European Journal of Neurology最新文献

{"title":"Cross-Country Inequalities in Disease Burden and Quality of Care of Stroke, 1990–2021: A Systematic Analysis of the Global Burden of Disease Study 2021","authors":"Zeyu Luo,&nbsp;Denan Jiang,&nbsp;Shiyi Shan,&nbsp;Jiali Zhou,&nbsp;Weidi Sun,&nbsp;Jing Wu,&nbsp;Jiayao Ying,&nbsp;Liying Zhou,&nbsp;Yajie Zhu,&nbsp;Peige Song,&nbsp;Kazem Rahimi","doi":"10.1111/ene.70050","DOIUrl":"10.1111/ene.70050","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>This study aims to assess the disease burden and care quality along with cross-country inequalities for stroke at global, regional, and national levels from 1990 to 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data on stroke were extracted from the Global Burden of Disease (GBD) study 2021 for the globe, five sociodemographic index (SDI) regions, 21 GBD regions, and 204 countries/territories. The disease burden was quantified using the age-standardized disability-adjusted life years rate (ASDR). Quality of care (QoC) was evaluated through the age-standardized QoC index (QCI). To assess cross-country disparities in both disease burden and age-standardized QCI, the slope index of inequality (SII) and the concentration index were utilized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 1990 to 2021, the global ASDR of stroke decreased from 3078.95 (95% uncertainty interval [UI]: 2893.58, 3237.34) to 1886.20 (95% UI: 1738.99, 2017.90) per 100,000 population, while the age-standardized QCI improved from 50.79 to 64.61. However, the results of inequalities showed worsening inequalities in both ASDR and QCI, with lower SDI countries shouldering a disproportionate burden and higher SDI countries maintaining higher QoC. The SII and concentration index for ASDR indicated a worsening inequality among lower SDI countries, with SII increasing to −2616.44 and the concentration index increasing to −0.1119 in 2021. Meanwhile, the SII and concentration index for age-standardized QCI showed a worsening inequality among higher SDI countries, with SII of 27.48 and concentration index of 0.0922 in 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite notable global advancements, significant disparities in stroke still exist, particularly in lower SDI regions facing high disease burdens and substandard care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 2","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of 80 patients diagnosed with reversible cerebral vasoconstriction syndrome in the Helsinki Metropolitan Area","authors":"Maria Girfanova,&nbsp;Nicolas Martinez-Majander,&nbsp;Laura Mannismäki,&nbsp;Gerli Sibolt,&nbsp;Marjaana Tiainen,&nbsp;Sami Curtze","doi":"10.1111/ene.16564","DOIUrl":"10.1111/ene.16564","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and purpose</h3>\u0000 \u0000 <p>Up to 80% of patients diagnosed with reversible cerebral vasoconstriction syndrome (RCVS) experience complications such as ischaemic stroke, intracerebral or subarachnoid haemorrhage or posterior reversible encephalopathy syndrome. The aim was to evaluate the incidence of complications in patients diagnosed with RCVS in our clinic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and methods</h3>\u0000 \u0000 <p>All adult patients (age &gt;16 years) diagnosed with RCVS at the Helsinki University Central Hospital during the period between 1 January 2016 and 31 December 2022 were retrospectively identified. Medical and follow-up data were collected from medical records.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighty patients diagnosed with RCVS were identified, of whom four patients had parenchymal lesions such as ischaemic stroke, intracerebral haemorrhage, posterior cerebral encephalopathy syndrome, subarachnoid haemorrhage or combinations thereof.