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Synthesis of 5-substituted-1,3,4-oxadiazole clubbed pyrazole and dihydropyrimidine derivatives as potent bioactive agents 5-取代-1,3,4-恶二唑棒状吡唑及二氢嘧啶衍生物的合成
European Chemical Bulletin Pub Date : 2021-01-01 DOI: 10.17628/ecb.2021.10.13-20
B. Patel, Tushar J. Karkar, Malay J. Bhatt
{"title":"Synthesis of 5-substituted-1,3,4-oxadiazole clubbed pyrazole and dihydropyrimidine derivatives as potent bioactive agents","authors":"B. Patel, Tushar J. Karkar, Malay J. Bhatt","doi":"10.17628/ecb.2021.10.13-20","DOIUrl":"https://doi.org/10.17628/ecb.2021.10.13-20","url":null,"abstract":"A series of 4-fluorophenylpyrazole clubbed 1,3,4-oxadiazole and 3,4-dihydropyrimidin-2(1 H )-ones were prepared by cyclization of Biginelli-type adducts. Structures were assigned on the basis of known spectral techniques. All the scaffolds were evaluated for in vitro antimicrobial activity by broth micro dilution bioassay method and in vitro antitubercular property by microplate alamar blue assay method. Compounds 3j and 3l containing -OH and -CH 3 groups were act as potent antimicrobials and antitubercular candidates with relatively low cytotoxicity on VERO cells.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67697616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Synthesis of novel anti-inflammatory usnic acid-based imidazolium salts 新型抗炎酸基咪唑盐的合成
European Chemical Bulletin Pub Date : 2021-01-01 DOI: 10.17628/ecb.2021.10.67-72
T. Somasekhar, Monisha Javadi, R. Sistla, U. Mallavadhani
{"title":"Synthesis of novel anti-inflammatory usnic acid-based imidazolium salts","authors":"T. Somasekhar, Monisha Javadi, R. Sistla, U. Mallavadhani","doi":"10.17628/ecb.2021.10.67-72","DOIUrl":"https://doi.org/10.17628/ecb.2021.10.67-72","url":null,"abstract":"Ten novel usnic acid based imidazolium salts were synthesized by employing a two-step protocol. The anti-inflammatory potential of the newly synthesised compounds was evaluated in vitro against cytokine proteins TNF- α and IL - 1 β secreted from U937 cells. Some of the imidazolium salts exhibited promising anti-inflammatory activity against the TNF- α and IL - 1β with IC 50 values ranging between 5.3 μM - 7.5 μM, which are many folds lower than that of the parent compound (>100 μM). Most significantly, substitution with electronegative groups in imidazolium salts of usnic acid found to be more potent and exhibiting enhanced anti-inflammatory activity.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67698389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis, characterization and antimicrobial activity of transition metal complexes of 4-[(2-hydroxy-4-methoxyphenyl)methyleneamino]-2,4-dihydro-3H-1,2,4-triazole-3-thione 4-[（2-羟基-4-甲氧基苯基）亚甲基氨基]-2,4-二氢-3H-1,2,4-三唑-3-硫酮过渡金属配合物的合成、表征及抗菌活性
European Chemical Bulletin Pub Date : 2020-12-13 DOI: 10.17628/ecb.2020.9.430-435
S. P. Bhale, A. Yadav, Pintu G. Pathare, S. Tekale, F. P. Franguelli, L. Kótai, R. Pawar
{"title":"Synthesis, characterization and antimicrobial activity of transition metal complexes of 4-[(2-hydroxy-4-methoxyphenyl)methyleneamino]-2,4-dihydro-3H-1,2,4-triazole-3-thione","authors":"S. P. Bhale, A. Yadav, Pintu G. Pathare, S. Tekale, F. P. Franguelli, L. Kótai, R. Pawar","doi":"10.17628/ecb.2020.9.430-435","DOIUrl":"https://doi.org/10.17628/ecb.2020.9.430-435","url":null,"abstract":"A novel nitrogen containing 4-[(2-hydroxy-4-methoxyphenyl)methyleneamino]-2,4-dihydro-3H-1,2,4-triazole-3-thione ligand (H2L) was synthesized by using an equimolar ratio of 4-amino-1,2,4-triazole-3-thione and 2-hydroxy-4-methoxybenzaldehyde. A series of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes was synthesized by using the ligand. The synthesized ligand and transition metal complexes were characterized by IR, 1H NMR, 13C NMR, Mass spectrometry, UV, XRD and TGA investigation methods. Spectral data suggests that the ligand acts as a tridentate SNO donor. Further, the synthesized H2L ligand and their metal complexes were screened for antimicrobial activity. The results of biological activities showed that the metal complexes have higher antifungal as well as antibacterial activity as compared to the parent H2L ligand against the tested microbes.