The Journal of Pediatric Academy最新文献_第2页

A Patient Diagnosed with Li-Campeau Syndrome and Biotinidase Deficiency 1例诊断为Li-Campeau综合征和生物素酶缺乏的患者

The Journal of Pediatric Academy Pub Date : 2023-08-14 DOI: 10.4274/jpea.2022.221

Müjgan Arslan, H. Özbaş, Şeyma Karakoç, Rüveyda Menekşe Karataş

引用次数: 0

Analyse of Febrile Neutropenia Attacks in Children With Acute Lymphoblastic Leukemia 急性淋巴细胞白血病患儿发热性中性粒细胞减少症发作分析

The Journal of Pediatric Academy Pub Date : 2023-08-10 DOI: 10.4274/jpea.2022.225

Meriban Karadoğan, F. Mutlu

{"title":"Analyse of Febrile Neutropenia Attacks in Children With Acute Lymphoblastic Leukemia","authors":"Meriban Karadoğan, F. Mutlu","doi":"10.4274/jpea.2022.225","DOIUrl":"https://doi.org/10.4274/jpea.2022.225","url":null,"abstract":"Febrile neutropenia (FN) is the most important cause of morbidity and mortality during treatment in childhood with acute lymphoblastic leukemia (ALL). The aim of this retrospective study was to assess clinical features, outcomes, treatment modalities, documented infection rates, and frequency of isolation of specific organisms from ALL patients treated by our Department of Pediatric Hematology and Oncology using Berlin-Frankfurt-Munich (BFM) protocols. In this study 132 children diagnosed with ALL and treated according to the ALL-BFM 2009 protocol at Kayseri City Hospital, Department of Pediatric Hematology and Oncology between July 2015 and May 2022 were enrolled and evaluated for episodes of FN during intensive chemotherapy. Treatment characteristics, the presence of relapse, duration of neutropenia, culture results, the choice and duration of antibiotics, and disease prognosis were retrospectively assessed using patient records. In 132 acute leukemia cases, 278 episodes of FN were observed aged 1.1 and 17.8 years (mean 7.1±4.9 years) in a male to female ratio of 1.5:1. Infection focus could be documented in 66 episodes (23.7%); pulmonary infections in 23 patients (34.8%), gastrointestinal tract infections in 20 patients (30.3%), in 10 patients urinary tract infections (15.1%), derma¬otological and soft tissue infections in 2 patients (3%). The causative infectious agent could be demonstrated in 92 (33%) episodes. The most common site of isolation was blood (86/92, 30.9%). While the most frequently identified bacterial infectious agents were Gram-positive bacteria (56 isolates, 20.1%), Gram-negative bacteria were identified in 28 isolates (n=10%). Fungal growth was detected in 6 (2.1%) patients and polymicrobial growth was detected in 3 (1.1%) patients. Of the 132 patients, 4 (3%) died due to infection 2 died during induction, and 2 died during reinduction phases. Centers should evaluate their results to identify changing epidemiological patterns and to treat FN early and efficiently.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121089782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Lupus Cases Related to TNF Inhibitors in Children 评估与TNF抑制剂相关的儿童狼疮病例

The Journal of Pediatric Academy Pub Date : 2023-07-21 DOI: 10.4274/jpea.2022.226

Şeyma Türkmen, N. Gerenli, B. Sözeri

引用次数: 0

Does the Use of Multiplex PCR Contribute to the Management of Paediatric Emergency Physicians in <2-Year-old Children with Acute Respiratory Infections? 多重PCR的应用是否有助于儿科急诊医师对2岁以下急性呼吸道感染患儿的管理?

