsp;Xuezheng Gao,&nbsp;Haohao Zhu","doi":"10.1016/j.euroneuro.2025.09.001","DOIUrl":"10.1016/j.euroneuro.2025.09.001","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"100 ","pages":"Pages 36-38"},"PeriodicalIF":6.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply from the Authors","authors":"Elisabet Jerlhag","doi":"10.1016/j.euroneuro.2025.09.005","DOIUrl":"10.1016/j.euroneuro.2025.09.005","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"100 ","pages":"Page 33"},"PeriodicalIF":6.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Jianjie Ju and Hui Chen","authors":"Alessandro Serretti","doi":"10.1016/j.euroneuro.2025.09.003","DOIUrl":"10.1016/j.euroneuro.2025.09.003","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"100 ","pages":"Pages 29-30"},"PeriodicalIF":6.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural connectomic signatures of childhood maltreatment across affective and psychotic disorders","authors":"Linda M. Bonnekoh ,&nbsp;Marius Gruber ,&nbsp;Cathrine Thams ,&nbsp;Kira Flinkenflügel ,&nbsp;Susanne Meinert ,&nbsp;Janik Goltermann ,&nbsp;Dominik Grotegerd ,&nbsp;Julia Hubbert ,&nbsp;Judith Krieger ,&nbsp;Christoph Jurischka ,&nbsp;Ruth H. Fellmeth ,&nbsp;Nils R. Winter ,&nbsp;Tim Hahn ,&nbsp;Elisabeth J. Leehr ,&nbsp;Nils Opel ,&nbsp;Marc Pawlitzki ,&nbsp;Paula Rehm ,&nbsp;Nina v. Werthern ,&nbsp;Sharmili Edwin Thanarajah ,&nbsp;Stefanie Fischer ,&nbsp;Jonathan Repple","doi":"10.1016/j.euroneuro.2025.09.009","DOIUrl":"10.1016/j.euroneuro.2025.09.009","url":null,"abstract":"<div><div>Exposure to childhood maltreatment (CM) is a crucial risk factor for affective disorders and schizophrenia, which are linked to structural brain network alterations. We hypothesized a significant association between CM and brain structural connectivity in a transdiagnostic sample. Participants included patients with major depressive disorder (<em>n</em> = 827), bipolar disorder (<em>n</em> = 134), schizophrenia spectrum disorders (<em>n</em> = 118), and healthy controls (<em>n</em> = 932) aged 18–65 from the Marburg-Muenster Affective Disorders Cohort Study. Structural brain networks were reconstructed from structural and diffusion-weighted MRI. CM was assessed using the Childhood Trauma Questionnaire (CTQ) based on established cut-offs. Analyses of covariance investigated the main effect of CM and the interaction of diagnosis and CM on global network metrics. In addition, network-based statistic (NBS) analyses were performed to identify the underlying subnetworks. History of CM was positively associated with the number of connections (p_FDR=0.01; CM: 95 %-CI=[533.9; 540.6], No CM: 95 %-CI=[529.1; 535.0]), normalized (p_FDR=0.02; CM: 95 %-CI=[0.860; 0.863], No CM: 95 %-CI=[0.857; 0.860]) and non-normalized network efficiency (p_FDR=0.01; CM: 95 %-CI=[0.405; 0.407], No CM: 95 %-CI=[0.403; 0.405]) and negatively associated with normalized network clustering (p_FDR=0.045; CM: 95 %-CI=[4.976; 5.065], No CM: 95 %-CI=[5.100; 5.150]). There were no significant interaction effects of CM and diagnosis. NBS analyses revealed a large network of edges, in which individuals with CM exhibited higher structural connectivity compared to those without, which persisted after correcting for diagnosis. These findings indicate a connectome signature of CM, marked by hyperconnectivity, across major mental disorders and in healthy individuals, suggesting that CM affects connectome architecture independent of present psychiatric diagnoses.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"100 ","pages":"Pages 42-52"},"PeriodicalIF":6.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter to the editor: “Compressed design, inflated conclusions? A cautionary note on vaporized DMT trials”","authors":"Fernanda Palhano-Fontes","doi":"10.1016/j.euroneuro.2025.09.008","DOIUrl":"10.1016/j.euroneuro.2025.09.008","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"100 ","pages":"Pages 40-41"},"PeriodicalIF":6.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Comparative receptor pharmacology of antipsychotic drugs based on normalized binding affinity data and breadth of interaction”","authors":"Parth Aphale,&nbsp;Shashank Dokania,&nbsp;Himanshu Shekhar","doi":"10.1016/j.euroneuro.2025.09.002","DOIUrl":"10.1016/j.euroneuro.2025.09.002","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"100 ","pages":"Page 34"},"PeriodicalIF":6.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}