European Journal of Endocrinology最新文献

{"title":"Use of skeletal muscle fiber composition to assess relationship between amino acid metabolism and insulin sensitivity.","authors":"Tova Eurén Magnusson, Sarah J Blackwood, Dominik Tischer, Timotej Strmeň, Marjan Pontén, Sebastian Edman, Oscar Horwath, William Apró, Marcus Moberg, Elin Chorell, Abram Katz","doi":"10.1093/ejendo/lvaf195","DOIUrl":"10.1093/ejendo/lvaf195","url":null,"abstract":"<p><strong>Objectives: </strong>Here we use skeletal muscle fiber composition to investigate whether defects in amino acid metabolism are involved in the early development of IR in healthy young individuals before the onset of clinical manifestations.</p><p><strong>Design: </strong>Two groups consisting of healthy young men and women, insulin-sensitive and insulin-resistant, were studied using a cross-sectional design.</p><p><strong>Methods: </strong>Biopsies were obtained from the vastus lateralis muscle, and an intravenous glucose tolerance test was performed. Plasma and muscle tissue were analyzed by metabolomics.</p><p><strong>Results: </strong>Subjects in group 1 (n = 20; age 28 ± 5 years; body mass index 22.3 ± 2.7 kg/m2) had an expression of type I muscle fibers and whole-body insulin sensitivity of 58.8% ± 5.7% and 1.8 ± 0.7 units, respectively. Subjects in group 2 (n = 16; age 25 ± 6 years; body mass index 22.6 ± 3.0 kg/m2) had an expression of type I muscle fibers and whole-body insulin sensitivity, respectively, of 29.8% ± 6.6% and 0.8 ± 0.3 units (P < .001 vs group 1 for both). Anserine and β-alanine contents in muscle were significantly higher and taurine lower in group 2 vs 1, consistent with the differences in muscle fiber composition between groups. Taurine correlated well with insulin sensitivity and expression of type I muscle fibers (r = 0.63; P < .001 for both). In contrast, there were no significant differences in plasma or tissue contents of glutamine, arginine, or branched-chain amino acids between groups.</p><p><strong>Conclusions: </strong>These data demonstrate that the early development of IR is not a consequence of defects in amino acid metabolism. Rather, defects in amino acid metabolism in diseased states are more likely a consequence of IR.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":"553-563"},"PeriodicalIF":5.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal thyroid volume and goitre diagnosis on ultrasonography is population-sensitive.","authors":"Massimo Giusti","doi":"10.1093/ejendo/lvaf187","DOIUrl":"10.1093/ejendo/lvaf187","url":null,"abstract":"","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":"L19-L20"},"PeriodicalIF":5.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter from Massimo Giusti.","authors":"Simone Kiel, Till Ittermann, Jean-François Chenot, Henry Völzke","doi":"10.1093/ejendo/lvaf188","DOIUrl":"10.1093/ejendo/lvaf188","url":null,"abstract":"","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":"R1-R2"},"PeriodicalIF":5.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose tissue signaling in aldosterone-producing adenomas: paracrine and endocrine effects.","authors":"Simon Kloock, Lisa Kagan, Christian Ziegler, Mugdha Srivastava, Anke Tönjes, Nada Rayes, Nicolas Schlegel, Niklas Geiger, Matthias Blüher, Martin Fassnacht, Ulrich Dischinger","doi":"10.1093/ejendo/lvaf190","DOIUrl":"10.1093/ejendo/lvaf190","url":null,"abstract":"<p><strong>Background: </strong>Primary aldosteronism increases the risk of cardiovascular and metabolic diseases, which might be influenced by different adipose tissue compartments. However, the interaction between the adrenal gland and different fat depots is not well understood and is the focus of this study.</p><p><strong>Methods: </strong>We analyzed subcutaneous adipose tissue (scAT) and periadrenal adipose tissue (paAT) from patients with aldosterone-producing adenomas (APAs; included scAT, n = 11; paAT, n = 18) and, as controls, nonfunctional adrenal adenomas (NFAs; included scAT, n = 7; paAT, n = 5). A subanalysis for KCNJ5-mutated APA (diagnosed through elevated 18-oxocortisol [18-oxoF] and 18-hydroxycortisol [18-OHF]) was conducted. RNA sequencing and immunohistochemistry of AT was performed (immunohistochemistry [IHC], only on scAT). Immunohistochemistry markers included adipokines (leptin, adiponectin) and transcription factors (eg, c-jun and calmodulin-dependent protein kinase II [CaMKII]).