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":"9 1","pages":"430"},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43739831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Leaves peroxidase and esterase isozymes in sunflower crops exposed to saline environment 盐渍环境下向日葵叶片过氧化物酶和酯酶同工酶的研究
European Chemical Bulletin Pub Date : 2020-12-05 DOI: 10.17628/ecb.2020.9.425-429
Chadia Ouazzani, A. Moustaghfir, A. Er-Ramly
{"title":"Leaves peroxidase and esterase isozymes in sunflower crops exposed to saline environment","authors":"Chadia Ouazzani, A. Moustaghfir, A. Er-Ramly","doi":"10.17628/ecb.2020.9.425-429","DOIUrl":"https://doi.org/10.17628/ecb.2020.9.425-429","url":null,"abstract":"Water deficit stress is one of the main problems determining the yield of many crop plants. The study of the effects of salinity on plant growth and development and the search for biochemical stress markers are of great importance in the selection of resistant species. Accumulation and antioxidant activities in response to salinity at different sunflower varieties constitute markers for genetic selection and improvement of plants in the face of tolerance to salinity. Electrophoretic analysis of zymograms of different sunflower varieties grown in a saline environment for 40 days revealed zymograms of peroxidases and esterases specific to varieties tolerant to the saline environment. Peroxidases activity extracted from leaves is augmented in relation to their involvement in the physiological process related to salinity tolerance. In susceptible varieties, peroxidases activity is decreased compared to normal conditions. Variability of activity and polymorphism of isozyme peroxidases and esterases in response to salinity at different sunflower varieties constitute markers for genetic selection and plant improvement in the face of salinity tolerance.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":"9 1","pages":"425"},"PeriodicalIF":0.0,"publicationDate":"2020-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44459075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of acetins from ethyl acetate via transesterification with glycerol using a sulphonic acid type ion-exchange resin 磺酸型离子交换树脂与甘油酯交换合成乙酸乙酯
European Chemical Bulletin Pub Date : 2020-11-29 DOI: 10.17628/ecb.2020.9.420-424
Sravanthi Veluturla, Archna Narula, Kamolpun Sathitsommon, L. V. Anirudh
{"title":"Synthesis of acetins from ethyl acetate via transesterification with glycerol using a sulphonic acid type ion-exchange resin","authors":"Sravanthi Veluturla, Archna Narula, Kamolpun Sathitsommon, L. V. Anirudh","doi":"10.17628/ecb.2020.9.420-424","DOIUrl":"https://doi.org/10.17628/ecb.2020.9.420-424","url":null,"abstract":"Demand for biodiesel has increased over the years as a substitute to petrol and diesel due to its environmental-friendly nature and lower cost. Glycerol being major by-product of the process constitutes 10 wt.% of the products hence conversion of glycerol to value added products such as acetins in the plant reduces the production cost of biodiesel. The present work focuses on the transesterification reaction between glycerol and ethyl acetate over heterogeneous catalyst, Amberlyst-15(wet). The batch studies were carried out and the effect of reaction parameters such as reaction time (1-7 h), glycerol to ethyl acetate molar ratio (1:3-1:12), temperature (50-70 o C), catalyst loading (2-5 w/w%) have been studied. The maximum conversion of glycerol obtained at (G : EA) molar ratio 1:6, reaction temperature of 70 ˚C and 4 w/w% catalyst loading for 7 h was 97.71 % and the selectivity of mono-, di- and triacetins were 36.7, 60.7 and 2.51 %, respectively. This provides an eco-friendly and sustainable path for valorisation of biodiesel derived glycerol.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44932247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Stabilization of dioxochromium(VI) in the complex with tetra[benzo]porphyrazine and two oxo ligands: DFT quantum-chemical consideration 四[苯并]卟啉和两个氧配体配合物中二氧铬(VI)的稳定性:DFT量子化学的考虑
