European Journal of Pain最新文献

{"title":"Loss of Glutaminase 1 in Small Sensory Neurons Prevents Nerve Injury Induced Mechanical Allodynia: Insights From Conditional Knockout Mice","authors":"Anabel Martínez-Padilla,&nbsp;Javier Márquez,&nbsp;Miguel Á. Huerta,&nbsp;Carolina Roza,&nbsp;Elsa Cisneros","doi":"10.1002/ejp.70069","DOIUrl":"https://doi.org/10.1002/ejp.70069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Glutamate, the primary neurotransmitter released by nociceptors, is predominantly synthesised by the enzyme Glutaminase 1 (GLS1). The involvement of GLS1 in pain pathways is well supported, as <i>Gls1</i> heterozygous mice exhibit altered nociception and GLS1 levels increase in the dorsal root ganglia (DRG) under chronic peripheral inflammation. However, the specific contribution of GLS1 in sensory neurons to the development and maintenance of chronic neuropathic pain remains unclear. To explore this, we specifically targeted GLS1 expression in nociceptors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used the Cre-LoxP system to generate a transgenic mouse with a specific deletion of <i>Gls1</i> gene in neurons expressing the Nav1.8 sodium channel. Gene deletion was assessed by genomic PCR and immunofluorescence. GLS1 conditional knockout (cKO) mice and control littermates, under naïve conditions or following spared nerve injury (SNI), were analysed for mechanical allodynia and for expression of GLS1 and other components of the glutamatergic system using real-time PCR and Western blotting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>GLS1 cKO mice exhibited a significant reduction in GLS1 levels in the DRG, particularly in medium- to small-sized neurons. GLS1 deficiency prevented the development of mechanical allodynia following peripheral nerve injury. SNI induced GLS1 upregulation in the DRG of control mice, but not in cKO mice. In the spinal cord, NMDA receptor expression decreased after SNI only in naïve animals, while GLS1 and other glutamate receptors remained unchanged under all conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Upregulation of GLS1 in sensory neurons after peripheral nerve injury contributes to mechanical allodynia. Targeting peripheral GLS1 could offer a potential analgesic strategy for neuropathic pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>We generated a transgenic mouse with a specific deletion of the <i>Gls1</i> gene in Nav1.8-expressing neurons to assess the role of peripheral GLS1 in pain transmission. GLS1 is not required for physiological pain but is essential for the development of mechanical allodynia after nerve injury. GLS1 is upregulated in nociceptors following nerve injury, suggesting enhanced glutamate signalling. Taken together, results suggest that targeting GLS1 expression in neuropathic conditions could be a potential therapeutic strategy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attentional Focus but Not Distraction or Expectations Influence Conditioned Pain Modulation in Healthy Adults","authors":"Amber Billens,&nbsp;Evy Dhondt,&nbsp;Emilyn Dierickx,&nbsp;Stefaan Van Damme,&nbsp;Indra De Greef,&nbsp;Sophie Van Oosterwijck,&nbsp;Mira Meeus,&nbsp;Jessica Van Oosterwijck","doi":"10.1002/ejp.70058","DOIUrl":"https://doi.org/10.1002/ejp.70058","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Despite extensive research on conditioned pain modulation (CPM), uncertainties remain regarding the role of cognitive mechanisms, such as attentional focus, distraction, and intrinsic a priori expectations, and the most optimal CPM protocol design (parallel vs. sequential). This study examined whether these cognitive factors influence CPM efficacy, and whether CPM magnitude differs between a parallel and sequential protocol.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Seventy-two healthy adults participated in this randomised cross-over study undergoing CPM evaluation, that is, pain pressure threshold assessment (=test stimulus) in response to hot water immersion (=conditioning stimulus (CS)) during four experimental protocols, that is, a neutral parallel protocol, a neutral sequential protocol, a sequential protocol with attentional focus on the CS-induced pain intensity, and a sequential protocol with attentional distraction from the CS. Pain expectations were recorded before each protocol.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Focusing attention on the CS during CPM assessment resulted in smaller CPM magnitudes compared to no attentional manipulation or distracting from the CS. Distracting from the CS did not affect CPM magnitude compared to no attentional manipulation, nor did a priori expectations. Although CPM magnitudes were not statistically different between the parallel and sequential CPM protocol, a sequential protocol provides higher mean magnitudes and responder rates.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Since attentional focus on the CS reduces CPM efficacy, it is recommended to not rate the CS pain intensity during CS application to prevent a reduction of the inhibitory effect. Furthermore, a sequential protocol is recommended over a parallel protocol as a ‘cleaner’ representation of pain modulation free of attentional sources of biases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Significance Statement&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Conditioned pain modulation (CPM) is an important biomarker reflecting pain processing, however, there is a high variability in CPM response, making it important to gain insight into the influencing factors and mechanisms of CPM. The results of this study suggest that attentional focus on the conditioning stimulus influences CPM magnitude, whereas a distraction task and intrinsic a priori expectations do not. In both therapeutic and preventive approaches, it is of great interest for clinicians to positively address factors influencing CPM.