</p><p><strong>Results: </strong>RNA sequencing showed numerous significantly different expressed genes: APA vs NFA in scAT (68 up, 259 down), in paAT (16 up, 117 down), and in scAT vs paAT of APA patients (826 up, 1632 down). The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis highlighted downregulated inflammation-associated pathways in both APA fat depots, while steroid-related pathways were upregulated especially in paAT of patients with KCNJ5 mutation, suggesting paracrine effects of aldosterone. Lipolysis-associated pathways were upregulated in the scAT of APA patients. Immunohistochemistry showed increased expression of angiotensin-converting enzyme 2 (ACE2), CaMKII, and c-jun in scAT from APA patients.</p><p><strong>Conclusions: </strong>RNA sequencing identified significant gene expression differences in fat compartments of APA patients, implying endocrine and paracrine effects of APAs. These findings might partly explain cardiovascular consequences of primary aldosteronism and could lead to new diagnostic strategies, especially through accessible scAT.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":"440-452"},"PeriodicalIF":5.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum steroid metabolome dynamics in infancy: a longitudinal cohort study of healthy infants.","authors":"Alexander Siegfried Busch, Marie Lindhardt Ljubicic, Emmie N Upners, Margit Bistrup Fischer, Casper P Hagen, Christa E Flück, Trine Holm Johannsen, Hanne Frederiksen, Anders Juul","doi":"10.1093/ejendo/lvaf193","DOIUrl":"10.1093/ejendo/lvaf193","url":null,"abstract":"<p><strong>Objective: </strong>The circulating steroid metabolome exhibits significant changes in both girls and boys during infancy, reflecting structural and functional changes in the adrenal cortex as well as the transient activation of the hypothalamic-pituitary-gonadal axis during minipuberty. However, longitudinal data characterizing these changes using liquid chromatography-tandem mass spectrometry (LC-MS/MS) remain limited. This study aimed to map the temporal dynamics of the serum steroid metabolome in healthy infants and establish sex- and age-specific reference curves.</p><p><strong>Design: </strong>Prospective, longitudinal birth cohort study (Copenhagen Minipuberty Study, 2016-2018; NCT02784184) including healthy, term, singleton newborns followed with repeated assessments during the first year of life.</p><p><strong>Methods: </strong>Serum levels of 16 steroid hormones were measured by LC-MS/MS in 88 girls and 101 boys in a total of 446 longitudinal samples. Age-specific reference values were modeled using Generalized Additive Models for Location, Scale and Shape (GAMLSS).</p><p><strong>Results: </strong>The steroid metabolome exhibited distinct patterns during infancy, characterized by increasing concentrations of cortisol and 11-deoxycorticosterone and decreasing levels eg, progesterone, 11-deoxycortisol, 17-hydroxyprogesterone, and androstenedione. These trends were largely independent of sex. Estimated activities of key steroidogenic enzymes did not differ significantly between sexes, except for sex steroid-related conversion; specifically, 17β-hydroxysteroid dehydrogenase activity was significantly higher in boys than girls (P < .001).</p><p><strong>Conclusions: </strong>These findings offer a comprehensive characterization of the serum steroid metabolome in healthy infants throughout the first year of life. The resulting age-specific reference curves may serve as valuable tools to support the clinical diagnosis and therapeutic monitoring of rare disorders of steroidogenesis. ClinicalTrials.gov ID: NCT01411527.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":"403-411"},"PeriodicalIF":5.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Hemodynamic Instability in Pheochromocytoma Surgery through Latent Class Analysis.","authors":"Laura Alberici, Claudio Ricci, Valentina Vicennati, Isabella Sophia Lucy Windle, Carlo Ingaldi, Marco Fichera, Saverio Selva, Eugenio Cosentino, Antonio De Leo, Caterina Balacchi, Cristina Nanni, Rocco D'Andrea, Riccardo Casadei, Guido Di Dalmazi","doi":"10.1093/ejendo/lvaf199","DOIUrl":"https://doi.org/10.1093/ejendo/lvaf199","url":null,"abstract":"<p><strong>Objective: </strong>Hemodynamic instability (HDI) during pheochromocytoma surgical resection remains a major anesthesiologic challenge. The definition of HDI is often arbitrary, limiting comparability and risk stratification. We aimed to develop an objective, data-driven classification of intraoperative HDI.