European Journal of Pain最新文献

{"title":"Temporal Associations of Physical Activity With Subsequent Knee Pain in Individuals With Knee Osteoarthritis: An Ecological Momentary Assessment Study","authors":"Alison H. Chang, Emma Hertel, Malene Kjær Bruun, Erika Maria Kristensen, Kristian Kjær-Staal Petersen, Michael Skovdal Rathleff","doi":"10.1002/ejp.70026","DOIUrl":"https://doi.org/10.1002/ejp.70026","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Physical activity (PA) is a first-line treatment for knee osteoarthritis and provides benefits for functional improvement and pain relief. However, movement-evoked pain often hinders PA participation and long-term adherence. The relationship between PA and pain is not fully understood and may vary across individuals. We examined the temporal associations between PA and subsequent knee pain in individuals with knee osteoarthritis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a 10-day ecological momentary assessment (EMA) cohort study, PA was recorded using an Actigraph accelerometer; momentary knee pain intensity was rated on a numeric rating scale in responses to four daily text prompts. Linear mixed-effects models examined within-day and between-day associations between PA and knee pain, adjusting for age, sex and BMI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The sample included up to 454 observations across 10 days from 17 participants (age = 64 ± 7 years, BMI = 27 ± 4 kg/m<sup>2</sup>, 61% women), each consisting of a temporal pair of PA minutes and subsequent momentary pain. Within-day, greater moderate-to-vigorous PA (MVPA) minutes were associated with a subsequent increase in knee pain (adjusted <i>β</i> = 0.112, 95% CI: 0.023, 0.201, <i>p</i> = 0.014); while light-intensity PA showed no association with subsequent pain (adjusted <i>β</i> = −0.003, 95% CI: −0.011, 0.005, <i>p</i> = 0.461). Current-day MVPA and light-intensity PA minutes were not associated with next-day knee pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While MVPA may temporarily increase knee pain, its impact was transient. Light-intensity PA showed no association with pain, suggesting it may be a suitable alternative for those with movement-evoked pain. Understanding these temporal patterns can help guide tailored pain management and PA adherence strategies. Further research is needed to confirm these preliminary findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>Understanding the dynamic relationship between PA and knee pain is crucial for optimising the management of knee OA. This exploratory study offers new insights by leveraging high-frequency data to examine the intra- and inter-day associations of MVPA and light-intensity PA with subsequent knee pain. The preliminary findings demonstrate that MVPA may lead to transient pain increases, while light-intensity PA is not associated with pain in","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Lysophosphatidic Acid Levels in Fibromyalgia and Other Painful Conditions in Female Patients","authors":"Joana Menezes,&nbsp;Jenny E. Jakobsson,&nbsp;Alex Bersellini Farinotti,&nbsp;Emerson Krock,&nbsp;Matthew A. Hunt,&nbsp;Nils Simon,&nbsp;Sigita Venckute Larsson,&nbsp;Lars Tanum,&nbsp;Kim Kultima,&nbsp;Eva Kosek,&nbsp;Camilla I. Svensson","doi":"10.1002/ejp.70022","DOIUrl":"https://doi.org/10.1002/ejp.70022","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous work found a decrease in lysophosphatidylcholines (LPCs) in fibromyalgia (FM) serum, prompting the hypothesis that this decrease could be due to increased conversion of LPC to lysophosphatidic acid (LPA) through autotaxin (ATX). LPA has pronociceptive functions, and increased LPA levels could modulate FM pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study quantified LPA levels in serum and lumbar cerebrospinal fluid (CSF) and serum ATX levels in FM patients, comparing with healthy controls (HCs), osteoarthritis (OA), degenerative disc disease (DDD) and lumbar disc herniation (LDH) patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found increased serum LPA levels in FM and OA patients, with no changes in FM lumbar CSF. Unexpectedly, a positive correlation between serum LPA and conditioned pain modulation was observed in FM patients, while LPA levels were correlated with pain intensity and Knee Injury and Osteoarthritis Outcome Scores in OA. Serum ATX levels in FM patients were comparable to those in HC but correlated significantly with FM LPA levels (in one cohort), as well as with pain duration and the maximal weekly pain intensity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study suggests that increased LPA levels play distinct roles in FM and OA patients. In FM, LPA levels were linked to less impaired inhibitory pain pathways, while LPA levels in OA correlated with pain intensity and knee-related impairment. ATX levels in FM serum are associated with pain intensity and duration. These findings underscore the complex role of LPA and ATX in FM pathophysiology. Future studies are essential to clarify LPA's specific roles and to develop therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>This study provides novel insights into the role of LPA in FM and other chronic pain conditions. Although ATX levels were unchanged in FM, a positive correlation between serum ATX and LPA supports the role of ATX in LPA conversion. These findings suggest complex lipid dysregulation in FM, with LPA potentially modulating pain pathways. Further research is needed to clarify LPA's role and its potential as a biomarker or therapeutic target.