European Chemical Bulletin Pub Date : 2020-11-25 DOI: 10.17628/ecb.2020.9.416-419
O. Mikhailov, D. Chachkov
{"title":"Stabilization of dioxochromium(VI) in the complex with tetra[benzo]porphyrazine and two oxo ligands: DFT quantum-chemical consideration","authors":"O. Mikhailov, D. Chachkov","doi":"10.17628/ecb.2020.9.416-419","DOIUrl":"https://doi.org/10.17628/ecb.2020.9.416-419","url":null,"abstract":"Based on the results of a quantum chemical consideration in the framework of DFT OPBE/TZVP and B3PW91/TZVP methods, the possibility of the self-existence of a chromium heteroligand complex with (NNNN)-donor macrocyclic ligand – tetra[benzo]porphyrazine and two oxo ligands where chromium oxidation degree is (+6), have been shown. The data on the key structural parameters and also, on multiplicity of the ground state of the given macrocyclic metal complex have also been presented.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46507970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synthesis, molecular docking and anti-inflammatory activity 2,4-dimethyl-N-(2-aryl)-3-furamides 2,4-二甲基-N-（2-芳基）-3-呋喃酰胺的合成、分子对接及抗炎活性
European Chemical Bulletin Pub Date : 2020-11-22 DOI: 10.17628/ecb.2020.9.410-415
Y. Matiichuk, Y. Horak, T. Chaban, V. Ogurtsov, L. Kostyshyn, V. Matiychuk
{"title":"Synthesis, molecular docking and anti-inflammatory activity 2,4-dimethyl-N-(2-aryl)-3-furamides","authors":"Y. Matiichuk, Y. Horak, T. Chaban, V. Ogurtsov, L. Kostyshyn, V. Matiychuk","doi":"10.17628/ecb.2020.9.410-415","DOIUrl":"https://doi.org/10.17628/ecb.2020.9.410-415","url":null,"abstract":"2,4-Dimethyl-N-aryl-3-furamides were synthesized by the reaction of 2,4-dimethyl-furan-3-carbonyl chloride with aromatic amines in dry dioxane in the presence of triethylamine. The structures of the obtained substances were confirmed by 1H NMR spectroscopy and elemental analysis. The synthesized compounds were preselected via molecular docking to be tested for their anti-inflammatory activity. The anti-inflammatory effect of the prepared compounds was investigated applying the carrageenan-induced paw edema model. The results have shown that the some novel furamides demonstrated considerable anti-inflammatory effect.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":"9 1","pages":"410"},"PeriodicalIF":0.0,"publicationDate":"2020-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46156662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, thermal stability and kinetic studies of copper(II) and cobalt(II) complexes derived from 4-aminobenzohydrazide and 2-mercaptobenzothiazole 4-氨基苯甲酰肼和2-巯基苯并噻唑铜（II）和钴（II）配合物的合成、热稳定性和动力学研究
European Chemical Bulletin Pub Date : 2020-11-11 DOI: 10.17628/ecb.2020.9.403-409
Maged S. Al-Fakeh