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The complication rate of RCVS is lower than in previously published cohorts. This may be related to better and earlier diagnostics and earlier withdrawal of possible triggers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 2","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Transthyretin Amyloidosis in Israel: Genetic Landscape and Clinical Characteristics","authors":"Amir Dori,&nbsp;Odelia Chorin,&nbsp;Noa Ruhrman-Shahar,&nbsp;Avi Fellner,&nbsp;Tayir Alon,&nbsp;Haike Reznik-Wolf,&nbsp;Ortal Barel,&nbsp;Dana Fourey,&nbsp;Osnat Itzhaki Ben Zadok,&nbsp;Yaron Aviv,&nbsp;Vera Nikitin,&nbsp;Merav Ben-David,&nbsp;Efrat Shavit-Stein,&nbsp;Rivka Goldis,&nbsp;Batia Kaplan,&nbsp;Daniela Shapiro,&nbsp;Elon Pras,&nbsp;Arthur Pollak,&nbsp;Vardiella Meiner,&nbsp;Michael Arad,&nbsp;Lior Greenbaum","doi":"10.1111/ene.70057","DOIUrl":"10.1111/ene.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hereditary transthyretin (ATTRv) amyloidosis is a rare, adult-onset autosomal-dominant disorder caused by pathogenic variants in the transthyretin (<i>TTR</i>) gene. Data about relevant variants in specific populations and typical initial manifestations may facilitate early diagnosis and treatment. We here describe the genetic landscape of ATTRv amyloidosis in Israel.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Genetic and clinical data of <i>TTR</i> variant carriers and ATTRv amyloidosis patients were collected from a national referral clinic and other subspecialty clinics in Israel. Genotype–phenotype correlations of the detected variants were detailed. In addition, two large Israeli exome sequence (ES) databases were screened for <i>TTR</i> variants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven heterozygous disease-causing variants in <i>TTR</i> were identified among 95 adults (52 males, 50.7%). The Ser77Tyr variant was found in 68 (71.6%) subjects of Jewish Yemenite ancestry. Val122Ile was found in 9 (9.4%) subjects and was the only variant detected in individuals of Arab ethnicity. Other variants were Thr60Ala, Val30Met, Val32Ala, Ala81Val, and Glu89Val. Thirty-five individuals were ATTRv amyloidosis patients (25 males, 71.4%), diagnosed at a mean age of 62.5 ± 6.7 years, and 23 (63.7%) were due to Ser77Tyr. Initial symptoms were mostly related to carpal tunnel syndrome, and the sensitivity of scintigraphy was low for Ser77Tyr but high for Thr60Ala and Val32Ala variants. <i>TTR</i> pathogenic variants were detected in 14 of approximately 36,600 subjects who underwent ES, including Val122Ile in 9 subjects of Arab ethnicity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Most ATTRv amyloidosis cases in Israel are attributable to the Ser77Tyr variant. However, other variants also contribute to disease occurrence, and testing is warranted in clinically suspected patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 2","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity and metabolic brain alterations in sleepwalkers","authors":"Greta Mainieri,&nbsp;Magali Jane Rochat,&nbsp;Elena Cantoni,&nbsp;Giovanni Sighinolfi,&nbsp;Micaela Mitolo,&nbsp;Giuseppe Loddo,&nbsp;Francesco Mignani,&nbsp;Susanna Mondini,&nbsp;Raffaele Lodi,&nbsp;Federica Provini,&nbsp;Caterina Tonon","doi":"10.1111/ene.70008","DOIUrl":"10.1111/ene.