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Information on the Time Course of Pain During an Episode of Acute Experimentally Induced Low Back Pain—A Randomised Experiment","authors":"M. Travers,&nbsp;B. M. Wand,&nbsp;D. Hince,&nbsp;W. Gibson,&nbsp;S. Meldgaard Hansen,&nbsp;T. Sigurðsson,&nbsp;S. Sorensen,&nbsp;T. Skuli Palsson","doi":"10.1002/ejp.70011","DOIUrl":"https://doi.org/10.1002/ejp.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We compared the time course of pain intensity ratings between two groups who were given different information during an episode of acute experimentally induced LBP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty weight-training naive and pain-free people participated in this randomised clinical experiment. Immediately after performing a back exercise intended to cause delayed onset muscle soreness, one group was told that their muscles had been damaged and advised they needed to protect their back over the coming days. The other group's symptoms were described in terms of tissue sensitisation, and they were advised to keep moving.</p>\u0000 \u0000 <p>The primary outcome was movement-evoked low back pain intensity measured using an 11-point numeric rating scale (NRS 0–10). Pain intensity was recorded at baseline, immediately after the intervention and then daily for 7 days. The method of generalised estimating equations (GEE) was used to estimate treatment effects for average daily pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Movement-evoked pain intensity scores changed over time in both groups (main effect of time: χ^2(7) = 246.2, <i>p</i> &lt; 0.001). However, the intervention did not affect movement-evoked pain intensity scores (main effect of group: χ^2(1) = 0.02, <i>p</i> &lt; 0.895). The adjusted mean difference between the groups was only −0.05/10 (95% CI –0.72 to 0.63, <i>p</i> = 0.895) when averaged across all time points.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We simulated an episode of low back pain and found that information based on tissue sensitivity and advice to remain active did not improve pain compared to information referencing tissue damage and advice to rest and protect the back.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>Contemporary clinical guidelines and models of care recommend avoiding pathoanatomical diagnostic labels and encourage clinicians to advise patients to stay active during an episode of acute low back pain (LBP).</p>\u0000 \u0000 <p>We simulated an episode of acute LBP and found that information based on tissue sensitivity and advice to remain active did not improve pain compared to information referencing tissue damage and advice to rest and protect the back. The results could be different if repeated in a clinical population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocebo Effect on Pain-Related Autonomic Responses in a State of Experimentally-Induced Sensitization","authors":"Florin Allmendinger,&nbsp;Jan Rosner,&nbsp;Thomas Egger,&nbsp;Paulina Simonne Scheuren,&nbsp;Michèle Hubli","doi":"10.1002/ejp.70029","DOIUrl":"https://doi.org/10.1002/ejp.70029","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Enhanced pain-related autonomic responses were reported after experimentally-induced secondary mechanical hyperalgesia (SMH) in healthy individuals as well as in a variety of chronic pain cohorts. Stimulus-induced autonomic responses can also be modulated by positive and negative expectations towards the applied stimulus. This study aimed to investigate the influence of negative expectations on pain-related autonomic responses after experimentally-induced SMH.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Forty healthy participants (20 females) were recruited and assigned to a NOCEBO or a NAïVE group. Phasic skin conductance responses (SCR) and tonic background skin conductance level (SCL) were recorded in response to 10 pinprick stimuli applied to both volar forearms. On one arm, all stimuli were applied (EXP-arm) before (PRE) and after (POST) an experimental heat pain model to induce SMH. The other arm served as the control (CTRL-arm). The NOCEBO group was instructed that the stimuli will be ‘more intense and painful’ in the POST-assessment. The NAïVE group did not receive any instructions. Pain ratings were matched to a numeric rating scale 4 across all assessments to control for subjective pain perception.