Environmental analysis, health and toxicology最新文献

{"title":"Ecological pollution and health risk monitoring assessment of polycyclic aromatic hydrocarbons and heavy metals in surface water, southeastern Nigeria.","authors":"Chisom Theresa Umeh, John Kanayochukwu Nduka, Daniel Omeodisemi Omokpariola, Joy Ebele Morah, Ebuka Chidiebere Mmaduakor, Nkechi Helen Okoye, Ekene-Echerebo Ifeoma Lilian, Ifeanyi Favor Kalu","doi":"10.5620/eaht.2023007","DOIUrl":"10.5620/eaht.2023007","url":null,"abstract":"<p><p>Polycyclic aromatic hydrocarbons (PAHs) and heavy metals (HMs) are predominant pollutants linked with anthropogenic activities across a host of environmental mediums. The level of pollution, ecological and health risk were assessed in surface water from Ekulu in Enugu metropolis, Nigeria for 17 PAHs and selected HMs (As, Cd, Cr, Cu, Pb, Ni, Zn) components. PAHs and HMs were determined using a gas chromatography-flame ionization detector (GC-FID) and atomic adsorption spectrophotometer (AAS). The total PAHs in station A (3.17mg/l), B (1.51mg/l), and C (1.83mg/l) were due to high molecular weight (HMW) PAHs than low molecular weight (HMW) PAHs. HMs contents were within USEPA and WHO minimum contamination levels (MCL) except Cr and Pb. The molecular diagnostics of PAHs showed that incomplete combustion of carbonaceous compounds was dominant, while petrogenic was insignificant across all samples. The ecological indices of PAHs and HMs varied from medium to high pollution due to anthropogenic activities that pose a threat to the ecosystem. The non-carcinogenic models showed that hazard index (HI) ranged from PAHs (0.027 - 0.083) and HMs (0.0067 - 0.087) which is less than unity implying no adverse health issues. The lifetime cancer risk (LCR) for PAHs (4.21×10-4 - 9.61×10-4) and HMs (1.72×10-5 - 3.98×10-5) suggested significant cancer risk is possible over some time for a population of 1 in 10,000 and 100,000 for both PAHs and HMs exposure for 70 years. Therefore, there is an urgent need for proper pollution control and mitigation plan to preserve both age groups from being continuously exposed to anthropogenic activities in the Ekulu River and further study should be carried out to monitor the available toxicants.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9734170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial neural network machine learning prediction of the smoking behavior and health risks perception of Indonesian health professionals.","authors":"Desy Nuryunarsih,&nbsp;Okatiranti Okatiranti,&nbsp;Lucky Herawati","doi":"10.5620/eaht.2023003","DOIUrl":"https://doi.org/10.5620/eaht.2023003","url":null,"abstract":"<p><p>Health professionals (HPs) can play an important role in influencing the smoking behavior of their patients and the implementation of smoke-free workplace policies. In some countries physicians and dentists may not have a no-smoking policy in place. Breathing in other people's tobacco smoke (second-hand smokers) increase the risk of smoking related diseases. Environmental Tobacco smoke ETS causes a similar range of diseases to active smoking, including various cancers, heart disease, stroke, and respiratory diseases. Little is known about the smoking-related attitudes and clinical practices of HPs in Indonesia. Evidence suggests that high smoking rates remain among male HPs; however, the risk perceptions and attitudes to smoking among Indonesian HPs have not been investigated using prediction model artificial neural networks. For this reason, we developed and validated an artificial neural network (ANN) to identify HPs with smoking behavior. The study population consisted of 240 HPs, including 108 (45%) physicians, and 132 (55%) dentists, with more female (n=159) than male participants (n=81) for both professions. Participants were randomly divided into two sets, the training (192) and test (48) sets. The input variables included gender, profession (doctor or dentist), knowledge regarding smoking-related diseases and awareness of smoking provided to their patients, smoke-free policy in place at their workplace, and smoking status. ANN was constructed with data from the training and selection sets and validated in the test set. The performance of ANN was simultaneously evaluated by discrimination and calibration. After the training, we completed the process using the test dataset with a multilayer perceptron network, determined by 36 input variables. Our results suggested that our final ANN concurrently had good precision (89%), accuracy (81%), sensitivity (85%), and area under the curve (AUC; 70%). ANN can be used as a promising tool for the prediction of smoking status based on health risk perceptions of HPs in Indonesia.