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 ","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Mechanisms and Psychosocial Variables in Patients With Chronic Pain After Total Knee Arthroplasty: Secondary Analysis From a Randomised Controlled Trial","authors":"Jesper Bie Larsen,&nbsp;Søren T. Skou,&nbsp;Mogens Laursen,&nbsp;Niels Henrik Bruun,&nbsp;Pascal Madeleine,&nbsp;Lars Arendt-Nielsen","doi":"10.1002/ejp.70064","DOIUrl":"https://doi.org/10.1002/ejp.70064","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Chronic pain after total knee arthroplasty (TKA) affects approx. 15%–20% of patients undergoing surgery. It is largely unexplained why some patients develop chronic pain after TKA, but several factors, e.g., central pain mechanisms and psychosocial factors, have been suggested. This study assessed central pain mechanisms and psychosocial factors in patients with chronic pain after TKA, receiving neuromuscular exercise and pain neuroscience education (PNE) as treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is the secondary analysis of a randomised controlled trial. Sixty-nine patients with chronic pain at least one-year post-TKA, experiencing an average daily pain intensity of ≥ 4 on a numerical rating scale, were recruited. Participants were randomised to receive either 12 weeks of group-based neuromuscular exercise and two sessions of group-based PNE or two sessions of group-based PNE alone. Outcomes measured included temporal summation of pain (TSP) and pressure pain thresholds at the index knee and forearm, conditioned pain modulation, PainDETECT scores, fear-avoidance beliefs and pain catastrophizing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study found a significant between-group difference in change from baseline to 12 months for TSP at the index knee, favouring the neuromuscular exercise and PNE group (−1.45, 95% CI −2.48 to −0.42, <i>p</i> = 0.006). This indicates less facilitated TSP in the neuromuscular exercise and PNE group after intervention. No significant between-group differences were observed for the remaining outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results indicated that neuromuscular exercise combined with PNE significantly reduced TSP at the index knee, suggesting a reduction in central pain amplification. The clinical importance of this exploratory finding should be further investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>This trial showed that neuromuscular exercises in combination with pain neuroscience education resulted on decreased pain sensitization, measured as temporal summation of pain, in patients with chronic pain after total knee arthroplasty. The clinical relevance of central amplification of pain remains unclear but point at improved pain processing, i.e., reduced pain amplification.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Position and Chronic Opioid Use After Hip Fracture Surgery: A Danish Population-Based Cohort Study","authors":"Nickolaj Risbo,&nbsp;Vera Ehrenstein,&nbsp;Per Hviid Gundtoft,&nbsp;Jan-Erik Gjertsen,&nbsp;Alma Becic Pedersen","doi":"10.1002/ejp.70063","DOIUrl":"https://doi.org/10.1002/ejp.70063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic opioid use is a common and serious consequence of hip fracture. We examined the association between socioeconomic position (SEP) and chronic opioid use after hip fracture surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using nationwide Danish registries, we included patients aged ≥ 65 years undergoing hip fracture surgery in 2012–2021 (<i>n</i> = 52,801). Cohabitation, liquid assets, and education were markers of SEP. Chronic opioid use was defined as ≥ 2 prescriptions of opioids 31–365 days post-surgery. For the same period, all opioid doses were converted to morphine milligram equivalents (MME), mg/day. We used log-binomial regression to estimate adjusted risk ratios (aRR) with 95%-confidence intervals (CI) comparing patients within each SEP marker, adjusting for relevant confounding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 1-year risks of chronic opioid use were 33% for patients living alone versus 30% for patients cohabiting (aRR 1.05 [CI 1.02–1.09]), 37% for low versus 28% for high levels of liquid assets (aRR 1.28 [CI 1.23–1.34]), and 33% for low versus 28% for high education (aRR 1.19 [CI 1.14–1.25]). Patients living alone used 11.5 MME mg/day versus 9.8 mg/day in patients cohabiting, patients with low liquid assets used 14.8 versus 7.9 mg/day in patients with high liquid assets, and patients with low education used 11.8 versus 7.9 mg/day in patients with high education.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>About a third of hip fracture patients are using opioids continuously in the year after surgery. Living alone, less liquid assets, and low education were associated with a higher risk of opioid use and dosage of use, both in preoperative opioid users and non-users.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>This study shows that among patients undergoing hip fracture surgery, low socioeconomic position measured by living alone, having less liquid assets or low education is associated with a higher risk of chronic opioid use and higher dosage of use in the first year postoperatively. Clinicians should consider socioeconomic position when prescribing opioids after hip fracture. The integration of less addictive opioids and non-pharmacological approaches in the pain management may reduce opioid use and improve patient safety.