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Only the combination of induced SMH and negative expectation (i.e., EXP-arm in the NOCEBO group) increased the pinprick-evoked phasic SCRs (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) from PRE to POST. Tonic background SCL increased from PRE to POST (&lt;i&gt;p&lt;/i&gt; &lt; 0.01) independent of stimulation area (i.e., EXP-arm or CTRL-arm) or group (i.e., NOCEBO or NAïVE).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;These results demonstrate facilitatory effects of top-down modulatory processes (i.e., negative expectations) on pain-related autonomic responses after experimentally-induced SMH.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Significance&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study showed a facilitatory effect of negative expectation on enhanced pain-related autonomic responses in a state of experimentally-induced sensitisation in healthy participants. Hence, pain-related autonomic responses are shaped by both bottom-up (nociceptive input) and top-down (expectation) modulatory processes. This leads to the clinical implication that increased pain-related autonomic responses reported in individuals with chronic pain might not solely reflect pain hypersensitivities through nociceptive sensitisation, but also exaggera","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Serum Brain-Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults","authors":"R. Ortolá,&nbsp;M. Sotos-Prieto,&nbsp;A. Carballo,&nbsp;S. Cabello-Plan,&nbsp;Aida Koni,&nbsp;V. Mustieles,&nbsp;L. M. García-Segura,&nbsp;A. R. Artalejo,&nbsp;F. Rodríguez-Artalejo,&nbsp;E. García-Esquinas","doi":"10.1002/ejp.70014","DOIUrl":"https://doi.org/10.1002/ejp.70014","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Serum brain-derived neurotrophic factor (BDNF) has emerged as a promising biomarker for chronic pain (CP) research and treatment. Yet, most human studies have been limited by small sample sizes, inadequate control of confounders and a lack of focus on sex and mental health differences.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study included data from 1932 community-dwelling individuals aged ≥ 65 years, randomly sampled from the Spanish general population. Serum BDNF was quantified by ELISA. CP characteristics were assessed using the European Chronic Pain Survey and classified according to electronic medical records (ICPC-2 codes). Linear regression models—adjusted for sociodemographic, lifestyle and clinical factors—and stratified analyses by sex and depression status (defined by Geriatric Depression Scale score, recent physician diagnosis or antidepressant use) were performed.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Among 962 men and 970 women, mean BDNF concentrations were 18.55 (5.66) ng/mL and 19.39 (5.77) ng/mL, respectively. Most participants reported pain in multiple locations (median 3 sites, interquartile range: 2–4). In 511 participants with CP, probable musculoskeletal pain was predominant (&lt;i&gt;n&lt;/i&gt; = 446), followed by nociplastic (&lt;i&gt;n&lt;/i&gt; = 71), neuropathic (&lt;i&gt;n&lt;/i&gt; = 54), visceral (&lt;i&gt;n&lt;/i&gt; = 51) and vascular pain (&lt;i&gt;n&lt;/i&gt; = 22). Notably, in non-depressed participants (&lt;i&gt;n&lt;/i&gt; = 1639), women with severe or interfering pain showed lower BDNF concentrations [β coefficient (95% confidence interval) = −2.62 ng/mL (−5.03, −0.22) and −3.09 ng/mL (−4.71, −1.47), respectively] compared to those without CP—a pattern not seen in men. Conversely, among men with depression (&lt;i&gt;n&lt;/i&gt; = 293), both severe [−5.12 g/mL (−9.26, −0.99)] and interfering [−4.95 g/mL (−8.29, −1.61)] pain were linked to lower BDNF, a trend absent in depressed women. Similar associations were observed in analyses of musculoskeletal and nociplastic pain subtypes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;While serum BDNF is a promising biomarker for CP, its reliability for gauging pain severity depends on patient sex and depression status. These factors must be considered to enhance the accuracy and clinical relevance of BDNF in CP evaluation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Significance&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our study is the first to reveal that the relationship between serum BDNF and chronic pain is distinctly modulated by ","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Disturbance as a Common Pathway in Painful Temporomandibular Disorders and Headaches—Implications for Cardiometabolic Risk","authors":"Miguel Meira e Cruz","doi":"10.1002/ejp.70024","DOIUrl":"https://doi.org/10.1002/ejp.70024","url":null,"abstract":"","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and Sleep Quality Effects on the Relationship Between Sleep Disruption and Pain Sensitivity","authors":"Elisabet Dortea Ragnvaldsdóttir Joensen,&nbsp;Laura Frederiksen,&nbsp;Signe Vindbæk Frederiksen,&nbsp;Emilie Stjernholm Valeur,&nbsp;Rocco Giordano,&nbsp;Emma Hertel,&nbsp;Kristian Kjær-Staal Petersen","doi":"10.1002/ejp.70023","DOIUrl":"https://doi.org/10.1002/ejp.