European Neuropsychopharmacology最新文献

{"title":"Dilemmas in psychedelic medicine: From ethics to regulation and equity","authors":"Albino J. Oliveira-Maia , Carolina Seybert","doi":"10.1016/j.euroneuro.2024.11.003","DOIUrl":"10.1016/j.euroneuro.2024.11.003","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"91 ","pages":"Pages 67-68"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the impact of comorbid posttraumatic stress disorder on ketamine's real-world effectiveness in treatment-resistant depression","authors":"Danica E. Johnson ,&nbsp;Nelson B. Rodrigues ,&nbsp;Sydney Weisz ,&nbsp;Noah Chisamore ,&nbsp;Erica S. Kaczmarek ,&nbsp;David C.J. Chen-Li ,&nbsp;Zoe Doyle ,&nbsp;J Don Richardson ,&nbsp;Rodrigo B. Mansur ,&nbsp;Roger S. McIntyre ,&nbsp;Joshua D. Rosenblat","doi":"10.1016/j.euroneuro.2024.11.008","DOIUrl":"10.1016/j.euroneuro.2024.11.008","url":null,"abstract":"<div><div>Depression with comorbid posttraumatic stress disorder (PTSD) is associated with more severe symptoms and a reduced response to traditional treatments. Although ketamine shows promise as a rapid-acting antidepressant for treatment-resistant depression (TRD), its effectiveness in patients with comorbid PTSD remains underexplored. Therefore, we conducted a retrospective analysis of 134 patients from the Canadian Rapid Treatment Center of Excellence to compare the effectiveness of four ketamine infusions (0.5–0.75 mg/kg) in reducing symptoms of depression and PTSD in TRD patients with and without comorbid PTSD.</div><div>A repeated-measures linear mixed model was used to evaluate the impact of comorbid PTSD on ketamine's antidepressant effectiveness, measured by the Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR16). Paired samples <em>t</em>-tests were used to assess changes in PTSD symptoms, measured by the PTSD Checklist for DSM-5 (PCL-5). We found a significant main effect of time on QIDS-SR16 scores, F(4, 209.32) = 36.67, <em>p</em> &lt; 0.001, but no significant group-by-time interaction (<em>p</em> = 0.895), suggesting that comorbid PTSD did not impact the antidepressant effectiveness of ketamine. Significant improvements in PTSD symptoms were observed in overall PCL-5 scores, t(66) = 6.66, <em>p</em> &lt; 0.001, and across all PCL-5 symptom clusters with moderate to large effect sizes.</div><div>In a real-world sample of TRD patients, ketamine was effective in reducing symptoms of depression and PTSD, regardless of PTSD comorbidity. These findings highlight ketamine's potential as a novel intervention for a patient population that is frequently non-responders to conventional treatments. Future randomized controlled trials should explore mediating factors of improvement and long-term effects.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"91 ","pages":"Pages 69-77"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of Xanomeline-trospium chloride on positive and negative symptoms in Schizophrenia: The role of dose","authors":"Tzu-Yen Hung ,&nbsp;Yo-Chia Hsu ,&nbsp;Yang-Chieh Brian Chen ,&nbsp;Chih-Wei Hsu","doi":"10.1016/j.euroneuro.2025.01.005","DOIUrl":"10.1016/j.euroneuro.2025.01.005","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"93 ","pages":"Pages 22-23"},"PeriodicalIF":6.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of antidepressant-like effect of imipramine, fluoxetine and ketamine in the forced swim test in mice: How much standardization does a positive control require?","authors":"Marcela Verginia de Medeiros ,&nbsp;Eduardo Antonio Rosa ,&nbsp;Gabriela Vissintainer ,&nbsp;Cilene Lino de Oliveira ,&nbsp;Bruno Jacson Martynhak","doi":"10.1016/j.euroneuro.2024.12.012","DOIUrl":"10.1016/j.euroneuro.2024.12.012","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"93 ","pages":"Pages 24-26"},"PeriodicalIF":6.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease continuum centered on Parkinson's disease","authors":"Ming Zheng","doi":"10.1016/j.euroneuro.2025.01.002","DOIUrl":"10.1016/j.euroneuro.2025.01.002","url":null,"abstract":"<div><div>Parkinson’s disease (PD), once viewed as a neurodegenerative disorder, is now increasingly recognized as part of a broader disease continuum, intricately linked to comorbidities across various organ systems. This study provides a snapshot of the disease continuum centered on PD, using a disease-wide association study (DWAS) involving 392,423 individuals—including 4,235 PD cases. This DWAS identifies disease clusters of PD comorbidities across the musculoskeletal, circulatory, digestive, and respiratory systems. Moreover, comorbidities were classified based on their temporal relationship to PD diagnosis: pre-PD comorbidities, such as hypertension and autoimmune disorders, may act as risk factors of PD onset, while post-PD comorbidities, including Alzheimer’s disease and renal disorders, highlight the systemic consequences of PD progression. These findings emphasize the critical need for early detection and intervention to manage comorbidities and potentially delay PD onset. Furthermore, this study advocates for integrated diagnostic and therapeutic strategies targeting shared risk factors, advancing a precision-medicine approach to improve patient care and long-term management of PD.