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Role of Serum Brain-Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults”","authors":"","doi":"10.1002/ejp.70065","DOIUrl":"https://doi.org/10.1002/ejp.70065","url":null,"abstract":"<p>Ortolá R, Sotos-Prieto M, Carballo-Casla A, Cabello-Plan S, Koni A, Mustieles V, García-Segura LM, Artalejo AR, Rodríguez-Artalejo F, García-Esquinas E. Role of Serum Brain-Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults. Eur J Pain. 2025 May;29(5):e70014.</p><p>In the list of authors, the name/surname “Adrián Carballo” was incomplete. It should have read: “Adrián Carballo-Casla”.</p><p>We apologise for this error.</p>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of Interdisciplinary Care Programs for Women With Persistent Pelvic Pain","authors":"Catherine Andrews,&nbsp;Marie-Louise Bird,&nbsp;Kim Jose,&nbsp;Leesa Van Niekerk","doi":"10.1002/ejp.70060","DOIUrl":"https://doi.org/10.1002/ejp.70060","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background and Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Persistent pelvic pain affects one in four women, with international guidelines recommending interdisciplinary care. However, much of the literature describing treatments for pelvic pain focus on the perspective of individual professions. This narrative scoping review aimed to increase understanding of interdisciplinary pelvic pain care in terms of the professions and treatment components included, coordination of care and the inclusion of people with lived experience (PWLE) in program development.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Databases and Data Treatment&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Guided by PRISMA guidelines for scoping reviews, systematic database searches were conducted in CINAHL, Scopus, Medline and PsychINFO to identify interdisciplinary programs for women with persistent pelvic pain, including pelvic pain diagnoses such as endometriosis, vulvodynia and painful bladder syndrome. Data were charted on number and type of professions (disciplines) included, treatment components, care organisation and coordination, and PWLE involvement.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The search yielded 1068 records; 69 full-text articles were reviewed, and 16 studies were eligible for inclusion. Commonly included professions were physiotherapy, psychology and gynaecology. Treatment components included assessment, education and pain management strategies. Information pertaining to the coordination of care between professions and the engagement of PWLE in program development was limited.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This review found significant variation in the structure and components of interdisciplinary pelvic pain care programs, emphasising the need for greater consistency in their development and implementation. Further empirical research is needed to evaluate the effectiveness of specific program components. Enhanced coordination among professions and increased involvement of PWLE in program design are also recommended.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Significance Statement&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This scoping review found wide variability in the processes of interdisciplinary pelvic pain care for women. Professions most frequently included were pelvic physiotherapy, psychology and gynaecology, and components most consistently included were assessment, education and pain management strategies. Coordination of care was poorly described, and people with lived experience (PWLE) were rarely involved in program d","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering Pain Experience in Adult Patients With Sickle Cell Disease: A Network Analysis of Pain-Related Factors in a Single French Sickle Cell Centre","authors":"D. Oudin Doglioni,&nbsp;M. Couette,&nbsp;S. Forté,&nbsp;F. Galacteros,&nbsp;M.-C. Gay","doi":"10.1002/ejp.70059","DOIUrl":"https://doi.org/10.1002/ejp.70059","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Sickle cell disease (SCD) is the most prevalent inherited haemoglobinopathy characterised by chronic pain with acute painful episodes due to vaso-occlusion. The effective management of pain by adults with SCD influences their health outcomes. Opioids remain essential for most pain syndromes, but non-pharmacological interventions are preferred for daily pain due to the risk of addiction. However, their effectiveness is variable. Understanding the underlying processes associated with pain is crucial for developing more effective non-pharmacological strategies. This study aimed to enhance comprehension of the pain mechanisms in SCD to identify potential areas of action for effective non-pharmacological interventions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;An evaluation was conducted on the severity and interference of pain, pain-related cognitions and emotions. We used network analysis to simultaneously examine the intricate relationships between these variables.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A pain intensity exceeding 4 at a steady state distinguishes a subgroup at elevated risk of negative pain-related emotions and cognitions. The network analysis revealed intricate interconnections, with three distinct subgroups of variables mimicking the Neuromatrix model (cognitive-evaluative, motivational-affective and sensory-discriminative subgroups). The derived directed acyclic graph suggests potential mechanisms between these three subgroups, with catastrophising having a pivotal role.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study extends previous research by providing a comprehensive network analysis of pain-related variables in SCD, offering novel insights into the complex interplay between pain experience, cognitions and emotions. These findings have important clinical implications, as they suggest that targeting dysfunctional pain cognitions and/or negative emotions may be beneficial for improving pain management and quality of life in SCD.