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/9b/eaht-38-1-e2023003.PMC10195675.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9495235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary characterization and probabilistic risk assessment of microplastics and potentially toxic elements (PTEs) in garri (cassava flake), a common staple food consumed in West Africa.","authors":"Christian Ebere Enyoh,&nbsp;Qingyue Wang,&nbsp;Mominul Haque Rabin,&nbsp;Rasheed Oluwafemi Bakare,&nbsp;Joseph Longji Dadiel,&nbsp;Wu Shangrong,&nbsp;Senlin Lu,&nbsp;Ifenna Ilechukwu","doi":"10.5620/eaht.2023005","DOIUrl":"https://doi.org/10.5620/eaht.2023005","url":null,"abstract":"<p><p>Garri from cassava is one of the most consumed foods in West Africa, hence this research was conducted to examine microplastics (MPs) and potentially toxic elements (PTEs) in garri from Nigeria (West Africa) and Japan. This is the first investigation on MPs in garri samples that has been reported in the literature. The study analyzed both packaged and unpackaged vended garri samples using microscopic/spectroscopic and X-ray fluorescence techniques for MPs and PTEs respectively. Microplastic particles in the garri samples ranged from (or were between) 2.00±2.00 - 175.00±25.16 particles/50 with &gt; 90 % as fragments and consisted of polyacrylamide, polyethylene terepthalate, polyvinyl alcohol, high density polyethylene, polyvinyl chloride acrylonitrile, polyethylene chlorinated, polypropylene with silicate mix, polychloroprene and polyethylene chlorosulphonated. The mean concentration of PTEs raged from ND to 0.07 mg/g for Cr and Mn, 0.73 to 5.63 mg/g for Fe, ND to 0.57mg/g for Co, 0.23 to 1.21 mg/g for Ni, 0.15 to 1.53 mg/g for Cu, and 0.12 to 0.63 mg/g for Zn. However, their daily intake was low for both adult and children as with the MPs. The sources of MPs and PTEs were mainly from the garri production processes, atmospheric dusts and during packaging. The non-carcinogenic risk for all samples was low for MPs while in openly vended garri, Ni and Cr in all sample poses carcinogenic risks. There is a need to improve indigenous garri processing techniques to minimize contamination. This research emphasizes the critical necessity to understand the consequences of MPs on human health.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/17/eaht-38-1-e2023005.PMC10195672.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9495238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mixture effect of propyl paraben and bisphenol A on the uterotrophic response in the ovariectomized rats after oral administration.","authors":"Juyoung Park,&nbsp;Handule Lee,&nbsp;Dal-Woong Choi,&nbsp;Kwangsik Park","doi":"10.5620/eaht.2023006","DOIUrl":"https://doi.org/10.5620/eaht.2023006","url":null,"abstract":"<p><p>Recent studies reported bisphenol A (BPA) and propyl paraben (PrP) are found in human urine, blood, and breast milk samples as well as in food, packaging, socks, and clothes. This means that the two chemicals co-exist in consumer products, and humans are exposed simultaneously to the mixture chemicals. However, the studies on the mixture effects of the two chemicals on human health are not enough. This study was designed to elucidate the effects of orally administered PrP, BPA, and their mixture effects on the uterotrophic response using ovariectomized rats. In addition, the correlation between the uterotrophic response and tissue concentrations of the two chemicals was studied to investigate whether one chemical has any effect on the absorption, distribution, or excretion of the other chemical. Histopathology, hematology, and plasma biochemistry analysis were also performed to evaluate the chemicals' toxicological effects in the treated rats. Although a significant increase in uterus weight (absolute and relative) was observed in the positive chemical (17β-estradiol) treated