EuropacePub Date : 2024-08-30DOI: 10.1093/europace/euae230
Elizabeth DeWitt, Jan Janousek, Susan P Etheridge
{"title":"Implantable cardioverter defibrillators in paediatric patients: yet another example of healthcare divergence?","authors":"Elizabeth DeWitt, Jan Janousek, Susan P Etheridge","doi":"10.1093/europace/euae230","DOIUrl":"10.1093/europace/euae230","url":null,"abstract":"","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical impact of atrial fibrillation progression in patients with heart failure with preserved ejection fraction: A report from the CHART-2 Study.","authors":"Tomohiro Ito, Takashi Noda, Kotaro Nochioka, Takashi Shiroto, Nobuhiko Yamamoto, Hiroyuki Sato, Takahiko Chiba, Yuhi Hasebe, Makoto Nakano, Hiroyuki Takahama, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa, Satoshi Yasuda","doi":"10.1093/europace/euae218","DOIUrl":"10.1093/europace/euae218","url":null,"abstract":"<p><strong>Aims: </strong>Atrial fibrillation (AF) frequently coexists with heart failure with preserved ejection fraction (HFpEF), and clinical outcomes of patients with AF vary depending on its subtype. While AF progression characterized by the transition from paroxysmal AF to persistent AF is sometimes observed, the incidence and clinical impact of AF progression in patients with HFpEF remain to be explored.</p><p><strong>Methods and results: </strong>We enrolled patients with HFpEF and paroxysmal AF from the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study. AF progression was defined as the transition from paroxysmal AF to persistent AF. A total of 718 patients (median age: 72 years, 36% were female) were enrolled. For a median follow-up of 6.0 years (interquartile range: 3.0-10.2 years), AF progression occurred in 105 patients (14.6%), with a cumulative incidence of 16.7% at 10 years. In the multivariable Cox proportional hazards model, previous hospitalization for heart failure [hazard ratio (HR) 1.74, 95% confidence interval (CI) 1.16-2.60; P = 0.007] and left atrial diameter (per 5-mm increase) (HR 1.37, 95% CI 1.20-1.55; P < 0.001) were significantly associated with AF progression. Furthermore, AF progression was significantly linked to worsening heart failure (adjusted HR 1.68, 95% CI 1.18-2.40; P = 0.004). Notably, 27 cases (26%) of worsening heart failure occurred within 1 year following AF progression.</p><p><strong>Conclusion: </strong>In patients with HFpEF, AF progression is significantly associated with adverse outcomes, particularly worsening heart failure. An increased risk is observed in the early phases following progression to persistent AF.</p><p><strong>Registration: </strong>Clinical Trials.gov Identifier: NCT00418041.</p>","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EuropacePub Date : 2024-08-30DOI: 10.1093/europace/euae216
Ivan Zeljkovic, Anaïs Gauthey, Martin Manninger, Katarzyna Malaczynska-Rajpold, Jacob Tfelt-Hansen, Lia Crotti, Elijah R Behr, Federico Migliore, Arthur Wilde, Julian Chun, Giulio Conte
{"title":"Genetic testing for inherited arrhythmia syndromes and cardiomyopathies: results of the European Heart Rhythm Association survey.","authors":"Ivan Zeljkovic, Anaïs Gauthey, Martin Manninger, Katarzyna Malaczynska-Rajpold, Jacob Tfelt-Hansen, Lia Crotti, Elijah R Behr, Federico Migliore, Arthur Wilde, Julian Chun, Giulio Conte","doi":"10.1093/europace/euae216","DOIUrl":"10.1093/europace/euae216","url":null,"abstract":"<p><strong>Aims: </strong>Indications and clinical impact of genetic testing for cardiac diseases have increased significantly over the past years. The aim of this physician-based European Heart Rhythm Association (EHRA) survey was to assess current clinical practice and access to genetic testing for cardiac diseases across European Society of Cardiology countries and to evaluate adherence to the 2022 EHRA/HRS/APHRS/LAHRS Expert Consensus Statement on genetic testing.