European Journal of Clinical Microbiology and Infectious Diseases最新文献_第4页

Evaluation of Regulatory T Cells in Chronic Hepatitis C Patients 慢性丙型肝炎患者调节性T细胞的评估

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-12-30 DOI: 10.36519/idcm.2021.68

Yesim Tuyji-Tok, A. Şener, Aysegul Aksoy-Gokmen, T. Demirdal, Selçuk Kaya

{"title":"Evaluation of Regulatory T Cells in Chronic Hepatitis C Patients","authors":"Yesim Tuyji-Tok, A. Şener, Aysegul Aksoy-Gokmen, T. Demirdal, Selçuk Kaya","doi":"10.36519/idcm.2021.68","DOIUrl":"https://doi.org/10.36519/idcm.2021.68","url":null,"abstract":"Background: Although there have been significant improvements in treatment strategies, hepatitis C infection is still among the most critical public health problems worldwide. Upon entry of hepatitis C virus (HCV) into host liver cells, many antagonist immune responses are induced, including the production of regulatory T cells (Tregs). The main function of Tregs is coordinating an appropriate immune response, including suppression of this response once it is no longer needed. Tregs protect cells from immunopathologic damage of HCVspecific T cells but, on the other hand, cause viral persistence, cirrhosis and hepatocellular carcinoma (HCC). In this study, we aimed to determine whether the evaluation of Tregs in hepatitis C patients was a useful method for indicating disease chronicity. Materials and Methods: The peripheral blood samples were taken from sixty volunteers, including 30 non-cirrhotic chronic hepatitis C patients and 30 healthy controls selected from infectious diseases outpatient/clinic service applicants. Their CD4+CD25high FoxP3+CD152+CD127low Treg distributions were measured by flow cytometry, using recently identified markers combined. Results: Treg percentages of the subjects with hepatitis C infection (7.97±1.25) were significantly higher than those of the healthy control group (4.29±1.37) (p<0.05). Additionally, the percentages of Tregs were strongly correlated with HCV RNA load (r=0.725, p<0.05) as well as serum AFP levels (r=0.711, p<0.05). Conclusion: Tregs are thought to play an important role in the immunology of HCV infection, thereby providing a promising method for the prediction of disease prognosis and for potentially developing new therapeutic strategies by targeting the Treg.","PeriodicalId":11964,"journal":{"name":"European Journal of Clinical Microbiology and Infectious Diseases","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79162810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do the Most Cited Web Sources Provide Proper Information on Influenza Vaccination? 被引用最多的网络来源是否提供了正确的流感疫苗接种信息?

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-12-30 DOI: 10.36519/10.36519/idcm.2021.71

E. M. Saricaoğlu, Ayda Gholizadeh, Cemre Kırım, Elif Yunt, Ihsan Mert Turk, İlker Anıl Celik, Kardelennur Yıldırım, Pelin Ozbakir, A. Azap

{"title":"Do the Most Cited Web Sources Provide Proper Information on Influenza Vaccination?","authors":"E. M. Saricaoğlu, Ayda Gholizadeh, Cemre Kırım, Elif Yunt, Ihsan Mert Turk, İlker Anıl Celik, Kardelennur Yıldırım, Pelin Ozbakir, A. Azap","doi":"10.36519/10.36519/idcm.2021.71","DOIUrl":"https://doi.org/10.36519/10.36519/idcm.2021.71","url":null,"abstract":"Objective: The Internet is increasingly preferred as a source of health-related information. However, several studies revealed deficiencies in the quality of web-based health information. Therefore, this study aimed to analyze the content and design of influenza vaccine-related websites. Materials and Methods: This study was conducted using a search engine, Google Search, in the Turkish language. We identified 15 influenza-related search terms, and for each term, the top ten links on the first page were included in the study after removing duplicate links. Then, we evaluated identified websites in terms of content and design criteria. Results: Seventy-one links related to influenza vaccination were evaluated in our study. The mean content criteria score of all selected websites was 11.5 points. While academic websites received the highest contents point with 22.5, news and hospital sites remained under the average with 10.5 and 8.9 points, respectively. Thirty-eight per cent of the websites had aesthetic/content professionalism, and 77.5% included contact information. References were shown only in 14.1% of websites. The websites with higher design criteria did not have higher content points. Conclusion: The Internet remains a frequently referenced source of information. The accuracy of the information on health topics included on the Internet is important in terms of public health. Unfortunately, according to our study, the top websites giving information on influenza vaccination were not well designed and had insufficient content.","PeriodicalId":11964,"journal":{"name":"European Journal of Clinical Microbiology and Infectious Diseases","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83967971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refik Saydam: A Pioneer in the Fight Against Infectious Diseases Refik Saydam:对抗传染病的先驱