{"title":"Synthesis, thermal stability and kinetic studies of copper(II) and cobalt(II) complexes derived from 4-aminobenzohydrazide and 2-mercaptobenzothiazole","authors":"Maged S. Al-Fakeh","doi":"10.17628/ecb.2020.9.403-409","DOIUrl":"https://doi.org/10.17628/ecb.2020.9.403-409","url":null,"abstract":"The divalent transition metal ions Cu (II) and Co (II) compounds of the formula; [ M(ABZH)(MBTH)Cl 2 (H 2 O) 2 ], (M = Cu (II) and Co (ІІ), ABZH=4-Aminobenzohydrazide (L1) and MBTH = 2-mercaptobenzthiazole (L2) have been synthesized and characterized. The two compounds has been designated based on elemental analysis, electronic spectral analysis, FT-IR , magnetic measurements and XRD. The thermal properties of copper(II) and cobalt(II) metal compounds in dynamic air have been analyzed via thermogravimetry(TG), and differential thermogravimetry(DTG). The kinetic analyses of the thermal decomposition for the two compounds were calculated by the Coats.Redfern and Horowitz.Metzger methods. The obtained kinetic parameters, display the kinetic compensation effect(KCE).","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":"9 1","pages":"403-409"},"PeriodicalIF":0.0,"publicationDate":"2020-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49232827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Development of promising cathode materials based on modified spinels for Li-Ion batteries 基于改性尖晶石的锂离子电池正极材料研究进展
European Chemical Bulletin Pub Date : 2020-11-04 DOI: 10.17628/ecb.2020.9.401-402
E. Kachibaia, T. Paikidze, R. Imnadze, Shukri S. Japaridze
{"title":"Development of promising cathode materials based on modified spinels for Li-Ion batteries","authors":"E. Kachibaia, T. Paikidze, R. Imnadze, Shukri S. Japaridze","doi":"10.17628/ecb.2020.9.401-402","DOIUrl":"https://doi.org/10.17628/ecb.2020.9.401-402","url":null,"abstract":"Lithium rich compounds represent a promising cathode material of Li-ion accumulators due to their valuable electrochemical properties and represent cathode material of the next generation high-performance lithium-ion batteries.2,3 These compounds are of great interest mostly because of the high capacity exceeding 250 mAh g-1. However, a number of disadvantages, such as voltage drop caused by unwanted phase transformations during cycling, as well as low operational performances still limit their application. Improved cycling stability can be achieved by cathode materials doping (modification). Regarding costs and raw materials, Fe-Mn-based systems are economically attractive cathodes for LIB containing Fe as a cheap promising alternative to commercial LiCoO2 and LiMn2O4.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":"9 1","pages":"401"},"PeriodicalIF":0.0,"publicationDate":"2020-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42343682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds 以色列和巴勒斯坦苋科植物:药用活性和独特化合物
European Chemical Bulletin Pub Date : 2020-10-31 DOI: 10.17628/ecb.2020.9.366-400
A. Azab
{"title":"Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds","authors":"A. Azab","doi":"10.17628/ecb.2020.9.366-400","DOIUrl":"https://doi.org/10.17628/ecb.2020.9.366-400","url":null,"abstract":"Amaranthaceae family is one of the largest and most diverse in the plant kingdom. While some of the plants of this family have important nutritional value, others are considered toxic and/or hazardous weeds and many efforts have been made in controlling them. But both categories were used by humans for traditional medicinal purposes, and some of them were extensively studied by modern science. In this review article, we will present some ethnomedicinal uses of the plants of this family, along with comprehensive literature survey of medicinal, biological and other activities. Information will be presented in tables for the convenience of readers, and many structures of natural products are presented. The extensive discussion section will focus mainly (but not only) on studies of active compounds production. This review article is about plants of this family in general and in particular about Amaranthaceae plants of our region. Conclusions and future research recommendations are also presented.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":"9 1","pages":"366"},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42492319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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