</p><p><strong>Methods and results: </strong>An online questionnaire composed of 28 questions was submitted to the EHRA Research Network and European Reference Network GUARD-Heart healthcare partners and promoted via dedicated social media channels. There were 357 respondents from 69 countries, 40% working in a hospital setting with a cardiac genetic service and/or a dedicated clinic focusing on inherited cardiac diseases and 27% with an onsite genetic laboratory. No genetic testing or low annual rate (<10/year) was declared by 39% of respondents. The majority of respondents (78%) declared issues or limitations to genetic testing access in their clinical practice. The main reasons for not providing or limited access to genetic testing were no availability of dedicated unit or genetic laboratory (35%) or reimbursement issues (25%). The most frequently reported indication for genetic testing was diagnostic purpose (55%). Most respondents (92%) declared offering genetic testing preceded by genetic counselling and 42% regular multidisciplinary evaluations for patients with cardiac genetic diseases. The perceived value of genetic testing in the diagnostic, prognostic, and therapeutic assessment was variable (67, 39, and 29%, respectively) and primarily based on the specific inherited disease. The majority of respondents recommended cascade genetic testing for the first-degree family members in case of pathogenic/likely pathogenic variant in the proband.</p><p><strong>Conclusion: </strong>This survey highlights a significant heterogeneity of genetic testing access and provision and issues attributable to the availability of dedicated unit/genetic laboratory and reimbursement. However, adequate adherence to indications in the current recommendations for genetic testing in patients with cardiac diseases was observed.</p>","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EuropacePub Date : 2024-08-30DOI: 10.1093/europace/euae222
Damir Erkapic, Konstantinos Roussopoulos, Marko Aleksic, Kay Felix Weipert, Korkut Sözener, Karel Kostev, Jens Allendörfer, Josef Rosenbauer, Samuel Sossalla, Dursun Gündüz, Christian Tanislav
{"title":"Microembolizations in the arterial cerebral circulation during atrial fibrillation ablation: cryoballoon technique advantages and neurocognitive safety-results of a prospective observational study.","authors":"Damir Erkapic, Konstantinos Roussopoulos, Marko Aleksic, Kay Felix Weipert, Korkut Sözener, Karel Kostev, Jens Allendörfer, Josef Rosenbauer, Samuel Sossalla, Dursun Gündüz, Christian Tanislav","doi":"10.1093/europace/euae222","DOIUrl":"10.1093/europace/euae222","url":null,"abstract":"<p><strong>Aims: </strong>The significance of micro-embolic signals (MESs) during atrial fibrillation (AF) ablation is unclear. Previous studies had limitations, and cryoballoon (CB) ablation patients were under-represented. Minimizing MESs is recommended due to their uncertain neurocognitive impact.</p><p><strong>Methods and results: </strong>This prospective observational study included AF patients from a German centre between February 2021 and August 2022. Patients were equally divided into paroxysmal (Group A) and persistent (Group B) AF. Group A received cryoballoon-pulmonary vein isolation only, while Group B also had left atrial roof ablation. MESs were detected using transcranial Doppler ultrasonography during ablation. Neurocognitive status was assessed pre- and post-procedure and at 3 months using the CERAD Plus battery. The study analyzed 100 patients with a median age of 65.5 years. A total of 19 698 MESs were observed, with 80% being gaseous and 20% solid in origin, primarily occurring during pulmonary vein angiography and the balloon freeze and thawing phase. The median MES per patient was 130 (IQR: 92-256) in total, 298 (IQR: 177-413) in bilateral (36%), and 110 (IQR: 71-130) in unilateral (64%) recordings. No significant difference in total MES counts was found between the groups. None of the 11 neuropsychological tests showed cognitive decline post-procedure or at 3 months.</p><p><strong>Conclusion: </strong>Our observations confirm that neurocognitive abilities are not affected either 24 h or 3 months after AF ablation using the CB technique. However, despite the low MES burden associated with the CB, more work is needed to reduce small embolic events during AF ablation.