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic pain affects around 20% of the global population and is influenced by various factors, including sleep quality. Studies indicate that sleep disruption can enhance pain sensitivity; however, it is unclear how sex and baseline sleep quality impact these findings. This study examines how sex and baseline sleep quality impact the effects of three nights of sleep disruption on pain sensitivity in healthy individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-nine participants (30 females) underwent two laboratory sessions, separated by three nights of sleep disruption. Pain sensitivity was measured using cuff and handheld algometry, and participants completed a battery of questionnaires on sleep quality, positive and negative affect, and pain catastrophising. Sleep patterns were collected through wrist actigraphy and self-reported sleep diaries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Temporal summation of pain was significantly facilitated in males (<i>p</i> &lt; 0.01), and pain during suprathreshold stimulation was increased for females (<i>p</i> &lt; 0.01) after the experimental sleep disruption. No differences in any QST parameters were found when comparing participants with good or poor sleep at baseline, but those with good baseline sleep rated the suprathreshold stimulation as more painful (<i>p</i> &lt; 0.05) after the experimental sleep disruption. Finally, having good or poor sleep quality at baseline was associated with a significant reduction in self-reported sleep quality and level of rest after the experimental sleep disruption (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study indicates that sleep disruption might impact sexes differently and indicates that prior sleep quality is less likely to impact this.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance</h3>\u0000 \u0000 <p>Sleep disruption protocols can mimic the sleep problems experienced by patients with chronic pain. The current study explains how different sexes respond to a 3-night sleep disruption protocol and explains how sleep quality at baseline might impact these results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Ability of Previous Pain and Disease Conditions on the Presentation of Post-COVID Pain in a Danish Cohort of Adult COVID-19 Survivors","authors":"Brian Duborg Ebbesen,&nbsp;Jakob Nebeling Hedegaard,&nbsp;Simon Grøntved,&nbsp;Rocco Giordano,&nbsp;César Fernández-de-las-Peñas,&nbsp;Lars Arendt-Nielsen","doi":"10.1002/ejp.70021","DOIUrl":"https://doi.org/10.1002/ejp.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Even though many post-COVID pain risk factors have been identified, little is known about the predictive profiles of these risk factors for the development of post-COVID pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data was collected from two separate questionnaires assessing demographics, pre-existing medical comorbidities, pain history, and post-COVID pain experience. Socioeconomic data and COVID-19 RT-PCR test results were collected from Danish registries. The study cohort (<i>n</i> = 68,028) was stratified into two groups reporting pre-COVID pain (<i>n</i> = 9090) and no pre-COVID pain (<i>n</i> = 55,938). Forward-selection prediction models were employed to identify predictor profiles for post-COVID pain in the full study cohort (Model 1) and the stratified groups with (Model 2) and without (Model 3) pre-COVID pain from 58 potential risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Model 1 achieved a 5-fold cross-validated AUC (cvAUC) of 0.68. Use of pain medication, stress, high income, age, female gender, and weight were the top predictors contributing to 97% of the model performance. Model 2 (cvAUC = 0.69) identified use of pain medication, breathing pain, stress, height, physical activity, and weight as the top predictors contributing to 98.6% of model predictive performance. Model 3 (cvAUC = 0.65) identified stress, female gender, weight, higher education, age, high income, and physical activity as the top predictors contributing to 98.5% of model predictive performance. Height was unique to Model 2, while being female and higher income were unique to Model 3.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The study highlights potential important predictors, and further research is needed to describe these in detail. The results may apply to the understanding of post-viral pain sequelae after other viral infections.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>The explorative study investigates the predictive ability of a battery of pre-COVID risk factors potentially associated with the development of post-COVID pain. This article presents the profiles of predictors of interest in COVID-19 survivors with and without pre-COVID pain. The results will contribute to the understanding of patient profiles that might develop post-COVID pain conditions and provide a first step towards focused clinical predictive research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryo-Induced Hypoalgesia: The Effects of an Acute Cryochamber Exposure on Pain Perception—A Randomised Controlled Cross-Over Trial","authors":"Fabian Tomschi,&nbsp;Alexander Schmidt,&nbsp;Thomas Cegla,&nbsp;Thomas Hilberg","doi":"10.1002/ejp.70017","DOIUrl":"https://doi.org/10.1002/ejp.