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Disorders of arousal (DoA) are characterized by an intermediate state between wakefulness and deep sleep, leading to incomplete awakenings from NREM sleep. Multimodal studies have shown subtle neurophysiologic alterations even during wakefulness in DoA. The aim of this study was to explore the brain functional connectivity in DoA and the metabolic profile of the anterior and posterior cingulate cortex, given its pivotal role in cognitive and emotional processing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifteen consecutive patients with DoA (9 males, mean age 26.3 ± 7.7) and 15 age- and sex-matched healthy controls (8 males, mean age 25.8 ± 3.6) were enrolled. All participants underwent a protocol including sleep and psychological evaluation scales and multimodal brain MRI with resting-state functional MRI and 1H-MR spectroscopy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The independent component analysis disclosed an altered resting-state functional connectivity (FC) in the patients' sensory motor network, with a higher connectivity strength in opercular cortex, precuneus, occipital pole, and lingual gyrus. The seed-based analysis revealed a decreased FC between posterior cingulate cortex (PCC) and several cerebral areas. Finally, spectroscopic imaging revealed a reduced content of glutamine in the PCC (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interpretation</h3>\u0000 \u0000 <p>The increased connectivity in the sensory-motor network of DoA patients could constitute a “facilitatory medium” enhancing motor circuit activation, while the connectivity and metabolic alterations of PCC might represent a trait functional feature, contributing to a dysfunctional arousal process and the difficulty to reach a complete awareness during DoA episodes. In addition, these alterations at rest might be related to daytime impairment reported by patients, requiring new strategies for DoA management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 2","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy Stands Nearby: A Pilot CT Perfusion Study on Post-Stroke Non-Convulsive Status Epilepticus","authors":"Elena Merli,&nbsp;Michele Romoli,&nbsp;Simone Galluzzo,&nbsp;Anna Zaniboni,&nbsp;Stefania Testoni,&nbsp;Sara Contardi,&nbsp;Emanuele Saverio Cece,&nbsp;Fabio Nobili,&nbsp;Eleonora Matteo,&nbsp;Gabriele Ricci,&nbsp;Luigi Simonetti,&nbsp;Andrea Zini","doi":"10.1111/ene.70043","DOIUrl":"10.1111/ene.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To investigate the relevance of hyperperfusion on computerised perfusion imaging (CTP) in the emergency setting in people with non-convulsive status epilepticus (NCSE) and previous stroke, to derive relevant aspects on the epileptogenic focus and the network recruited for NCSE propagation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We enrolled consecutive adult patients with acute-onset NCSE and a previous stroke at a single institution undergoing CTP and EEG during symptoms. All patients underwent standard imaging including CT, CTP, CT angiograms and standard EEG within 30 min from hospital arrival. Age-/sex-matched NCSE without previous stroke cases and recurrent ischaemic stroke cases were included to test for accuracy of hyperperfusion rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 15 patients had a previous stroke and developed NCSE (mean age 78 years, 46.7% female). All patients had hyperperfusion on CTP imaging (mean onset-to-CTP 184 min). Only one case showed hyperperfusion limited to the previous stroke lesion, and one had a combination of lesional and peri-lesional hyperperfusion. All remaining cases (<i>n</i> = 13) had exclusive extra-lesional involvement. Five cases had multiple separated hyperperfused areas, and five had ipsilateral intra-thalamic hyperperfusion. No correlation emerged between onset-to-CTP timing and hyperperfusion (<i>p</i> value for CTP = 0.66, CBV = 0.28, MTT = 0.28, reverse <i>T</i>_max = 0.66). Hyperperfusion was present in NCSE cases only and in none of age-/sex-matched ischaemic stroke cases (<i>n</i> = 18).