The Journal of Pediatric Academy Pub Date : 2023-06-22 DOI: 10.4274/jpea.2023.207

O. Aydın, Bengu Baydur, I. Baba, A. Alp, O. Teksam

{"title":"Does the Use of Multiplex PCR Contribute to the Management of Paediatric Emergency Physicians in <2-Year-old Children with Acute Respiratory Infections?","authors":"O. Aydın, Bengu Baydur, I. Baba, A. Alp, O. Teksam","doi":"10.4274/jpea.2023.207","DOIUrl":"https://doi.org/10.4274/jpea.2023.207","url":null,"abstract":"Multiplex polymerase chain reaction (PCR) is used to detect respiratory viruses in pediatric emergency departments, but its indications and interpretation of results must still be clear. In the present study, we examined the effect of detecting a viral agent with multiplex PCR on patient management. Infants and toddlers, aged between 1-24 months, who presented to the pediatric emergency department with respiratory tract infection complaints and underwent multiplex-PCR between 1 January 2014 and 28 February 2020 were included in the study. Patients with at least one agent detected were considered as the study group, and patients without detection were considered as the control group. The same design was implemented only for patients with chronic diseases. A total of 1106 patients were recruited [median age: 6.7 months (range: 2.9-13.0 months)]. Seven hundred and eighty-nine in the study group and 317 in the control group. There were no significant differences between the groups in hospital admissions (study group: 271 admissions; control group: 89 admissions; p=0.055), length of hospital stay duration [mean ± standard deviation: 3.09±7.87 days (study group) and 2.6±7.79 days (control group); p=0.045], or antibiotic use [234 patients (study group) and 77 patients (control group); p=0.078]. When these variables were examined only for those with chronic diseases, there was no difference again. Although multiplex PCR is an ideal method with high sensitivity, specificity, and cost-effectiveness, the limits of its clinical application need to be clarified. We did not observe significant differences in the treatment of patients with detected viral agents.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122517021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pragmatic Management of Hand Involvement in Extended Oligoarticular Juvenile Idiopathic Arthritis: Ultrasound-guided Serial Interphalangeal Joint Injections 扩展性少关节幼年特发性关节炎手部受损伤的实用管理:超声引导的连续指间关节注射

The Journal of Pediatric Academy Pub Date : 2023-06-22 DOI: 10.4274/jpea.2023.206

İsa Cüce, Rıdvan Yildizhan, Enes Veziroğlu, A. Paç Kısaarslan

引用次数: 0

Increase in Odontogenic Cervicofacial Infection Requiring Hospitalization in Children During COVID-19 Quarantine COVID-19隔离期间儿童牙源性颈面感染住院病例增加

The Journal of Pediatric Academy Pub Date : 2023-06-22 DOI: 10.4274/jpea.2023.203

Taylan Çelik, Lara Karaaslan

{"title":"Increase in Odontogenic Cervicofacial Infection Requiring Hospitalization in Children During COVID-19 Quarantine","authors":"Taylan Çelik, Lara Karaaslan","doi":"10.4274/jpea.2023.203","DOIUrl":"https://doi.org/10.4274/jpea.2023.203","url":null,"abstract":"The aim of this study was to evaluate the effect of Coronavirus disease-2019 (COVID-19) quarantines on children hospitalizedfor odontogenic cervicofacial infection. The data of patients aged 1 month-18 years, who were followed up with the diagnosis ofodontogenic cervicofacial infection in Çanakkale Onsekiz Mart University Hospital between January 2019 and June 2021 wasexamined, retrospectively. Thirteen patients with a mean age of 8.5±3.8, 7 of whom were male were included in the study. Three of the patients were diagnosed in the pre-COVID-19 period and 10 of them were diagnosed in the second year of COVID-19. Five patients had a known history of dental caries. On physical examination, it was determined that all patients had dental caries in the area corresponding to the infection site. Four patients required abscess drainage, all of whom were presenting in the second year of COVID-19, we isolated Eikenella corrodens, Streptococcus anginosus and Streptococcus intermedius microorganisms in 3 patients. The mean duration of hospitalization was 5.3±3 days. In conclusion, COVID-19 quarantine causes an increase in odontogenic cervicofacial infection requiring intravenous antibiotics and abscess drainage.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126067104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety Levels of Children with Primary Ciliary Dyskinesia and Their Mothers at the Beginning of the COVID-19 Pandemic and Change in the First Year COVID-19大流行初期原发性纤毛运动障碍儿童及其母亲的焦虑水平及其第一年的变化