</p>","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing simultaneous hybrid ablation with stand-alone thoracoscopic surgical ablation for the treatment of non-paroxysmal atrial fibrillation: a prospective randomized controlled trial.","authors":"Zhe Zheng, Yan Yao, Haojie Li, Chunyu Yu, Lihui Zheng, Ligang Ding, Lingmin Wu, Sipeng Chen, Hengqiang Lin, Ying Meng","doi":"10.1093/europace/euae226","DOIUrl":"10.1093/europace/euae226","url":null,"abstract":"<p><strong>Aims: </strong>Advanced atrial fibrillation (AF) is currently a dilemma for electrophysiologists when choosing a minimally invasive treatment strategy. Previous studies have demonstrated the outcome of either catheter ablation or thoracoscopic surgical ablation (SA) is unsatisfactory in these patients. Whether hybrid ablation (HA) could improve outcomes in these patients is unknown. The purpose of this study was to evaluate the clinical efficacy of HA for the treatment of advanced AF.</p><p><strong>Methods and results: </strong>A randomized controlled trial was designed to enrol patients with persistent AF (PerAF) and enlarged left atrium or long-standing persistent AF (LSPAF) who were randomized to HA or thoracoscopic SA at a 1:1 ratio. The primary endpoint was freedom from any recurrence of AF off antiarrhythmic drugs (AADs) 12 months after operation. The primary endpoint was monitored by 7-day electrocardiogram monitoring devices. One hundred patients were enrolled. The mean age was 58.5 ± 7.6 years, and the mean left atrial diameter (LAD) was 50.1 ± 6.1 mm. At 12 months, freedom from AF off AADs was recorded in 71.4% (35/49) of patients in HA group and 45.8% (22/48) in SA group [odds ratio 2.955, 95% confidence interval (1.275-6.848), P = 0.014]. HA significantly reduced patients' AF burden (30.2% in SA group and 14.8% in HA group, P = 0.048) and the LAD (mean differences: -5.53 ± 4.97 mm in HA group and -3.27 ± 5.20 mm in SA group, P = 0.037) at 12 months after operation.</p><p><strong>Conclusion: </strong>In patients with PerAF and enlarged left atrium or LSPAF, HA achieved better freedom from AF after 1 year of follow-up compared with thoracoscopic SA.</p>","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EuropacePub Date : 2024-08-30DOI: 10.1093/europace/euae204
Andreas Goette, Domenico Corradi, Dobromir Dobrev, Luis Aguinaga, Jose-Angel Cabrera, Sumeet S Chugh, Joris R de Groot, Laurie Soulat-Dufour, Guilherme Fenelon, Stephane N Hatem, Jose Jalife, Yenn-Jiang Lin, Gregory Y H Lip, Gregory M Marcus, Katherine T Murray, Hui-Nam Pak, Ulrich Schotten, Naohiko Takahashi, Takanori Yamaguchi, William A Zoghbi, Stanley Nattel, Lluis Mont, Joseph G Akar, Nazem Akoum, Till Althoff, Juan Carlos Diaz, Jean-Baptiste Guichard, Amir Jadidi, Jonathan Kalman, Han Lim, Ricardo Alkmim Teixeira
{"title":"Atrial cardiomyopathy revisited-evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS).","authors":"Andreas Goette, Domenico Corradi, Dobromir Dobrev, Luis Aguinaga, Jose-Angel Cabrera, Sumeet S Chugh, Joris R de Groot, Laurie Soulat-Dufour, Guilherme Fenelon, Stephane N Hatem, Jose Jalife, Yenn-Jiang Lin, Gregory Y H Lip, Gregory M Marcus, Katherine T Murray, Hui-Nam Pak, Ulrich Schotten, Naohiko Takahashi, Takanori Yamaguchi, William A Zoghbi, Stanley Nattel, Lluis Mont, Joseph G Akar, Nazem Akoum, Till Althoff, Juan Carlos Diaz, Jean-Baptiste Guichard, Amir Jadidi, Jonathan Kalman, Han Lim, Ricardo Alkmim Teixeira","doi":"10.1093/europace/euae204","DOIUrl":"10.1093/europace/euae204","url":null,"abstract":"<p><strong>Aims: </strong>The concept of \"atrial cardiomyopathy\" (AtCM) had been percolating through the literature since its first mention in 1972. Since then, publications using the term were sporadic until the decision was made to convene an expert working group with representation from four multinational arrhythmia organizations to prepare a consensus document on atrial cardiomyopathy in 2016 (EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication). Subsequently, publications on AtCM have increased progressively.