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Hyperperfusion involves cortical areas external to the previous lesion site during NCSE, supporting the relevance of networks for the spatial evolution of epileptic activity and limited relevance of the lesion site for the propagation of the epileptiform activity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 2","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thank You to Our Peer Reviewers in 2024","authors":"","doi":"10.1111/ene.70046","DOIUrl":"https://doi.org/10.1111/ene.70046","url":null,"abstract":"&lt;p&gt;&lt;b&gt;Didier Leys&lt;/b&gt; (&lt;i&gt;Editor-in-Chief&lt;/i&gt;), &lt;b&gt;Claudia Sommer&lt;/b&gt; (&lt;i&gt;Deputy Editor&lt;/i&gt;), &lt;b&gt;Barbara Borroni&lt;/b&gt;, &lt;b&gt;Andrew Chan, Mark Edwards, Alessandro Tessitore, and Kristl Vonck&lt;/b&gt; (&lt;i&gt;Associate Editors&lt;/i&gt;), &lt;b&gt;Paulo Caramelli&lt;/b&gt; and &lt;b&gt;Isabel Martins&lt;/b&gt; (&lt;i&gt;Guest Editor&lt;/i&gt;s)&lt;/p&gt;&lt;p&gt;Thank all the reviewers from around the world who have provided expert advice to ensure the publication of the best quality articles in the &lt;i&gt;European Journal of Neurology&lt;/i&gt; and the journal of the &lt;i&gt;European Academy of Neurology&lt;/i&gt;. Their feedback is crucial to improve the quality of manuscripts and of neurological care provided to patients. The names of those who reviewed manuscripts for the &lt;i&gt;European Journal of Neurology&lt;/i&gt; in 2024 are listed below. Our warmest gratitude goes to all of them.&lt;/p&gt;&lt;p&gt;&lt;i&gt;*indicates those who reviewed four manuscripts in 2024&lt;/i&gt;, &lt;i&gt;**indicates those who reviewed five to eight&lt;/i&gt;, and &lt;i&gt;***indicates those who reviewed nine or more&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;Aamodt, Anne Hege&lt;/p&gt;&lt;p&gt;Abbadessa, Gianmarco&lt;/p&gt;&lt;p&gt;\u0000 &lt;b&gt;Abdelhalk, Ahmed*&lt;/b&gt;\u0000 &lt;/p&gt;&lt;p&gt;Abu-Rumeileh, Samir&lt;/p&gt;&lt;p&gt;Accorroni, A.&lt;/p&gt;&lt;p&gt;Adhikary, Asit Baran&lt;/p&gt;&lt;p&gt;Afsin, Emine&lt;/p&gt;&lt;p&gt;Agarwal, Smriti&lt;/p&gt;&lt;p&gt;Aguglia, Umberto&lt;/p&gt;&lt;p&gt;Aguiar De Sousa, Diana&lt;/p&gt;&lt;p&gt;Aguirre-Vidal, Yoshajandith&lt;/p&gt;&lt;p&gt;Ahmadizar, Fariba&lt;/p&gt;&lt;p&gt;Aktas, O.&lt;/p&gt;&lt;p&gt;Alberici, Antonella&lt;/p&gt;&lt;p&gt;Albo, Zimbul&lt;/p&gt;&lt;p&gt;Alboini, Paolo&lt;/p&gt;&lt;p&gt;Algoet, Chloé&lt;/p&gt;&lt;p&gt;Alhusaini, Saud&lt;/p&gt;&lt;p&gt;\u0000 &lt;b&gt;Allen, Jeffrey A.*&lt;/b&gt;\u0000 &lt;/p&gt;&lt;p&gt;Almqvist, Tove&lt;/p&gt;&lt;p&gt;Alonso, Angelika&lt;/p&gt;&lt;p&gt;Alpkvist, Peter&lt;/p&gt;&lt;p&gt;Altomare, Daniele&lt;/p&gt;&lt;p&gt;Alves, Pedro&lt;/p&gt;&lt;p&gt;Al-Zuhairy, Ali&lt;/p&gt;&lt;p&gt;Amaro, Sergio&lt;/p&gt;&lt;p&gt;Anagnostakou, Vania&lt;/p&gt;&lt;p&gt;Anagnostou, Evangelos&lt;/p&gt;&lt;p&gt;\u0000 &lt;b&gt;Andersen, Henning*&lt;/b&gt;\u0000 &lt;/p&gt;&lt;p&gt;Anderson, Craig&lt;/p&gt;&lt;p&gt;Andrew, Melissa K.