The Journal of Pediatric Academy Pub Date : 2023-06-22 DOI: 10.4274/jpea.2023.208

P. Asfuroğlu, T. Şişmanlar Eyüboğlu, A. Aslan, Tuğba Ramaslı Gürsoy, A. Ş. Soysal Acar, D. Yapar, M. Ilhan

{"title":"Anxiety Levels of Children with Primary Ciliary Dyskinesia and Their Mothers at the Beginning of the COVID-19 Pandemic and Change in the First Year","authors":"P. Asfuroğlu, T. Şişmanlar Eyüboğlu, A. Aslan, Tuğba Ramaslı Gürsoy, A. Ş. Soysal Acar, D. Yapar, M. Ilhan","doi":"10.4274/jpea.2023.208","DOIUrl":"https://doi.org/10.4274/jpea.2023.208","url":null,"abstract":"We aimed to assess anxiety of children with primary ciliary dyskinesia (PCD) and their primary caregivers at the beginning of Coronavirus disease-2019 (COVID-19) pandemic and change in levels of anxiety in first year with prolongation of pandemic. This was a two-step study; first step was questionnaire-based, conducted via teleconference. In first step, 29 patients and 105 healthy children and their mothers were participated; 25 children with PCD and their mothers were in second step. Demographic characteristics, clinical informations were recorded. Children’s and mothers’ state and trait anxiety levels were assessed and compared. Anxiety levels of mothers of patients were assessed according to clinical characteristics of children. Mothers’ knowledge of COVID-19 and effect of teleconference on their anxiety was evaluated. State anxiety levels in the first year of pandemic of children with PCD and their mothers were also compared. Compared to control group, state anxiety of children in 13-18 age group and trait anxiety of their mothers were lower (p<0.05). In both groups, trait and state anxiety of 13-18 years old children and mothers positively correlated. Trait anxiety of mothers of patients negatively correlated with patients’ FEV1 and MEF25-75. Patients’ mothers reported feeling less anxiety at the end of teleconference. Anxiety of mothers of patients (especially under 9 years old) had increased as pandemic continued. At the beginning of pandemic, children with PCD were less anxious than healthy children, and their mothers had lower trait anxiety than mothers of healthy children. Being followed for chronic disease and obtaining information about COVID-19 may have reduced anxiety of children with PCD and their mothers. However, as pandemic continues, need to protect their children with PCD from infection, especially of mothers with younger children, may have raised their concerns.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122696979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney Tumors in Children 儿童肾脏肿瘤

The Journal of Pediatric Academy Pub Date : 2023-06-22 DOI: 10.4274/jpea.2023.237

Şefika Akyol

引用次数: 0

Evaluation of Leukemia and Solid Tumors in Refugee Children in Turkey: A Tertiary Center Experience 评价白血病和实体瘤的难民儿童在土耳其:三级中心经验

The Journal of Pediatric Academy Pub Date : 2023-06-22 DOI: 10.4274/jpea.2023.209

Ayça Koca Yozgat, Derya Özyörük, S. Emir, A. Demir, Arzu Yazal Erdem, C. B. Aker, Zeliha Güzelküçük, İnci Yaman Bajin, D. Kaçar, N. Yaralı, N. Özbek