</p><p><strong>Methods and results: </strong>The present consensus document elaborates the 2016 AtCM document further to implement a simple AtCM staging system (AtCM stages 1-3) by integrating biomarkers, atrial geometry, and electrophysiological changes. However, the proposed AtCM staging needs clinical validation. Importantly, it is clearly stated that the presence of AtCM might serve as a substrate for the development of atrial fibrillation (AF) and AF may accelerates AtCM substantially, but AtCM per se needs to be viewed as a separate entity.</p><p><strong>Conclusion: </strong>Thus, the present document serves as a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS) to contribute to the evolution of the AtCM concept.</p>","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11431804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EuropacePub Date : 2024-08-30DOI: 10.1093/europace/euae231
Christopher R Zörner, Jacob Tønnesen, Lise Da Riis-Vestergaard, Charlotte Middelfart, Regitze Hein, Peter Vibe Rasmussen, Martin H Ruwald, Gunnar Gislason, Morten Lock Hansen
{"title":"Disparities in the access to atrial fibrillation ablation in Denmark: who gets ablated, who neglected?","authors":"Christopher R Zörner, Jacob Tønnesen, Lise Da Riis-Vestergaard, Charlotte Middelfart, Regitze Hein, Peter Vibe Rasmussen, Martin H Ruwald, Gunnar Gislason, Morten Lock Hansen","doi":"10.1093/europace/euae231","DOIUrl":"10.1093/europace/euae231","url":null,"abstract":"<p><strong>Aims: </strong>Atrial fibrillation (AF) is a common arrhythmia associated with reduced quality of life that can lead to serious complications such as stroke and heart failure. Ablation is a safe and effective treatment for AF but is not offered equally to all patients. The aim of this study is to identify demographic groups more or less likely to undergo AF ablation.</p><p><strong>Methods and results: </strong>All patients with newly diagnosed AF between 2010 and 2018 were identified in the Danish nationwide registries. The association between gender, age, level of education and attachment to the job market, and the likelihood of receiving AF ablation was investigated using multivariable Cox proportional hazard analysis. Cumulative incidence was calculated using the Aalen-Johansen estimator. A total of 176 248 patients were included. Men were more likely to receive ablation than women (7% vs. 3%). Patients aged 25-44 and 45-64 were most likely to receive ablation, while only 0.7% of patients aged 80 or above received ablation. The rate of ablation significantly decreased with decreasing level of education. Full-time employed patients were most likely to receive ablation, followed by self-employed, unemployed, on sick leave, undergoing education, and early retired patients. Retired patients were the least likely to receive ablation (3%).</p><p><strong>Conclusion: </strong>This study found that women, older patients, patients with lower levels of education, and patients on social benefits are less likely to receive AF ablation. These findings suggest that there are significant social and economic disparities in AF ablation treatment in Denmark.</p>","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EuropacePub Date : 2024-08-30DOI: 10.1093/europace/euae202
Frederic Franceschi, Linda Koutbi, Baptiste Maille
{"title":"Phrenic nerve palsy and pulsed field ablation procedures for atrial fibrillation.","authors":"Frederic Franceschi, Linda Koutbi, Baptiste Maille","doi":"10.1093/europace/euae202","DOIUrl":"10.1093/europace/euae202","url":null,"abstract":"","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EuropacePub Date : 2024-08-30DOI: 10.1093/europace/euae213
Rafal Gardas, Danuta Loboda, Jolanta Biernat, Tomasz Soral, Piotr Kulesza, Sylwia Gladysz-Wanha, Michal Joniec, Mateusz Sajdok, Kamil Zub, Krzysztof S Golba