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-12-30 DOI: 10.36519/idcm.2021.109

Cemaliye Başaran

引用次数: 0

Antifungal susceptibility profile of Candida spp. causing candidemia in an Indonesian tertiary hospital 印度尼西亚一家三级医院念珠菌引起念珠菌病的抗真菌敏感性分析

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-12-21 DOI: 10.51559/jcmid.v1i2.5

A. Wulandari, Rebriarina Hapsari, Mujahidah, Desvita Sari, Iva Puspitasari, D. Pramukarso

{"title":"Antifungal susceptibility profile of Candida spp. causing candidemia in an Indonesian tertiary hospital","authors":"A. Wulandari, Rebriarina Hapsari, Mujahidah, Desvita Sari, Iva Puspitasari, D. Pramukarso","doi":"10.51559/jcmid.v1i2.5","DOIUrl":"https://doi.org/10.51559/jcmid.v1i2.5","url":null,"abstract":"Introduction: Invasive candidiasis has emerged as a significant public health problem in recent years, and candidemia is the most common form. Identification of the Candida species is important since some Candida species showed an increasing trend of resistance to commonly used antifungal agents. This study was conducted to describe primary demographic data and the distribution of Candida species along with their antifungal susceptibility profiles among patients with candidemia.\u0000Methods: We conducted a retrospective descriptive study on patients with candidemia and their Candida species identification and antifungal susceptibility testing (ID&AST) results at Dr. Kariadi Hospital, Indonesia, from January 2017 to December 2020. Identification and antifungal susceptibility testing of Candida species during these 4 years were determined using the Vitek-2 system. After collecting the data, it was analyzed by using SPSS 25.sav. The data was analyzed distributively, and was presented by table and barchart.\u0000Result: A total of 85 Candida species were isolated from 74 patients. Infant age (58.10%) and intensive care (64.86%) patients contributed to most of the candidemia cases. The three most common Candida species isolated during the study period were C. parapsilosis (36.9%), C. tropicalis (25%), and C. albicans (25%). Among all Candida isolates, 98.9% were susceptible to Fluconazole and Voriconazole, 99% were susceptible to Caspofungin, Micafungin, and Flucytosine, 95.7 % were susceptible to Amphotericin B. Echinocandin resistance emerged in 2020 from a C. glabrata isolate.\u0000Conclusion: The present study, conducted in a tertiary care Indonesian hospital, showed the predominance of non-albicans Candida with favorable antifungal susceptibility profiles.","PeriodicalId":11964,"journal":{"name":"European Journal of Clinical Microbiology and Infectious Diseases","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91223719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A rare finding of Burkholderia pseudomallei isolate from neck abscess, 4 years after the last report in Makassar: a case report 在望加锡最后一次报告4年后，从颈部脓肿中发现罕见的假马利氏伯克霍尔德菌分离物:一例报告

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-12-21 DOI: 10.51559/jcmid.v1i2.8