</p><p><strong>Methods: </strong>Hemodynamic variables, including systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and mean arterial pressure (MAP), were collected at five intraoperative time points. Latent class analysis (LCA) was used to classify patients into two groups: low-risk (l-HDI) and high-risk (h-HDI) HDI classes. We compared four LCA models based on different combinations of variables (SBP+DBP, SBP+DBP+HR, MAP, MAP+HR) to identify the optimal classification of HDI, using AIC and BIC for model selection.</p><p><strong>Results: </strong>Among 92 patients, the LCA model based solely on intraoperative MAP yielded the best classification of HDI (AIC: 3783; BIC: 3824). Two latent classes were identified: high-risk HDI (n = 32, 34.8%) and low-risk HDI (n = 60, 65.2%). MAP values were significantly different between the two groups during anesthesia induction (89 vs. 102 mmHg, p < 0.001), pneumoperitoneum induction (83 vs. 94 mmHg, p = 0.002), gland manipulation (95 vs. 131 mmHg, p < 0.001), and immediately post-adrenal vein ligation (79 vs. 83 mmHg, p = 0.039). Multivariable logistic regression showed that patients' age (OR 1.04 per year; 95% CI 1.01-1.02; p=0.047) and symptomatic presentation (OR 15.35; 95% CI 4.19-56.2; p<0.001) were strongly associated with HDI.</p><p><strong>Conclusion: </strong>This study proposes a reproducible and objective classification of intraoperative HDI in pheochromocytoma surgery based on MAP-derived latent class analysis.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IGF-I and symptoms of acromegaly according to time since somatostatin receptor ligand injection.","authors":"Ilan Remba-Shapiro, Júnia R O L Schweizer, Alberto Moscona-Nissan, Karen J P Liebert, Pamela S Jones, Katharina Schilbach, Jessica Naredo Rojas, Michelle Adams, Vicky O Cheng, Nicholas A Tritos, Martin Bidlingmaier, Lisa B Nachtigall","doi":"10.1093/ejendo/lvaf200","DOIUrl":"https://doi.org/10.1093/ejendo/lvaf200","url":null,"abstract":"<p><strong>Background: </strong>Somatostatin receptor ligands (SRLs) are the mainstay pharmacotherapy for acromegaly. Patients report symptoms towards the end of the injection cycle. However, the correlation between IGF-I and patient-reported outcomes (PROMs) has not been evaluated in this context.</p><p><strong>Objective: </strong>To determine IGF-I, PROMs, and SRL concentration variability in patients with acromegaly receiving long-acting SRLs.</p><p><strong>Methods: </strong>Quality of life surveys, early and late phase (weeks 1 and 4 after SRL injection) biochemical markers, and SRL concentrations were obtained in 20 patients receiving monthly SRLs during two injection cycles. All IGF-I levels were measured using both mass spectrometry (LC-MS) and an immunoassay (IDS-iSYS).</p><p><strong>Results: </strong>IGF-I concentrations were higher during late vs. early phase of cycle 2 using LC-MS (179.5±85.6 ng/mL vs. 154.8±80.2 ng/mL, p=0.045) and IDS-iSYS (201.2±86.3 ng/mL vs. 165.5±75.8 ng/mL, p=0.023) assays. In cycle 1, PASQ scores worsened in week 4 (18.10±11.96) compared to week 2 (15.53±9.94; p=0.011) and week 3 (15.00±12.49; p=0.021). SRL concentrations were lower during late phase (3563±1444 pg/mL vs. 2588±1085 pg/mL; p=0.008). Change in (Δ)SRL negatively correlated with ΔIGF-I IDS-iSYS (r=-0.385, p=0.047). ΔACROQoL physical significantly correlated with ΔIGF-I. Δsoluble alpha-klotho (sαKL) corelated with ΔPASQ score (r=0.337, p=0.034) and swelling (r=0.335, p=0.035).</p><p><strong>Conclusions: </strong>IGF-I concentrations increased according to time since SRL injection. PROMs fluctuated, correlating with IGF-I and sαKL changes. Measuring IGF-I at the end of the injection cycle is advisable. Decreases in SRL concentration suggest phase-based differences in IGF-I concentrations. These findings inform personalized approaches to acromegaly, with titration of therapy based on individual IGF-I and/or PROMs fluctuation.