group, there were no statistical differences in the uterus weight between the vehicle control and the chemical-treated groups. However, a slight increase in the endometrial glands and a change in the cuboidal to columnar epithelium of the endometrial epithelium were observed in the mixture-treated group. There was no significant toxicity in all treated groups by the hematology and plasma biochemistry analysis results. The results of tissue distribution showed that BPA was mostly detected in the liver while PrP was not detected in most tissues, and the BPA level was higher when the rats were treated with PrP than without PrP, suggesting that PrP may increase the absorption of BPA after oral administration.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/2c/eaht-38-1-e2023006.PMC10195673.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9495236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early immune response of neuronal cells (U87) to heavy metal Cd or Pb exposure.","authors":"Eun Ju Oh,&nbsp;Jae-Sik Jeon,&nbsp;Qian-Wen Wang,&nbsp;Jae Kyung Kim","doi":"10.5620/eaht.2023004","DOIUrl":"https://doi.org/10.5620/eaht.2023004","url":null,"abstract":"<p><p>Heavy metals such as lead (Pb) and cadmium (Cd) exist as particulate matter (PM) in the air and can cause biological damage to cells, animals, and humans. However, the mechanism underlying the toxic effects of heavy metals on nerve cells has not yet been completely identified. Glioma is the most common and fatal tumor in the central nervous system; the U87 human glioblastoma cell line is commonly used when researching brain cancer, including aggressive malignant gliomas. Therefore, in this study, cell viability, cytotoxicity, and interleukin-6 (IL-6) levels were analyzed to confirm the effect of Cd and Pb exposure on U87 cells. On confirming the absence of significant effects on cell viability at low concentrations of heavy metals, Cd and Pb exposure had no effect on lactic acid dehydrogenase (LDH) activity at the concentrations (1 μg/L, 30 μg/L, and 1 mg/L) used in this study, and there was a remarkable effect of Cd and Pb exposure on the inflammatory response of these cells. Our findings provide a basis for future research elucidating the effects of heavy metal exposure on cellular pathology. Systematic studies with higher heavy metal concentrations and precision are warranted to deepen our understanding of the relationship between heavy metal exposure and neuronal responses.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/98/eaht-38-1-e2023004.PMC10195674.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9495237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating potential public health risks and challenges from hazardous materials contained in electronic waste items in a developing country setting.","authors":"Onyenekenwa C Eneh,&nbsp;Chinemelum A Eneh,&nbsp;Cosmas I Eneonwo,&nbsp;Andy Okosun,&nbsp;Vera Emenuga,&nbsp;Nicholas I Obi,&nbsp;Idu R Egbenta,&nbsp;Martin C Oloto,&nbsp;Obinna Ubani,&nbsp;Peter A Akah","doi":"10.5620/eaht.2023001","DOIUrl":"https://doi.org/10.5620/eaht.2023001","url":null,"abstract":"<p><p>Sustainable Development Goals (SDGs) Targets 12.4 and 3.9 aim to reduce deaths and illnesses from hazardous chemicals and to achieve environmentally friendly management of chemical and wastes. Electronic wastes, which contain hazardous chemicals, are rapidly generated in poor countries due to demand for affordable near-end-of-life internet-enabled gadgets that soon wear out and are improperly disposed due to ignorance, throw-away mentality and dearth of waste management infrastructure. This study identified hazardous chemicals contained in significant quantities in e-waste items, described their public health challenges and suggested mitigation measures. Results showed that mercury, polychlorinated biphenyls (PCBs), cadmium, lead and beryllium oxide were hazardous chemicals contained in significant quantities in e-waste items. The study recommended the formulation of appropriate environmental health education technology policy (AEHETP) to guide stakeholders to design education, preventive, therapeutic and decontamination plans for awareness creation and raising to address the toxic effects of e-waste items on users in poor countries.