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"93 ","pages":"Pages 19-21"},"PeriodicalIF":6.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low dose oral ketamine treatment on post-traumatic stress disorder (PTSD) (OKTOP): An open-label pilot study","authors":"Bonnie L. Quigley ,&nbsp;Adem T. Can ,&nbsp;Megan Dutton ,&nbsp;Cyrana C. Gallay ,&nbsp;Grace Forsyth ,&nbsp;Monique Jones ,&nbsp;Fiona Randall ,&nbsp;Trish Wilson ,&nbsp;Jim Lagopoulos ,&nbsp;Daniel F. Hermens","doi":"10.1016/j.euroneuro.2025.01.003","DOIUrl":"10.1016/j.euroneuro.2025.01.003","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"93 ","pages":"Pages 17-18"},"PeriodicalIF":6.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary evidence should be treated as such: Response to “Is creatine useful as adjuvant in cognitive-behavioural therapy for depression?”","authors":"Riccardo De Giorgi ,&nbsp;Nima Norbu Sherpa ,&nbsp;Edoardo Giuseppe Ostinelli","doi":"10.1016/j.euroneuro.2024.12.015","DOIUrl":"10.1016/j.euroneuro.2024.12.015","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"93 ","pages":"Pages 15-16"},"PeriodicalIF":6.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A specific GPR56/ADGRG1 splicing isoform is associated with antidepressant response in major depressive disorder","authors":"Montaine Lion ,&nbsp;El Chérif Ibrahim ,&nbsp;Elodie Caccomo-Garcia ,&nbsp;Julie Bourret ,&nbsp;Guillaume Cinquanta ,&nbsp;Olfa Khalfallah ,&nbsp;Nicolas Glaichenhaus ,&nbsp;Laetitia Davidovic ,&nbsp;Philippe Courtet ,&nbsp;Gustavo Turecki ,&nbsp;Eleni Tzavara ,&nbsp;Raoul Belzeaux","doi":"10.1016/j.euroneuro.2025.01.001","DOIUrl":"10.1016/j.euroneuro.2025.01.001","url":null,"abstract":"<div><div>Major Depressive Episode (MDE) is one of the most common psychiatric disorders. Often difficult to treat, this disease is one of the leading causes of suicide. A recent study showed an association between <em>GPR56/ADGRG1</em> mRNA, MDE and response to antidepressant treatment in blood and in brain. Among <em>GPR56</em> splicing variant, the S4 isoform has recently been associated with microglial synaptic pruning, while microglia are already known as a central player in MDE. Therefore, we hypothesized that S4 is the specific isoform associated to MDE and antidepressant response. To test our hypothesis, an <em>in silico</em> analysis was first performed to identify the different proteins and transcript isoforms of <em>GPR56</em>. This analysis allowed to design PCR and qPCR primers. <em>GPR56</em> total, S4 and S3 were assessed by RT-qPCR in leukocytes from a cohort of 46 MDE patients including non-responders (NR, <em>n</em> = 31) and responders-remitters (R, <em>n</em> = 17) to antidepressant treatment. We replicated the result of one of our previous studies, which described an increase in total <em>GPR56</em> mRNA in Rs. Additionally, we observed that this variation differs among mRNA splicing variants, with S4 exhibiting a similar pattern of variation while S3 shows no significant change. The differences observed withstood statistical correction for covariates of interest such as smoking, gender and suicidal ideation, demonstrating the robustness of the model. These findings confirm our hypothesis that certain mRNA splicing variants of <em>GPR56</em> may play a more significant role in depression. This study highlighted a link between the <em>GPR56-S4</em> and response to antidepressant treatment.</div></div>","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"93 ","pages":"Pages 5-14"},"PeriodicalIF":6.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiRNAs and extracellular vesicles in psychiatry: Potential biomarkers, therapeutic advances, and animal models","authors":"Lluis Miquel-Rio ,&nbsp;Gerard Anmella ,&nbsp;Analia Bortolozzi","doi":"10.1016/j.euroneuro.2024.12.011","DOIUrl":"10.1016/j.euroneuro.2024.12.011","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"93 ","pages":"Pages 3-4"},"PeriodicalIF":6.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D imaging and geometric morphometrics of facial dysmorphology and asymmetry indicate gestational timings of dysmorphogenesis in schizophrenia and bipolar disorder","authors":"John L. Waddington ,&nbsp;Federico M. Sukno","doi":"10.1016/j.euroneuro.2024.12.007","DOIUrl":"10.1016/j.euroneuro.2024.12.007","url":null,"abstract":"","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"93 ","pages":"Pages 1-2"},"PeriodicalIF":6.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}