{"title":"Extraction of lumenless pacing leads from the His bundle and left bundle branch area: outcomes of the high-volume centre.","authors":"Rafal Gardas, Danuta Loboda, Jolanta Biernat, Tomasz Soral, Piotr Kulesza, Sylwia Gladysz-Wanha, Michal Joniec, Mateusz Sajdok, Kamil Zub, Krzysztof S Golba","doi":"10.1093/europace/euae213","DOIUrl":"10.1093/europace/euae213","url":null,"abstract":"<p><strong>Aims: </strong>The application of conduction system pacing (CSP) in clinical practice is growing, and the need for lead extraction will also increase. The data on outcomes and safety of CSP lead extraction are limited. The aim of this study was to assess procedural outcomes and safety of CSP lead removal.</p><p><strong>Methods and results: </strong>Forty-seven patients from the EXTRACT Registry with the indication for CSP lead removal were enrolled in the study conducted at the Department of Electrocardiology in Katowice, Poland. Extraction technique, outcomes, safety, and complication were evaluated. Forty-three (91.5%) leads were successfully removed, and 41 (87.2%) were removed with traction only. The dwelling time of 28 extracted leads was longer than 1 year, and the oldest extracted lead was implanted for 89 months. Seven (14.9%) leads were removed from the left bundle branch (LBB) area and 36 from the His bundle (HB). Transient complete atrioventricular block occurred during the procedure in two patients. In 27 out of 31 attempts (87.1%), new CSP leads were implanted: nine (33.3%) HB pacing leads and 18 (66.7%) LBB area pacing leads.</p><p><strong>Conclusion: </strong>The CSP lead extraction is safe and feasible with a low complication rate and high rate of CSP lead reimplantation.</p>","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EuropacePub Date : 2024-08-30DOI: 10.1093/europace/euae220
Luigi Di Biase, Jacopo Marazzato, Tara Gomez, Eric Byun, Fengwei Zou, Vito Grupposo, Sanghamitra Mohanty, Vincenzo Mirco La Fazia, Giuseppe Ammirati, Aung Lin, Domingo Ynoa Garcia, Domenico Della Rocca, Amin Al Ahamad, Marco Schiavone, Alessio Gasperetti, Michael Freilich, Juan Cedeno Serna, Giovanni Forleo, Xu Liu, Dhanunjaya Lakkireddy, Claudio Tondo, Andrea Natale, Xiao-Dong Zhang
{"title":"Application repetition and electrode-tissue contact result in deeper lesions using a pulsed-field ablation circular variable loop catheter.","authors":"Luigi Di Biase, Jacopo Marazzato, Tara Gomez, Eric Byun, Fengwei Zou, Vito Grupposo, Sanghamitra Mohanty, Vincenzo Mirco La Fazia, Giuseppe Ammirati, Aung Lin, Domingo Ynoa Garcia, Domenico Della Rocca, Amin Al Ahamad, Marco Schiavone, Alessio Gasperetti, Michael Freilich, Juan Cedeno Serna, Giovanni Forleo, Xu Liu, Dhanunjaya Lakkireddy, Claudio Tondo, Andrea Natale, Xiao-Dong Zhang","doi":"10.1093/europace/euae220","DOIUrl":"10.1093/europace/euae220","url":null,"abstract":"<p><strong>Aims: </strong>Pulsed-field ablation (PFA) is a novel, myocardial-selective, non-thermal ablation modality used to target cardiac arrhythmias. Although prompt electrogram (EGM) signal disappearance is observed immediately after PFA application in the pulmonary veins, whether this finding results in adequate transmural lesions is unknown. The aim of this study is to check whether application repetition and catheter-tissue contact impact lesion formation during PFA.</p><p><strong>Methods and results: </strong>A circular loop PFA catheter was used to deliver repeated energy applications with various levels of contact force. A benchtop vegetal potato model and a beating heart ventricular myocardial model were utilized to evaluate the impact of application repetition, contact force, and catheter repositioning on contiguity and lesion depth. Lesion development occurred over 18 h in the vegetal model and over 6 h in the porcine model. Lesion formation was found to be dependent on application repetition and contact. In porcine ventricles, single and multiple stacked applications led to a lesion depth of 3.5 ± 0.7 and 4.4 ± 1.3 mm, respectively (P = 0.002). Furthermore, the greater the catheter-tissue contact, the more contiguous and deeper the lesions in the vegetal model (1.0 ± 0.9 mm with no contact vs. 5.4 ± 1.4 mm with 30 g of force; P = 0.0001).</p><p><strong>Conclusion: </strong>Pulsed-field ablation delivered via a circular catheter showed that both repetition and catheter contact led independently to deeper lesion formation. These findings indicate that endpoints for effective PFA are related more to PFA biophysics than to mere EGM attenuation.</p>","PeriodicalId":11981,"journal":{"name":"Europace","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}