&lt;/p&gt;&lt;p&gt;Androdias, Géraldine&lt;/p&gt;&lt;p&gt;Angelini, Corrado&lt;/p&gt;&lt;p&gt;Appeltshauser, Luise&lt;/p&gt;&lt;p&gt;Araújo, Rui&lt;/p&gt;&lt;p&gt;Arba, Francesco&lt;/p&gt;&lt;p&gt;Arboix, Adria&lt;/p&gt;&lt;p&gt;Arsava, Ethem&lt;/p&gt;&lt;p&gt;Arshad, Qadeer&lt;/p&gt;&lt;p&gt;Arsovska, Anita&lt;/p&gt;&lt;p&gt;Ascherio, Alberto&lt;/p&gt;&lt;p&gt;Asseyer, Susanna&lt;/p&gt;&lt;p&gt;Aster, Hans-Christoph&lt;/p&gt;&lt;p&gt;\u0000 &lt;b&gt;Attarian, Shahram**&lt;/b&gt;\u0000 &lt;/p&gt;&lt;p&gt;Audebert, Heinrich&lt;/p&gt;&lt;p&gt;Audoin, Bertrand&lt;/p&gt;&lt;p&gt;Bain, Peter&lt;/p&gt;&lt;p&gt;Baizabal-Carvallo, José&lt;/p&gt;&lt;p&gt;Baka, Panoraia&lt;/p&gt;&lt;p&gt;Balabanski, Anna&lt;/p&gt;&lt;p&gt;Balayssac, David&lt;/p&gt;&lt;p&gt;Baldelli, Luca&lt;/p&gt;&lt;p&gt;Ballester, Ly&lt;/p&gt;&lt;p&gt;Ballve, Alejandro&lt;/p&gt;&lt;p&gt;Banerjee, Soma&lt;/p&gt;&lt;p&gt;Bankstahl, Jens P.&lt;/p&gt;&lt;p&gt;Barber, Pa.&lt;/p&gt;&lt;p&gt;Barbera, Mariagnese&lt;/p&gt;&lt;p&gt;Barloese, Mads&lt;/p&gt;&lt;p&gt;Barnett, Carolina&lt;/p&gt;&lt;p&gt;Baron, Jean-Claude&lt;/p&gt;&lt;p&gt;Batla, Amit&lt;/p&gt;&lt;p&gt;Baum, Petra&lt;/p&gt;&lt;p&gt;Bax, Francesco&lt;/p&gt;&lt;p&gt;Baykan-Baykal, Betul&lt;/p&gt;&lt;p&gt;Beare, Richard&lt;/p&gt;&lt;p&gt;Beatriz Gago-Veiga, Ana&lt;/p&gt;&lt;p&gt;Bede, Peter&lt;/p&gt;&lt;p&gt;Beier, Christoph&lt;/p&gt;&lt;p&gt;Beier, Dagmar&lt;/p&gt;&lt;p&gt;Béjot, Yannick&lt;/p&gt;&lt;p&gt;Ben Assayag, Einor&lt;/p&gt;&lt;p&gt;Benakis, Corinne&lt;/p&gt;&lt;p&gt;Benbadis, Selim&lt;/p&gt;&lt;p&gt;Ben-Shabat, Ilan&lt;/p&gt;&lt;p&gt;Benussi, Alberto&lt;/p&gt;&lt;p&gt;Berciano, José&lt;/p&gt;&lt;p&gt;Bereczki, Dániel&lt;/p&gt;&lt;p&gt;Bergquist, Filip&lt;/p&gt;&lt;p&gt;Bernasconi, Neda&lt;/p&gt;&lt;p&gt;Berzero, Giulia&lt;/p&gt;&lt;p&gt;Bessi, Valentina&lt;/p","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-utility analysis of a coadjutant telemedicine intervention for fall prevention in Parkinson's disease","authors":"Esther Cubo,&nbsp;Mohammad Rohani,&nbsp;Negin Eissazade,&nbsp;Álvaro Garcia-Bustillo,&nbsp;José Miguel Ramírez-Sanz,&nbsp;José Luis Garrido-Labrador,&nbsp;Alicia Olivares-Gil,&nbsp;Florita Valiñas-Sieiro Rn,&nbsp;Marta Allende-Río Rn,&nbsp;Josefa Gonzalez-Santos,&nbsp;Jerónimo Javier Gonzalez-Bernal,&nbsp;José Trejo,&nbsp;Sara Calvo-Simal,&nbsp;José Francisco Diez-Pastor,&nbsp;David García-García,&nbsp;Álvar Arnaiz-González","doi":"10.1111/ene.16561","DOIUrl":"10.1111/ene.16561","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and purpose</h3>\u0000 \u0000 <p>Adopting telemedicine (TM) enables improved access to specialized care and reduces barriers. The aim was to assess the cost-utility of a coadjutant multidisciplinary TM programme for fall prevention compared to standard in-office visits for individuals with Parkinson's disease (PD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was an 8-month single-blind randomized controlled trial. TM and control groups received in-office visits and standard management care at baseline, 4 and 8 months. In addition, the TM group received remote multidisciplinary visits for 4 months. Gait, motor and non-motor symptoms, daily living activities, balance and frailty were measured using PD-recommended rating scales and wearable sensors. Clinical characteristics were compared at each visit using baseline scores, gender and age as covariates. The incremental cost-effectiveness ratio (ICER) and quality-adjusted life years (QALYs) were calculated at each visit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty patients were included: 25 patients in the TM group (48% males, mean age 71.1 ± 9.0 years) and 25 patients in the control group (52% males, mean age 69.2 ± 9.4 years). Compared to controls, in the TM group similar QALYs were found but, in contrast, significant improvements in daily living activities, depression, apathy, freezing of gait, balance, quality of life and frailty (all <i>p</i> values &lt;0.05). The use of coadjutant TM intervention in addition to in-office visits was efficient for depression, apathy, freezing of gait, balance and frailty with ICERs, ranging from 91.55 € for non-motor symptoms to 1677.4 € for frailty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Telemedicine could be considered an efficient coadjutant intervention for PD, especially for non-motor symptoms, enhancing health outcomes and accessibility.