Synthesis of 5-substituted-1,3,4-oxadiazole clubbed pyrazole and dihydropyrimidine derivatives as potent bioactive agents

A series of 4-fluorophenylpyrazole clubbed 1,3,4-oxadiazole and 3,4-dihydropyrimidin-2(1 H )-ones were prepared by cyclization of Biginelli-type adducts. Structures were assigned on the basis of known spectral techniques. All the scaffolds were evaluated for in vitro antimicrobial activity by broth micro dilution bioassay method and in vitro antitubercular property by microplate alamar blue assay method. Compounds 3j and 3l containing -OH and -CH 3 groups were act as potent antimicrobials and antitubercular candidates with relatively low cytotoxicity on VERO cells.