European Neuropsychopharmacology最新文献

{"title":"Disease-wide association study uncovers disease continuum network of unipolar depression","authors":"Ming Zheng","doi":"10.1016/j.euroneuro.2024.12.009","DOIUrl":"10.1016/j.euroneuro.2024.12.009","url":null,"abstract":"<div><div>Unipolar depression is typically regarded as a psychiatric disorder, yet it frequently coexists with various major diseases. This study employs a Disease-Wide Association Study (DWAS) approach to map the disease continuum surrounding unipolar depression, analyzing data from a registry cohort of 392,423 individuals, including 43,280 diagnosed cases of unipolar depression. Significant associations were identified between depression and comorbidities across multiple organ systems, including both mental and physical disorders. Next, temporal analysis categorized these comorbidities based on their onset relative to depression into short-term (1-year), mid-term (5-year), and long-term (15-year) periods, discovering temporal consistent associations with comorbidities such as schizophrenia, anxiety disorders, post-traumatic stress disorder (PTSD), asthma, hypothyroidism, type 2 diabetes, cardiac arrhythmias, and cancer. These findings highlight the interconnected nature of depression within a broader disease continuum network. Recognizing depression within this systemic framework supports the adoption of personalized medicine strategies tailored to individual comorbidity profiles, enabling therapeutic targeting of shared pathogenic mechanisms that concurrently address both depression and its associated comorbidities.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 74-76"},"PeriodicalIF":6.1,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy, tolerability, and safety of xanomeline-trospium chloride for schizophrenia: A systematic review and meta-analysis","authors":"Nicholas Fabiano ,&nbsp;Stanley Wong ,&nbsp;Carl Zhou ,&nbsp;Christoph U. Correll ,&nbsp;Mikkel Højlund ,&nbsp;Marco Solmi","doi":"10.1016/j.euroneuro.2024.11.013","DOIUrl":"10.1016/j.euroneuro.2024.11.013","url":null,"abstract":"<div><div>The United States Food and Drug Administration approved xanomeline-trospium combination for schizophrenia on September-26–2024. We conducted a PRISMA 2020-compliant systematic review with random-effects meta-analysis on the efficacy and safety of xanomeline-trospium in randomized controlled trials in patients with schizophrenia (MEDLINE, EMBASE, Cochrane, PsycINFO, October-01–2024). Co-primary outcomes were Positive And Negative Syndrome Scale (PANSS) total score (standardized mean difference=SMD), and all-cause discontinuation (risk ratio=RR). Cochrane's Risk of Bias (RoB) Tool 2 and GRADE were used. Xanomeline-trospium (<em>k</em> = 3, schizophrenia acute exacerbation, RoB=low, baseline <em>N</em> = 690, males=75.5 %, age=44.3 + 11.0, duration=5 weeks) outperformed placebo on PANSS total (SMD=-0.56, 95 % confidence interval/CI=-0.72/-0.40), positive (SMD=-0.59, 95 %CI=-0.75/-0.43), negative (SMD=-0.33, 95 %CI=-0.49/-0.17), and Marder Factor negative symptom score (SMD=-0.36, 95 %CI=-0.60/-0.13), Clinical Global Impression-Severity (SMD=-0.54, 95 %CI=-0.71/-0.37) (GRADE=moderate), and response (≥30 % reduction from baseline: RR=2.13, 95 %CI=1.66–2.75). Risk of ≥7 % weight gain (RR=0.46, 95 %CI=0.25–0.87, NNT=19), low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol levels were reduced, while risk was increased for vomiting, hypertension, nausea, dry mouth, dyspepsia, constipation (RR=7.60, 95 %CI=1.50–38.57 to RR=2.72, 95 %CI=1.63–4.55), any adverse event (RR=1.33, 95 %CI=1.18–1.51, NNT=6), triglyceride levels and supine heart rate (GRADE=moderate to high). Conversely, the risk was not increased for any other, serious, or severe adverse events or all-cause discontinuation. In post-hoc analyses, xanomeline-trospium outperformed placebo regarding response (≥20 % and ≥30 % threshold) starting at week 2, negative symptoms in patients with prominent negative symptoms, and cognitive symptoms in patients ≥1 standard deviation below the general population norm. Further, pro-/anti-cholinergic side effects were mild-moderate and mostly transient. Xanomeline-trospium is an effective treatment for schizophrenia with a unique tolerability profile, potentially addressing unmet needs.