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial DNA (mtDNA) as fluid biomarker in neurodegenerative disorders: A systematic review","authors":"Barbara Risi,&nbsp;Alberto Imarisio,&nbsp;Giada Cuconato,&nbsp;Alessandro Padovani,&nbsp;Enza Maria Valente,&nbsp;Massimiliano Filosto","doi":"10.1111/ene.70014","DOIUrl":"10.1111/ene.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Several studies evaluated peripheral and cerebrospinal fluid (CSF) mtDNA as a putative biomarker in neurodegenerative diseases, often yielding inconsistent findings. We systematically reviewed the current evidence assessing blood and CSF mtDNA levels and variant burden in Parkinson's disease (PD), Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Multiple sclerosis (MS) was also included as a paradigm of chronic neuroinflammation-driven neurodegeneration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Medline, Embase, Scopus and Web of Science were searched for articles published from inception until October 2023. Studies focused on mtDNA haplogroups or hereditary pathogenic variants were excluded. Critical appraisal was performed using the Quality Assessment for Diagnostic Accuracy Studies criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-nine original studies met our a priori-defined inclusion criteria. The majority of CSF-focused studies showed (i) decreased mtDNA levels in PD and AD; (ii) increased levels in MS compared to controls. No studies evaluated CSF mtDNA in ALS. Results focused on blood cell-free and intracellular mtDNA were contradictory, even within studies evaluating the same disease. This poor reproducibility is likely due to the lack of consideration of the many factors known to affect mtDNA levels. mtDNA damage and methylation levels were increased and reduced in patients compared to controls, respectively. A few studies investigated the correlation between mtDNA and disease severity, with conflicting results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Additional well-designed studies are needed to evaluate CSF and blood mtDNA profiles as putative biomarkers in neurodegenerative diseases. The identification of “mitochondrial subtypes” of disease may enable novel precision medicine strategies to counteract neurodegeneration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS): Regression-based norms for German-speaking countries","authors":"I. K. Penner,&nbsp;J. Baijot,&nbsp;M. Filser,&nbsp;S. Bätge,&nbsp;L. Raithel,&nbsp;E. Toth,&nbsp;A. Renner,&nbsp;G. Nagels","doi":"10.1111/ene.16495","DOIUrl":"10.1111/ene.16495","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and purpose</h3>\u0000 \u0000 <p>Cognitive impairment in multiple sclerosis (MS) is common and is associated with problems in employment, driving ability, and quality of life. Since cognitive impairment at time of diagnosis is predictive of disability progression, early assessment and annual monitoring is recommended. The Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS) was introduced as a time-efficient screening tool that can easily be applied in standard clinical care. However, besides application, tests need to be analysed and the raw values obtained must be interpreted accordingly. Since normative values have not been available for German-speaking countries, BICAMS has not been implemented in clinical routine. The aim of this