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/45/86/eaht-38-1-e2023001.PMC10195677.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9488087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic hepatitis after exposure to humidifier disinfectant: A case series report.","authors":"Hyung Doo Kim,&nbsp;Hwan-Cheol Kim,&nbsp;Jong-Han Leem","doi":"10.5620/eaht.2023002","DOIUrl":"https://doi.org/10.5620/eaht.2023002","url":null,"abstract":"<p><p>Health damage from humidifier disinfectants is an unprecedented environmental health disaster. Humidifier disinfectants were used broadly in Korea from 1994 to 2011. Most studies have focused on respiratory problems because of the exposure route and primary respiratory symptoms. This overlooks the previous research results that humidifier disinfectants could move to extrapulmonary organs and induce toxic effects. Thus, the objective of this study was to examine toxic hepatitis cases developed after inhaling humidifier disinfectant. We focused on the indications of toxic hepatitis in two pediatric cases and one female adult case. All patients were exposed to humidifier disinfectants in a residential space. These disinfectants all contained polyhexamethylene guanidine (PHMG). Rapid increases in blood hepatic enzyme levels were seen. Two patients were discharged after treatment. Death occurred in one patient who was diagnosed with fulminant hepatitis of unknown cause. This human case series study supports prior knowledge that hepatotoxicity can occur by inhaling humidifier disinfectant.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/96/eaht-38-1-e2023002.PMC10195676.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9488088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of veterinary antibiotics in poultry manure from two farms in Ibadan, Nigeria: Ecotoxicological implications in manure-amended soil.","authors":"Akinranti Ajibola,&nbsp;Damilola Olatunji,&nbsp;Olalekan Bayode","doi":"10.5620/eaht.2022038","DOIUrl":"https://doi.org/10.5620/eaht.2022038","url":null,"abstract":"<p><p>Veterinary antibiotics are commonly used in poultry farming for preventing diseases and promoting growth. As a result of their incomplete metabolism in poultry birds, veterinary antibiotics are usually excreted and are frequently detected in poultry manures. Veterinary antibiotics in poultry manure applied onto soil may pose serious ecological effect to the terrestrial and aquatic environment. In the present work, the occurrence of three veterinary antibiotics (sulfamethoxazole, sulfadimidine and trimethoprim), categorized as veterinary antimicrobial agents of critical importance, was investigated in poultry manure from two poultry farms in Nigeria. The potential ecotoxicological risk of target veterinary antibiotics in poultry manure-amended soil was also assessed. A modified quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction was adopted for the extraction of target veterinary antibiotics and instrumental analysis was achieved by high performance liquid chromatography. Sulfamethoxazole, sulfadimidine and trimethoprim were quantified in poultry manures from the poultry farms up to 12.7 μg g-1, 16.1 μg g-1 and 33.8 μg g-1, respectively. Sulfamethoxazole and trimethoprim in poultry manure-amended soil presented low risk to Eisenia fetida (earthworm). The ecological effect of sulfamethoxazole for the root length of rice was high in Farm B and medium in Farm A. Sulfamethoxazole presented high risk to aquatic organisms while sulfadimidine and trimethoprim posed medium risk and low risk, respectively to aquatic organisms. The results indicated that residual veterinary antibiotics in poultry manures could have adverse effects on crops after application to agricultural soil. There is a need for effective enlightenment programs for poultry farmers in Nigeria to bring about awareness on the environmental and toxicological impact of the excessive and uncontrolled use of veterinary antibiotics in poultry farming and the adverse ecological implications of poultry manure application on farmlands.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/67/b9/eaht-37-4-e2022038.PMC10014739.