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway compression in a neonate with thyroid dyshormonogenesis due to SLC26A7 defect.","authors":"Yasuhiro Hirano, Kazuhiro Shimura, Marie Mitani-Konno, Naoya Fukushima, Tomonobu Hasegawa, Satoshi Narumi","doi":"10.1093/ejendo/lvaf198","DOIUrl":"https://doi.org/10.1093/ejendo/lvaf198","url":null,"abstract":"<p><p>SLC26A7 encodes an apical iodide transporter in thyroid follicular cells, and causes, when mutated, congenital hypothyroidism (CH). We report a patient diagnosed with goitrous CH, who initially presented with neck enlargement and inspiratory stridor on day 3 of life. Levothyroxine therapy resulted in prompt improvement in upper airway compression, and surgical interventions were avoided. The levothyroxine dosage per body weight was gradually reduced to 0.5 μg/kg/day by age 11 months. Genomic sequencing of CH-related genes identified compound heterozygous protein-truncating SLC26A7 variants: c.612_613dup, p.Ser207Tyrfs*31 and c.1498C>T, p.Gln500*. We emphasize the importance of considering genetic etiologies in cases of neonatal goiter with upper airway compression, particularly in the absence of exposure to excessive iodine or antithyroid drugs.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The endocrine aspects of endometriosis.","authors":"Felice Petraglia, Silvia Vannuccini, Marie-Madeleine Dolmans, Anna Rosa Speciale, Mathilde Bourdon, Louis Marcellin, Jacques Donnez, Charles Chapron","doi":"10.1093/ejendo/lvaf192","DOIUrl":"https://doi.org/10.1093/ejendo/lvaf192","url":null,"abstract":"<p><p>Endometriosis is a chronic gynecologic disease of reproductive-age women, causing menstrual pain and infertility. Endocrine and inflammatory mechanisms drive its development, with estrogen/progesterone imbalance contributing to extrauterine implantation and persistence of ectopic endometrial cells. Chronic pain also induces stress-related disorders, worsening the quality of life. Infertility results from inflammatory, ovarian, and endometrial changes, and adverse pregnancy outcomes are reported. Diagnosis of endometriosis is clinical and imaging-based. Furthermore, gastrointestinal, urinary, or autoimmune comorbidities complicate endometriosis management. Hormonal treatments, including progestins, estro-progestins, GnRH analogs or oral antagonists, suppress menstruation and relieve pain. The relevant endocrine aspects and the systemic comorbidities make endometriosis a syndrome that requires a multidisciplinary diagnostic and therapeutic approach.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural history of non-functioning pituitary microadenomas: a systematic review and individual participant data meta-analysis.","authors":"V B Boesen, T H Hansen, M Motawea, M Fleseriu, E V Varlamov, A J Han, S A Imran, V Munro, M Alenazi, W J Inder, N Lenders, R A Damilano, N L Monteserin, A G Lania, G Carosi, G Mantovani, D Hordejuk, L Min, U B Kaiser, S D Rikvold, J Krogh","doi":"10.1093/ejendo/lvaf189","DOIUrl":"https://doi.org/10.1093/ejendo/lvaf189","url":null,"abstract":"<p><strong>Objective: </strong>Increased frequency of neuroimaging has led to enhanced identification of small non-functioning pituitary adenomas (NFPAs) leading, in many cases, to extensive follow-up. However, the value of ongoing monitoring of these incidental lesions remains unclear.The study aims to determine the need for surgical intervention and assess the risks of developing new endocrinopathies during follow-up in patients with conservatively treated micro-NFPAs.</p><p><strong>Design: </strong>A systematic review and individual participant data meta-analysis.</p><p><strong>Methods: </strong>We conducted a bibliographical search of PubMed and EMBASE to identify relevant studies. Authors of eligible studies were invited to share individual participant data.Cohort studies including patients with conservatively treated micro-NFPAs with at least one follow-up MRI were considered eligible.Fourteen studies met inclusion criteria. Six authors provided individual participant data (N=647). Data were re-analyzed for verification. In cases of discrepancies the original authors were contacted for authentication.</p><p><strong>Results: </strong>Risk estimates were reported as number of events per 100 person-years (PYs). Estimates were pooled using the two-step approach. Overall probability of surgery was 0.2/100PYs (95%CI: 0.0 to 0.4; I2=28%). Probability of surgery due to visual impairment was 0.1/100PYs (95%CI: 0.0 to 0.2; I2=0%). Both were independent of baseline tumor size (≥6 mm or <6 mm), sex, or age (p-values>0.40). Risk of developing a new endocrinopathy was 1.0/100PYs (95%CI: 0.4 to 1.6; I2=0%).Data for classical meta-analysis were available for 7 studies (N=1089) and supported the individual participant data results.</p><p><strong>Conclusions: </strong>These data suggest that routine follow-up of micro-NFPAs can be reduced significantly and that available guidelines should be revisited.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}