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Significance Statement&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study was the first to use network analyses to understand simultaneously multiple relationships between variables referring to pain, and pain-related negative emotions and cognitions in adults with SCD. Findings, providing support to the Neuromatrix model, offer novel insight to better understand pain and the associated negative emotions and cognition in SCD. The derived direct","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive and Personality Profiles of Patients With Chronic Trigeminal Neuralgia","authors":"Anton Pashkov,&nbsp;Elena Filimonova,&nbsp;Azniv Martirosyan,&nbsp;Galina Moisak,&nbsp;Jamil Rzaev","doi":"10.1002/ejp.70054","DOIUrl":"https://doi.org/10.1002/ejp.70054","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients suffering from chronic pain are known to exhibit distinctive personality traits and impaired neuropsychological performance across various cognitive domains. However, there is currently a lack of comprehensive evidence regarding cognitive and behavioural functioning patterns in patients with trigeminal neuralgia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, we aimed to thoroughly characterise a range of psychological and neuropsychological variables in a sample of 73 patients and 34 healthy controls, and to assess their relationship with pain intensity and duration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our findings revealed that patients with trigeminal pain scored significantly higher on measures of anxiety, depression, perceived stress, alexithymia, pain catastrophizing, harm avoidance and lower on the Self-transcendence subscale compared to healthy controls. Additionally, these patients demonstrated lower performance scores on tasks assessing working memory and verbal fluency. The regression model with Rey complex figure copy, backward digit span and perceived stress scores taken as predictors accounted for 32% of the pain intensity variance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings may provide valuable insights for the development of personalised treatment plans for patients with trigeminal neuralgia, specifically targeting their unique personality traits and cognitive impairments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance</h3>\u0000 \u0000 <p>Our work expands the current understanding of cognitive deficits and personality traits in patients with chronic facial pain. Furthermore, this study provides additional evidence that psychological and neuropsychological factors significantly contribute to the patients' perception of pain.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Kidney Disease as a Relevant Comorbidity in the Association Between Chronic Postsurgical Pain and Dementia Risk","authors":"Amir Reza Akbari,&nbsp;Benyamin Alam","doi":"10.1002/ejp.70053","DOIUrl":"https://doi.org/10.1002/ejp.70053","url":null,"abstract":"","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Opioid Use Before and After Parkinson's Disease Diagnosis","authors":"Majd Al-Sagheer,&nbsp;Niina Karttunen,&nbsp;Anne Paakinaho,&nbsp;Marjaana Koponen,&nbsp;Valtteri Kaasinen,&nbsp;Sirpa Hartikainen,&nbsp;Miia Tiihonen,&nbsp;Anna-Maija Tolppanen","doi":"10.1002/ejp.70056","DOIUrl":"https://doi.org/10.1002/ejp.70056","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pain is a common symptom of Parkinson's disease (PD). It occurs also as a prodromal sign of PD. It has not yet been described how the use of analgesics changes over time in persons with PD. We investigated the incidence of opioid use from 5 years before to 5 years after PD diagnosis and compared the incidence to a matched cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 15,763 people diagnosed with incident PD in 2001–2014 and 62,907 matched comparison persons without PD from the Finnish nationwide register-based study on Parkinson's disease (FINPARK). Initiation rates of opioid use during the follow-up were calculated in 6-month time windows, and the difference between persons with and without PD was described using incidence rate ratios (IRRs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Opioid initiation was more common among persons with PD (37.0%) compared to people without PD (31.2%). The difference between the groups emerged 3 years before the PD diagnosis IRR 1.33 (1.16–1.53), and remained until the end of the follow-up. Mild opioids, such as tramadol and codeine, were the most commonly initiated opioids, and the largest difference in their use was observed 6 months prior to the diagnosis date, while differences in strong opioids emerged after the PD diagnosis. Initiation rates increased over time and remained above those of the comparison group after the PD diagnosis for all opioid classes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings demonstrate the incidence of moderate/severe pain in PD, which requires treatment with opioid-class analgesics. Further studies are needed to understand the long-term impact of opioid use in persons with PD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>Initiation rate of opioids is increased in persons with Parkinson's disease already at premotor or early motor stage, before the diagnosis is confirmed. Shift towards stronger opioids is observed over the disease progress. Further studies are needed to investigate optimized pain management strategies in Parkinson's disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}