Andi Meutiah Ilhamjaya, Munawir Muhammad, Ahmad Rahmat Ramadhan, R. Sjahril

{"title":"A rare finding of Burkholderia pseudomallei isolate from neck abscess, 4 years after the last report in Makassar: a case report","authors":"Andi Meutiah Ilhamjaya, Munawir Muhammad, Ahmad Rahmat Ramadhan, R. Sjahril","doi":"10.51559/jcmid.v1i2.8","DOIUrl":"https://doi.org/10.51559/jcmid.v1i2.8","url":null,"abstract":"Introduction: Burkholderia pseudomallei is the causative agent of melioidosis, known as Whitmore's disease, a tropical disease in humans. The bacteria can infect humans or animals, mostly found in contaminated water and soil. It spreads by direct contact with contaminated sources, inhalation or ingestion of contaminated dust or water droplets, or contact with soil through skin abrasions. Melioidosis is highly endemic in Southeast Asia and Northern Australia but rare in Makassar.\u0000Case description: A 44-year-old woman shows a red mass on the right neck, reddish, palpable, ±6x5x4mm in size, and is soft in consistency and has a cystic impression. Direct gram showed purulent mixed with blood. 24 hours after incubation under aerobic conditions, grew small colonies, smooth, cream in color, non-lactose fermenter on Mac Conkey agar. Indirect gram shows a small, gram-negative rod (safety pins appearance). The colonies were positive in the catalase and oxidase test, with citrate and urease test was negative. Burkholderia pseudomallei was identified by Vitek2 with 97% Probability. It was susceptible to doxycycline, ceftazidime, and Trimethoprim/Sulfamethoxazole.\u0000Conclusion: This is a rare finding in a clinical isolate found in Makassar. A newly emerged case, four years after the last report in Makassar. This is still a challenge to public health problems in Makassar, must be reported consistently and never lost to follow up to get proper treatment.","PeriodicalId":11964,"journal":{"name":"European Journal of Clinical Microbiology and Infectious Diseases","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84977213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Tocilizumab Therapy On Patient Outcome In Severe COVID-19 Pneumonia 托珠单抗治疗对重症COVID-19肺炎患者预后的影响

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-08-31 DOI: 10.36519/idcm.2021.51

M. Yıldız, F. Sultanova, H. S. Özger, Merve Büyükkörük, K. Erbay, Ü. Gaygısız, A. Tufan, Ö. Gülbahar, Fatma Zehra Özcan, Nazlı Elif Kuscu, Deniz Gazioglu, Beyza Çiftçi, F. Sen, E. Senol, Kenan Hızal, Özlem Güzel Tunçcan, Pınar Aysert Yıldız, Yeşim Yıldız, M. Dizbay

引用次数: 0

The effects of polypharmacy, nutritional and functional status on the progression of COVID-19 in older adults 多种药物、营养和功能状况对老年人COVID-19进展的影响

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-08-31 DOI: 10.36519/idcm.2021.60

Asiye Bahar Kaçmaz, P. Soysal, S. G. Tan, B. Durdu, Y. Akkoyunlu, Hamza Ogün, Fatmanur Karaköse-Okyaltırık, Sibel Bölükcü, G. Okay, Bilge Sümbül, Bedia Gülen, Ertan Sönmez, M. Meriç-Koç, R. Kazancioglu

引用次数: 0

COVID-19 Vaccination in The Wake of a Fourth Wave of the Pandemic: An Evidence-Based Strategy is Desperately Needed 第四波大流行过后的COVID-19疫苗接种:迫切需要循证战略

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-08-31 DOI: 10.36519/idcm.2021.82

M. Akova

引用次数: 3

Diabetic Foot Infections and Outcomes: A Single Center Study 糖尿病足部感染和结果:一项单中心研究

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-08-31 DOI: 10.36519/idcm.2021.62

D. Yapar, Özlem Akdoğan, Murat Kendirci, Aysel Kocagül Çelikbaş, N. Baykam

引用次数: 1

Predictors of COVID-19 among Healthcare Workers who were Exposed to COVID-19 暴露于COVID-19的医护人员中COVID-19的预测因素

European Journal of Clinical Microbiology and Infectious Diseases Pub Date : 2021-08-31 DOI: 10.36519/idcm.2021.74

Ç. Erol, Tugba Yanik-Yalcin, N. Sarı, Özlem Azap Kurt, H. Arslan

引用次数: 1