study was to calculate German normative BICAMS data to improve the current diagnostic process for people with MS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Healthy control subjects in different age categories were recruited to enable regression-based norm analysis. Raw scores for each BICAMS test were converted into scaled scores before they were regressed for age, age squared, gender, and education. The obtained scores were then normalised to a <i>z</i>-score by dividing the difference between the scaled score and the predicted score by the root mean squared error of the model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In all, 237 HCs were recruited (68.8% female, 31.2% male) and examined with BICAMS. Datasets entered the regression-based norms analysis and formed the basis for a final <i>z</i>-score calculation. To simplify handling in everyday clinical practice, nomograms and look-up tables were created which provide clinicians with age- and education-corrected norms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our work fills the gaps between BICAMS application, evaluation and interpretation and will make a significant contribution to more regular cognitive assessment of MS patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Signal Abnormalities on Brain MRI in Post-Anoxic Super-Refractory Status Epilepticus: A Single-Center Retrospective Study","authors":"Susanna Diamanti,&nbsp;Francesco Pasini,&nbsp;Cristina Capraro,&nbsp;Mirko Patassini,&nbsp;Elisa Bianchi,&nbsp;Matteo Pozzi,&nbsp;Marco Normanno,&nbsp;Anna Coppo,&nbsp;Paolo Remida,&nbsp;Leonello Avalli,&nbsp;Carlo Ferrarese,&nbsp;Giuseppe Foti,&nbsp;Simone Beretta","doi":"10.1111/ene.70045","DOIUrl":"10.1111/ene.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Epileptiform activity, including status epilepticus (SE), occurs in up to one-third of comatose survivors of cardiac arrest and may predict poor outcome. The relationship between SE and hypoxic–ischemic brain injury (HIBI) is not established.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a single-center retrospective study on consecutive patients with post-anoxic super-refractory SE. HIBI was graded as non-widespread (group 1) or widespread (group 2) by qualitative analysis of DWI/ADC and T2w-FLAIR. Between-group differences in the rate of poor neurological outcome at 6 months (primary outcome), SE resolution and consciousness recovery before discharge, and mortality at 6 months (secondary outcomes) were investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From January 2011 to February 2023, 40 patients were included. HIBI was widespread in 45% of patients and non-widespread in 55%. The rate of poor neurological outcome at 6 months was 27% in group 1 and 83% in group 2 (OR 12.8, CI 95% [2.5–64.3], <i>p</i> = 0.002). The rate of consciousness recovery before discharge was 73% in group 1 versus 22% in group 2 (OR 8.8, CI 95% [1.9–40.3], <i>p</i> = 0.005). SE resolved in 95% of patients in group 1 versus 67% in group 2 (OR 10.5, CI 95% [1.1–97.9], <i>p</i> = 0.039). Mortality rate at 6 months was 27% in group 1 versus 50% in group 2 (OR 0.4, CI 95% [0.1–1.9], <i>p</i> = 0.303).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with widespread HIBI had higher odds of poor outcome at 6 months, lower probability of SE resolution and of consciousness recovery before discharge compared to those with non-widespread HIBI. Mortality at 6 months did not differ significantly between the two groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11954,"journal":{"name":"European Journal of Neurology","volume":"32 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}