{"title":"Evaluation of Leukemia and Solid Tumors in Refugee Children in Turkey: A Tertiary Center Experience","authors":"Ayça Koca Yozgat, Derya Özyörük, S. Emir, A. Demir, Arzu Yazal Erdem, C. B. Aker, Zeliha Güzelküçük, İnci Yaman Bajin, D. Kaçar, N. Yaralı, N. Özbek","doi":"10.4274/jpea.2023.209","DOIUrl":"https://doi.org/10.4274/jpea.2023.209","url":null,"abstract":"Cancer care is progressively became as a significant worldwide challenge. Wars can cause destructions and delays in cancer diagnosis and treatment of displaced people. Cancer cure rates need to be improved in indefensible populations such as refugees. In this study, we purposed to highlight the clinical peculiarities and outcomes of refugee children with cancer in our hospital. Our purpose was to present our findings and contribute to improve the health care for these children. Seventy one refugee pediatric patients admitted to the oncology and hematology units of our hospital between April 2011 and January 2019 were included in this study. The demographic characteristics of the patients at the initial diagnosis, their countries of origin, living conditions, histopathological diagnoses, treatments, relapse, and mortality data were analyzed retrospectively from the patient files. The median age of patients was 6.5±4.5 years, and the male-to-female ratio was 39/32. While 44 patients (61.9%) presented with complaints and had primary diagnoses in our hospital, the remaining 27 patients (38.1%) were diagnosed in their country and applied to our hospital for treatment. Our mean follow-up period was 18.2±18.8 months (1-90 months). As a result, 44 patients (62%) were alive and 22 (31%) were dead. The survival rate without relapse in the second year was 83.6%. Two and fiveyear survival rates were 77.5% vs. 58.1% respectively. Compared to Turkish children, lower survival rates were found in refugee children. In addition to cancer-specific factors such as tumor type and stage, some problems such as shelter, communication, adherence to treatment, and difficulties supplying medicine may be responsible for lower survival rates in refugee children. Further studies are needed to improve the survival rates of patients.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129052512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pneumococcal Meningitis with Serotype 7 Who Develops 12. Nerve Paralysis 血清型为7的肺炎球菌脑膜炎。神经麻痹

The Journal of Pediatric Academy Pub Date : 2023-06-22 DOI: 10.4274/jpea.2023.205

F. Kılınç, N. Tapaç, Ümmühan Çay, Özlem Özgür Gündeşlioğlu, D. Alabaz

{"title":"Pneumococcal Meningitis with Serotype 7 Who Develops 12. Nerve Paralysis","authors":"F. Kılınç, N. Tapaç, Ümmühan Çay, Özlem Özgür Gündeşlioğlu, D. Alabaz","doi":"10.4274/jpea.2023.205","DOIUrl":"https://doi.org/10.4274/jpea.2023.205","url":null,"abstract":"Meningitis is an inflammatory disease of the leptomeninges surrounding the spinal cord and brain. Streptococcus pneumoniae (S. pneumoniae) is the most common cause of bacterial meningitis in infants and children older than one month. In this report, we present a 13-month-old infant who, after receiving three doses of the 13-valent conjugated pneumococcal vaccine, had nervus hypoglossus paralysis as a result of serotype 7 S. pneumoniae meningitis. She was admitted into our center with complaints of high fever for 2 days, apathy that started in the last 24 hours, and a tendency for sleeping. Penicillin and ceftriaxone susceptible S. pneumoniae grew in cerebrospinal fluid culture. Antibiotic treatment was completed in six weeks as she had a millimetric abscess in MR imaging. Considering common variable immunodeficiency in the patient who was examined for immunodeficiency, intravenous immunoglobulin treatment was started. The physical examination results of the patient were entirely improved. In conclusion, meningitis is a pediatric emergency with a high mortality and complication rate. If meningitis is managed on time and correctly it can heal without sequelae. Vaccination is crucial for prevention. Despite vaccination, although rare, infection with vaccine strains may occur. Patients infected with vaccine strains may require evaluation in terms of immunodeficiency.","PeriodicalId":118905,"journal":{"name":"The Journal of Pediatric Academy","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124691390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0