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Whole-body cryotherapy (WBC) is a treatment that involves exposing the entire body to extremely cold temperatures and is used in therapeutic and sports scientific settings. Here, cryotherapy is often used to alleviate pain, but its underlying pain physiological effects are under-researched. This study aims to explore whether a 3-min cryochamber application results in cryo-induced hypoalgesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>24 healthy male participants successfully conducted this randomised controlled crossover study consisting of a 3-min WBC (cryochamber at −87°C) and a 3-min control (ambient temperature) session. Pressure pain thresholds (PPT [Newton/cm²]) were measured at the rectus femoris, knee joint, deltoid muscle and sternum pre and post0, post5, post15 and post30.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results revealed a significant ‘condition’ × ‘time’ interaction (<i>p</i> &lt; 0.001, <i>η</i>²_partial = 0.280) for PPT_Total (pooled for one average value) with hypoalgesia observed after WBC (<i>p</i> &lt; 0.001; pre: 77.0 ± 17.2, post0: 89.6 ± 18.6, post5: 83.6 ± 19.4, post15: 83.1 ± 18.2, post30: 80.8 ± 17.7) and no change following the control (<i>p</i> = 0.873; pre: 75.1 ± 18.8, post0: 75.3 ± 19.4, post5: 74.6 ± 19.2, post15: 75.7 ± 19.3, post30: 75.3 ± 19.1). The same pattern was observed for individual landmarks. Between-group differences were consistently observed, with higher values following the WBC. No significant ‘time’ × ‘intervention’ × ‘landmark’ interaction effect (<i>p</i> = 0.439) was found.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrates that a three-minute cryochamber exposure induces robust hypoalgesia in healthy participants, as indicated by increased PPT, lasting up to 30 min but gradually declining over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>Whole-body cryotherapy significantly induces short-term hypoalgesia, with increased mechanical pain thresholds lasting up to 30 minutes. Compared to ambient temperature, cryotherapy provided greater pain relief across multiple body landmarks, with 82.6% of participants experiencing hypoalgesia. These findings highlight the potential of cryotherapy for pain management and support further research on its long-term efficacy and clinical applications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Proteomic Analysis of Patients With Herpes Zoster to Identify Predictors of Postherpetic Neuralgia Risk","authors":"Tianqi Zhang,&nbsp;Naikun Wang,&nbsp;Tong Zhu,&nbsp;Jin Xu,&nbsp;Mengjiao Tan,&nbsp;Ran Wang,&nbsp;Ying Han","doi":"10.1002/ejp.70015","DOIUrl":"https://doi.org/10.1002/ejp.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Postherpetic neuralgia (PHN) is a common and severe complication of herpes zoster (HZ). However, the understanding of the pathological mechanism relevant in the earlier phase of PHN is limited. This study aimed to explore the association of plasma proteins with PHN risk and identify candidate proteins to predict PHN during the acute phase of HZ infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Liquid chromatography tandem mass spectrometry (LC–MS/MS)-based proteomic technology was used to profile characteristic proteins in 31 patients with HZ infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The levels of 318 plasma proteins were quantified in acute HZ infected patients by untargeted proteomics. Twenty-four plasma proteins were dysregulated in HZ infected patients developing PHN compared with recovered patients. Among these proteins, 16 plasma proteins may be correlated with PHN risk. TTR, NCAM1 and SH3BGRL3 were first proposed as candidate biomarkers for PHN. The baseline level of TTR increased, and NCAM1 and SH3BGRL3 decreased in the PHN group. They may affect the prognosis of HZ through extracellular exosome and complement activation (classical pathway). Besides, the baseline level of TTR may positively correlate with the pain severity of PHN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Altered abundance of plasma proteins in HZ infected patients was associated with PHN risk. In this study, TTR, NCAM1 and SH3BGRL3 were identified as potential predictors of PHN in early HZ infected patients. These results contribute to revealing the pathological mechanism and potential therapeutic targets of PHN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance Statement</h3>\u0000 \u0000 <p>This study first proved that protein expression in HZ infected patients with opposite outcomes is different, and proposed three potential biomarkers to predict PHN risk in the acute phase of HZ infection. Further research is needed to determine whether protein expression is related to the severity of pain.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}