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 62-73"},"PeriodicalIF":6.1,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrelationships between polygenic risk scores, cognition, symptoms, and functioning in first-episode psychosis: A network analysis approach","authors":"Gustavo J. Gil-Berrozpe ,&nbsp;Alex G. Segura ,&nbsp;Ana M. Sánchez-Torres ,&nbsp;Silvia Amoretti ,&nbsp;Eloi Giné-Servén ,&nbsp;Eduard Vieta ,&nbsp;Gisela Mezquida ,&nbsp;Antonio Lobo ,&nbsp;Ana Gonzalez-Pinto ,&nbsp;Alvaro Andreu-Bernabeu ,&nbsp;Alexandra Roldán ,&nbsp;Maria Florencia Forte ,&nbsp;Josefina Castro ,&nbsp;Daniel Bergé ,&nbsp;Natalia Rodríguez ,&nbsp;Alejandro Ballesteros ,&nbsp;Sergi Mas ,&nbsp;Manuel J. Cuesta ,&nbsp;Miquel Bernardo ,&nbsp;PEPs group","doi":"10.1016/j.euroneuro.2024.12.002","DOIUrl":"10.1016/j.euroneuro.2024.12.002","url":null,"abstract":"<div><div>Psychopathological manifestations and cognitive impairments are core features of psychotic disorders. Polygenic risk scores (PRS) offer insights into the relationships between genetic vulnerability, symptomatology, and cognitive impairments. This study used a network analysis to explore the connections between PRS, cognition, psychopathology, and overall functional outcomes in individuals experiencing a first episode of psychosis (FEP). The study sample comprised 132 patients with FEP. Genetic data were used to construct PRS for mental disorders and cognitive traits via PRS-continuous shrinkage. We conducted comprehensive clinical and neuropsychological assessments at 2 months post-diagnosis and again at a 2-year follow-up. A network analysis was performed to generate two distinct networks and their centrality indices, encompassing 19 variables across domains such as symptoms, cognition, functioning, and PRS. Variables were grouped within related domains, and stronger relationships were observed within domains than between them. PRS for schizophrenia showed weak negative associations with attention, working memory, and verbal memory, while PRS for cognitive performance showed weak positive associations with attention. Negative symptoms were negatively associated with functioning and verbal memory at both the 2-month and 2-year assessments, as well as with social cognition at 2 years. Poor functioning was moderately related to greater severity of Positive and Negative Syndrome Scale dimensions. This study identified pathways linking PRS, cognition, symptoms, and functioning, suggesting that genetic risk may serve as a marker of vulnerability and disorder progression. The findings also highlight the importance of considering genetic predispositions alongside clinical and cognitive factors to better understand the heterogeneity of psychotic disorders.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 52-61"},"PeriodicalIF":6.1,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities to advance microRNA research in psychiatry","authors":"Alba Navarro-Flores ,&nbsp;Urs Heilbronner","doi":"10.1016/j.euroneuro.2024.12.010","DOIUrl":"10.1016/j.euroneuro.2024.12.010","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 26-28"},"PeriodicalIF":6.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic evidence of GLP-1 receptor as target for the treatment of substance use disorders","authors":"Fernando Facal ,&nbsp;Javier Costas","doi":"10.1016/j.euroneuro.2024.12.008","DOIUrl":"10.1016/j.euroneuro.2024.12.008","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 48-49"},"PeriodicalIF":6.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is creatine useful as adjuvant in cognitive-behavioural therapy for depression?","authors":"Guilherme Nobre Nogueira ,&nbsp;Marisa Bezerra de Araújo ,&nbsp;Pedro Lucas Santana da Silveira ,&nbsp;Juliana Lícia Rabelo Cavalcante ,&nbsp;Anna Giulia Pinheiro Ferreira ,&nbsp;Giovanna Cavalcante Pardi ,&nbsp;Amanda Medeiros Fernandes ,&nbsp;Fabio Gomes de Matos e Souza ,&nbsp;Luísa Weber Bisol","doi":"10.1016/j.euroneuro.2024.12.003","DOIUrl":"10.1016/j.euroneuro.2024.12.003","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 50-51"},"PeriodicalIF":6.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory health in serious mental illness","authors":"Fernando Sarramea ,&nbsp;María José Jaén-Moreno","doi":"10.1016/j.euroneuro.2024.12.004","DOIUrl":"10.1016/j.euroneuro.2024.12.004","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 23-25"},"PeriodicalIF":6.