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9119364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Andrographis paniculata protects against brain hippocampus and cerebellum from mercury chloride induced damage by attenuating oxidative stress.","authors":"Eduitem Sunday Otong,&nbsp;Wusa Makena,&nbsp;Abel Yashim Solomon,&nbsp;Sebastine Anthony Bazabang,&nbsp;Aisha Aminu,&nbsp;Rachael Henry","doi":"10.5620/eaht.2022027","DOIUrl":"https://doi.org/10.5620/eaht.2022027","url":null,"abstract":"<p><p>Mercury chloride (HgCl2) is a neurotoxicant that remains a health hazard despite numerous efforts to reduce its levels in the environment. The use of medicinal plants in treating various diseases and other toxic agents has grown popular owing to their effectiveness and affordable rates. Andrographis paniculata (A. paniculata) is a plant with astringent and detoxifying characteristics and is widely used worldwide for its medicinal and antioxidant benefits. This study aimed to investigate the possible protective effects of A. paniculata aqueous extract against HgCl2-induced memory impairment, oxidative stress, and brain damage. Twenty-five adult Wistar rats were randomly divided into five groups: control, HgCl2 0.5 mg/kg, HgCl2+AP 250 mg/kg, HgCl2+AP 500 mg/kg, or HgCl2+Ascorbic acid 200 mg/kg. For 28 days, administrations were given through oral gavage once a day. HgCl2 injection resulted in memory impairment, increased glutamate concentrations in the brain, and the production of oxidative stress. Memory impairment was prevented in A. paniculata-treated groups by balancing the levels of AChE and dopamine activities, which then lowered glutamate concentration, avoided oxidative stress, and improved histopathological alterations in the brain. A. paniculata alleviated HgCl2-induced memory impairment in Wistar rats by increasing the memory index, regulating neurotransmitter levels, and reducing oxidative stress.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/1d/eaht-37-4-e2022027.PMC10014741.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9119367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissues toxicity attenuation by vitamin E on oxidative damage induced by diazinon.","authors":"Kavoos Tahmasebi,&nbsp;Mahvash Jafari,&nbsp;Javad Heydari,&nbsp;Alireza Asgari,&nbsp;Maryam Salehi,&nbsp;Saeed Khazaie,&nbsp;Mohammad Saleh Abedini","doi":"10.5620/eaht.2022036","DOIUrl":"https://doi.org/10.5620/eaht.2022036","url":null,"abstract":"<p><p>Organophosphorus insecticides such as diazinon (DZN) are used worldwide in industry, veterinary practice, and agriculture. They may induce oxidative stress in different tissues. The use of antioxidants can protect tissues against oxidative stress. The aim of this study was to investigate the prophylactic and therapeutic roles of vitamin E against DZN-induced oxidative damage and biochemical alterations in various tissues of male Wistar rats. Thirty rats were divided into five groups: Control group received only corn oil as DZN solvent, DZN group received 100 mg/kg of DZN, E group received 150 mg/kg of vitamin E, E-DZN group received vitamin E and then dosed with DZN and DZN-E group received DZN and then dosed with vitamin E. All injections were carried out intraperitoneally. Plasma and various tissues were prepared and evaluated. Results showed that acute administration of DZN caused a significant induction of oxidative damage in the tested tissues via increased malondialdehyde level and some plasma biochemical indices, depletion of glutathione (GSH), reduced cholinesterase activity and change in the activities of superoxide dismutase, catalase and glutathione-S transferase. Treatment of rats with vitamin E resulted in an elevation in the level of GSH, normalizing the antioxidant enzymes activities and decreasing lipid peroxidation, although all these tests did not return to the normal level in certain tissues. The findings of this study suggest that both prophylactic and therapeutic treatments of rats with vitamin E provide a protective role against DZN-induced oxidative stress and cholinergic hyperactivity through free radicals scavenging and membrane stabilizing.</p>","PeriodicalId":11867,"journal":{"name":"Environmental analysis, health and toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/db/eaht-37-4-e2022036.PMC10014748.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9121017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}