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrasting genetic burden for bipolar disorder: Early onset versus late onset in an older adult bipolar disorder sample","authors":"Laura Montejo ,&nbsp;Brisa Sole ,&nbsp;Giovanna Fico ,&nbsp;Janos L. Kalman ,&nbsp;Monika Budde ,&nbsp;Urs Heilbronner ,&nbsp;Vincenzo Oliva ,&nbsp;Michele De Prisco ,&nbsp;Sara Martin-Parra ,&nbsp;Andrea Ruiz ,&nbsp;Anabel Martinez-Aran ,&nbsp;Kristina Adorjan ,&nbsp;Peter Falkai ,&nbsp;Maria Heilbronner ,&nbsp;Mojtaba Oraki Kohshour ,&nbsp;Daniela Reich-Erkelenz ,&nbsp;Sabrina K. Schaupp ,&nbsp;Eva C. Schulte ,&nbsp;Fanny Senner ,&nbsp;Thomas Vogl ,&nbsp;Carla Torrent","doi":"10.1016/j.euroneuro.2024.12.001","DOIUrl":"10.1016/j.euroneuro.2024.12.001","url":null,"abstract":"<div><div>Older Adults with Bipolar Disorder (OABD) represent a heterogeneous group, including those with early and late onset of the disorder. Recent evidence shows both groups have distinct clinical, cognitive, and medical features, tied to different neurobiological profiles. This study explored the link between polygenic risk scores (PRS) for bipolar disorder (PRS-BD), schizophrenia (PRS-SCZ), and major depressive disorder (PRS-MDD) with age of onset in OABD. PRS-SCZ, PRS-BD, and PRS-MDD among early vs late onset were calculated. PRS was used to infer posterior SNP effect sizes using a fully Bayesian approach. Demographic, clinical, and cognitive variables were also analyzed. Logistic regression analysis was used to estimate the amount of variation of each group explained by standardized PRS-SCZ, PRS-MDD, and PRS-BD. A total of 207 OABD subjects were included (144 EOBD; 63 LOBD). EOBD showed higher PRS-BD compared to LOBD (<em>p</em> = 0.005), while no association was found between age of onset and PRS-SCZ or PRS-MDD. Compared to LOBD, EOBD individuals also showed a higher likelihood for suicide attempts (<em>p</em> = 0.01), higher presence of psychotic symptoms (<em>p</em> = 0.003), higher prevalence of BD-I (<em>p</em> = 0.002), higher rates of familiarity for any psychiatric disorder (<em>p</em> = 0.004), and lower processing speed measured with Trail-Making Test part A (<em>p</em> = 0.03). OABD subjects with an early onset showed a greater genetic burden for BD compared to subjects with a late onset. These findings contribute to the notion that EOBD and LOBD may represent different forms of OABD, particularly regarding the genetic predisposition to BD.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 29-37"},"PeriodicalIF":6.1,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal structure and its relationship with premorbid, clinical, and cognitive variables in young Spanish patients with early course schizophrenia spectrum disorders","authors":"Jairo M. González-Díaz ,&nbsp;Bernardo Sánchez Dalmau ,&nbsp;Anna Camós-Carreras ,&nbsp;Salut Alba-Arbalat ,&nbsp;Silvia Amoretti ,&nbsp;Maria Florencia Forte ,&nbsp;Maria Serra-Navarro ,&nbsp;Sergi Salmerón ,&nbsp;Anaid Pérez-Ramos ,&nbsp;Eduard Vieta ,&nbsp;Carla Torrent ,&nbsp;Miquel Bernardo","doi":"10.1016/j.euroneuro.2024.12.006","DOIUrl":"10.1016/j.euroneuro.2024.12.006","url":null,"abstract":"<div><div>Emerging evidence suggests that retinal structural alterations are present in schizophrenia spectrum disorders (SSD), potentially reflecting broader neurodevelopmental and neurodegenerative processes. This cross-sectional study investigates retinal thickness and its clinical correlations in a sample of early-course SSD patients compared to healthy controls (HCs). One hundred-two eyes from 26 SSD cases and 25 age- and sex-matched HCs were included. Retinal structure was evaluated using Spectral-Domain Optical Coherence Tomography (SD-OCT), focusing on the peripapillary retinal nerve fiber layer (pRNFL), macular volume/thickness, and ganglion cell-inner plexiform layer (GCL+IPL) thickness. Although SSD cases showed increased peripapillary retinal nerve fiber layer (pRNFL) thickness in specific quadrants, most retinal parameters did not differ significantly between groups. Preliminary associations were observed between retinal measures, premorbid adjustment, DUP, and cognitive performance. These findings, while suggesting the potential of retinal imaging as a tool for early detection and monitoring of psychotic disorders, must be interpreted with caution. Further longitudinal and multimodal research is warranted to explore the association between these retinal changes and neuroinflammation, neurodegeneration, and overall brain health in SSD patients.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 38-47"},"PeriodicalIF":6.1,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the past: The risks and rewards of post-hoc findings","authors":"Vincenzo Oliva ,&nbsp;Eduard Vieta","doi":"10.1016/j.euroneuro.2024.12.005","DOIUrl":"10.1016/j.euroneuro.2024.12.005","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"92 ","pages":"Pages 21-22"},"PeriodicalIF":6.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}